WO1992010193A3 - Derives d'homo-prostaglandines utilises comme hypotenseurs oculaires - Google Patents

Derives d'homo-prostaglandines utilises comme hypotenseurs oculaires Download PDF

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Publication number
WO1992010193A3
WO1992010193A3 PCT/US1991/009288 US9109288W WO9210193A3 WO 1992010193 A3 WO1992010193 A3 WO 1992010193A3 US 9109288 W US9109288 W US 9109288W WO 9210193 A3 WO9210193 A3 WO 9210193A3
Authority
WO
WIPO (PCT)
Prior art keywords
homo
ocular hypotensives
prostaglandin derivatives
prostaglandin
derivatives
Prior art date
Application number
PCT/US1991/009288
Other languages
English (en)
Other versions
WO1992010193A2 (fr
Inventor
Ming Fai Chan
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Priority to BR9107162A priority Critical patent/BR9107162A/pt
Priority to EP92902760A priority patent/EP0562006B1/fr
Priority to ES92902760T priority patent/ES2113942T3/es
Priority to DE69129238T priority patent/DE69129238T2/de
Priority to AU91482/91A priority patent/AU654167B2/en
Priority to JP4502971A priority patent/JPH06503345A/ja
Publication of WO1992010193A2 publication Critical patent/WO1992010193A2/fr
Publication of WO1992010193A3 publication Critical patent/WO1992010193A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des dérivés d'homo-prostaglandines. Plus particulièrement, la présente invention concerne des dérivés 1a-homo de prostaglandines naturelles et synthétiques, les composés correspondants bis- et trishomo-prostaglandines, et leurs 1-esters et sels. Les composés d'homo-prostaglandines de la présente invention sont des hypotenseurs oculaires puissants et sont particulièrement appropriés au traitement du glaucome.
PCT/US1991/009288 1990-12-10 1991-12-05 Derives d'homo-prostaglandines utilises comme hypotenseurs oculaires WO1992010193A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BR9107162A BR9107162A (pt) 1990-12-10 1991-12-05 Derivados da homo-prostaglandina como hipotensivos oculares
EP92902760A EP0562006B1 (fr) 1990-12-10 1991-12-05 Derives d'homo-prostaglandines utilises comme hypotenseurs oculaires
ES92902760T ES2113942T3 (es) 1990-12-10 1991-12-05 Derivados de la homo-prostaglandina como hipotensores oculares.
DE69129238T DE69129238T2 (de) 1990-12-10 1991-12-05 Okulare hypotensive homo-prostaglandinderivate
AU91482/91A AU654167B2 (en) 1990-12-10 1991-12-05 Homo-prostaglandin derivatives as ocular hypotensives
JP4502971A JPH06503345A (ja) 1990-12-10 1991-12-05 眼圧降下剤としてのホモ−プロスタグランジン誘導体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62465990A 1990-12-10 1990-12-10
US624,659 1990-12-10

Publications (2)

Publication Number Publication Date
WO1992010193A2 WO1992010193A2 (fr) 1992-06-25
WO1992010193A3 true WO1992010193A3 (fr) 1992-10-29

Family

ID=24502829

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/009288 WO1992010193A2 (fr) 1990-12-10 1991-12-05 Derives d'homo-prostaglandines utilises comme hypotenseurs oculaires

Country Status (11)

Country Link
EP (1) EP0562006B1 (fr)
JP (1) JPH06503345A (fr)
AT (1) ATE164763T1 (fr)
AU (1) AU654167B2 (fr)
BR (1) BR9107162A (fr)
CA (1) CA2096944A1 (fr)
DE (1) DE69129238T2 (fr)
ES (1) ES2113942T3 (fr)
HU (1) HUT64305A (fr)
IE (1) IE914261A1 (fr)
WO (1) WO1992010193A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011856A (en) * 1990-03-12 1991-04-30 Allergan, Inc. Use of prostaglandin F3 α as an ocular hypotensive agent
US5288754A (en) * 1992-02-04 1994-02-22 Allergan, Inc. Polar C-1 esters of prostaglandins
US6124353A (en) * 1992-11-12 2000-09-26 Allergan Sales, Inc. Method of treating ocular hypertension with 8-epi prostaglandins
KR950000664A (ko) * 1993-06-14 1995-01-03 우에노 도시오 신규한 13,14-디히드로-피지에프 2 베타(PGF2β) 및 이의 이소프로필 에스테르

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7885M (fr) * 1967-02-16 1970-05-04
DE2118686A1 (de) * 1970-04-20 1971-11-11 The Upjohn Co., Kalamazoo, Mich. (V.StA.) Prostaglandinverbindungen und Verfahren zu ihrer Herstellung
EP0008227A1 (fr) * 1978-08-16 1980-02-20 American Cyanamid Company Compositions pharmaceutiques pour usage topique à base de prostaglandines
EP0253094A2 (fr) * 1986-05-16 1988-01-20 Research Development Corporation of Japan Utilisation des substances prostaglandine D2-actives pour le traitement de l'hypertension oculaire et du glaucome
WO1988006448A1 (fr) * 1987-02-27 1988-09-07 Allergan, Inc. Prostaglandines utiles pour diminuer la pression intraoculaire

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7885M (fr) * 1967-02-16 1970-05-04
DE2118686A1 (de) * 1970-04-20 1971-11-11 The Upjohn Co., Kalamazoo, Mich. (V.StA.) Prostaglandinverbindungen und Verfahren zu ihrer Herstellung
EP0008227A1 (fr) * 1978-08-16 1980-02-20 American Cyanamid Company Compositions pharmaceutiques pour usage topique à base de prostaglandines
EP0253094A2 (fr) * 1986-05-16 1988-01-20 Research Development Corporation of Japan Utilisation des substances prostaglandine D2-actives pour le traitement de l'hypertension oculaire et du glaucome
WO1988006448A1 (fr) * 1987-02-27 1988-09-07 Allergan, Inc. Prostaglandines utiles pour diminuer la pression intraoculaire

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Prostaglandins in Hematology, March 4-5, 1976, Spectrum Publ., Inc. (New York, US) J.C. Cornette et al.: "Radioimmunoassay of prostaglandins and their metabolites", pages 69-85, see page 82, top of the page (cited in the application) *
Prostaglandins, vol. 10, no. 3, September 1975, L.D. Tobias et al.: "The biosynthesis of 1a,1b-dihomo-PGE2* and 1a,1b-dihomo-PFG2alpha from 7,10,13,16-docosatetraenoic acid by an acetone-pentane powder of sheep vesicular gland microsomes", pages 443-469, see abstract *

Also Published As

Publication number Publication date
IE914261A1 (en) 1992-06-17
JPH06503345A (ja) 1994-04-14
EP0562006A1 (fr) 1993-09-29
AU9148291A (en) 1992-07-08
HUT64305A (en) 1993-12-28
BR9107162A (pt) 1994-06-21
EP0562006B1 (fr) 1998-04-08
CA2096944A1 (fr) 1992-06-11
AU654167B2 (en) 1994-10-27
HU9301364D0 (en) 1993-09-28
ES2113942T3 (es) 1998-05-16
DE69129238D1 (de) 1998-05-14
WO1992010193A2 (fr) 1992-06-25
ATE164763T1 (de) 1998-04-15
DE69129238T2 (de) 1998-12-03

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