WO1993009808A1 - PROCEDES PERMETTANT DE DETECTER ET D'ISOLER L'uPA-R ET D'INHIBER LA LIAISON DE L'uPA A L'uPA-R - Google Patents

PROCEDES PERMETTANT DE DETECTER ET D'ISOLER L'uPA-R ET D'INHIBER LA LIAISON DE L'uPA A L'uPA-R Download PDF

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Publication number
WO1993009808A1
WO1993009808A1 PCT/US1992/008977 US9208977W WO9309808A1 WO 1993009808 A1 WO1993009808 A1 WO 1993009808A1 US 9208977 W US9208977 W US 9208977W WO 9309808 A1 WO9309808 A1 WO 9309808A1
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WO
WIPO (PCT)
Prior art keywords
upa
antibody
vol
cells
binding
Prior art date
Application number
PCT/US1992/008977
Other languages
English (en)
Inventor
Ikuko F. Mizukami
Robert F. Todd, Iii
Original Assignee
The Regents Of The University Of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of Michigan filed Critical The Regents Of The University Of Michigan
Priority to EP92922134A priority Critical patent/EP0642354A4/fr
Priority to JP5509252A priority patent/JPH07501524A/ja
Publication of WO1993009808A1 publication Critical patent/WO1993009808A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Des anticorps dirigés contre la protéine Mo3 sont susceptibles de se lier au récepteur de l'activateur de plasminogène du type urokinase (uPA-R), ou d'inhiber la liaison de l'activateur de plasminogène du type urokinase (uPA) à l'uPA-R.
PCT/US1992/008977 1991-11-18 1992-10-27 PROCEDES PERMETTANT DE DETECTER ET D'ISOLER L'uPA-R ET D'INHIBER LA LIAISON DE L'uPA A L'uPA-R WO1993009808A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP92922134A EP0642354A4 (fr) 1991-11-18 1992-10-27 PROCEDES PERMETTANT DE DETECTER ET D'ISOLER L'uPA-R ET D'INHIBER LA LIAISON DE L'uPA A L'uPA-R.
JP5509252A JPH07501524A (ja) 1991-11-18 1992-10-27 ｕＰＡ−Ｒの検出・分離方法及びｕＰＡのｕＰＡ−Ｒへの結合阻止方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79320891A 1991-11-18 1991-11-18
US793,208 1991-11-18

Publications (1)

Publication Number Publication Date
WO1993009808A1 true WO1993009808A1 (fr) 1993-05-27

Family

ID=25159386

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/008977 WO1993009808A1 (fr) 1991-11-18 1992-10-27 PROCEDES PERMETTANT DE DETECTER ET D'ISOLER L'uPA-R ET D'INHIBER LA LIAISON DE L'uPA A L'uPA-R

Country Status (4)

Country Link
EP (1) EP0642354A4 (fr)
JP (1) JPH07501524A (fr)
CA (1) CA2123874A1 (fr)
WO (1) WO1993009808A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028014A2 (fr) * 1993-05-28 1994-12-08 Chiron Corporation Peptides inhibiteurs de l'activite des recepteurs d'urokinase
US6025142A (en) * 1994-07-08 2000-02-15 Boehringer Mannheim Gmbh Hydrophobic u-PAR binding site
EP0982036A1 (fr) * 1998-08-28 2000-03-01 Wilex Biotechnology GmbH Modulation de l'adhesion cellulaire a médiation de la Beta-2-integrin
EP1064005A1 (fr) * 1998-03-23 2001-01-03 Shafaat A. Rabbani Utilisation du recepteur des activateurs du plasminogene d'urokinase comme cible pour le depistage des metastases
WO2007120693A2 (fr) * 2006-04-10 2007-10-25 Astrazeneca Ab AGENTS DE LIAISON CIBLÉS, DIRIGÉS CONTRE L'uPAR, ET UTILISATIONS
US8105602B2 (en) 2006-12-08 2012-01-31 Tactic Pharma, Llc Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
Blood Cells, Volume 16, No. 1, issued 1990, R.F. TODD III et al., "Human Mononuclear Phagocyte Activation Antigens", pages 167-179, especially pages 169-176. *
Cancer and Metastasis Reviews, Volume 9, issued December 1990, J.E. TESTA et al., "The Role of Urokinase-Type Plasminogen Activator in Aggressive Tumor Cell Behavior", pages 353-367, see Abstract. *
D. CARNEY et al., "Genes and Cancer", published 1990 by John Wiley and Sons, Ltd (N.Y.), pages 173-181, see entire document. *
Federation of European Biochemical Societies, Volume 288, No. 1-2, issued August 1991, E. RONNE et al., "Cell-Induced Potentiation of the Plasminogen Activation System is Abolished by a Monoclonal Antibody that Recognized the NH2-Terminal Domain of the Urokinase Receptor", pages 233-236, see entire document. *
J.A. ROTH, "Monoclonal Antibodies in Cancer", published 1986 by Futura Publishing Company Inc. (Mount Kisco, N.Y.), pages 289-321, especially pages 309-321. *
Journal of Immunologic Methods, Volume 130, No. 1, issued 12 June 1990, U. ZACHARIAS et al., "Inhibition of Urokinase Activity and Prevention of Urokinase Receptor Binding by Monoclonal Antibodies", pages 81-90, especially Abstract. *
Journal of Investigative Dermatology, Volume 94, issued March 1990, M. DEL ROSSO et al., "Role of Specific Membrane Receptors in Urokinase-Dependent Migration of Human Keratinocytes", pages 310-316, see entire document. *
Proceedings of the National Academy of Sciences, Volume 86, issued July 1989, J.C. KIRCHHEIMER et al., "Functional Inhibition of Endogenously Produced Urokinase Decreases Cell Proliferation in a Human Melanoma Cell Line", pages 5424-5428, especially pages 5424-5425. *
Science, Volume 252, issued June 1991, T.A. WALDMANN, "Monoclonal Antibodies in Diagnosis and Therapy", pages 1657-1662, see entire document. *
See also references of EP0642354A4 *
The Journal of Cell Biology, Volume 104, No. 4, issued April 1987, J. POLLANEN et al., "Distinct Localization of Urokinase-Type Plasminogen Activator and its Type 1 Inhibitor under Cultured Human Fibroblasts and Sarcoma Cells", pages 1085-1096, especially 1085-1086. *
The Journal of Immunology, Volume 137, No. 2, issued 15 July 1986, D.Y. LIU et al., "A Monoclonal Antibody Specific for a Monocyte-Macrophage Membrane Component Blocks the Human Monocyte Response to Migration Inhibitory Factor", pages 448-455, see entire document. *
The Journal of Immunology, Volume 144, No. 5, issued 01 March 1990, I.F. MIZUKAMI et al., "A Structural Characterization of the Mo3 Activation Antigen Expressed on the Plasma Membrane of Human Mononuclearphagocytes", pages 1841-1848, especially pages 1841-1842. *
Thrombosis and Haemostasis, Volume 56, No. 2, issued 21 October 1986, M.L. NOLLI et al., "A Monoclonal Antibody that Recognizes the Receptor Binding Region of Human Urokinase Plasminogen Activator", pages 214-218, see entire document. *
Thrombosis and Haemostasis, Volume 62, No. 3, issued 1989, A. CORTI et al., "Epitope Mapping of the Anti-Urokinase Monoclonal Antibody 5B4 by Isolated Domains of Urokinase", pages 934-939, see entire document. *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028014A2 (fr) * 1993-05-28 1994-12-08 Chiron Corporation Peptides inhibiteurs de l'activite des recepteurs d'urokinase
WO1994028014A3 (fr) * 1993-05-28 1995-01-26 Chiron Corp Peptides inhibiteurs de l'activite des recepteurs d'urokinase
US5679782A (en) * 1993-05-28 1997-10-21 Chiron Corporation Oligonucleotides encloding peptide inhibitors of urokinase receptor activity
US6025142A (en) * 1994-07-08 2000-02-15 Boehringer Mannheim Gmbh Hydrophobic u-PAR binding site
EP1064005A1 (fr) * 1998-03-23 2001-01-03 Shafaat A. Rabbani Utilisation du recepteur des activateurs du plasminogene d'urokinase comme cible pour le depistage des metastases
EP1064005A4 (fr) * 1998-03-23 2004-06-09 Shafaat A Rabbani Utilisation du recepteur des activateurs du plasminogene d'urokinase comme cible pour le depistage des metastases
EP0982036A1 (fr) * 1998-08-28 2000-03-01 Wilex Biotechnology GmbH Modulation de l'adhesion cellulaire a médiation de la Beta-2-integrin
WO2007120693A2 (fr) * 2006-04-10 2007-10-25 Astrazeneca Ab AGENTS DE LIAISON CIBLÉS, DIRIGÉS CONTRE L'uPAR, ET UTILISATIONS
WO2007120693A3 (fr) * 2006-04-10 2008-05-29 Amgen Fremont Inc AGENTS DE LIAISON CIBLÉS, DIRIGÉS CONTRE L'uPAR, ET UTILISATIONS
JP2009533446A (ja) * 2006-04-10 2009-09-17 アストラゼネカ アクチボラグ ｕＰＡＲに対して向けられる標的化結合剤および該結合剤の使用
EP2357202A1 (fr) * 2006-04-10 2011-08-17 AstraZeneca AB Agents de liaison ciblés, dirigés contre l'uPAR, et utilisations
US8105602B2 (en) 2006-12-08 2012-01-31 Tactic Pharma, Llc Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof

Also Published As

Publication number Publication date
EP0642354A1 (fr) 1995-03-15
JPH07501524A (ja) 1995-02-16
CA2123874A1 (fr) 1993-05-27
EP0642354A4 (fr) 1995-07-12

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