NO941629L - Peptides that inhibit 1L-1 - Google Patents
Peptides that inhibit 1L-1Info
- Publication number
- NO941629L NO941629L NO941629A NO941629A NO941629L NO 941629 L NO941629 L NO 941629L NO 941629 A NO941629 A NO 941629A NO 941629 A NO941629 A NO 941629A NO 941629 L NO941629 L NO 941629L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- ring
- amino acid
- peptides
- inhibit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Di-, tri og tetrapeptider hvor den siste a-aminosyren er basert på asparaginsyre og bundet til en rest A5 som er H, CF3, -Z1-Z2-Y2 hvor hver av Z^ og Z2 uavhenging er en direkte binding eller en d-aminosyrerest og Y2 er NH2, C^alkylamino, di-CCi^alkyDamino eller et heterosyklisk radikal bundet ved et nitrogen til Z2, -CHj-Xj-Yj hvor Xt er O eller S og Y3 er heteroaryl, -CH2-Y3, substituert fenyl, ringsubstituert fen- oksymetylen eller fenyltiometylen, ringsubstituert pyridyl- oksymetylen, eller et radikal -CHj-Xj-CO-Y, hvor Xj er O eller S og Y4 er trialkylmetyl eller substistuert fenyl eller pyri- dyl, i fri form eller i saltform, og som har farmakologisk aktivitet, f.eks. inhibering av IL-lp-frigivelse.Di-, tri- and tetrapeptides where the last α-amino acid is based on aspartic acid and bound to a residue A5 which is H, CF3, -Z1-Z2-Y2 where each of Z amino acid residue and Y 2 are NH 2, C 1-6 alkylamino, di-CC 1-4 alkydamino or a heterocyclic radical attached by a nitrogen to Z 2, -CH 2 -X 2 -Y 2 , ring-substituted phenoxymethylene or phenylthiomethylene, ring-substituted pyridyloxymethylene, or a radical -CH₂-X₂-CO-Y, wherein X X is O or S and Y and having pharmacological activity, e.g. inhibition of IL-1β release.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919123326A GB9123326D0 (en) | 1991-11-04 | 1991-11-04 | Improvements in or relating to organic compounds |
PCT/EP1992/002472 WO1993009135A1 (en) | 1991-11-04 | 1992-10-29 | Peptides inhibiting il-1 beta release |
Publications (2)
Publication Number | Publication Date |
---|---|
NO941629D0 NO941629D0 (en) | 1994-05-03 |
NO941629L true NO941629L (en) | 1994-07-04 |
Family
ID=10703998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO941629A NO941629L (en) | 1991-11-04 | 1994-05-03 | Peptides that inhibit 1L-1 |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0611375A1 (en) |
JP (1) | JPH07500828A (en) |
AU (1) | AU2885292A (en) |
CA (1) | CA2116653A1 (en) |
CZ (1) | CZ106794A3 (en) |
FI (1) | FI942061A (en) |
GB (1) | GB9123326D0 (en) |
HU (1) | HUT68200A (en) |
IL (1) | IL103612A0 (en) |
MX (1) | MX9206306A (en) |
NO (1) | NO941629L (en) |
NZ (1) | NZ244985A (en) |
PT (1) | PT101027A (en) |
SK (1) | SK51194A3 (en) |
WO (1) | WO1993009135A1 (en) |
ZA (1) | ZA928511B (en) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
DE69226820T2 (en) * | 1991-06-21 | 1999-05-12 | Merck & Co., Inc., Rahway, N.J. | Peptidyl derivatives as inhibitors of interleukin-1B converting enzymes |
AU3666893A (en) * | 1992-02-21 | 1993-09-13 | Merck & Co., Inc. | Peptidyl derivatives as inhibitors of interleukin-1beta converting enzyme |
EP0618223A3 (en) * | 1993-03-08 | 1996-06-12 | Sandoz Ltd | Peptides inhibiting interleukin 1-bêta release useful as antiinflammatory agents. |
TW494094B (en) * | 1993-04-29 | 2002-07-11 | Vertex Pharma | Peptide analogs as irreversible interleukin-1β protease inhibitors and pharmaceutical compositions comprising the same |
US5985838A (en) * | 1993-04-29 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Peptide analogs as irreversible interleukin-1β protease inhibitors |
US5462939A (en) * | 1993-05-07 | 1995-10-31 | Sterling Winthrop Inc. | Peptidic ketones as interleukin-1β-converting enzyme inhibitors |
JPH0789951A (en) * | 1993-06-03 | 1995-04-04 | Sterling Winthrop Inc | Interleukin-1 beta transfer enzyme inhibitor |
ATE170868T1 (en) * | 1993-06-04 | 1998-09-15 | Vertex Pharma | PEPTIDE PHOSPHINYLOXYMETHYL KETONES AS INHIBITORS OF INTERLEUKIN-1 BETA-CONVERTING ENZYMES |
US5843905A (en) * | 1993-06-04 | 1998-12-01 | Vertex Pharmaceuticals, Incorporated | Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors |
WO1995005192A1 (en) * | 1993-08-13 | 1995-02-23 | Merck & Co., Inc. | SUBSTITUTED KETONE DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
US5714484A (en) * | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
US5486623A (en) * | 1993-12-08 | 1996-01-23 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
US5552400A (en) * | 1994-06-08 | 1996-09-03 | Sterling Winthrop Inc. | Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors |
US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5565430A (en) * | 1994-08-02 | 1996-10-15 | Sterling Winthrop Inc. | Azaaspartic acid analogs as interleukin-1β converting enzyme inhibitors |
GB2292149A (en) * | 1994-08-09 | 1996-02-14 | Ferring Res Ltd | Peptide inhibitors of pro-interleukin-1beta converting enzyme |
US6162828A (en) * | 1995-03-31 | 2000-12-19 | Takeda Chemical Industries, Ltd. | Cysteine protease inhibitor |
US5798442A (en) * | 1995-04-21 | 1998-08-25 | Merck Frosst Canada, Inc. | Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases |
EP0761680A3 (en) * | 1995-09-12 | 1999-05-06 | Ono Pharmaceutical Co., Ltd. | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity |
US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
WO1997024339A1 (en) * | 1995-12-27 | 1997-07-10 | Ono Pharmaceutical Co., Ltd. | Tetrazole derivatives and drugs containing the same as the active ingredient |
US5869519A (en) * | 1996-12-16 | 1999-02-09 | Idun Pharmaceuticals, Inc. | C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US5968927A (en) | 1996-09-20 | 1999-10-19 | Idun Pharmaceuticals, Inc. | Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes |
US6184244B1 (en) * | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US5877197A (en) * | 1996-12-16 | 1999-03-02 | Karanewsky; Donald S. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6306613B1 (en) | 1997-02-26 | 2001-10-23 | Ciblex Corporation | Modulators of leaderless protein export and methods for identifying and using the same |
AU6339198A (en) * | 1997-02-26 | 1998-09-18 | Ciblex Corporation | Inhibitors of leaderless protein export |
DE69925581T2 (en) | 1998-03-09 | 2006-04-27 | Vertex Pharmaceuticals Inc., Cambridge | 1,2-DIAZEPANDERIVATE AS INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME |
KR100928878B1 (en) | 1998-03-19 | 2009-11-30 | 버텍스 파마슈티칼스 인코포레이티드 | Inhibitors of caspases |
US7157430B2 (en) | 1998-10-22 | 2007-01-02 | Idun Pharmaceuticals, Inc. | (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases |
US6242422B1 (en) | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
BR0009610A (en) * | 1999-04-09 | 2002-02-13 | Cytovia Inc | Caspase inhibitors and their use |
US6525024B1 (en) | 2000-04-17 | 2003-02-25 | Idun Pharmaceuticals, Inc. | Inhibitors of the ICE/ced-3 family of cysteine proteases |
EP1712239A3 (en) | 2000-05-12 | 2007-08-22 | Immunex Corporation | Interleukin-1 inhibitors in the treatment of diseases |
PE20011350A1 (en) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROPHARMAC OF AN INHIBITOR OF INTERLEUKIN-1ß CONVERTER ENZYME (ICE) |
CA2418720A1 (en) * | 2000-09-13 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
EP1483241A4 (en) | 2002-03-08 | 2006-12-13 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
EP2399916B1 (en) | 2004-03-12 | 2014-12-10 | Vertex Pharmaceuticals Incorporated | Process and intermediates for the preparation of aspartic acetal caspase ihnhibitors |
EP1778221A2 (en) | 2004-05-27 | 2007-05-02 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
CN101979403A (en) * | 2010-09-13 | 2011-02-23 | 沈陵陵 | Novel broad caspase inhibitor and preparation method and application thereof |
EP2635906A4 (en) | 2010-11-05 | 2014-04-02 | Univ Brandeis | Ice inhibiting compounds and uses thereof |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
CN108473499B (en) | 2015-11-13 | 2021-07-23 | 诺华股份有限公司 | Novel pyrazolopyrimidine derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991015577A1 (en) * | 1990-04-04 | 1991-10-17 | Black, Roy, A. | INTERLEUKIN 1'beta' PROTEASE |
-
1991
- 1991-11-04 GB GB919123326A patent/GB9123326D0/en active Pending
-
1992
- 1992-10-29 AU AU28852/92A patent/AU2885292A/en not_active Abandoned
- 1992-10-29 CA CA002116653A patent/CA2116653A1/en not_active Abandoned
- 1992-10-29 CZ CZ941067A patent/CZ106794A3/en unknown
- 1992-10-29 JP JP5508146A patent/JPH07500828A/en active Pending
- 1992-10-29 SK SK511-94A patent/SK51194A3/en unknown
- 1992-10-29 HU HU9401303A patent/HUT68200A/en active IP Right Revival
- 1992-10-29 EP EP92922580A patent/EP0611375A1/en not_active Withdrawn
- 1992-10-29 WO PCT/EP1992/002472 patent/WO1993009135A1/en not_active Application Discontinuation
- 1992-11-02 NZ NZ244985A patent/NZ244985A/en unknown
- 1992-11-02 IL IL103612A patent/IL103612A0/en unknown
- 1992-11-02 PT PT101027A patent/PT101027A/en not_active Application Discontinuation
- 1992-11-03 MX MX9206306A patent/MX9206306A/en unknown
- 1992-11-04 ZA ZA928511A patent/ZA928511B/en unknown
-
1994
- 1994-05-03 NO NO941629A patent/NO941629L/en unknown
- 1994-05-04 FI FI942061A patent/FI942061A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO941629D0 (en) | 1994-05-03 |
HUT68200A (en) | 1995-05-29 |
NZ244985A (en) | 1995-06-27 |
FI942061A0 (en) | 1994-05-04 |
PT101027A (en) | 1994-02-28 |
ZA928511B (en) | 1994-05-04 |
MX9206306A (en) | 1993-05-01 |
FI942061A (en) | 1994-05-04 |
WO1993009135A1 (en) | 1993-05-13 |
CA2116653A1 (en) | 1993-05-13 |
GB9123326D0 (en) | 1991-12-18 |
AU2885292A (en) | 1993-06-07 |
IL103612A0 (en) | 1993-04-04 |
EP0611375A1 (en) | 1994-08-24 |
HU9401303D0 (en) | 1994-08-29 |
JPH07500828A (en) | 1995-01-26 |
CZ106794A3 (en) | 1994-12-15 |
SK51194A3 (en) | 1995-02-08 |
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