WO1993016664A1 - Disque intervertebral artificiel - Google Patents

Disque intervertebral artificiel Download PDF

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Publication number
WO1993016664A1
WO1993016664A1 PCT/GB1993/000386 GB9300386W WO9316664A1 WO 1993016664 A1 WO1993016664 A1 WO 1993016664A1 GB 9300386 W GB9300386 W GB 9300386W WO 9316664 A1 WO9316664 A1 WO 9316664A1
Authority
WO
WIPO (PCT)
Prior art keywords
cavity
disc
elastomeric material
reinforcement
band
Prior art date
Application number
PCT/GB1993/000386
Other languages
English (en)
Inventor
Carolyn Margot Cooper
Original Assignee
Limbs & Things Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Limbs & Things Limited filed Critical Limbs & Things Limited
Publication of WO1993016664A1 publication Critical patent/WO1993016664A1/fr

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Classifications

    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30965—Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30014—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30069—Properties of materials and coating materials elastomeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30069—Properties of materials and coating materials elastomeric
    • A61F2002/3007—Coating or prosthesis-covering structure made of elastic material, e.g. of elastomer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30074—Properties of materials and coating materials stretchable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/3011—Cross-sections or two-dimensional shapes
    • A61F2002/30112—Rounded shapes, e.g. with rounded corners
    • A61F2002/30133—Rounded shapes, e.g. with rounded corners kidney-shaped or bean-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30563—Special structural features of bone or joint prostheses not otherwise provided for having elastic means or damping means, different from springs, e.g. including an elastomeric core or shock absorbers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30957—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30963—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using templates, e.g. grid charts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0057—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof stretchable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0015—Kidney-shaped, e.g. bean-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility

Definitions

  • the present invention relates to an artificial spinal disc and a method of making an artificial spinal disc.
  • an artificial spinal disc In the medical field, for research and teaching purposes and for use in practising surgical techniques, there is a need for an artificial spinal disc.
  • a disc can either be used as such or several can be included in an artificial spine.
  • the key to simulation of the accurate movement of the different sections of the spine is the production of working artificial intervertebral discs which must be securely attached top and bottom to the vertebrae as in life. Thus when the spine is flexed, the discs are extended or retracted.
  • an artificial spinal disc comprising a body of moulded elastomeric material.
  • an artificial spinal disc comprising moulding elastomeric material to form a body.
  • Said elastomeric material preferably comprises a polyurethane elastomer.
  • the body includes a circumferential reinforcement, for example a band of reinforcing material such as net material.
  • said reinforcement is such that it is less stretchable in the circumferential direction of the body than orthogonal to that direction.
  • Said body could be formed with an internal space, which space could be filled with a pliable material, which pliable material could comprise cured elastomeric material for example.
  • the body is preferably made using the steps of:-
  • said elastomeric material could be applied over said support material by covering said cavity with a mould portion and applying elastomeric material between said mould portion and the cavity and over said support material.
  • Said support material could also provide such pliable material.
  • Figures 1 to 3 illustrate the production of a band of reinforcing material for use in an artificial spinal disc, Figure 4 illustrating the stretchability of the band;
  • Figures 5 to 11 illustrate steps in the production of the disc; and Figure 12 is a cross-section through the finished disc.
  • a piece 1 of fisherman's net is pinned to a frame 2 so that it is stretched under tension in one direction.
  • the stretched piece 1 is then starched so that the result is that it will stretch substantially no more in the direction in which it was stretched but will do so in the orthogonal direction.
  • a template 3 having a shape which corresponds to the circumferential profile of a spinal disc is then laid on to the piece 1 of net, extending longitudinally in the direction in which the piece 1 was stretched.
  • the outline of the template 3 is then drawn on to the piece 1 and then the outline is cut around to produce a reinforcing band 4 for the artificial spinal disc - see Figure 3.
  • a die is made of the patterns of several reinforcing bands and several such bands are stamped out at a time using the die.
  • a band 4 represents the annulus of a spinal disc and it allows the disc wall to stretch superiorally/inferiorally but substantially not to extend its perimeter - see Figure 4 in which the band 4 can stretch in the directions of arrows Y but substantially cannot stretch in the directions of arrows X.
  • a polyurethane elastomer is then painted (or injected) over the base and side wall of a cavity 5 of a mould 6 (see Figure 5), the cavity 5 generally having the shape of a spinal disc.
  • the reinforcing band 4 is then laid in around the side wall of the cavity 5 - see Figure 6.
  • a lid 7 having a plug 8 is carefully fitted on to the mould 6 (see Figure 7), the plug 8 being somewhat smaller than the cavity 5 with the band 4 in it, to enable a hollow shape to be cast.
  • the polyurethane elastomer is injected via a syringe 9 through one of two holes 10 in the lid 7 until the space between the plug 8 and the band 4 is full.
  • the mould is sprayed with release agent.
  • a mixture 11 of a polyurethane elastomer and plasticizer (such as that sold under the trade name "Flabbercast” by B.J.B. Enterprises, Inc., of 13912 Nautilus Drive, Garden Grove, California 92643, USA) is poured into the hollow cavity defined by the set polyurethane elastomer to within about 2mm from the top - see Figure 9.
  • a generally flat lid 12 having a shallow cavity 13 in the general shape of a vertebra is carefully fitted on to the mould 6 with the cavity 13 overlying the now filled cavity 5 - see Figure 10.
  • the polyurethane elastomer is injected via the syringe 9 through one of the holes 14 in the lid 12 until the space above the cured mixture 11 is full (see Figure 11), the cured mixture 11 providing support material for this step.
  • Figure 12 is a section through an artificial spinal disc manufactured according to the foregoing, reference numeral 16 denoting the polyurethane elastomer.
  • the set mixture 11 now serves as pliable material inside the artificial disc.
  • the body 15 is now usable as an artificial spinal disc, for example in an artificial spine (see below), for the purposes of demonstrating the structure of a spinal disc itself, and to simulate the properties of such a disc as found in life.
  • such bodies 15 may be filled with different mixtures 11, of different cured hardnesses.
  • a simulated, artificial spinal disc in the form of a body 15 may also be used to demonstrate a prolapsed and herniated disc by making it so that a certain amount of the cured mixture 11 can escape through the disc's side wall in the form of a bladder when under pressure. When pressure is released, the mixture 11 is retracted back into the disc to re-establish normal anatomy.
  • Rings of elastomer could be added to the body 15 to simulate a degenerated disc as found in injury or the aged.
  • a modelling wax is then laid over the components, to represent connecting ligaments and spinal nerves.
  • the assembly is then moulded in silicone rubber and surrounded with an epoxy resin case to produce a silicone rubber mould.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Neurology (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Analysis (AREA)
  • Pure & Applied Mathematics (AREA)
  • Computational Mathematics (AREA)
  • Medical Informatics (AREA)
  • Geometry (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Algebra (AREA)
  • Business, Economics & Management (AREA)
  • Educational Administration (AREA)
  • Educational Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Prostheses (AREA)

Abstract

Un disque intervertébral artificiel comprend un corps (15) composé d'un élastomère de polyuréthanne moulé (16) et pourvu d'un élément de renforcement circonférentiel sous forme d'une bande (4) d'un matériau à mailles, ainsi que d'un espace interne rempli d'un matériau souple (11).
PCT/GB1993/000386 1992-02-28 1993-02-25 Disque intervertebral artificiel WO1993016664A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9204263.9 1992-02-28
GB929204263A GB9204263D0 (en) 1992-02-28 1992-02-28 Artificial spinal disc

Publications (1)

Publication Number Publication Date
WO1993016664A1 true WO1993016664A1 (fr) 1993-09-02

Family

ID=10711189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/000386 WO1993016664A1 (fr) 1992-02-28 1993-02-25 Disque intervertebral artificiel

Country Status (3)

Country Link
AU (1) AU3638893A (fr)
GB (1) GB9204263D0 (fr)
WO (1) WO1993016664A1 (fr)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US5549679A (en) * 1994-05-20 1996-08-27 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
WO1999000074A1 (fr) * 1997-06-25 1999-01-07 Bridport-Gundry Plc Implant chirurgical
WO1999011203A1 (fr) 1997-08-28 1999-03-11 Sabitzer Ronald J Prothese pour la colonne vertebrale
US5951301A (en) * 1995-06-09 1999-09-14 Simulab Corporation Anatomical simulator for videoendoscopic surgical training
FR2776805A1 (fr) * 1998-03-30 1999-10-01 Eurosurgical Structure anatomique pour la formation de chirurgiens a la chirurgie orthopedique, notamment rachidienne
WO2004033516A1 (fr) * 2002-10-08 2004-04-22 Ranier Limited Fabrication haute precision de produits polyurethanne tels que des implants de disques intervertebraux presentant une variation graduelle de module
US6780016B1 (en) 2000-10-23 2004-08-24 Christopher C. Toly Human surgical trainer and methods for training
WO2004089257A1 (fr) * 2003-04-14 2004-10-21 Mathys Medizinaltechnik Ag Implant intervertebral
WO2006099969A2 (fr) * 2005-03-24 2006-09-28 Fehling Ag Procede et dispositif pour produire des implants pour colonne vertebrale
US7226481B2 (en) 2000-07-21 2007-06-05 Spineology, Inc. Expandable porous mesh bag device and methods of use for reduction, filling, fixation, and supporting of bone
WO2007087364A2 (fr) * 2006-01-25 2007-08-02 Salumedica, Llc Procede de production d’implants en hydrogel de pva et dispositifs correspondants
WO2007087366A3 (fr) * 2006-01-25 2007-09-20 Spinemedica Corp Implants de disques vertebraux avec des quilles souples et procedes de fabrication d'implants
US7665995B2 (en) 2000-10-23 2010-02-23 Toly Christopher C Medical training simulator including contact-less sensors
US7850454B2 (en) 2000-10-23 2010-12-14 Toly Christopher C Simulated anatomical structures incorporating an embedded image layer
US7857626B2 (en) 2000-10-23 2010-12-28 Toly Christopher C Medical physiological simulator including a conductive elastomer layer
US7879103B2 (en) 2005-04-15 2011-02-01 Musculoskeletal Transplant Foundation Vertebral disc repair
US7910124B2 (en) 2004-02-06 2011-03-22 Georgia Tech Research Corporation Load bearing biocompatible device
US7942104B2 (en) 2007-01-22 2011-05-17 Nuvasive, Inc. 3-dimensional embroidery structures via tension shaping
US7946236B2 (en) 2007-01-31 2011-05-24 Nuvasive, Inc. Using zigzags to create three-dimensional embroidered structures
US7959683B2 (en) * 2006-07-25 2011-06-14 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US8002830B2 (en) 2004-02-06 2011-08-23 Georgia Tech Research Corporation Surface directed cellular attachment
US8262731B2 (en) 2002-05-23 2012-09-11 Pioneer Surgical Technology, Inc. Artificial disc device
US8282681B2 (en) 2007-08-13 2012-10-09 Nuvasive, Inc. Bioresorbable spinal implant and related methods
US8377135B1 (en) 2008-03-31 2013-02-19 Nuvasive, Inc. Textile-based surgical implant and related methods
EP2907481A1 (fr) 2014-02-12 2015-08-19 HO-MED Handelsgesellschaft m.b.H. Implant destiné à l'intégration entre des vertèbres de la colonne vertébrale et kit destiné à la fabrication d'un tel implant
US9155578B2 (en) 2012-02-28 2015-10-13 DePuy Synthes Products, Inc. Expandable fastener
US9155543B2 (en) 2011-05-26 2015-10-13 Cartiva, Inc. Tapered joint implant and related tools
US9233011B2 (en) 2006-09-15 2016-01-12 Pioneer Surgical Technology, Inc. Systems and apparatuses for inserting an implant in intervertebral space
US9241807B2 (en) 2011-12-23 2016-01-26 Pioneer Surgical Technology, Inc. Systems and methods for inserting a spinal device
US9351852B2 (en) 2002-05-23 2016-05-31 Pioneer Surgical Technology, Inc. Artificial disc device
US9445916B2 (en) 2003-10-22 2016-09-20 Pioneer Surgical Technology, Inc. Joint arthroplasty devices having articulating members
US9510877B2 (en) 2007-11-14 2016-12-06 DePuy Synthes Products, Inc. Hybrid bone fixation element and methods of using the same
US9907663B2 (en) 2015-03-31 2018-03-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
US10037715B2 (en) 2013-10-16 2018-07-31 Simulab Corporation Detecting insertion of needle into simulated vessel using a conductive fluid
US10350072B2 (en) 2012-05-24 2019-07-16 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US10758374B2 (en) 2015-03-31 2020-09-01 Cartiva, Inc. Carpometacarpal (CMC) implants and methods
USD907771S1 (en) 2017-10-09 2021-01-12 Pioneer Surgical Technology, Inc. Intervertebral implant
US11147682B2 (en) 2017-09-08 2021-10-19 Pioneer Surgical Technology, Inc. Intervertebral implants, instruments, and methods

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Cited By (79)

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WO1994023671A1 (fr) * 1993-04-20 1994-10-27 Howmedica Inc. Noyau de disque intervertebral en hydrogel a renflement lateral reduit
US5534028A (en) * 1993-04-20 1996-07-09 Howmedica, Inc. Hydrogel intervertebral disc nucleus with diminished lateral bulging
US5549679A (en) * 1994-05-20 1996-08-27 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US5571189A (en) * 1994-05-20 1996-11-05 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
EP0764008A1 (fr) * 1994-05-20 1997-03-26 Stephen D. Kuslich Implant en toile expansible pour stabiliser le segment spinal
EP0764008A4 (fr) * 1994-05-20 1999-06-09 Stephen D Kuslich Implant en toile expansible pour stabiliser le segment spinal
US5951301A (en) * 1995-06-09 1999-09-14 Simulab Corporation Anatomical simulator for videoendoscopic surgical training
WO1999000074A1 (fr) * 1997-06-25 1999-01-07 Bridport-Gundry Plc Implant chirurgical
US6093205A (en) * 1997-06-25 2000-07-25 Bridport-Gundry Plc C/O Pearsalls Implants Surgical implant
WO1999011203A1 (fr) 1997-08-28 1999-03-11 Sabitzer Ronald J Prothese pour la colonne vertebrale
FR2776805A1 (fr) * 1998-03-30 1999-10-01 Eurosurgical Structure anatomique pour la formation de chirurgiens a la chirurgie orthopedique, notamment rachidienne
WO1999050808A1 (fr) * 1998-03-30 1999-10-07 Eurosurgical Structure anotomique pour la formation de chirurgiens a la chirurgie orthopedique, notamment rachidienne
US7226481B2 (en) 2000-07-21 2007-06-05 Spineology, Inc. Expandable porous mesh bag device and methods of use for reduction, filling, fixation, and supporting of bone
US6780016B1 (en) 2000-10-23 2004-08-24 Christopher C. Toly Human surgical trainer and methods for training
US8323029B2 (en) 2000-10-23 2012-12-04 Toly Christopher C Medical physiological simulator including a conductive elastomer layer
US8162668B2 (en) 2000-10-23 2012-04-24 Simulab Corporation Medical training simulator including contact-less sensors
US7665995B2 (en) 2000-10-23 2010-02-23 Toly Christopher C Medical training simulator including contact-less sensors
US7857626B2 (en) 2000-10-23 2010-12-28 Toly Christopher C Medical physiological simulator including a conductive elastomer layer
US7850454B2 (en) 2000-10-23 2010-12-14 Toly Christopher C Simulated anatomical structures incorporating an embedded image layer
US8262731B2 (en) 2002-05-23 2012-09-11 Pioneer Surgical Technology, Inc. Artificial disc device
US9351852B2 (en) 2002-05-23 2016-05-31 Pioneer Surgical Technology, Inc. Artificial disc device
US8882837B2 (en) 2002-10-08 2014-11-11 Ranier Limited High precision manufacture of polyurethane products such as spinal disc implants having gradual modulus variation
WO2004033516A1 (fr) * 2002-10-08 2004-04-22 Ranier Limited Fabrication haute precision de produits polyurethanne tels que des implants de disques intervertebraux presentant une variation graduelle de module
US8353960B2 (en) 2002-10-08 2013-01-15 Ranier Limited High precision manufacture of polyurethane products such as spinal disc implants having a gradual modulus variation
US9089439B2 (en) 2003-04-14 2015-07-28 DePuy Synthes Products, Inc. Intervertebral implant
US8690946B2 (en) 2003-04-14 2014-04-08 DePuy Synthes Products, LLC Intervertebral implant
AU2003213975B2 (en) * 2003-04-14 2008-06-26 Synthes Gmbh Intervertebral implant
KR101007648B1 (ko) * 2003-04-14 2011-01-13 신세스 게엠바하 추간판 임플란트
WO2004089257A1 (fr) * 2003-04-14 2004-10-21 Mathys Medizinaltechnik Ag Implant intervertebral
US8382838B2 (en) 2003-04-14 2013-02-26 Synthes Usa, Llc Intervertebral implant
US7429270B2 (en) 2003-04-14 2008-09-30 Synthes (U.S.A.) Intervertebral implant
JP2006522613A (ja) * 2003-04-14 2006-10-05 マシーズ メディツィナルテヒニク アクチエンゲゼルシャフト 椎間インプラント
US9445916B2 (en) 2003-10-22 2016-09-20 Pioneer Surgical Technology, Inc. Joint arthroplasty devices having articulating members
US8895073B2 (en) 2004-02-06 2014-11-25 Georgia Tech Research Corporation Hydrogel implant with superficial pores
US8002830B2 (en) 2004-02-06 2011-08-23 Georgia Tech Research Corporation Surface directed cellular attachment
US8486436B2 (en) 2004-02-06 2013-07-16 Georgia Tech Research Corporation Articular joint implant
US7910124B2 (en) 2004-02-06 2011-03-22 Georgia Tech Research Corporation Load bearing biocompatible device
WO2006099969A3 (fr) * 2005-03-24 2006-12-07 Fehling Ag Procede et dispositif pour produire des implants pour colonne vertebrale
WO2006099969A2 (fr) * 2005-03-24 2006-09-28 Fehling Ag Procede et dispositif pour produire des implants pour colonne vertebrale
US7879103B2 (en) 2005-04-15 2011-02-01 Musculoskeletal Transplant Foundation Vertebral disc repair
WO2007087364A2 (fr) * 2006-01-25 2007-08-02 Salumedica, Llc Procede de production d’implants en hydrogel de pva et dispositifs correspondants
WO2007087364A3 (fr) * 2006-01-25 2007-11-29 Salumedica Llc Procede de production d’implants en hydrogel de pva et dispositifs correspondants
WO2007087366A3 (fr) * 2006-01-25 2007-09-20 Spinemedica Corp Implants de disques vertebraux avec des quilles souples et procedes de fabrication d'implants
US20120010712A1 (en) * 2006-01-25 2012-01-12 Guilhem Denoziere Molds used to produce pva hydrogel implants and related implants
US8603171B2 (en) 2006-01-25 2013-12-10 Mimedx Group, Inc. Spinal disc implants with flexible keels and methods of fabricating implants
US8038920B2 (en) 2006-01-25 2011-10-18 Carticept Medical, Inc. Methods of producing PVA hydrogel implants and related devices
US7959683B2 (en) * 2006-07-25 2011-06-14 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US9693872B2 (en) 2006-09-15 2017-07-04 Pioneer Surgical Technology, Inc. Intervertebral disc implant
US10080667B2 (en) 2006-09-15 2018-09-25 Pioneer Surgical Technology, Inc. Intervertebral disc implant
US9233011B2 (en) 2006-09-15 2016-01-12 Pioneer Surgical Technology, Inc. Systems and apparatuses for inserting an implant in intervertebral space
US7942104B2 (en) 2007-01-22 2011-05-17 Nuvasive, Inc. 3-dimensional embroidery structures via tension shaping
US7946236B2 (en) 2007-01-31 2011-05-24 Nuvasive, Inc. Using zigzags to create three-dimensional embroidered structures
US8282681B2 (en) 2007-08-13 2012-10-09 Nuvasive, Inc. Bioresorbable spinal implant and related methods
US9510877B2 (en) 2007-11-14 2016-12-06 DePuy Synthes Products, Inc. Hybrid bone fixation element and methods of using the same
US8377135B1 (en) 2008-03-31 2013-02-19 Nuvasive, Inc. Textile-based surgical implant and related methods
US10376368B2 (en) 2011-05-26 2019-08-13 Cartiva, Inc. Devices and methods for creating wedge-shaped recesses
US9155543B2 (en) 2011-05-26 2015-10-13 Cartiva, Inc. Tapered joint implant and related tools
US9526632B2 (en) 2011-05-26 2016-12-27 Cartiva, Inc. Methods of repairing a joint using a wedge-shaped implant
US11278411B2 (en) 2011-05-26 2022-03-22 Cartiva, Inc. Devices and methods for creating wedge-shaped recesses
US11944545B2 (en) 2011-05-26 2024-04-02 Cartiva, Inc. Implant introducer
US9241807B2 (en) 2011-12-23 2016-01-26 Pioneer Surgical Technology, Inc. Systems and methods for inserting a spinal device
US10980575B2 (en) 2011-12-23 2021-04-20 Pioneer Surgical Technology, Inc. Instrument for inserting a spinal device
US11696786B2 (en) 2011-12-23 2023-07-11 Pioneer Surgical Technology, Inc. Instrument for inserting a spinal device
US10159514B2 (en) 2011-12-23 2018-12-25 Pioneer Surgical Technology, Inc. Method of implanting a bone plate
US9155578B2 (en) 2012-02-28 2015-10-13 DePuy Synthes Products, Inc. Expandable fastener
US10350072B2 (en) 2012-05-24 2019-07-16 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US10037715B2 (en) 2013-10-16 2018-07-31 Simulab Corporation Detecting insertion of needle into simulated vessel using a conductive fluid
EP2907481A1 (fr) 2014-02-12 2015-08-19 HO-MED Handelsgesellschaft m.b.H. Implant destiné à l'intégration entre des vertèbres de la colonne vertébrale et kit destiné à la fabrication d'un tel implant
US9907663B2 (en) 2015-03-31 2018-03-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
US10973644B2 (en) 2015-03-31 2021-04-13 Cartiva, Inc. Hydrogel implants with porous materials and methods
US11717411B2 (en) 2015-03-31 2023-08-08 Cartiva, Inc. Hydrogel implants with porous materials and methods
US11839552B2 (en) 2015-03-31 2023-12-12 Cartiva, Inc. Carpometacarpal (CMC) implants and methods
US10758374B2 (en) 2015-03-31 2020-09-01 Cartiva, Inc. Carpometacarpal (CMC) implants and methods
US11020231B2 (en) 2015-04-14 2021-06-01 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US10952858B2 (en) 2015-04-14 2021-03-23 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US11701231B2 (en) 2015-04-14 2023-07-18 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US11147682B2 (en) 2017-09-08 2021-10-19 Pioneer Surgical Technology, Inc. Intervertebral implants, instruments, and methods
USD968613S1 (en) 2017-10-09 2022-11-01 Pioneer Surgical Technology, Inc. Intervertebral implant
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