WO1993002681A1 - Prostaglandin-e1 formulation - Google Patents
Prostaglandin-e1 formulation Download PDFInfo
- Publication number
- WO1993002681A1 WO1993002681A1 PCT/EP1992/001684 EP9201684W WO9302681A1 WO 1993002681 A1 WO1993002681 A1 WO 1993002681A1 EP 9201684 W EP9201684 W EP 9201684W WO 9302681 A1 WO9302681 A1 WO 9302681A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- liposomes
- prostaglandin
- active ingredient
- formulation
- pgei
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
Definitions
- the active ingredient (PGEi) can subsequently be added to an already formed liposome solution without the liposomes flocculating.
- the effectiveness of the PGEi after intravenous administration of the liposome formulation is independent of whether the active substance was encapsulated in liposomes (transmembrane loading technique) or whether it was subsequently added to liposomes (without transmembrane loading technique).
- the invention therefore relates to a formulation for prostaglandin egg consisting of an ampoule with a liposome solution and an ampoule which contains the prostaglandin E in solid or dissolved form.
- the liposome solution is prepared in a known manner (cf. for example US 4,737,323).
- Phospholipids possibly in a mixture with cholesterol
- synthetic lipids cf. EP 331 091
- Solvents are conceivable in which the active ingredient is stable in storage and can be applied parenterally.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92916379A EP0596970A1 (en) | 1991-07-31 | 1992-07-23 | Prostaglandin-e 1? formulation |
JP5503231A JPH06509568A (en) | 1991-07-31 | 1992-07-23 | Prostaglandin E↓1-Preparation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4125255.1 | 1991-07-31 | ||
DE19914125255 DE4125255A1 (en) | 1991-07-31 | 1991-07-31 | PROSTAGLANDIN E (DOWN ARROW) 1 (DOWN ARROW) FORMULATION |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993002681A1 true WO1993002681A1 (en) | 1993-02-18 |
Family
ID=6437340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1992/001684 WO1993002681A1 (en) | 1991-07-31 | 1992-07-23 | Prostaglandin-e1 formulation |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0596970A1 (en) |
JP (1) | JPH06509568A (en) |
CA (1) | CA2113443A1 (en) |
DE (1) | DE4125255A1 (en) |
MX (1) | MX9204183A (en) |
WO (1) | WO1993002681A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995018620A1 (en) * | 1994-01-11 | 1995-07-13 | The Liposome Company, Inc. | Treatment using arachidonic acid metabolite and particulate formulations |
US6030639A (en) * | 1994-01-11 | 2000-02-29 | The Liposome Company, Inc. | Treatment using prostoglandin and particulate formulations |
US11369617B2 (en) | 2016-09-15 | 2022-06-28 | Camurus Ab | Prostacyclin analogue formulations |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4309579C3 (en) * | 1993-03-24 | 2000-01-27 | Sanol Arznei Schwarz Gmbh | Pharmaceutical composition in the form of a pack |
DK0722323T3 (en) * | 1994-08-05 | 2000-04-03 | Inpharma Sa | Compositions containing troxerutin complexed with phosphatidylcholine for topical treatment of erectile impotence |
AU7454698A (en) * | 1997-06-06 | 1998-12-21 | Shionogi & Co., Ltd. | Improvement in medicament administration system |
CA2356959C (en) * | 1998-12-22 | 2009-03-31 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Water-insoluble drug delivery system |
US6682758B1 (en) | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
ES2698161T3 (en) | 2014-04-08 | 2019-01-31 | Pantex Int S P A | Absorbent sanitary article comprising a multilayer material |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2305972A1 (en) * | 1975-04-04 | 1976-10-29 | Schering Ag | LYOPHILIZED POWDERS CONTAINING PROSTAGLANDINS |
WO1988009170A1 (en) * | 1987-05-22 | 1988-12-01 | The Liposome Company, Inc. | Prostaglandin-lipid formulations |
US4814270A (en) * | 1984-09-13 | 1989-03-21 | Becton Dickinson And Company | Production of loaded vesicles |
-
1991
- 1991-07-31 DE DE19914125255 patent/DE4125255A1/en not_active Withdrawn
-
1992
- 1992-07-16 MX MX9204183A patent/MX9204183A/en unknown
- 1992-07-23 WO PCT/EP1992/001684 patent/WO1993002681A1/en not_active Application Discontinuation
- 1992-07-23 EP EP92916379A patent/EP0596970A1/en not_active Withdrawn
- 1992-07-23 CA CA 2113443 patent/CA2113443A1/en not_active Abandoned
- 1992-07-23 JP JP5503231A patent/JPH06509568A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2305972A1 (en) * | 1975-04-04 | 1976-10-29 | Schering Ag | LYOPHILIZED POWDERS CONTAINING PROSTAGLANDINS |
US4814270A (en) * | 1984-09-13 | 1989-03-21 | Becton Dickinson And Company | Production of loaded vesicles |
WO1988009170A1 (en) * | 1987-05-22 | 1988-12-01 | The Liposome Company, Inc. | Prostaglandin-lipid formulations |
Non-Patent Citations (1)
Title |
---|
Chem. Pharm. Bull., Band 37, Nr. 11, 1989, Pharmaceutical Society of Japan, H. JIZOMOTO et al.: "Encapsulation of drugs by lyophilized empty dipalmitoylphosphatidylcholine liposomes: effect of calcium ion", Seiten 3066-3069, siehe das ganze Artikel * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995018620A1 (en) * | 1994-01-11 | 1995-07-13 | The Liposome Company, Inc. | Treatment using arachidonic acid metabolite and particulate formulations |
AU682753B2 (en) * | 1994-01-11 | 1997-10-16 | Liposome Company, Inc., The | Treatment using arachidonic acid metabolite and particulate formulations |
US6030639A (en) * | 1994-01-11 | 2000-02-29 | The Liposome Company, Inc. | Treatment using prostoglandin and particulate formulations |
US11369617B2 (en) | 2016-09-15 | 2022-06-28 | Camurus Ab | Prostacyclin analogue formulations |
Also Published As
Publication number | Publication date |
---|---|
DE4125255A1 (en) | 1993-02-04 |
CA2113443A1 (en) | 1993-02-18 |
JPH06509568A (en) | 1994-10-27 |
MX9204183A (en) | 1993-01-01 |
EP0596970A1 (en) | 1994-05-18 |
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