WO1994007523A1 - Antimicrobial peptides - Google Patents

Antimicrobial peptides Download PDF

Info

Publication number
WO1994007523A1
WO1994007523A1 PCT/US1993/009414 US9309414W WO9407523A1 WO 1994007523 A1 WO1994007523 A1 WO 1994007523A1 US 9309414 W US9309414 W US 9309414W WO 9407523 A1 WO9407523 A1 WO 9407523A1
Authority
WO
WIPO (PCT)
Prior art keywords
seq
peptides
antimicrobial
arg
oligopeptide
Prior art date
Application number
PCT/US1993/009414
Other languages
English (en)
French (fr)
Inventor
William Shafer
Jan Pohl
Original Assignee
Emory University
University Of Georgia Research Foundation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University, University Of Georgia Research Foundation, Inc. filed Critical Emory University
Priority to AT93923208T priority Critical patent/ATE217885T1/de
Priority to EP93923208A priority patent/EP0665754B1/de
Priority to JP6509361A priority patent/JPH08502262A/ja
Priority to CA002145313A priority patent/CA2145313C/en
Priority to DE69331953T priority patent/DE69331953D1/de
Publication of WO1994007523A1 publication Critical patent/WO1994007523A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
PCT/US1993/009414 1992-10-02 1993-10-01 Antimicrobial peptides WO1994007523A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT93923208T ATE217885T1 (de) 1992-10-02 1993-10-01 Antimikrobielle polypeptide
EP93923208A EP0665754B1 (de) 1992-10-02 1993-10-01 Antimikrobielle polypeptide
JP6509361A JPH08502262A (ja) 1992-10-02 1993-10-01 抗微生物性ペプチド
CA002145313A CA2145313C (en) 1992-10-02 1993-10-01 Antimicrobial peptides
DE69331953T DE69331953D1 (de) 1992-10-02 1993-10-01 Antimikrobielle polypeptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/956,848 US5447914A (en) 1990-06-21 1992-10-02 Antimicrobial peptides
US07/956,848 1992-10-02

Publications (1)

Publication Number Publication Date
WO1994007523A1 true WO1994007523A1 (en) 1994-04-14

Family

ID=25498768

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/009414 WO1994007523A1 (en) 1992-10-02 1993-10-01 Antimicrobial peptides

Country Status (7)

Country Link
US (2) US5447914A (de)
EP (1) EP0665754B1 (de)
JP (1) JPH08502262A (de)
AT (1) ATE217885T1 (de)
CA (1) CA2145313C (de)
DE (1) DE69331953D1 (de)
WO (1) WO1994007523A1 (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858758A (en) * 1997-05-07 1999-01-12 Incyte Pharmaceuticals, Inc. Human serine protease precursor
WO2000069890A1 (en) * 1999-05-17 2000-11-23 Stroemberg Nicklas Prevention of dental caries
WO2002040536A2 (en) * 2000-11-15 2002-05-23 Emory University Acylated antimicrobial peptides
CN115028704A (zh) * 2022-03-16 2022-09-09 东北农业大学 一种抗酶解抗菌肽n1及其制备方法和应用

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627262A (en) * 1989-07-05 1997-05-06 The Board Of Regents Of The University Of Oklahoma Method and composition for the treatment of septic shock
US5885965A (en) * 1991-11-01 1999-03-23 Periodontix, Inc. Anti-fungal D-amino acid histatin-based peptides
US5646119A (en) * 1991-11-01 1997-07-08 Periodontix, Inc. D-amino acid histatin-based peptides as anti-fungal and anti-bacterial agents
US6653442B1 (en) 1993-07-20 2003-11-25 Intrabiotics Pharmaceuticals, Inc. Protegrins
US6159936A (en) * 1993-07-20 2000-12-12 The Regents Of The University Of California Compositions and methods for treating and preventing microbial and viral infections
US5804558A (en) * 1993-07-20 1998-09-08 University Of California Protegrins
JPH09508359A (ja) * 1994-01-14 1997-08-26 ゾーマ コーポレイション 抗グラム陽性細菌学的方法および物質
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
AU6682796A (en) * 1995-07-21 1997-02-18 New York University Type ii phospholipase a2 and its use in killing gram-positive bacteria
US5688489A (en) * 1995-09-15 1997-11-18 Resolution Pharmaceuticals, Inc. Non-receptor mediated imaging agents
US5994306A (en) * 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins
US5916872A (en) * 1996-07-24 1999-06-29 Intrabiotics Pharmaceuticals, Inc. Cyclic peptides having broad spectrum antimicrobial activity
US5962733A (en) * 1996-09-25 1999-10-05 Vets Plus, Inc. Glutamine containing electrolyte solution for calf scours
SE9604593D0 (sv) * 1996-12-13 1996-12-13 Sbl Vaccin Ab Antimicrobially active polypeptides
US6300318B1 (en) * 1997-09-16 2001-10-09 Peter E. Nielsen Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor
WO1999064439A2 (en) * 1998-06-12 1999-12-16 Case Western Reserve University Methods for increasing cationic antimicrobial peptides
US6592814B2 (en) 1998-10-02 2003-07-15 Johnson & Johnson Vision Care, Inc. Biomedical devices with antimicrobial coatings
US6107460A (en) 1999-03-01 2000-08-22 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use thereof
FR2804326B1 (fr) * 2000-01-27 2002-10-18 Ellipse Pharmaceuticals Procede de sterilisation par traitement sous hautes pressions de principes actifs sensibles
US6482396B1 (en) 2001-05-15 2002-11-19 Campina Melkunie B.V. Methods for treating or preventing diseases of the oral cavity
US7550558B2 (en) * 2001-06-01 2009-06-23 Fundacao De Ampara A Pesquiso Do Estado De Sao Paolo (Fapesp) Antimicrobial peptides and methods for identifying and using such peptides
US7033769B2 (en) 2002-05-23 2006-04-25 The United States Of America As Represented By The Secretary Of The Army Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
US20060258596A1 (en) * 2003-02-14 2006-11-16 Walsh Timothy R Antimicrobial agents
US7576060B2 (en) * 2003-11-07 2009-08-18 The Trustees Of The University Of Pennsylvania Inhibition of adhesion and migration of an endothelial cell to fibronectin by neutrophil alpha-defensins
US7243909B2 (en) * 2004-12-10 2007-07-17 Koplin Edward C Collector sump cooling tower
WO2006065977A2 (en) 2004-12-15 2006-06-22 The Regents Of The University Of Colorado Antimicrobial peptides and methods of use
US8017337B2 (en) * 2007-04-19 2011-09-13 Molecular Detection, Inc. Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria
WO2010042534A1 (en) * 2008-10-06 2010-04-15 The Regents Of The University Of Colorado, A Body Corporate Peptides and methods of use
GB0821687D0 (en) 2008-11-28 2008-12-31 Secr Defence Peptides
GB0821707D0 (en) * 2008-11-28 2008-12-31 Secr Defence Peptides
EP2437770A4 (de) * 2009-06-05 2013-11-06 Univ Colorado Regents Antimikrobielle peptide
EP3384938A1 (de) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Manipulierte nukleinsäuren und verfahren zur verwendung davon
AU2013243949A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
AU2013243948A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
EP3374391B1 (de) 2015-11-10 2024-04-17 Visterra, Inc. Antikörpermolekülarzneimittelkonjugate die an lipopolysaccharide binden und verwendungen davon
US11890319B2 (en) 2017-01-18 2024-02-06 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
CN109232717B (zh) * 2018-08-31 2021-08-20 东北农业大学 一种针对革兰氏阴性菌靶向抗菌肽及制作方法与应用
CN111533787B (zh) * 2020-03-30 2022-02-08 东北农业大学 一种线性抗菌肽及其制备方法和应用
EP4126064A1 (de) 2020-04-03 2023-02-08 Visterra, Inc. Antikörpermolekül-wirkstoff-konjugate und verwendungen davon
CN114149483B (zh) * 2021-05-28 2023-05-30 中国科学院大连化学物理研究所 一种抗菌肽组合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725576A (en) * 1983-12-29 1988-02-16 Research Foundation Of State University Of New York Fungicidal polypeptide compositions containing L-histidine and methods for use therefore
AU8228591A (en) * 1990-06-21 1992-01-07 Emory University Antimicrobial peptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Biochemistry, Vol. 26, No. 8, issued 1987, "Molecular Cloning of Human Cathepsin G: Structural Similarity to Mast Cell and Cytotoxic T Lymphocyte Proteinases", pages 2289-93, see entire document. *
Proc. Natl. Acad. Sci. USA, Vol. 84, issued April 1987, SINHA et al., "Primary Structure of Human Neutrophil Elastase", pages 2228-32, see entire document. *
Proc. Natl. Acad. Sci., USA, Vol. 86, issued July 1989, GABAY et al., "Antibiotic Protein of Human Polymorphonuclear Leukocytes", pages 5610-14, see entire document. *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858758A (en) * 1997-05-07 1999-01-12 Incyte Pharmaceuticals, Inc. Human serine protease precursor
WO2000069890A1 (en) * 1999-05-17 2000-11-23 Stroemberg Nicklas Prevention of dental caries
US6974859B1 (en) 1999-05-17 2005-12-13 Nicklas Stromberg Prevention of dental caries
WO2002040536A2 (en) * 2000-11-15 2002-05-23 Emory University Acylated antimicrobial peptides
WO2002040536A3 (en) * 2000-11-15 2002-11-21 Univ Emory Acylated antimicrobial peptides
CN115028704A (zh) * 2022-03-16 2022-09-09 东北农业大学 一种抗酶解抗菌肽n1及其制备方法和应用
CN115028704B (zh) * 2022-03-16 2023-07-07 东北农业大学 一种抗酶解抗菌肽n1及其制备方法和应用

Also Published As

Publication number Publication date
CA2145313A1 (en) 1994-04-14
EP0665754A4 (de) 1996-06-12
DE69331953D1 (de) 2002-06-27
CA2145313C (en) 1999-09-21
ATE217885T1 (de) 2002-06-15
US5798336A (en) 1998-08-25
JPH08502262A (ja) 1996-03-12
EP0665754B1 (de) 2002-05-22
EP0665754A1 (de) 1995-08-09
US5447914A (en) 1995-09-05

Similar Documents

Publication Publication Date Title
CA2145313C (en) Antimicrobial peptides
AU711526B2 (en) Anti-fungal D-amino acid histatin-based peptides
CA2223505C (en) Anti-fungal and anti-bacterial histatin-based peptides
EP0750506B1 (de) Antimikrobielle zubereitungen mit breitem spektrum und verfahren zu ihrer nutzung
US5912230A (en) Anti-fungal and anti-bacterial histatin-based peptides
EP0689550B1 (de) Antimikrobielles peptid aus rinderneutrophilen
EP1853620A2 (de) Antimikrobielle hexapeptide
WO1992001462A1 (en) Amphiphilic peptide compositions and analogues thereof
EP0846128A2 (de) Antimikrobielle kationische peptide und methoden zu ihrer identifizierung
US5885965A (en) Anti-fungal D-amino acid histatin-based peptides
Shafer et al. Tailoring an antibacterial peptide of human lysosomal cathepsin G to enhance its broad-spectrum action against antibiotic-resistant bacterial pathogens
Shafer et al. Synthetic peptides of human lysosomal cathepsin G with potent antipseudomonal activity
CA2285673C (en) Cyclic analogs of histatins
WO1991019512A1 (en) Antimicrobial peptides
JP2002508390A (ja) 抗真菌および抗細菌ペプチド
WO2002040536A2 (en) Acylated antimicrobial peptides
US6444645B1 (en) Crosslink-stabilized indolicidin analogs
WO1995013822A1 (en) Modified arginine-containing lytic peptides and method of making the same by glyoxylation

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2145313

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1993923208

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1993923208

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1993923208

Country of ref document: EP