WO1994006498A1 - Inhalateur - Google Patents

Inhalateur Download PDF

Info

Publication number
WO1994006498A1
WO1994006498A1 PCT/GB1993/002013 GB9302013W WO9406498A1 WO 1994006498 A1 WO1994006498 A1 WO 1994006498A1 GB 9302013 W GB9302013 W GB 9302013W WO 9406498 A1 WO9406498 A1 WO 9406498A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
medicament
inhalation device
air inlet
movement
Prior art date
Application number
PCT/GB1993/002013
Other languages
English (en)
Inventor
Michael Trevor Shepherd
Alastair Robert Clarke
Bruce James Renfrew
Original Assignee
Fisons Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929220083A external-priority patent/GB9220083D0/en
Priority claimed from GB929220077A external-priority patent/GB9220077D0/en
Application filed by Fisons Plc filed Critical Fisons Plc
Priority to AU48295/93A priority Critical patent/AU4829593A/en
Publication of WO1994006498A1 publication Critical patent/WO1994006498A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/14—Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws

Definitions

  • This invention relates to inhalation devices and in particular to devices for the inhalation of powdered medicament contained in capsules.
  • powdered medicament is often supplied in capsules which are loaded into a dispensing device wherein the medicament is released from the capsule then inhaled by the patient.
  • GB 1122284 discloses one such device for the inhalation of powdered medicament from a capsule, a preferred embodiment of this device is sold o under the name SPINHALERTM.
  • This device has the disadvantage that it must be dismantled for insertion of a capsule prior to inhalation and again to remove the empty capsule after inhalation. Dismantling the device can prove very difficult especially for those with impaired hand movement such as the elderly.
  • a medicament inhalation device including a housing defining a through-going pathway provided at one end with an air inlet, and at the other end with a mouthpiece; a drive member rotatably mounted in the housing on a shaft which is coaxial with the longitudinal axi o of the housing, the drive member having, on a portion adjacent to the air inlet, mounting means adapted to engage a medicament capsule, and the drive member being so mounted on the shaft that the passage of a stream of air through the pathway causes rotational and vibrational movement of the drive member; characterised in that the air inlet is adapted to act as a capsule port through which a 5 capsule can be inserted into the mounting means.
  • the device according to the invention preferably includes release means to permit removal of a capsule from the mounting means through the air inlet. -.
  • Drive members suitable for use in the device according to the invention 0 include propellers having two or more rotor vanes or blades symmetrically disposed about a central axis or hub, such that impingement of an air stream on the rotor vanes or blades causes rotation of the propeller about the axis or hub.
  • the drive member preferably includes a sleeve-like bearing for mounting over the shaft of the device.
  • the drive member may be freely mounted on the shaft, however, we prefer the drive member to be retained on the shaft by retaining means
  • the retaining means may comprise a circumferential ridge formed on the interior wall of the sleeve-like bearing which is received by a circumferential recess formed on the shaft or vice versa.
  • the retaining means prevents the drive member falling of the shaft if the device needs to be dismantled, e.g. for cleaning.
  • the vibrational component of the movement of the drive member is essential for release of medicament from the capsule and to obtain constant and reproducible results from the inhalation device.
  • Vibrational movement of the drive member may be effected by controlling the dimensions of said member as described in GB 1122284 and GB 1301856 (Fisons pic) the disclosures of which are incorporated herein by reference.
  • the device according to the invention preferably includes piercing means for piercing a capsule held in the mounting means.
  • Suitable piercing mechanisms will b apparent to those skilled in the art and include e.g. pins or blades.
  • the piercing means preferably takes the form of one or more, e.g. two, spring biassed pins.
  • Piercing of the capsule may be effected by a cam surface moving over the spring biassed pins, the reciprocal movement of the cam surface allowing the pins to withdraw from the capsule under their spring bias.
  • cam surfaces these are preferably provided on the inside of a sleeve slidably mounted on the housing of the device.
  • the device may be used for dispensing medicament contained i pre-pierced capsules, i.e. capsules the walls of which are provided with one or more apertures during manufacture; in this case it is not necessary for the device to includ piercing means.
  • the air inlet of the device must be large enough to enable it to function as capsule port for the insertion of a medicament capsule into the mounting means.
  • the air inlet preferably comprises a circular aperture having a diameter slightly larger than the diameter of a capsule to be inserted into the mounting means.
  • the device may be provided with additional air inlets, for example, positioned radially around the capsule port air inlet.
  • the housing of the device may act to guide a capsule inserted through the air inlet into the mounting means, this may be achieved by providing a constriction in the housing between the air inlet and the mounting means. This constriction may .. also act to restrict the air stream which flows through the pathway upon inhalation b a patient at the mouthpiece, thus increasing the velocity of air past the capsule and aiding in the release of medicament therefrom.
  • the mounting means preferably includes resilient jaws adapted engage a medicament capsule.
  • the drive member includes rotor vanes these are preferably integrally moulded with the resilient jaws of the mounting means.
  • the device according to the invention preferably includes release means and mounting means including resilient jaws, wherein movement of the release means from a first position to a second position disengages the capsule from the mounting means. Movement of the release means from a first position to a second position may either move the jaws from an engaged to a disengaged position, or transport the capsule from an engaged to a disengaged position.
  • the release means When the drive member includes rotor vanes integrally moulded with the resilient jaws then movement of the release means from a first (rest) position to a second (release) position preferably urges the rotor vanes away from the air inlet thereby causing jaws to move from an engaged to a disengaged position.
  • the release means transports the capsule from an engaged to a disengaged position, the release means preferably includes an ejection arm which is adapted to urge the capsule out of the mounting means and through the air inlet. In a first (rest) position the ejection arm will be retracted from the mounting means an upon movement to a second (release) position will slide up inside the mounting means thereby ejecting the capsule. Movement of the ejection arm may be effected by an expulsion collar slidably mounted on the drive member.
  • the device according to the invention includes release means movement of the release means from a first to a second position is preferably effected by a sleeve slidably mounted on the housing.
  • the sleeve preferably performs the dual function of moving the release means and actuating piercing means. Therefore, in a preferred embodiment of the device, movement of the sleeve from a rest position in a direction parallel to the longitudinal axis of housing actuates piercing means for piercing a capsule held in the mounting means; and movement of the sleeve from the rest position in the opposite direction moves the release means from a first position to a second position.
  • the device comprises release means this is preferably biased into a - first position, i.e a rest position in which a capsule can be inserted into, and engaged by, the mounting means.
  • the device may, if desired, be fitted with a non-return valve so that air may only be inhaled and not blown through the device by the patient.
  • the device may be constructed of any suitable material, preferably of a synthetic thermoplastic resin, e.g. high density polyethylene, acrylonitrile butadiene styrene (ABS), or DELRINTM; in which case it can be made by an injection moulding technique.
  • a synthetic thermoplastic resin e.g. high density polyethylene, acrylonitrile butadiene styrene (ABS), or DELRINTM; in which case it can be made by an injection moulding technique.
  • the capsules for use with the device according to the invention are preferably cylindrical, they may be made from any material which can be pierced, e.g. gelatin.
  • the device may be used for dispensing any powdered medicament which is conventionally administered by inhalation to the lung or nose.
  • medicaments include drugs for use in the prophylactic or remedial treatment of reversible obstructive airways disease.
  • Specific medicaments which may be mentioned include, for example, sodium cromoglycate and nedocromil sodium; inhaled steroids such as beclomethasone dipropionate, tipredane, and fluticasone; anticholinergic agents such as ipratropium bromide; bronchodilators, e.g. salmeterol, salbutamol, reproterol, terbutaline, albuterol and fenoterol; and salts thereof.
  • bronchodilators e.g. salmeterol, salbutamol, reproterol, terbutaline, albuterol and fenoterol
  • salts thereof e.g. salmeterol, salbutamol, reproterol, terbutaline,
  • Devices according to the invention have advantages over known inhalation devices in that the procedures for insertion of the medicament capsule into the device, and for removal of the empty capsule from the device after inhalation, are considerably simplified. Furthermore, since the device does not need to be dismantled for insertion/removal of the capsule, the patient is less likely to inadvertently injure themselves on the piercing means; and the propeller-like member, if freely mounted on the shaft, cannot fall off the shaft during the insertion/removal procedure.
  • Figure 1 is a perspective view of a device according to the invention.
  • Figure 2 is a longitudinal section of the device of Figure 1 in the rest position
  • Figure 3 is a section along the line III-III of Figure 2;
  • Figure 4 is a longitudinal section of the device of Figure 1 in the release position;
  • Figure 5 is a perspective view of an alternative device according to the invention.
  • Figure 6 is a longitudinal section of the device of Figure 5 in the rest position
  • Figure 7 is a section along the line VII- VII of Figure 6;
  • Figure 8 is a longitudinal section of the device of Figure 5 in the release position
  • a medicament inhalation device comprises a generally cylindrical housing (1) describing a through-going pathway.
  • the housing (1) is provided at one end with a mouthpiece portion (2), optionally having a removable mouthpiece cover (not shown), and provided at the other end with an air inlet (3).
  • a shaft (4) is rigidly mounted coaxially with the housing (1), the end of shaft (4) adjacent to the mouthpiece (2) end of housing (1) being supported by cross members (5).
  • Propeller (6) having a sleeve-like bearing (7) is mounted on shaft (4).
  • Shaft (4) is provided with a circumferential recess (8) which receives a circumferential ridge (9) formed on the interior wall of bearing (7) such that dissociation of the shaft (4) and the propeller (6) is prevented.
  • Propeller (6) is provided with a capsule mounting cup (10) comprising four resilient segments (11), shown best in Figure 3, which is adapted of engage a capsule (12) containing powdered medicament to be inhaled.
  • Propeller (6) is also provided with four rotor vanes (13) integrally moulded with segments (11), which cause the propeller (6) to rotate on shaft (4) when air is drawn through the pathway, as during inhalation. ..
  • Two stainless steel piercing needles (14), spring biased into the rest position s shown in Figures 2, are provided on housing (1).
  • One end of each needle (14) being secured to the housing (1), the other end being curved inwards such that they point towards a capsule (12) engaged by segments (11) of cup (10).
  • a sleeve (15) is slidably mounted on housing (1).
  • cam surfaces may be integrally moulded with the sleeve, however, for ease of manufacture they may be moulded separately and located in the sleeve during assembly of the device).
  • sleeve (15) turns inwards on itself thus s defining the walls of the air inlet (3).
  • Sleeve (15) extends further within housing (1) to form a circular release collar (17) which is located between the air inlet (3) and rotor vanes (13).
  • the collar (17) is adapted to apply downwards pressure onto rotor vanes (13) thus urging them away from the air inlet (3), thereby causing the segments (11) of cup 0 (10) to splay outwards.
  • the air inlet end of sleeve (15) urges needles (14) slightly inwards against their bias, this effect may be further enhanced by the provision of cam surfaces within the sleeve.
  • a capsule (12) containing powdered medicament to be inhaled is inserted through air inlet (3) and engaged by the segments (11) of cup (10).
  • Sleeve 5 (15) is then moved in the direction of arrow A in Figure 2 causing the cam surfaces
  • the patient then inhales through mouthpiece (2), thereby drawing air 0 through the pathway in the direction of arrow B in Figure 2.
  • the flow of air through the pathway causes the propeller (6) to rotate about shaft (4) and also to vibrate.
  • the medicament is thereby dispensed from capsule (12) through the apertures formed by needles (14), entrained in the air flow and inhaled by the patient.
  • the device is held with the air inlet (3) pointing downwards and sleeve (15) is moved over housing (1) in the direction of arrow C in Figure 4 (this may be achieved by pushing the sleeve and .. mouthpiece towards each other).
  • release collar (17) presses onto rotor vanes (13), s the pressure on rotor vanes (13) causing segments (11) to splay outwards from the base of cup (10) thus disengaging the empty capsule (12) which falls out of the housing (1) through the air inlet, as shown in Figure 4.
  • the sleeve (15) then returns to its rest position under the bias of needles (14) and the inhalation device is once more ready for use.
  • the release means includes a cylindrical ejection collar (18) slidably mounted around the housing (1).
  • the collar (18) is provided with projecting lugs (19) which cooperate with corresponding lugs (20) provided on the inside of sleeve (15).
  • Ejection collar (18) is also provided with two transverse arms (21) which project into housing (1). s Arms (21) abut against the base of a secondary ejection collar (22) slidably mounted around sleeve-like bearing (7). The secondary ejection collar (22) has two arms (23) running parallel to bearing (7) which extend through the base of mounting cup (10). Ejection collar (18) is biased into the rest position shown in Figure 6 by spring (24). In use, a capsule (12) containing medicament to be inhaled is inserted o through air inlet (3) and engaged by the segments (11) of cup (10). Sleeve (15) is then moved in the direction of arrow D in Figure 6 causing the cam surfaces (16) to engage needles (14) and pierce capsule (12).
  • sleeve (15) is moved in the direction of arrow E in Figure 8, lugs (19, 20) slide the ejection collar (18) over housing (1) against the bias of spring 5 (24).
  • the arms (21) of the ejection collar (18) push the secondary ejection collar (22) up the bearing (4) and arms (23) are raised into cup (10) thereby ejecting the empty capsule (12) out of the housing (1) through the air inlet (23).
  • the sleeve (15) then returns to its rest position under the bias of spring (24) and the inhalation device is once more ready for use.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

Inhalateur de médicament comprenant: un boîtier (1) définissant un passage traversant (1) muni à l'une des extrémités d'une entrée d'air (3), et à l'autre extrémité d'un embout buccal (2); et un organe d'entraînement (6) monté rotatif dans le boîtier (2) sur un arbre (4) qui est coaxial avec l'axe longitudinal du boîtier (1). L'organe d'entraînement (6) comporte, sur une partie adjacente à l'entrée d'air (3), un moyen de fixation (10) adapté pour venir en prise avec une capsule de médicament (12). Par ailleurs, l'organe d'entraînement (6) est monté sur l'arbre (4) de telle sorte que le passage d'un écoulement d'air dans le passage provoque le mouvement rotatif et vibrationnel de l'organe d'entraînement (6). L'invention est caractérisée en ce que l'entrée d'air (3) est adaptée pour agir comme un orifice à travers lequel on peut introduire une gélule (12) dans le moyen de fixation (10).
PCT/GB1993/002013 1992-09-23 1993-09-23 Inhalateur WO1994006498A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU48295/93A AU4829593A (en) 1992-09-23 1993-09-23 Inhalation device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929220083A GB9220083D0 (en) 1992-09-23 1992-09-23 Inhalation device
GB929220077A GB9220077D0 (en) 1992-09-23 1992-09-23 Inhalation device
GB9220077.3 1992-09-23
GB9220083.1 1992-09-23

Publications (1)

Publication Number Publication Date
WO1994006498A1 true WO1994006498A1 (fr) 1994-03-31

Family

ID=26301671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/002013 WO1994006498A1 (fr) 1992-09-23 1993-09-23 Inhalateur

Country Status (2)

Country Link
AU (1) AU4829593A (fr)
WO (1) WO1994006498A1 (fr)

Cited By (71)

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US6679256B2 (en) 1999-12-17 2004-01-20 Nektar Therapeutics Systems and methods for extracting powders from receptacles
WO2005097175A2 (fr) 2004-03-31 2005-10-20 Centocor, Inc. Corps mimetiques glp-1 humains, compositions, procedes et utilisations
US7252087B2 (en) 2003-11-08 2007-08-07 Boehringer Ingelheim International Gmbh Powder inhaler
WO2007118858A1 (fr) * 2006-04-15 2007-10-25 Boehringer Ingelheim International Gmbh Inhalateur
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WO2008021237A1 (fr) 2006-08-10 2008-02-21 Arubor Corporation Thérapie locale de troubles inflammatoires des voies aériennes inférieures avec des inhibiteurs de cytokine proinflammatoire
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