WO1993025898A1 - Mediateurs destines a des enzymes du type oxydoreductases - Google Patents

Mediateurs destines a des enzymes du type oxydoreductases Download PDF

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Publication number
WO1993025898A1
WO1993025898A1 PCT/GB1993/001179 GB9301179W WO9325898A1 WO 1993025898 A1 WO1993025898 A1 WO 1993025898A1 GB 9301179 W GB9301179 W GB 9301179W WO 9325898 A1 WO9325898 A1 WO 9325898A1
Authority
WO
WIPO (PCT)
Prior art keywords
ligand
compound
group
transition metal
sandwich
Prior art date
Application number
PCT/GB1993/001179
Other languages
English (en)
Inventor
Nigel Forrow
Stephen Walters
Original Assignee
Medisense, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medisense, Inc. filed Critical Medisense, Inc.
Priority to EP93913284A priority Critical patent/EP0598095A1/fr
Priority to JP50123994A priority patent/JP3288044B2/ja
Publication of WO1993025898A1 publication Critical patent/WO1993025898A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention concerne des complexes semi-sandwichs de métaux de transition comprenant un π-ligand unique comportant une liaison π délocalisée qu'on utilise comme médiateurs de transfert d'électrons entre une électrode et une protéine redox, par exemple une enzyme du type oxydoréductase telle que celle existant dans un capteur enzymatique ampérométrique. Les composés appropriés comprennent des complexes de formule générale: π-ligand)M(non-π-ligand)n. Dans cette formule, le complexe est chargé ou neutre, π-ligand représente le ligand unique à liaison π, M représente l'atome de métal de transition, n représente le nombre de ligands qui ne sont pas des π-ligands, et les n non-π-ligands sont identiques ou différents, univalents ou multivalents, et servent à satisfaire la valence du métal de transition M.
PCT/GB1993/001179 1992-06-05 1993-06-03 Mediateurs destines a des enzymes du type oxydoreductases WO1993025898A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP93913284A EP0598095A1 (fr) 1992-06-05 1993-06-03 Mediateurs destines a des enzymes du type oxydoreductases
JP50123994A JP3288044B2 (ja) 1992-06-05 1993-06-03 酸化還元酵素に対するメディエータ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9212010.4 1992-06-05
GB929212010A GB9212010D0 (en) 1992-06-05 1992-06-05 Mediators to oxidoreductase enzymes

Publications (1)

Publication Number Publication Date
WO1993025898A1 true WO1993025898A1 (fr) 1993-12-23

Family

ID=10716653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/001179 WO1993025898A1 (fr) 1992-06-05 1993-06-03 Mediateurs destines a des enzymes du type oxydoreductases

Country Status (5)

Country Link
EP (1) EP0598095A1 (fr)
JP (1) JP3288044B2 (fr)
CA (1) CA2115052A1 (fr)
GB (1) GB9212010D0 (fr)
WO (1) WO1993025898A1 (fr)

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057158A1 (fr) * 1997-06-12 1998-12-17 Clinical Micro Sensors, Inc. Detection d'analytes au moyen d'une energie de reorganisation
US6977151B2 (en) 1996-11-05 2005-12-20 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
US7056669B2 (en) 1996-11-05 2006-06-06 Clinical Micro Sensors, Inc. AC methods for the detection of nucleic acids
US7384749B2 (en) 1996-11-05 2008-06-10 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
US7935481B1 (en) 1999-07-26 2011-05-03 Osmetech Technology Inc. Sequence determination of nucleic acids using electronic detection
USRE44695E1 (en) 2003-12-05 2014-01-07 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8690796B2 (en) 2002-04-19 2014-04-08 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
WO2014114810A1 (fr) 2013-01-28 2014-07-31 Roche Diagnostics Gmbh Nouvelles glucose oxydases dérivées d'aspergillus niger
US8845550B2 (en) 2001-06-12 2014-09-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8845549B2 (en) 2002-04-19 2014-09-30 Sanofi-Aventis Deutschland Gmbh Method for penetrating tissue
US8877035B2 (en) 2005-07-20 2014-11-04 Bayer Healthcare Llc Gated amperometry methods
US8905945B2 (en) 2002-04-19 2014-12-09 Dominique M. Freeman Method and apparatus for penetrating tissue
US8945910B2 (en) 2003-09-29 2015-02-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9005527B2 (en) 2006-10-24 2015-04-14 Bayer Healthcare Llc Transient decay amperometry biosensors
US9034639B2 (en) 2002-12-30 2015-05-19 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US9089294B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US9089678B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9110013B2 (en) 2005-09-30 2015-08-18 Bayer Healthcare Llc Gated voltammetry methods
US9144401B2 (en) 2003-06-11 2015-09-29 Sanofi-Aventis Deutschland Gmbh Low pain penetrating member
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9261476B2 (en) 2004-05-20 2016-02-16 Sanofi Sa Printable hydrogel for biosensors
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9451908B2 (en) 2006-10-04 2016-09-27 Dexcom, Inc. Analyte sensor
US9504413B2 (en) 2006-10-04 2016-11-29 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US9560993B2 (en) 2001-11-21 2017-02-07 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US9561000B2 (en) 2003-12-31 2017-02-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9839386B2 (en) 2002-04-19 2017-12-12 Sanofi-Aventis Deustschland Gmbh Body fluid sampling device with capacitive sensor
US10980461B2 (en) 2008-11-07 2021-04-20 Dexcom, Inc. Advanced analyte sensor calibration and error detection
US11000215B1 (en) 2003-12-05 2021-05-11 Dexcom, Inc. Analyte sensor
US11382539B2 (en) 2006-10-04 2022-07-12 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0309905D0 (en) * 2003-04-30 2003-06-04 E2V Technologics Ltd Electrochemical sensing assays
US8454820B2 (en) * 2009-09-09 2013-06-04 National Institute Of Advanced Industrial Science And Technology Electrochemical molecular recognition probes
CN112795243B (zh) * 2020-12-31 2022-10-04 德莱森(北京)医疗科技有限公司 媒介体结构在导电墨水功能材料中的应用

Citations (4)

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Publication number Priority date Publication date Assignee Title
EP0127958A2 (fr) * 1983-05-05 1984-12-12 MediSense, Inc. Electrodes pour des détecteurs
EP0150602A2 (fr) * 1983-12-20 1985-08-07 Genetics International, Inc. Composés de bore et carbone dans des électrodes de transfert d'électrons
EP0230786A1 (fr) * 1985-12-24 1987-08-05 MediSense, Inc. Dosage du cholestérol et de ses dérivés
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127958A2 (fr) * 1983-05-05 1984-12-12 MediSense, Inc. Electrodes pour des détecteurs
EP0150602A2 (fr) * 1983-12-20 1985-08-07 Genetics International, Inc. Composés de bore et carbone dans des électrodes de transfert d'électrons
EP0230786A1 (fr) * 1985-12-24 1987-08-05 MediSense, Inc. Dosage du cholestérol et de ses dérivés
WO1992004466A1 (fr) * 1990-09-01 1992-03-19 Environmental & Medical Products Ltd Capteur biologique electrochimique stable

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LLOYD M.K. ET AL.: "Voltammetric Oxidation of Arene, Cycloheptatriene, and Cycloheptatrienyl Tricarbonyl Complexes of Chromium", JOURNAL OF THE CHEMICAL SOCIETY, DALTON TRANSACTIONS, LETCHWORTH GB, vol. 1973, no. 17, 1973, pages 1768 - 1770, XP000654403, DOI: doi:10.1039/dt9730001768 *
MCCLEVERTY J.A. ET AL.: "Transition Metal Dithiolene Complexes. IX. Manganese pi-Cyclopentadienyl(nitrosyl)dithiolene and Related Metal Complexes", INORGANIC CHEMISTRY, EASTON US, vol. 8, no. 6, June 1969 (1969-06-01), pages 1340 - 1347, XP000654386, DOI: doi:10.1021/ic50076a028 *
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Cited By (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056669B2 (en) 1996-11-05 2006-06-06 Clinical Micro Sensors, Inc. AC methods for the detection of nucleic acids
US7384749B2 (en) 1996-11-05 2008-06-10 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
US6977151B2 (en) 1996-11-05 2005-12-20 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
US7514228B2 (en) 1997-06-12 2009-04-07 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US7267939B2 (en) 1997-06-12 2007-09-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
WO1998057158A1 (fr) * 1997-06-12 1998-12-17 Clinical Micro Sensors, Inc. Detection d'analytes au moyen d'une energie de reorganisation
US7935481B1 (en) 1999-07-26 2011-05-03 Osmetech Technology Inc. Sequence determination of nucleic acids using electronic detection
US9694144B2 (en) 2001-06-12 2017-07-04 Sanofi-Aventis Deutschland Gmbh Sampling module device and method
US9937298B2 (en) 2001-06-12 2018-04-10 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8845550B2 (en) 2001-06-12 2014-09-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9802007B2 (en) 2001-06-12 2017-10-31 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9560993B2 (en) 2001-11-21 2017-02-07 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US9724021B2 (en) 2002-04-19 2017-08-08 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9072842B2 (en) 2002-04-19 2015-07-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8905945B2 (en) 2002-04-19 2014-12-09 Dominique M. Freeman Method and apparatus for penetrating tissue
US9498160B2 (en) 2002-04-19 2016-11-22 Sanofi-Aventis Deutschland Gmbh Method for penetrating tissue
US9907502B2 (en) 2002-04-19 2018-03-06 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9839386B2 (en) 2002-04-19 2017-12-12 Sanofi-Aventis Deustschland Gmbh Body fluid sampling device with capacitive sensor
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9089294B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US9089678B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8845549B2 (en) 2002-04-19 2014-09-30 Sanofi-Aventis Deutschland Gmbh Method for penetrating tissue
US9339612B2 (en) 2002-04-19 2016-05-17 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9186468B2 (en) 2002-04-19 2015-11-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8690796B2 (en) 2002-04-19 2014-04-08 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9034639B2 (en) 2002-12-30 2015-05-19 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US9144401B2 (en) 2003-06-11 2015-09-29 Sanofi-Aventis Deutschland Gmbh Low pain penetrating member
US10034628B2 (en) 2003-06-11 2018-07-31 Sanofi-Aventis Deutschland Gmbh Low pain penetrating member
US8945910B2 (en) 2003-09-29 2015-02-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US8929968B2 (en) 2003-12-05 2015-01-06 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8911369B2 (en) 2003-12-05 2014-12-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US11020031B1 (en) 2003-12-05 2021-06-01 Dexcom, Inc. Analyte sensor
US11000215B1 (en) 2003-12-05 2021-05-11 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US9579053B2 (en) 2003-12-05 2017-02-28 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US10299712B2 (en) 2003-12-05 2019-05-28 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US10188333B2 (en) 2003-12-05 2019-01-29 Dexcom, Inc. Calibration techniques for a continuous analyte sensor
USRE44695E1 (en) 2003-12-05 2014-01-07 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US9561000B2 (en) 2003-12-31 2017-02-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US9261476B2 (en) 2004-05-20 2016-02-16 Sanofi Sa Printable hydrogel for biosensors
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US8877035B2 (en) 2005-07-20 2014-11-04 Bayer Healthcare Llc Gated amperometry methods
US10670553B2 (en) 2005-09-30 2020-06-02 Ascensia Diabetes Care Holdings Ag Devices using gated voltammetry methods
US9835582B2 (en) 2005-09-30 2017-12-05 Ascensia Diabetes Care Holdings Ag Devices using gated voltammetry methods
US11435312B2 (en) 2005-09-30 2022-09-06 Ascensia Diabetes Care Holdings Ag Devices using gated voltammetry methods
US9110013B2 (en) 2005-09-30 2015-08-18 Bayer Healthcare Llc Gated voltammetry methods
US11399745B2 (en) 2006-10-04 2022-08-02 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US11382539B2 (en) 2006-10-04 2022-07-12 Dexcom, Inc. Analyte sensor
US10136844B2 (en) 2006-10-04 2018-11-27 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US9504413B2 (en) 2006-10-04 2016-11-29 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US9451908B2 (en) 2006-10-04 2016-09-27 Dexcom, Inc. Analyte sensor
US10349873B2 (en) 2006-10-04 2019-07-16 Dexcom, Inc. Analyte sensor
US9005527B2 (en) 2006-10-24 2015-04-14 Bayer Healthcare Llc Transient decay amperometry biosensors
US11091790B2 (en) 2006-10-24 2021-08-17 Ascensia Diabetes Care Holdings Ag Determining analyte concentration from variant concentration distribution in measurable species
US10190150B2 (en) 2006-10-24 2019-01-29 Ascensia Diabetes Care Holdings Ag Determining analyte concentration from variant concentration distribution in measurable species
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
US10980461B2 (en) 2008-11-07 2021-04-20 Dexcom, Inc. Advanced analyte sensor calibration and error detection
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
WO2014114810A1 (fr) 2013-01-28 2014-07-31 Roche Diagnostics Gmbh Nouvelles glucose oxydases dérivées d'aspergillus niger

Also Published As

Publication number Publication date
EP0598095A1 (fr) 1994-05-25
CA2115052A1 (fr) 1993-12-23
GB9212010D0 (en) 1992-07-15
JPH06509877A (ja) 1994-11-02
JP3288044B2 (ja) 2002-06-04

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