WO1993009135A1 - Peptides inhibiting il-1 beta release - Google Patents
Peptides inhibiting il-1 beta release Download PDFInfo
- Publication number
- WO1993009135A1 WO1993009135A1 PCT/EP1992/002472 EP9202472W WO9309135A1 WO 1993009135 A1 WO1993009135 A1 WO 1993009135A1 EP 9202472 W EP9202472 W EP 9202472W WO 9309135 A1 WO9309135 A1 WO 9309135A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- radical
- compound
- amino
- alkyl
- Prior art date
Links
- 0 CC1C(C2)*2CCC1 Chemical compound CC1C(C2)*2CCC1 0.000 description 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92922580A EP0611375A1 (en) | 1991-11-04 | 1992-10-29 | Peptides inhibiting il-1 beta release |
SK511-94A SK51194A3 (en) | 1991-11-04 | 1992-10-29 | Peptides |
JP5508146A JPH07500828A (en) | 1991-11-04 | 1992-10-29 | Peptides that inhibit IL-1β release |
NO941629A NO941629L (en) | 1991-11-04 | 1994-05-03 | Peptides that inhibit 1L-1 |
FI942061A FI942061A (en) | 1991-11-04 | 1994-05-04 | IL-1 beta inhibitory peptides |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9123326.2 | 1991-11-04 | ||
GB919123326A GB9123326D0 (en) | 1991-11-04 | 1991-11-04 | Improvements in or relating to organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993009135A1 true WO1993009135A1 (en) | 1993-05-13 |
Family
ID=10703998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1992/002472 WO1993009135A1 (en) | 1991-11-04 | 1992-10-29 | Peptides inhibiting il-1 beta release |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0611375A1 (en) |
JP (1) | JPH07500828A (en) |
AU (1) | AU2885292A (en) |
CA (1) | CA2116653A1 (en) |
CZ (1) | CZ106794A3 (en) |
FI (1) | FI942061A (en) |
GB (1) | GB9123326D0 (en) |
HU (1) | HUT68200A (en) |
IL (1) | IL103612A0 (en) |
MX (1) | MX9206306A (en) |
NO (1) | NO941629L (en) |
NZ (1) | NZ244985A (en) |
PT (1) | PT101027A (en) |
SK (1) | SK51194A3 (en) |
WO (1) | WO1993009135A1 (en) |
ZA (1) | ZA928511B (en) |
Cited By (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0618223A2 (en) * | 1993-03-08 | 1994-10-05 | Sandoz Ltd. | Peptides inhibiting interleukin 1-bêta release useful as antiinflammatory agents |
EP0623606A2 (en) * | 1993-05-07 | 1994-11-09 | Sterling Winthrop Inc. | Peptidic ketones as interleukin-1beta-converting enzyme inhibitors |
EP0623592A1 (en) * | 1993-04-29 | 1994-11-09 | Sterling Winthrop Inc. | Peptide analogs as irreversible interleukin-1beta protease inhibitors |
EP0627926A1 (en) * | 1992-02-21 | 1994-12-14 | Merck & Co., Inc. (a New Jersey corp.) | PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME |
EP0644198A1 (en) * | 1993-06-03 | 1995-03-22 | Sterling Winthrop Inc. | Alpha-heteroaryloxymethyl ketones as interleukin-1beta converting enzyme inhibitors |
EP0644197A1 (en) * | 1993-06-04 | 1995-03-22 | Sterling Winthrop Inc. | Peptidic phosphinyloxymethyl ketones as interleukin-1beta-converting enzyme inhibitors |
WO1995015749A1 (en) * | 1993-12-08 | 1995-06-15 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
US5434248A (en) * | 1991-06-21 | 1995-07-18 | Merck & Co., Inc. | Peptidyl derivatives as inhibitors of interleukin-1β converting enzyme |
WO1995035308A1 (en) * | 1994-06-17 | 1995-12-28 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
GB2292149A (en) * | 1994-08-09 | 1996-02-14 | Ferring Res Ltd | Peptide inhibitors of pro-interleukin-1beta converting enzyme |
WO1996030395A2 (en) * | 1995-03-31 | 1996-10-03 | Takeda Chemical Industries, Ltd. | Cysteine protease inhibitor |
EP0761680A2 (en) * | 1995-09-12 | 1997-03-12 | Ono Pharmaceutical Co., Ltd. | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity |
EP0764167A1 (en) * | 1994-06-08 | 1997-03-26 | Sanofi Winthrop, Inc. | Bicycling lactam inhibitor of interleukin-1-beta converting enzyme |
EP0767661A1 (en) * | 1994-08-02 | 1997-04-16 | Sanofi Winthrop, Inc. | Azaaspartic acid analogs as interleukin-1 beta converting enzyme inhibitors |
WO1997024339A1 (en) * | 1995-12-27 | 1997-07-10 | Ono Pharmaceutical Co., Ltd. | Tetrazole derivatives and drugs containing the same as the active ingredient |
US5656627A (en) * | 1994-06-17 | 1997-08-12 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5714484A (en) * | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
US5798442A (en) * | 1995-04-21 | 1998-08-25 | Merck Frosst Canada, Inc. | Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases |
US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
US5843905A (en) * | 1993-06-04 | 1998-12-01 | Vertex Pharmaceuticals, Incorporated | Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors |
US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5866545A (en) * | 1993-08-13 | 1999-02-02 | Merck & Co., Inc. | Substituted ketone derivatives as inhibitors of interleukin-1β converting enzyme |
US5869519A (en) * | 1996-12-16 | 1999-02-09 | Idun Pharmaceuticals, Inc. | C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5877197A (en) * | 1996-12-16 | 1999-03-02 | Karanewsky; Donald S. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US5968927A (en) * | 1996-09-20 | 1999-10-19 | Idun Pharmaceuticals, Inc. | Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes |
US5985838A (en) * | 1993-04-29 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Peptide analogs as irreversible interleukin-1β protease inhibitors |
US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
WO2000023421A1 (en) * | 1998-10-22 | 2000-04-27 | Idun Pharmaceuticals, Inc. | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES |
US6083706A (en) * | 1997-02-26 | 2000-07-04 | Ciblex Corporation | Inhibitors of leaderless protein export |
US6184244B1 (en) * | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
US6306613B1 (en) | 1997-02-26 | 2001-10-23 | Ciblex Corporation | Modulators of leaderless protein export and methods for identifying and using the same |
US6426413B1 (en) | 1998-03-09 | 2002-07-30 | Vertex Pharmaceuticals Incorporated | Inhibitors of caspases |
JP2002541237A (en) * | 1999-04-09 | 2002-12-03 | サイトビア インコーポレイテッド | Caspase inhibitors and uses thereof |
US6525024B1 (en) | 2000-04-17 | 2003-02-25 | Idun Pharmaceuticals, Inc. | Inhibitors of the ICE/ced-3 family of cysteine proteases |
US6531474B1 (en) | 1998-03-19 | 2003-03-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of caspases |
US7087604B2 (en) | 2002-03-08 | 2006-08-08 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
US7157430B2 (en) | 1998-10-22 | 2007-01-02 | Idun Pharmaceuticals, Inc. | (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases |
US7288624B2 (en) | 1994-06-17 | 2007-10-30 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US7381827B2 (en) | 2004-03-12 | 2008-06-03 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
US7417029B2 (en) | 2000-05-19 | 2008-08-26 | Vertex Pharmaceuticals Incorporated | Prodrug of an ice inhibitor |
US7531570B2 (en) | 2004-05-27 | 2009-05-12 | Vertex Pharmaceuticals Incorporated | Treatment of diseases using ICE inhibitors |
EP2241328A1 (en) | 2000-05-12 | 2010-10-20 | Immunex Corporation | Interleukin-1 inhibitors in the treatment of diseases |
CN101979403A (en) * | 2010-09-13 | 2011-02-23 | 沈陵陵 | Novel broad caspase inhibitor and preparation method and application thereof |
US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
US9352010B2 (en) | 2011-07-22 | 2016-05-31 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
WO2017081641A1 (en) | 2015-11-13 | 2017-05-18 | Novartis Ag | Novel pyrazolo pyrimidine derivatives |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20020500A1 (en) * | 2000-09-13 | 2002-06-25 | Vertex Pharma | DERIVATIVES OF PIPERIDINE, TETRAHYDROQUINOLINE, TETRAHYDROISOQUINOLINE AS DANDRUFF INHIBITORS |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991015577A1 (en) * | 1990-04-04 | 1991-10-17 | Black, Roy, A. | INTERLEUKIN 1'beta' PROTEASE |
-
1991
- 1991-11-04 GB GB919123326A patent/GB9123326D0/en active Pending
-
1992
- 1992-10-29 JP JP5508146A patent/JPH07500828A/en active Pending
- 1992-10-29 HU HU9401303A patent/HUT68200A/en active IP Right Revival
- 1992-10-29 CA CA002116653A patent/CA2116653A1/en not_active Abandoned
- 1992-10-29 EP EP92922580A patent/EP0611375A1/en not_active Withdrawn
- 1992-10-29 CZ CZ941067A patent/CZ106794A3/en unknown
- 1992-10-29 SK SK511-94A patent/SK51194A3/en unknown
- 1992-10-29 AU AU28852/92A patent/AU2885292A/en not_active Abandoned
- 1992-10-29 WO PCT/EP1992/002472 patent/WO1993009135A1/en not_active Application Discontinuation
- 1992-11-02 PT PT101027A patent/PT101027A/en not_active Application Discontinuation
- 1992-11-02 NZ NZ244985A patent/NZ244985A/en unknown
- 1992-11-02 IL IL103612A patent/IL103612A0/en unknown
- 1992-11-03 MX MX9206306A patent/MX9206306A/en unknown
- 1992-11-04 ZA ZA928511A patent/ZA928511B/en unknown
-
1994
- 1994-05-03 NO NO941629A patent/NO941629L/en unknown
- 1994-05-04 FI FI942061A patent/FI942061A/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991015577A1 (en) * | 1990-04-04 | 1991-10-17 | Black, Roy, A. | INTERLEUKIN 1'beta' PROTEASE |
Non-Patent Citations (4)
Title |
---|
EDITORS: SMITH ET AL // AUTHORS: WEIDNER ET AL 'Proceedings 12th American Peptide Symposium, June 1991 // Comparison of peptide and protein substrates for interleukin-1beta convertase' , ESCOM , LEIDEN, HOLLAND * |
JOURNAL OF BIOLOGICAL CHEMISTRY vol. 265, no. 24, August 1990, BALTIMORE, USA pages 14526 - 14528 SLEATH ET AL 'Substrate specificity of the protease that processes human Interleukin-1beta' * |
PETTIT ET AL 'Synthetic peptides ( Volume 1 )' 1970 , VAN NOSTRAND REINHOOLD COMPANY , NEW YORK, USA * |
VOELTER ET AL 'Tripeptides and fragments ( Volume 3 )' 1983 , GEORG THIEME VERLAG , STUTTGART, GERMANY * |
Cited By (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5434248A (en) * | 1991-06-21 | 1995-07-18 | Merck & Co., Inc. | Peptidyl derivatives as inhibitors of interleukin-1β converting enzyme |
EP0627926A1 (en) * | 1992-02-21 | 1994-12-14 | Merck & Co., Inc. (a New Jersey corp.) | PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME |
EP0627926A4 (en) * | 1992-02-21 | 1997-01-29 | Merck & Co Inc | PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1-g(b) CONVERTING ENZYME. |
US5430128A (en) * | 1992-02-21 | 1995-07-04 | Merck & Co., Inc. | Peptidyl derivatives as inhibitors of interleukin-1β converting enzyme |
EP0618223A3 (en) * | 1993-03-08 | 1996-06-12 | Sandoz Ltd | Peptides inhibiting interleukin 1-bêta release useful as antiinflammatory agents. |
EP0618223A2 (en) * | 1993-03-08 | 1994-10-05 | Sandoz Ltd. | Peptides inhibiting interleukin 1-bêta release useful as antiinflammatory agents |
EP0623592A1 (en) * | 1993-04-29 | 1994-11-09 | Sterling Winthrop Inc. | Peptide analogs as irreversible interleukin-1beta protease inhibitors |
AU676887B2 (en) * | 1993-04-29 | 1997-03-27 | Vertex Pharmaceuticals Incorporated | Peptide analogs as irreversible interleukin-beta protease inhibitors |
US5985838A (en) * | 1993-04-29 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Peptide analogs as irreversible interleukin-1β protease inhibitors |
US6576614B1 (en) | 1993-04-29 | 2003-06-10 | Vertex Pharmaceuticals Incorporated | Peptide analogs as irreversible interleukin-1β protease inhibitors |
EP0623606A2 (en) * | 1993-05-07 | 1994-11-09 | Sterling Winthrop Inc. | Peptidic ketones as interleukin-1beta-converting enzyme inhibitors |
EP0623606A3 (en) * | 1993-05-07 | 1994-12-07 | Sterling Winthrop Inc. | Peptidic ketones as interleukin-1beta-converting enzyme inhibitors |
EP0644198A1 (en) * | 1993-06-03 | 1995-03-22 | Sterling Winthrop Inc. | Alpha-heteroaryloxymethyl ketones as interleukin-1beta converting enzyme inhibitors |
AU690102B2 (en) * | 1993-06-03 | 1998-04-23 | Vertex Pharmaceuticals Incorporated | Aplha-heteroaryloxymethyl ketones as interleukin-1beta converting enzyme inhibitors |
EP0644197A1 (en) * | 1993-06-04 | 1995-03-22 | Sterling Winthrop Inc. | Peptidic phosphinyloxymethyl ketones as interleukin-1beta-converting enzyme inhibitors |
US5843905A (en) * | 1993-06-04 | 1998-12-01 | Vertex Pharmaceuticals, Incorporated | Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors |
US5866545A (en) * | 1993-08-13 | 1999-02-02 | Merck & Co., Inc. | Substituted ketone derivatives as inhibitors of interleukin-1β converting enzyme |
US5714484A (en) * | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
US5486623A (en) * | 1993-12-08 | 1996-01-23 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
US6147188A (en) * | 1993-12-08 | 2000-11-14 | Prototek, Inc. | α- (1,3- or 1, 2- dicarbonylenol ether methyl ketones as cysteine protease inhibitors |
WO1995015749A1 (en) * | 1993-12-08 | 1995-06-15 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
US5663380A (en) * | 1993-12-08 | 1997-09-02 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
US5925772A (en) * | 1993-12-08 | 1999-07-20 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
EP1391461A1 (en) * | 1994-06-08 | 2004-02-25 | Vertex Pharmaceuticals Incorporated | Bicyclic lactam inhibitors of interleukin-1-beta converting enzyme |
EP0764167A4 (en) * | 1994-06-08 | 1997-09-17 | Sanofi Winthrop Inc | Bicycling lactam inhibitor of interleukin-1-beta converting enzyme |
EP0764167A1 (en) * | 1994-06-08 | 1997-03-26 | Sanofi Winthrop, Inc. | Bicycling lactam inhibitor of interleukin-1-beta converting enzyme |
US7772366B2 (en) | 1994-06-17 | 2010-08-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US7288624B2 (en) | 1994-06-17 | 2007-10-30 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US6103711A (en) * | 1994-06-17 | 2000-08-15 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
WO1995035308A1 (en) * | 1994-06-17 | 1995-12-28 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
CZ298625B6 (en) * | 1994-06-17 | 2007-11-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1 beta converting enzyme, method of their selection and pharmaceutical compositions in which the inhibitors are comprised |
US5656627A (en) * | 1994-06-17 | 1997-08-12 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
EP1394175A1 (en) * | 1994-06-17 | 2004-03-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1beta converting enzyme |
US6025147A (en) * | 1994-06-17 | 2000-02-15 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1 β converting enzyme |
AP797A (en) * | 1994-06-17 | 2000-01-07 | Vertex Pharma | Inhibitors of interleukin-1B converting enzyme. |
EP2123665A3 (en) * | 1994-06-17 | 2010-02-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1Beta converting enzyme |
EP2123665A2 (en) | 1994-06-17 | 2009-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1Beta converting enzyme |
EP0767661A1 (en) * | 1994-08-02 | 1997-04-16 | Sanofi Winthrop, Inc. | Azaaspartic acid analogs as interleukin-1 beta converting enzyme inhibitors |
EP0767661A4 (en) * | 1994-08-02 | 1998-06-10 | Sanofi Winthrop Inc | Azaaspartic acid analogs as interleukin-1 beta converting enzyme inhibitors |
GB2292149A (en) * | 1994-08-09 | 1996-02-14 | Ferring Res Ltd | Peptide inhibitors of pro-interleukin-1beta converting enzyme |
WO1996030395A2 (en) * | 1995-03-31 | 1996-10-03 | Takeda Chemical Industries, Ltd. | Cysteine protease inhibitor |
WO1996030395A3 (en) * | 1995-03-31 | 1996-12-27 | Takeda Chemical Industries Ltd | Cysteine protease inhibitor |
US6162828A (en) * | 1995-03-31 | 2000-12-19 | Takeda Chemical Industries, Ltd. | Cysteine protease inhibitor |
US5798442A (en) * | 1995-04-21 | 1998-08-25 | Merck Frosst Canada, Inc. | Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases |
EP0761680A3 (en) * | 1995-09-12 | 1999-05-06 | Ono Pharmaceutical Co., Ltd. | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity |
EP0761680A2 (en) * | 1995-09-12 | 1997-03-12 | Ono Pharmaceutical Co., Ltd. | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity |
US5710153A (en) * | 1995-09-12 | 1998-01-20 | Ono Phramaceutical Co., Ltd. | Tetrazole compound |
US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US8119631B2 (en) | 1995-12-20 | 2012-02-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
EP2083014A2 (en) | 1995-12-20 | 2009-07-29 | Vertex Pharmceuticals Incorporated | Inhibitors of interleukin-1ß converting enzyme |
US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
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Also Published As
Publication number | Publication date |
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IL103612A0 (en) | 1993-04-04 |
FI942061A0 (en) | 1994-05-04 |
ZA928511B (en) | 1994-05-04 |
PT101027A (en) | 1994-02-28 |
NO941629L (en) | 1994-07-04 |
FI942061A (en) | 1994-05-04 |
SK51194A3 (en) | 1995-02-08 |
AU2885292A (en) | 1993-06-07 |
CZ106794A3 (en) | 1994-12-15 |
HU9401303D0 (en) | 1994-08-29 |
NO941629D0 (en) | 1994-05-03 |
GB9123326D0 (en) | 1991-12-18 |
MX9206306A (en) | 1993-05-01 |
NZ244985A (en) | 1995-06-27 |
JPH07500828A (en) | 1995-01-26 |
HUT68200A (en) | 1995-05-29 |
CA2116653A1 (en) | 1993-05-13 |
EP0611375A1 (en) | 1994-08-24 |
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