NO941629L - Peptides that inhibit 1L-1 - Google Patents

Peptides that inhibit 1L-1

Info

Publication number
NO941629L
NO941629L NO941629A NO941629A NO941629L NO 941629 L NO941629 L NO 941629L NO 941629 A NO941629 A NO 941629A NO 941629 A NO941629 A NO 941629A NO 941629 L NO941629 L NO 941629L
Authority
NO
Norway
Prior art keywords
substituted
ring
amino acid
peptides
inhibit
Prior art date
Application number
NO941629A
Other languages
Norwegian (no)
Other versions
NO941629D0 (en
Inventor
Richard Heng
Trevor Glyn Payne
Laszlo Revesz
Beat Weidmann
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of NO941629D0 publication Critical patent/NO941629D0/en
Publication of NO941629L publication Critical patent/NO941629L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Di-, tri og tetrapeptider hvor den siste a-aminosyren er basert på asparaginsyre og bundet til en rest A5 som er H, CF3, -Z1-Z2-Y2 hvor hver av Z^ og Z2 uavhenging er en direkte binding eller en d-aminosyrerest og Y2 er NH2, C^alkylamino, di-CCi^alkyDamino eller et heterosyklisk radikal bundet ved et nitrogen til Z2, -CHj-Xj-Yj hvor Xt er O eller S og Y3 er heteroaryl, -CH2-Y3, substituert fenyl, ringsubstituert fen- oksymetylen eller fenyltiometylen, ringsubstituert pyridyl- oksymetylen, eller et radikal -CHj-Xj-CO-Y, hvor Xj er O eller S og Y4 er trialkylmetyl eller substistuert fenyl eller pyri- dyl, i fri form eller i saltform, og som har farmakologisk aktivitet, f.eks. inhibering av IL-lp-frigivelse.Di-, tri- and tetrapeptides where the last α-amino acid is based on aspartic acid and bound to a residue A5 which is H, CF3, -Z1-Z2-Y2 where each of Z amino acid residue and Y 2 are NH 2, C 1-6 alkylamino, di-CC 1-4 alkydamino or a heterocyclic radical attached by a nitrogen to Z 2, -CH 2 -X 2 -Y 2 , ring-substituted phenoxymethylene or phenylthiomethylene, ring-substituted pyridyloxymethylene, or a radical -CH₂-X₂-CO-Y, wherein X X is O or S and Y and having pharmacological activity, e.g. inhibition of IL-1β release.

NO941629A 1991-11-04 1994-05-03 Peptides that inhibit 1L-1 NO941629L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919123326A GB9123326D0 (en) 1991-11-04 1991-11-04 Improvements in or relating to organic compounds
PCT/EP1992/002472 WO1993009135A1 (en) 1991-11-04 1992-10-29 Peptides inhibiting il-1 beta release

Publications (2)

Publication Number Publication Date
NO941629D0 NO941629D0 (en) 1994-05-03
NO941629L true NO941629L (en) 1994-07-04

Family

ID=10703998

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941629A NO941629L (en) 1991-11-04 1994-05-03 Peptides that inhibit 1L-1

Country Status (16)

Country Link
EP (1) EP0611375A1 (en)
JP (1) JPH07500828A (en)
AU (1) AU2885292A (en)
CA (1) CA2116653A1 (en)
CZ (1) CZ106794A3 (en)
FI (1) FI942061A (en)
GB (1) GB9123326D0 (en)
HU (1) HUT68200A (en)
IL (1) IL103612A0 (en)
MX (1) MX9206306A (en)
NO (1) NO941629L (en)
NZ (1) NZ244985A (en)
PT (1) PT101027A (en)
SK (1) SK51194A3 (en)
WO (1) WO1993009135A1 (en)
ZA (1) ZA928511B (en)

Families Citing this family (49)

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Publication number Priority date Publication date Assignee Title
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
EP0519748B1 (en) * 1991-06-21 1998-09-02 Merck & Co. Inc. Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme
EP0627926B1 (en) * 1992-02-21 1998-08-05 Merck & Co., Inc. (a New Jersey corp.) PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME
EP0618223A3 (en) * 1993-03-08 1996-06-12 Sandoz Ltd Peptides inhibiting interleukin 1-bêta release useful as antiinflammatory agents.
TW494094B (en) * 1993-04-29 2002-07-11 Vertex Pharma Peptide analogs as irreversible interleukin-1β protease inhibitors and pharmaceutical compositions comprising the same
US5985838A (en) 1993-04-29 1999-11-16 Vertex Pharmaceuticals, Inc. Peptide analogs as irreversible interleukin-1β protease inhibitors
US5462939A (en) * 1993-05-07 1995-10-31 Sterling Winthrop Inc. Peptidic ketones as interleukin-1β-converting enzyme inhibitors
JPH0789951A (en) * 1993-06-03 1995-04-04 Sterling Winthrop Inc Interleukin-1 beta transfer enzyme inhibitor
US5843905A (en) * 1993-06-04 1998-12-01 Vertex Pharmaceuticals, Incorporated Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors
ES2122145T3 (en) * 1993-06-04 1998-12-16 Vertex Pharma PEPTIDIC PHOSPHINYLOXIMETHYL-KETONES AS INHIBITORS OF THE CONVERTED ENZYME OF INTERLEUKIN-1 BETA.
AU7714594A (en) * 1993-08-13 1995-03-14 Merck & Co., Inc. Substituted ketone derivatives as inhibitors of interleukin-1beta converting enzyme
US5714484A (en) * 1993-12-08 1998-02-03 Prototek, Inc. α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors
US5486623A (en) * 1993-12-08 1996-01-23 Prototek, Inc. Cysteine protease inhibitors containing heterocyclic leaving groups
US5552400A (en) * 1994-06-08 1996-09-03 Sterling Winthrop Inc. Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5565430A (en) * 1994-08-02 1996-10-15 Sterling Winthrop Inc. Azaaspartic acid analogs as interleukin-1β converting enzyme inhibitors
GB2292149A (en) * 1994-08-09 1996-02-14 Ferring Res Ltd Peptide inhibitors of pro-interleukin-1beta converting enzyme
CA2215211A1 (en) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
US5798442A (en) * 1995-04-21 1998-08-25 Merck Frosst Canada, Inc. Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases
EP0761680A3 (en) * 1995-09-12 1999-05-06 Ono Pharmaceutical Co., Ltd. Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
WO1997024339A1 (en) * 1995-12-27 1997-07-10 Ono Pharmaceutical Co., Ltd. Tetrazole derivatives and drugs containing the same as the active ingredient
US5869519A (en) * 1996-12-16 1999-02-09 Idun Pharmaceuticals, Inc. C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US5968927A (en) 1996-09-20 1999-10-19 Idun Pharmaceuticals, Inc. Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6184244B1 (en) * 1996-12-16 2001-02-06 Idun Pharmaceuticals, Inc. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6306613B1 (en) 1997-02-26 2001-10-23 Ciblex Corporation Modulators of leaderless protein export and methods for identifying and using the same
KR20000075739A (en) * 1997-02-26 2000-12-26 시블렉스 코포레이션 Inhibitors of leaderless protein export
WO1999046248A1 (en) 1998-03-09 1999-09-16 Vertex Pharmaceuticals Incorporated 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors
AP2000001919A0 (en) 1998-03-19 2000-09-30 Vertex Pharma Inhibitors of caspases.
US7157430B2 (en) 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
US6242422B1 (en) 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
AU4213500A (en) * 1999-04-09 2000-11-14 Cytovia, Inc. Caspase inhibitors and the use thereof
US6525024B1 (en) 2000-04-17 2003-02-25 Idun Pharmaceuticals, Inc. Inhibitors of the ICE/ced-3 family of cysteine proteases
EP1282435A2 (en) 2000-05-12 2003-02-12 Immunex Corporation Interleukin-1 inhibitors in the treatment of diseases
PE20011350A1 (en) 2000-05-19 2002-01-15 Vertex Pharma PROPHARMAC OF AN INHIBITOR OF INTERLEUKIN-1ß CONVERTER ENZYME (ICE)
JP2004509120A (en) * 2000-09-13 2004-03-25 バーテックス　ファーマシューティカルズ　インコーポレイテッド Caspase inhibitors and their uses
US7087604B2 (en) 2002-03-08 2006-08-08 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
SG150546A1 (en) 2004-03-12 2009-03-30 Vertex Pharma Processes and intermediates
CA2567080A1 (en) 2004-05-27 2005-12-15 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
CN101979403A (en) * 2010-09-13 2011-02-23 沈陵陵 Novel broad caspase inhibitor and preparation method and application thereof
EP2635907A4 (en) 2010-11-05 2014-04-16 Univ Brandeis Ice cleaved alpha-synuclein a biomarker
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
BR112018009511A2 (en) 2015-11-13 2018-11-06 Novartis Ag pyrazolo pyrimidine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015577A1 (en) * 1990-04-04 1991-10-17 Black, Roy, A. INTERLEUKIN 1'beta' PROTEASE

Also Published As

Publication number Publication date
WO1993009135A1 (en) 1993-05-13
CZ106794A3 (en) 1994-12-15
FI942061A0 (en) 1994-05-04
EP0611375A1 (en) 1994-08-24
GB9123326D0 (en) 1991-12-18
HUT68200A (en) 1995-05-29
AU2885292A (en) 1993-06-07
ZA928511B (en) 1994-05-04
PT101027A (en) 1994-02-28
MX9206306A (en) 1993-05-01
SK51194A3 (en) 1995-02-08
HU9401303D0 (en) 1994-08-29
NZ244985A (en) 1995-06-27
IL103612A0 (en) 1993-04-04
CA2116653A1 (en) 1993-05-13
JPH07500828A (en) 1995-01-26
NO941629D0 (en) 1994-05-03
FI942061A (en) 1994-05-04

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