DE69331953D1 - Antimikrobielle polypeptide - Google Patents

Antimikrobielle polypeptide

Info

Publication number
DE69331953D1
DE69331953D1 DE69331953T DE69331953T DE69331953D1 DE 69331953 D1 DE69331953 D1 DE 69331953D1 DE 69331953 T DE69331953 T DE 69331953T DE 69331953 T DE69331953 T DE 69331953T DE 69331953 D1 DE69331953 D1 DE 69331953D1
Authority
DE
Germany
Prior art keywords
seq
gram
peptides
strains
negative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69331953T
Other languages
English (en)
Inventor
William Shafer
Jan Pohl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
University of Georgia Research Foundation Inc UGARF
Original Assignee
Emory University
University of Georgia Research Foundation Inc UGARF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University, University of Georgia Research Foundation Inc UGARF filed Critical Emory University
Application granted granted Critical
Publication of DE69331953D1 publication Critical patent/DE69331953D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DE69331953T 1992-10-02 1993-10-01 Antimikrobielle polypeptide Expired - Lifetime DE69331953D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/956,848 US5447914A (en) 1990-06-21 1992-10-02 Antimicrobial peptides
PCT/US1993/009414 WO1994007523A1 (en) 1992-10-02 1993-10-01 Antimicrobial peptides

Publications (1)

Publication Number Publication Date
DE69331953D1 true DE69331953D1 (de) 2002-06-27

Family

ID=25498768

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69331953T Expired - Lifetime DE69331953D1 (de) 1992-10-02 1993-10-01 Antimikrobielle polypeptide

Country Status (7)

Country Link
US (2) US5447914A (de)
EP (1) EP0665754B1 (de)
JP (1) JPH08502262A (de)
AT (1) ATE217885T1 (de)
CA (1) CA2145313C (de)
DE (1) DE69331953D1 (de)
WO (1) WO1994007523A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627262A (en) * 1989-07-05 1997-05-06 The Board Of Regents Of The University Of Oklahoma Method and composition for the treatment of septic shock
US5646119A (en) * 1991-11-01 1997-07-08 Periodontix, Inc. D-amino acid histatin-based peptides as anti-fungal and anti-bacterial agents
US5885965A (en) * 1991-11-01 1999-03-23 Periodontix, Inc. Anti-fungal D-amino acid histatin-based peptides
US6159936A (en) * 1993-07-20 2000-12-12 The Regents Of The University Of California Compositions and methods for treating and preventing microbial and viral infections
US6653442B1 (en) 1993-07-20 2003-11-25 Intrabiotics Pharmaceuticals, Inc. Protegrins
US5804558A (en) * 1993-07-20 1998-09-08 University Of California Protegrins
EP0754050B1 (de) * 1994-01-14 2002-06-26 XOMA Technology Ltd. Anti gram positive bakterielle verfahren und mittel
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
AU6682796A (en) 1995-07-21 1997-02-18 New York University Type ii phospholipase a2 and its use in killing gram-positive bacteria
US5688489A (en) * 1995-09-15 1997-11-18 Resolution Pharmaceuticals, Inc. Non-receptor mediated imaging agents
US5994306A (en) * 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins
US5916872A (en) * 1996-07-24 1999-06-29 Intrabiotics Pharmaceuticals, Inc. Cyclic peptides having broad spectrum antimicrobial activity
US5962733A (en) * 1996-09-25 1999-10-05 Vets Plus, Inc. Glutamine containing electrolyte solution for calf scours
SE9604593D0 (sv) * 1996-12-13 1996-12-13 Sbl Vaccin Ab Antimicrobially active polypeptides
US5858758A (en) * 1997-05-07 1999-01-12 Incyte Pharmaceuticals, Inc. Human serine protease precursor
US6300318B1 (en) 1997-09-16 2001-10-09 Peter E. Nielsen Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor
AU4564599A (en) * 1998-06-12 1999-12-30 Case Western Reserve University Methods for increasing cationic antimicrobial peptides
US6592814B2 (en) 1998-10-02 2003-07-15 Johnson & Johnson Vision Care, Inc. Biomedical devices with antimicrobial coatings
US6107460A (en) 1999-03-01 2000-08-22 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use thereof
SE9901773D0 (sv) 1999-05-17 1999-05-17 Nicklas Stroemberg Förebyggande av karies i tänderna
FR2804326B1 (fr) * 2000-01-27 2002-10-18 Ellipse Pharmaceuticals Procede de sterilisation par traitement sous hautes pressions de principes actifs sensibles
AU2002220079A1 (en) * 2000-11-15 2002-05-27 Emory University Acylated antimicrobial peptides
US6482396B1 (en) 2001-05-15 2002-11-19 Campina Melkunie B.V. Methods for treating or preventing diseases of the oral cavity
US7550558B2 (en) * 2001-06-01 2009-06-23 Fundacao De Ampara A Pesquiso Do Estado De Sao Paolo (Fapesp) Antimicrobial peptides and methods for identifying and using such peptides
US7033769B2 (en) 2002-05-23 2006-04-25 The United States Of America As Represented By The Secretary Of The Army Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
US20060258596A1 (en) * 2003-02-14 2006-11-16 Walsh Timothy R Antimicrobial agents
US7576060B2 (en) * 2003-11-07 2009-08-18 The Trustees Of The University Of Pennsylvania Inhibition of adhesion and migration of an endothelial cell to fibronectin by neutrophil alpha-defensins
US7243909B2 (en) * 2004-12-10 2007-07-17 Koplin Edward C Collector sump cooling tower
US8252737B2 (en) * 2004-12-15 2012-08-28 The Regents Of The University Of Colorado Antimicrobial peptides and methods of use
EP2150625B1 (de) 2007-04-19 2013-03-20 Molecular Detection Inc. Verfahren, zusammensetzungen und kits zur erkennung und analyse von antibiotika-resistenten bakterien
WO2010042534A1 (en) * 2008-10-06 2010-04-15 The Regents Of The University Of Colorado, A Body Corporate Peptides and methods of use
GB0821687D0 (en) 2008-11-28 2008-12-31 Secr Defence Peptides
GB0821707D0 (en) * 2008-11-28 2008-12-31 Secr Defence Peptides
WO2010141760A2 (en) * 2009-06-05 2010-12-09 The Regents Of The University Of Colorado, A Body Corporate Antimicrobial peptides
WO2013039861A2 (en) 2011-09-12 2013-03-21 modeRNA Therapeutics Engineered nucleic acids and methods of use thereof
AU2013243949A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
CA2868398A1 (en) 2012-04-02 2013-10-10 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
CA3004790A1 (en) 2015-11-10 2017-05-18 Visterra, Inc. Lipopolysaccharide binding antibody-antimicrobial peptide conjugates and uses thereof
AU2018209940A1 (en) 2017-01-18 2019-07-11 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
CN109232717B (zh) * 2018-08-31 2021-08-20 东北农业大学 一种针对革兰氏阴性菌靶向抗菌肽及制作方法与应用
CN111533787B (zh) * 2020-03-30 2022-02-08 东北农业大学 一种线性抗菌肽及其制备方法和应用
EP4126064A1 (de) 2020-04-03 2023-02-08 Visterra, Inc. Antikörpermolekül-wirkstoff-konjugate und verwendungen davon
CN114149483B (zh) * 2021-05-28 2023-05-30 中国科学院大连化学物理研究所 一种抗菌肽组合物及其应用
CN115028704B (zh) * 2022-03-16 2023-07-07 东北农业大学 一种抗酶解抗菌肽n1及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725576A (en) * 1983-12-29 1988-02-16 Research Foundation Of State University Of New York Fungicidal polypeptide compositions containing L-histidine and methods for use therefore
WO1991019512A1 (en) * 1990-06-21 1991-12-26 University Of Georgia Research Foundation, Inc. Antimicrobial peptides

Also Published As

Publication number Publication date
ATE217885T1 (de) 2002-06-15
CA2145313A1 (en) 1994-04-14
CA2145313C (en) 1999-09-21
EP0665754A1 (de) 1995-08-09
US5447914A (en) 1995-09-05
EP0665754A4 (de) 1996-06-12
WO1994007523A1 (en) 1994-04-14
US5798336A (en) 1998-08-25
JPH08502262A (ja) 1996-03-12
EP0665754B1 (de) 2002-05-22

Similar Documents

Publication Publication Date Title
DE69331953D1 (de) Antimikrobielle polypeptide
US5470950A (en) Biologically active amphiphilic peptide compositions and uses therefor
US5239059A (en) Ion-channel forming peptides
KR102544364B1 (ko) Romo1 유래 항균 펩타이드 및 그 변이체
EP1019084A4 (de) Neue antimikrobielle polypeptide und verfahren für ihre verwendung.
US5424290A (en) Biologically active peptides and uses therefor
KR20180052178A (ko) 흰점박이꽃무지에서 유래한 항균 펩타이드 프로테티아마이신 1 및 그의 조성물
US5235038A (en) Deletion and substitution analogues of melittin peptide
DE69908885T2 (de) NEUARTIGES AUS -i(PARASILURUS ASOTUS) ISOLIERTES ANTIMIKROBIELLES PEPTID UND SEINE VERWENDUNG
MXPA03005386A (es) Proteina protectora recombinante de streptococcus pneumoniae.
AU654714B2 (en) Novel peptide compositions and uses therefor
KR20180052181A (ko) 흰점박이꽃무지에서 유래한 항균 펩타이드 프로테티아마이신 2 및 그의 조성물
US5114921A (en) Amphiphilic peptides and use thereof
ATE285786T1 (de) Säugetierabkömmliche peptide zur behandlung von mikrobiellen infektionen
WO1999015548A3 (en) Isolated and recombinant antimicrobial peptides thrombocidin-1 (tc-1) and thrombocidin-2 (tc-2) or variants thereof
EP3160487B1 (de) Antimikrobielle zusammensetzungen für die veterinärmedizin
CA2363713A1 (en) Lantibiotic
US6531573B1 (en) Antifungal and antibacterial peptides
US20060258596A1 (en) Antimicrobial agents
Conlon The potential of frog skin antimicrobial peptides for development into therapeutically valuable anti-infective agents
WO2002040536A3 (en) Acylated antimicrobial peptides
HUP0401586A2 (hu) Baktériumellenes szer
EP0455719A1 (de) SYNERGISTISCHE ZUSAMMENSETZUNG ENTHALTEND EIN MAGAININ PEPTID UND EIN PGLa PEPTID
AU2016269417A1 (en) Disinfectant and antimicrobial compositions, in particular for the veterinary field
Kawai et al. Innate defense peptides in the oral cavity