WO1993013706A2 - Procede optique de controle des hematocrites dans le sang arteriel - Google Patents

Procede optique de controle des hematocrites dans le sang arteriel Download PDF

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Publication number
WO1993013706A2
WO1993013706A2 PCT/US1993/000334 US9300334W WO9313706A2 WO 1993013706 A2 WO1993013706 A2 WO 1993013706A2 US 9300334 W US9300334 W US 9300334W WO 9313706 A2 WO9313706 A2 WO 9313706A2
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WO
WIPO (PCT)
Prior art keywords
blood
light
pulsatile
wavelengths
hematocrit
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Application number
PCT/US1993/000334
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English (en)
Inventor
Joseph M. Schmitt
Original Assignee
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services
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Publication date
Application filed by The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services filed Critical The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services
Publication of WO1993013706A2 publication Critical patent/WO1993013706A2/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring haematocrit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow

Definitions

  • the present invention relates to methods and apparatus for measuring blood hematocrit. More particularly, the present invention relates to non-
  • Anemia is associated with many pathological conditions that result in a loss or reduced production
  • red blood cells including renal failure, bone-marrow aplasia secondary to radiation therapy, and red-cell sickling. Although rarer, excessive production of red cells (polycythemia) is also seen clinically in patients with congenital heart disease and pulmonary emphysema.
  • PCV packed-cell volume
  • Another object of the present invention is to provide a method of measuring blood hematocrit. Another object of the present invention is to provide a non-invasive method of measuring blood hematocrit.
  • a further object of the present invention is to provide a method of simultaneously measuring oxygen saturation and hemoglobin concentration of blood.
  • An even further object of the present invention is to provide an apparatus for measuring blood hematocrit.
  • a still further object of the present invention is to provide an apparatus for non-invasively measuring blood hematocrit.
  • a still further object of the present invention is to provide a tissue phantom which simulates the optical properties of a perfused finger.
  • the present invention provides a method of measuring blood hematocrit which involves: directing first and second wavelengths of light through a blood sample; determining the ratio between pulsatile and non- pulsatile diffuse transmittances measured at each of the first and second wavelengths of light from the blood sample; and determining blood hematocrit of the blood sample from the ratio between pulsatile and non-pulsatile diffuse transmittances measured at each of the first and second wavelengths of light from the blood sample.
  • the present invention further provides an apparatus for measuring blood hematocrit which includes: a sample holder for receiving a blood sample; a first light generating means for generating light within the isobestic region of oxyhemoglobin: a second light generating means for generating light within the isobestic region of deoxyhemoglobin; means for directing light from the first and second light generating means to the sample holder; means for receiving light from the sample holder; means for measuring pulsatile and non-pulsatile diffuse transmittances from the sample holder; and means for determining ratios of the measured pulsatile and non-pulsatile diffuse transmittances from the sample holder.
  • the present invention also provides a tissue phantom for simulating optical properties of a perfused finger which includes two interwoven networks of randomly distributed tubes, wherein one of the tube networks is filled with a fixed volume of a blood standard and another of the tube networks is adapted to be injected with a blood standard to simulate a pulsatile increase in blood volume.
  • Figure 1 is an absorption spectra of water, deoxygenated red blood cells (Hb), and oxygenated red blood cells (Hb0 2 ) in the 700 nm to 1350 nm spectral region.
  • Figure 2 is a schematic diagram of an apparatus for measuring the hematocrit of blood according to one embodiment of the present invention.
  • Figure 3 is a schematic illustration of a tissue phantom which simulates the optical properties of a perfused finger according to one embodiment of the present invention.
  • Figure 4 is a schematic diagram of an apparatus for measuring the hematocrit of blood according to another embodiment of the present invention.
  • Figure 5a is a graph of optical transmissions of whole blood at 800 nm and 1300 nm at various hemoglobin concentrations.
  • Figure 5b is a graph of the ratio between the optical densities of Fig. 5a at various hemoglobin concentrations.
  • Figure 6 is a graph which compares theoretical predictions of measurements of blood hematocrit with experimental test results.
  • Blood hematocrit is routinely determined in clinics by analysis of blood samples.
  • the present invention provides a non-invasive method for measuring arterial blood hematocrit which, when combined with pulse oximetry, enables simultaneous monitoring of hemoglobin concentration and oxygen saturation.
  • the present invention is based on the same principles underlying pulse oximetry, except according to the present invention, two light sources which emit close to isobestic wavelengths of oxy/deoxyhemoglobin in the near-infrared band are employed.
  • hematocrit is related to the ratios of the pulsatile and non-pulsatile components of the diffuse intensity transmitted through a blood-perfused tissue at isobestic wavelengths of oxy/deoxyhemoglobin in the near-infrared band. Based upon the inventor's discovery, an apparatus as described below has been developed for non-invasively measuring hemoglobin concentration and oxygen saturation.
  • the optical density of whole blood has a strong dependence on the density of red cells in the blood and on the concentration and oxygenation state of the hemoglobin contained in the cells.
  • the optical density of whole blood is altered as a result of changes in both scattering and absorption.
  • the macroscopic absorption and transport-corrected scattering coefficients of whole blood can be related to hematocrit as follows:
  • H blood hematocrit (assumed to be equal to the volume fraction of red blood cells, neglecting the small fraction of white cells and other formed • elements) ;
  • i volume of a red blood cell ( ⁇ m );
  • S hemoglobin oxygen saturation;
  • ⁇ 2 absorption cross-section of an oxygenated red cell ( ⁇ m 2 ) ;
  • C__ m , a nd e a nd _ are the mi l limo lar extinction coeffic °ients (mM ⁇ ?_. • L -1 • cm -1 ) of oxyhemoglobin and deoxyhemoglobin , respectively , and ⁇ - ⁇ rbc is the
  • the optical-density ratio has, in general, a more complicated dependence on d and H than that given by Eq. (8). Nonetheless , as shown below, the optical-density ratio has been observed to maintain its linear dependence on hematocrit provided that d is less than a few millimeters.
  • the technique of pulse oximetry has been shown to provide a satisfactory solution to the challenging problem of measuring changes in the optical absorption of blood contained in highly scattering skin tissues (Yoshiya, Vol. 18, supra; Tremper, Vol. 70, supra ) .
  • the pulsatile optical signals measured by a pulse oximeter result from changes in the bulk absorption coefficient of the skin induced by a transient increase in blood volume during cardiac systole.
  • the blood-perfused tissue is treated as a homogeneous mixture of blood and bloodless skin tissues through which photons diffuse. Changes in the intensity measured by sources and detectors placed on the skin are calculated using a simple photon-diffusion theory. In earlier studies, this approach has proven useful in the analysis of multiple scattering effects on pulse oximetry (Schmitt, "A simple Photon Diffusion Analysis of the Effects of Multiple Scattering on Pulse Oximetry", IEEE Trans. Biomed. Eng., Vol. 88 (1991), pages 1194-1203) .
  • k 2 -k 1 ⁇ [exp(- ⁇ t d)-exp(o_d)]/[exp(-o_d)-exp(ad)] ⁇ (lib)
  • the diffuse intensity, I received by a collimated detector located on the opposite side of the tissue slab can then be obtained as follows:
  • ⁇ can be obtained by adding the absorption coefficients of the individual absorbers in the tissue, which mainly comprise hemoglobin, water, and assorted pigment chromophores. By limiting interest to intensities measured at isobestic wavelengths, it is unnecessary to distinguish the volume fractions of venous and arterial blood. With these assumptions, the total absorption coefficient is simply
  • V, and V are the volume fractions of blood and water
  • ⁇ C a L g represents absorption by other unspecified substances.
  • a pulsatile (“ac”) variation is superimposed on the time- averaged ("dc") intensity received by the detector. The ratio of the pulsatile to the average intensity is then,
  • the quantity (3 ⁇ ⁇ * /2 s ⁇ a ⁇ )1 at a particular wave _length can be obtained by fitting the slope of the In [ r I ( r ) ] - vs - r surface-reemittance curve .
  • a single photodiode 6 e.g., an InGaAs photodiode
  • This optical configuration was chosen to approximate the plane-parallel conditions under which the photon- diffusion model discussed above was desired.
  • Voltages proportional to scattered intensities at both wavelengths of each laser diode were measured simultaneously by a pair of lock- in amplifiers 8a, 8b, each referenced to the modulation frequency of one of the laser diodes by reference oscillators 9a and 9b.
  • the tissue model or phantom shown in Fig. 3 was designed to simulate the optical properties of a moderately-perfused finger.
  • the tissue phantom consisted of two interweaved networks of randomly distributed plastic tubes (0.25 mm ID) embedded in a liquid scattering medium.
  • One network 10 was composed of rigid polystyrene tubing occupying about 2% of the total scattering volume; the other network 11, which occupied about 1% of the scattering volume, was composed of soft silastic tubing.
  • the rigid tubing 10 was filled with a fixed volume of whole blood which simulated the reservoir of non-pulsatile blood in the skin. To simulate a small pulsatile increase in the blood volume, whole blood was injected into the network of silastic tubing.
  • the intensity recorded before injection represented the non-pulsatile component (I, ) and the difference between the intensity recorded before and after injection represented the pulsatile component of the diffuse intensity (I ).
  • Blood samples having a known hematocrit were prepared by mixing packed human red cells and plasma obtained from the blood bank. Before mixing, the initial hematocrit of the packed cells was determined by measuring the cell volume fraction in centrifuged capillary-tube samples.
  • the scattering liquid in which the tubing networks were e bedded consisted of a mixture of 0.99- ⁇ m-diameter polystyrene spheres 12 (Polyscience, Inc.), water, and glycerol in a glass-walled sample chamber (5.9 mm thickness).
  • 1.3 vol.% of spheres were used in a 1:1 mixture of glycerol and water to obtain a transport-corrected scattering coefficient equal to 1.73 mm “ and 1.26 mm “ at 800 and 1300 nm, respectively (values were calculated using Mie scattering theory; the calculated anisotropy parameter of the spheres in the mixture was 0.91 at 820 nm and 0.83 at 1300 nm) .
  • Glycerol which has a lower absorption coefficient than water at 1300 nm (0.044 mm " vs. 0.14 mm- ), was added to reduce the absorption coefficient of the mixture at 1300 nm to about 0.092 mm " .
  • the absorption coefficient of the water/glycerol mixture was very small ( ⁇ 0.003 mm ); therefore, absorption at this wavelength was mainly determined by the volume of blood in the tubing network.
  • FIG. 2 To obtain reemittance measurements from live human skin, the instrumentation shown in Fig. 2 was modified slightly. As shown in Fig. 4, the fiber bundles 2 were replaced by a single optic fiber 13 and the light from both laser diodes la and lb was focused on an end of optic fiber 13. An identical optic fiber 14 was attached to the photodiode 6. To adjust the distance between the source and detector fibers (13 and 14), a calibrated position was used. Figure 4 shows a human finger 15 positioned between optical fibers 13 and 14.
  • Photoplethysmograms were recorded holding the tip of the optic fiber 13 against the top surface of the index finger 15. A photodiode 6 contacted the bottom surface of the finger 15 via optic fiber 14. In another embodiment, optical fiber 14 was eliminated and the lower surface of finger 15 rested on photodiode 6.
  • the output signals from the lock-in amplifiers were band ⁇ pass filtered (0.5 - 10 Hz) to separate the ac and dc intensity signals, which were subsequently processed using a microcomputer-based data acquisition system (not shown) .
  • Fig. 3a The intensity of light transmitted through a 1.85 mm thick sample of fresh, fully oxygenated whole blood at 800 nm and 1300 nm is shown in Fig. 3a as a function of blood hematocrit.
  • the photon path lengths in skin tissue at 800 nm and 1300 nm are not well-defined; they depend on the concentration of the absorbing substances (mainly water and hemoglobin) and scatterers in the skin, as well as the dimensions of the illuminated volume.
  • the blood absorption values were calculated according to Eqs. (3) and (4) , using the measured absorption data plotted in Fig. 1; the scattering coefficient of blood was calculated by Mie theory (Bonner, Vol. 4, supra ..
  • the scattering coefficients shown in Table 1 were estimated using the surface-ree ittance measurement technique discussed above. According to the Table 1 values, the optical coefficients of the in vitro model used in the present experiments corresponded to those of a 10 mm-thick finger containing 1-3 vol.% of blood and 65 vol.% of water.
  • the ratio varied by a factor of about 2.5 over the range of hematocrits between 15% and 60%.
  • the volume of blood in the rigid tubing network (denoted as "V, " in the figure) , which mainly affected the background absorption at 830 nm, did not appear to have a strong effect on the R vs. H relationship.
  • the theoretical curves shown in the figure, which were obtained using the photon-diffusion theory discussed above fit the experimental data well.
  • the ac-dc intensity ratio at each wavelength was calculated using Eq. (14), with 1. given by Eq. (12).
  • the total absorption coefficient of the experimental scattering medium was calculated by adding the absorption coefficients of the water/glycerol mixture and blood (Table 1), according to Eq. (13), and the total scattering coefficient was assumed to be equal to that of the polystyrene spheres in the water/glycerol mixture.
  • the present invention provides a method and apparatus which can be used to non-invasively measure blood hematocrit by dual- wavelength, near-infrared photoplethysmography.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Appareil et procédé de mesure des hématocrites sanguins consistant à faire passer une première et une seconde longueurs d'ondes de lumière à travers un échantillon sanguin, à déterminer le rapport entre des facteurs de transmissions diffuses pulsatiles et non pulsalites mesurés à chacune des première et seconde longueurs d'ondes de lumière provenant de l'échantillon sanguin, et à déterminer les hématocrites sanguins de l'échantillon sanguin à partir du rapport entre les facteurs de transmissions diffuses pulsatiles et non pulsatiles mesurés à chacune des première et seconde longueurs d'ondes de lumière provenant de l'échantillon sanguin. L'une des première et seconde longueurs d'ondes de lumière se trouve à l'intérieur de la région isobestique d'oxyhémoglobine et l'autre se trouve à l'intérieur de la région isobestique de désoxyhémoglobine. Un tissu fantôme de simulation des propriétés optiques d'un doigt perfusé est utilisé pour tester le procédé et l'appareil.
PCT/US1993/000334 1992-01-17 1993-01-15 Procede optique de controle des hematocrites dans le sang arteriel WO1993013706A2 (fr)

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US822,018 1992-01-17

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Publication number Priority date Publication date Assignee Title
EP0648085A1 (fr) * 1993-05-07 1995-04-19 BTI Holdings, Inc. Simulation pour oxymetre par impulsions
WO1995020757A1 (fr) * 1994-01-31 1995-08-03 Minnesota Mining And Manufacturing Company Procede et appareil de prediction non sanglante d'hematocrite
EP0693900A1 (fr) * 1993-04-12 1996-01-31 Noninvasive Medical Technology Corporation Systeme et procede de surveillance non invasive de l'hematocrite
EP0714628A1 (fr) * 1994-11-30 1996-06-05 TOA MEDICAL ELECTRONICS CO., Ltd. Analyseur destiné à l'examen non-invasif du sang
US5598842A (en) * 1993-09-03 1997-02-04 Toa Medical Electronics Co., Ltd. Non-invasive blood analyzer and method using the same
EP0801316A2 (fr) * 1996-04-10 1997-10-15 Ohmeda Inc. Instrument photopléthysmographe avec coupleur multimode en optique intégrée
US5791345A (en) * 1993-09-03 1998-08-11 Toa Medical Electronics Co., Ltd. Non-invasive blood analyzer
EP0875201A1 (fr) * 1995-12-27 1998-11-04 TOA MEDICAL ELECTRONICS CO., Ltd. Appareil pour examen sanguin non invasif
US5983120A (en) * 1995-10-23 1999-11-09 Cytometrics, Inc. Method and apparatus for reflected imaging analysis
WO2001015596A1 (fr) * 1999-08-31 2001-03-08 Cme Telemetrix Inc. Dispositif de verification de haute precision d'un analyseur spectral
US6241663B1 (en) 1998-05-18 2001-06-05 Abbott Laboratories Method for improving non-invasive determination of the concentration of analytes in a biological sample
US6353226B1 (en) 1998-11-23 2002-03-05 Abbott Laboratories Non-invasive sensor capable of determining optical parameters in a sample having multiple layers
WO2002075289A2 (fr) * 2001-03-16 2002-09-26 Nellcor Puritan Bennett Incorporated Procede et appareil pour ameliorer la precision de mesures d'hematocrite non effractives
US6526298B1 (en) 1998-05-18 2003-02-25 Abbott Laboratories Method for the non-invasive determination of analytes in a selected volume of tissue
WO2003023499A2 (fr) * 2001-09-12 2003-03-20 Tecan Trading Ag Dispositif optique, systeme et utilisation
US6615061B1 (en) 1998-11-23 2003-09-02 Abbott Laboratories Optical sensor having a selectable sampling distance for determination of analytes
US6662031B1 (en) 1998-05-18 2003-12-09 Abbott Laboratoies Method and device for the noninvasive determination of hemoglobin and hematocrit
US6662030B2 (en) 1998-05-18 2003-12-09 Abbott Laboratories Non-invasive sensor having controllable temperature feature
US6862534B2 (en) 2001-12-14 2005-03-01 Optiscan Biomedical Corporation Method of determining an analyte concentration in a sample from an absorption spectrum
US6944486B2 (en) 1997-03-12 2005-09-13 Optiscan Biomedical Corporation Method and apparatus for determining analyte concentration using phase and magnitude detection of a radiation transfer function
US7009180B2 (en) 2001-12-14 2006-03-07 Optiscan Biomedical Corp. Pathlength-independent methods for optically determining material composition
US7043287B1 (en) 1998-05-18 2006-05-09 Abbott Laboratories Method for modulating light penetration depth in tissue and diagnostic applications using same
US7236811B2 (en) 2001-03-16 2007-06-26 Nellcor Puritan Bennett Incorporated Device and method for monitoring body fluid and electrolyte disorders
US7239902B2 (en) 2001-03-16 2007-07-03 Nellor Puritan Bennett Incorporated Device and method for monitoring body fluid and electrolyte disorders
US7271912B2 (en) 2003-04-15 2007-09-18 Optiscan Biomedical Corporation Method of determining analyte concentration in a sample using infrared transmission data
US7277741B2 (en) 2004-03-09 2007-10-02 Nellcor Puritan Bennett Incorporated Pulse oximetry motion artifact rejection using near infrared absorption by water
US7400918B2 (en) 1998-07-04 2008-07-15 Edwards Lifesciences Measurement of blood oxygen saturation
US7657292B2 (en) 2001-03-16 2010-02-02 Nellcor Puritan Bennett Llc Method for evaluating extracellular water concentration in tissue
US7684842B2 (en) 2006-09-29 2010-03-23 Nellcor Puritan Bennett Llc System and method for preventing sensor misuse
EP1094745B1 (fr) * 1998-07-04 2010-05-19 Whitland Research Limited Mesure non invasive d'analytes sanguins
US8109882B2 (en) 2007-03-09 2012-02-07 Nellcor Puritan Bennett Llc System and method for venous pulsation detection using near infrared wavelengths
US8116852B2 (en) 2006-09-29 2012-02-14 Nellcor Puritan Bennett Llc System and method for detection of skin wounds and compartment syndromes
US8135448B2 (en) 2001-03-16 2012-03-13 Nellcor Puritan Bennett Llc Systems and methods to assess one or more body fluid metrics
US8175665B2 (en) 2007-03-09 2012-05-08 Nellcor Puritan Bennett Llc Method and apparatus for spectroscopic tissue analyte measurement
US8180419B2 (en) 2006-09-27 2012-05-15 Nellcor Puritan Bennett Llc Tissue hydration estimation by spectral absorption bandwidth measurement
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US8280469B2 (en) 2007-03-09 2012-10-02 Nellcor Puritan Bennett Llc Method for detection of aberrant tissue spectra
US8315685B2 (en) 2006-09-27 2012-11-20 Nellcor Puritan Bennett Llc Flexible medical sensor enclosure
US8346327B2 (en) 2007-03-09 2013-01-01 Covidien Lp Method for identification of sensor site by local skin spectrum data
US8357090B2 (en) 2007-03-09 2013-01-22 Covidien Lp Method and apparatus for estimating water reserves
US8386000B2 (en) 2008-09-30 2013-02-26 Covidien Lp System and method for photon density wave pulse oximetry and pulse hemometry
US8433382B2 (en) 2008-09-30 2013-04-30 Covidien Lp Transmission mode photon density wave system and method
US8494604B2 (en) 2009-09-21 2013-07-23 Covidien Lp Wavelength-division multiplexing in a multi-wavelength photon density wave system
US8521247B2 (en) 2010-12-29 2013-08-27 Covidien Lp Certification apparatus and method for a medical device computer
US8600469B2 (en) 2005-09-29 2013-12-03 Covidien Lp Medical sensor and technique for using the same
US8690864B2 (en) 2007-03-09 2014-04-08 Covidien Lp System and method for controlling tissue treatment
US8788001B2 (en) 2009-09-21 2014-07-22 Covidien Lp Time-division multiplexing in a multi-wavelength photon density wave system
US8913800B2 (en) 2004-06-01 2014-12-16 Lumidigm, Inc. Optical biometrics imaging with films
US8965473B2 (en) 2005-09-29 2015-02-24 Covidien Lp Medical sensor for reducing motion artifacts and technique for using the same
EP1447658B1 (fr) * 2003-02-11 2015-10-21 Bayer HealthCare LLC Tête de mesure à plusieurs longueurs d'onde s'utilisant dans la determination d'analytes dans des fluides physiologiques
WO2015176955A1 (fr) * 2014-05-21 2015-11-26 Koninklijke Philips N.V. Dispositif et procédé de détermination non invasive de la valeur d'hématocrite d'un sujet
US9833146B2 (en) 2012-04-17 2017-12-05 Covidien Lp Surgical system and method of use of the same
US9895068B2 (en) 2008-06-30 2018-02-20 Covidien Lp Pulse oximeter with wait-time indication
WO2019138377A1 (fr) * 2018-01-09 2019-07-18 Medtronic Monitoring, Inc. Système et procédé de surveillance non invasive du taux d'hématocrite
US10475529B2 (en) 2011-07-19 2019-11-12 Optiscan Biomedical Corporation Method and apparatus for analyte measurements using calibration sets
US10548491B2 (en) 2015-01-30 2020-02-04 Koninklijke Philips N.V. Photoplethysmography apparatus
US11039768B2 (en) 2018-01-09 2021-06-22 Medtronic Monitoring, Inc. System and method for non-invasive monitoring of hemoglobin
US11051727B2 (en) 2018-01-09 2021-07-06 Medtronic Monitoring, Inc. System and method for non-invasive monitoring of advanced glycation end-products (AGE)
US11879827B2 (en) * 2020-04-29 2024-01-23 Becton, Dickinson And Company Methods for modulation and synchronous detection in a flow cytometer and systems for same
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EP0693900A4 (fr) * 1993-04-12 1997-05-07 Noninvasive Medical Technology Systeme et procede de surveillance non invasive de l'hematocrite
EP0648085A4 (fr) * 1993-05-07 1997-02-12 Biotek Instr Inc Simulation pour oxymetre par impulsions.
EP0648085A1 (fr) * 1993-05-07 1995-04-19 BTI Holdings, Inc. Simulation pour oxymetre par impulsions
US5791345A (en) * 1993-09-03 1998-08-11 Toa Medical Electronics Co., Ltd. Non-invasive blood analyzer
US5598842A (en) * 1993-09-03 1997-02-04 Toa Medical Electronics Co., Ltd. Non-invasive blood analyzer and method using the same
WO1995020757A1 (fr) * 1994-01-31 1995-08-03 Minnesota Mining And Manufacturing Company Procede et appareil de prediction non sanglante d'hematocrite
US5553615A (en) * 1994-01-31 1996-09-10 Minnesota Mining And Manufacturing Company Method and apparatus for noninvasive prediction of hematocrit
US5755226A (en) * 1994-01-31 1998-05-26 Minnesota Mining And Manufacturing Company Method and apparatus for noninvasive prediction of hematocrit
EP0714628A1 (fr) * 1994-11-30 1996-06-05 TOA MEDICAL ELECTRONICS CO., Ltd. Analyseur destiné à l'examen non-invasif du sang
US5983120A (en) * 1995-10-23 1999-11-09 Cytometrics, Inc. Method and apparatus for reflected imaging analysis
US6104939A (en) * 1995-10-23 2000-08-15 Cytometrics, Inc. Method and apparatus for reflected imaging analysis
EP0875201A1 (fr) * 1995-12-27 1998-11-04 TOA MEDICAL ELECTRONICS CO., Ltd. Appareil pour examen sanguin non invasif
EP0875201A4 (fr) * 1995-12-27 1999-11-10 Toa Medical Electronics Appareil pour examen sanguin non invasif
EP1371323A1 (fr) * 1995-12-27 2003-12-17 Sysmex Corporation Appareil pour examen sanguin non invasif
US6061583A (en) * 1995-12-27 2000-05-09 Sysmex Corporation And Ken Ishihara Noninvasive blood analyzer
EP0801316A2 (fr) * 1996-04-10 1997-10-15 Ohmeda Inc. Instrument photopléthysmographe avec coupleur multimode en optique intégrée
US6944486B2 (en) 1997-03-12 2005-09-13 Optiscan Biomedical Corporation Method and apparatus for determining analyte concentration using phase and magnitude detection of a radiation transfer function
US7006857B2 (en) 1997-03-12 2006-02-28 Optiscan Biomedical Corporation Method for determining analyte concentration using periodic temperature modulation and phase detection
US6654620B2 (en) 1998-05-18 2003-11-25 Abbott Laboratories Method for improving non-invasive determination of the concentration of analytes in a biological sample
US6526298B1 (en) 1998-05-18 2003-02-25 Abbott Laboratories Method for the non-invasive determination of analytes in a selected volume of tissue
US7043287B1 (en) 1998-05-18 2006-05-09 Abbott Laboratories Method for modulating light penetration depth in tissue and diagnostic applications using same
US6241663B1 (en) 1998-05-18 2001-06-05 Abbott Laboratories Method for improving non-invasive determination of the concentration of analytes in a biological sample
US6662030B2 (en) 1998-05-18 2003-12-09 Abbott Laboratories Non-invasive sensor having controllable temperature feature
US6662031B1 (en) 1998-05-18 2003-12-09 Abbott Laboratoies Method and device for the noninvasive determination of hemoglobin and hematocrit
EP1094745B1 (fr) * 1998-07-04 2010-05-19 Whitland Research Limited Mesure non invasive d'analytes sanguins
US7400918B2 (en) 1998-07-04 2008-07-15 Edwards Lifesciences Measurement of blood oxygen saturation
US7774037B2 (en) 1998-07-04 2010-08-10 Whitland Research Limited Non-invasive measurement of blood analytes
US6353226B1 (en) 1998-11-23 2002-03-05 Abbott Laboratories Non-invasive sensor capable of determining optical parameters in a sample having multiple layers
US6615061B1 (en) 1998-11-23 2003-09-02 Abbott Laboratories Optical sensor having a selectable sampling distance for determination of analytes
US6630673B2 (en) 1998-11-23 2003-10-07 Abbott Laboratories Non-invasive sensor capable of determining optical parameters in a sample having multiple layers
WO2001015596A1 (fr) * 1999-08-31 2001-03-08 Cme Telemetrix Inc. Dispositif de verification de haute precision d'un analyseur spectral
US6657717B2 (en) 1999-08-31 2003-12-02 Cme Telemetrix Inc. Device for verifying the accuracy of a spectral analyzer
US6614521B2 (en) 1999-08-31 2003-09-02 Cme Telemetrix Inc. Device for verifying the accuracy of a spectral analyzer
US6606509B2 (en) 2001-03-16 2003-08-12 Nellcor Puritan Bennett Incorporated Method and apparatus for improving the accuracy of noninvasive hematocrit measurements
US8135448B2 (en) 2001-03-16 2012-03-13 Nellcor Puritan Bennett Llc Systems and methods to assess one or more body fluid metrics
US8457722B2 (en) 2001-03-16 2013-06-04 Covidien Lp Device and method for monitoring body fluid and electrolyte disorders
US8229529B2 (en) 2001-03-16 2012-07-24 Nellcor Puritan Bennett Llc Device and method for monitoring body fluid and electrolyte disorders
US8509866B2 (en) 2001-03-16 2013-08-13 Covidien Lp Device and method for monitoring body fluid and electrolyte disorders
US7236811B2 (en) 2001-03-16 2007-06-26 Nellcor Puritan Bennett Incorporated Device and method for monitoring body fluid and electrolyte disorders
US7239902B2 (en) 2001-03-16 2007-07-03 Nellor Puritan Bennett Incorporated Device and method for monitoring body fluid and electrolyte disorders
WO2002075289A2 (fr) * 2001-03-16 2002-09-26 Nellcor Puritan Bennett Incorporated Procede et appareil pour ameliorer la precision de mesures d'hematocrite non effractives
WO2002075289A3 (fr) * 2001-03-16 2002-11-21 Nellcor Puritan Bennett Inc Procede et appareil pour ameliorer la precision de mesures d'hematocrite non effractives
US7657292B2 (en) 2001-03-16 2010-02-02 Nellcor Puritan Bennett Llc Method for evaluating extracellular water concentration in tissue
WO2003023499A3 (fr) * 2001-09-12 2003-10-16 Tecan Trading Ag Dispositif optique, systeme et utilisation
WO2003023499A2 (fr) * 2001-09-12 2003-03-20 Tecan Trading Ag Dispositif optique, systeme et utilisation
US6862534B2 (en) 2001-12-14 2005-03-01 Optiscan Biomedical Corporation Method of determining an analyte concentration in a sample from an absorption spectrum
US7009180B2 (en) 2001-12-14 2006-03-07 Optiscan Biomedical Corp. Pathlength-independent methods for optically determining material composition
US7096124B2 (en) 2001-12-14 2006-08-22 Optiscan Biomedical Corporation Method of determining an analyte concentration in a sample from an absorption spectrum
EP1447658B1 (fr) * 2003-02-11 2015-10-21 Bayer HealthCare LLC Tête de mesure à plusieurs longueurs d'onde s'utilisant dans la determination d'analytes dans des fluides physiologiques
US7271912B2 (en) 2003-04-15 2007-09-18 Optiscan Biomedical Corporation Method of determining analyte concentration in a sample using infrared transmission data
US8175670B2 (en) 2004-03-09 2012-05-08 Nellcor Puritan Bennett Llc Pulse oximetry signal correction using near infrared absorption by water
US8195263B2 (en) 2004-03-09 2012-06-05 Nellcor Puritan Bennett Llc Pulse oximetry motion artifact rejection using near infrared absorption by water
US7277741B2 (en) 2004-03-09 2007-10-02 Nellcor Puritan Bennett Incorporated Pulse oximetry motion artifact rejection using near infrared absorption by water
US8913800B2 (en) 2004-06-01 2014-12-16 Lumidigm, Inc. Optical biometrics imaging with films
US8965473B2 (en) 2005-09-29 2015-02-24 Covidien Lp Medical sensor for reducing motion artifacts and technique for using the same
US8600469B2 (en) 2005-09-29 2013-12-03 Covidien Lp Medical sensor and technique for using the same
US8219170B2 (en) 2006-09-20 2012-07-10 Nellcor Puritan Bennett Llc System and method for practicing spectrophotometry using light emitting nanostructure devices
US8180419B2 (en) 2006-09-27 2012-05-15 Nellcor Puritan Bennett Llc Tissue hydration estimation by spectral absorption bandwidth measurement
US8315685B2 (en) 2006-09-27 2012-11-20 Nellcor Puritan Bennett Llc Flexible medical sensor enclosure
US8116852B2 (en) 2006-09-29 2012-02-14 Nellcor Puritan Bennett Llc System and method for detection of skin wounds and compartment syndromes
US7684842B2 (en) 2006-09-29 2010-03-23 Nellcor Puritan Bennett Llc System and method for preventing sensor misuse
US8280469B2 (en) 2007-03-09 2012-10-02 Nellcor Puritan Bennett Llc Method for detection of aberrant tissue spectra
US8346327B2 (en) 2007-03-09 2013-01-01 Covidien Lp Method for identification of sensor site by local skin spectrum data
US8357090B2 (en) 2007-03-09 2013-01-22 Covidien Lp Method and apparatus for estimating water reserves
US8265724B2 (en) 2007-03-09 2012-09-11 Nellcor Puritan Bennett Llc Cancellation of light shunting
US8175665B2 (en) 2007-03-09 2012-05-08 Nellcor Puritan Bennett Llc Method and apparatus for spectroscopic tissue analyte measurement
US8109882B2 (en) 2007-03-09 2012-02-07 Nellcor Puritan Bennett Llc System and method for venous pulsation detection using near infrared wavelengths
US8690864B2 (en) 2007-03-09 2014-04-08 Covidien Lp System and method for controlling tissue treatment
US8275553B2 (en) 2008-02-19 2012-09-25 Nellcor Puritan Bennett Llc System and method for evaluating physiological parameter data
US9895068B2 (en) 2008-06-30 2018-02-20 Covidien Lp Pulse oximeter with wait-time indication
US8386000B2 (en) 2008-09-30 2013-02-26 Covidien Lp System and method for photon density wave pulse oximetry and pulse hemometry
US8433382B2 (en) 2008-09-30 2013-04-30 Covidien Lp Transmission mode photon density wave system and method
US8788001B2 (en) 2009-09-21 2014-07-22 Covidien Lp Time-division multiplexing in a multi-wavelength photon density wave system
US8494604B2 (en) 2009-09-21 2013-07-23 Covidien Lp Wavelength-division multiplexing in a multi-wavelength photon density wave system
US8521247B2 (en) 2010-12-29 2013-08-27 Covidien Lp Certification apparatus and method for a medical device computer
US10475529B2 (en) 2011-07-19 2019-11-12 Optiscan Biomedical Corporation Method and apparatus for analyte measurements using calibration sets
US9833146B2 (en) 2012-04-17 2017-12-05 Covidien Lp Surgical system and method of use of the same
WO2015176955A1 (fr) * 2014-05-21 2015-11-26 Koninklijke Philips N.V. Dispositif et procédé de détermination non invasive de la valeur d'hématocrite d'un sujet
CN106456029A (zh) * 2014-05-21 2017-02-22 皇家飞利浦有限公司 用于无创地确定对象的红细胞比容值的设备和方法
US10582885B2 (en) 2014-05-21 2020-03-10 Koninklijke Philips N.V. Device and method for noninvasively determining the hematocrit value of a subject
CN106456029B (zh) * 2014-05-21 2019-11-26 皇家飞利浦有限公司 用于无创地确定对象的红细胞比容值的设备和方法
US10548491B2 (en) 2015-01-30 2020-02-04 Koninklijke Philips N.V. Photoplethysmography apparatus
WO2019138377A1 (fr) * 2018-01-09 2019-07-18 Medtronic Monitoring, Inc. Système et procédé de surveillance non invasive du taux d'hématocrite
US11039768B2 (en) 2018-01-09 2021-06-22 Medtronic Monitoring, Inc. System and method for non-invasive monitoring of hemoglobin
US11051727B2 (en) 2018-01-09 2021-07-06 Medtronic Monitoring, Inc. System and method for non-invasive monitoring of advanced glycation end-products (AGE)
US11154224B2 (en) 2018-01-09 2021-10-26 Medtronic Monitoring, Inc. System and method for non-invasive monitoring of hematocrit concentration
US11918351B2 (en) 2018-01-09 2024-03-05 Medtronic Monitoring, Inc. System and method for non-invasive monitoring of hemoglobin
US12109020B2 (en) 2018-01-09 2024-10-08 Medtronic Monitoring, Inc. System and method for non-invasive monitoring of advanced glycation end-products (AGE)
US11879827B2 (en) * 2020-04-29 2024-01-23 Becton, Dickinson And Company Methods for modulation and synchronous detection in a flow cytometer and systems for same
CN118121196A (zh) * 2024-05-07 2024-06-04 北京航天长峰股份有限公司 一种hct预测方法、系统、设备及介质
CN118121196B (zh) * 2024-05-07 2024-07-12 北京航天长峰股份有限公司 一种hct预测方法、系统、设备及介质

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