WO1992009574A3 - Derives polyaminopyrrolecarboxamido, leurs procedes de preparation et compositions pharmaceutiques les contenant - Google Patents

Derives polyaminopyrrolecarboxamido, leurs procedes de preparation et compositions pharmaceutiques les contenant Download PDF

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Publication number
WO1992009574A3
WO1992009574A3 PCT/EP1991/002220 EP9102220W WO9209574A3 WO 1992009574 A3 WO1992009574 A3 WO 1992009574A3 EP 9102220 W EP9102220 W EP 9102220W WO 9209574 A3 WO9209574 A3 WO 9209574A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
processes
preparation
pharmaceutical compositions
aminopyrrolecarboxamido
Prior art date
Application number
PCT/EP1991/002220
Other languages
English (en)
Other versions
WO1992009574A2 (fr
Inventor
Fabio Animati
Federico Arcamone
Paolo Lombardi
Cristina Rossi
Original Assignee
Menarini Farma Ind
Bristol Myers Squibb Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Farma Ind, Bristol Myers Squibb Spa filed Critical Menarini Farma Ind
Publication of WO1992009574A2 publication Critical patent/WO1992009574A2/fr
Publication of WO1992009574A3 publication Critical patent/WO1992009574A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Abstract

Dérivés polyaminopyrrolecarboxamido répondant à la formule générale (I) et leurs sels pharmaceutiquement acceptables. Dans ladite formule, X1, X2 et X3 sont identiques ou différents et représentent un groupe -CONH- ou NHCO-, à condition que le cas où X1 = X2 = X3 = -CONH- soit exclu. On a également prévu des procédés de préparation de ces dérivés ainsi que des compositions pharmaceutiques contenant ceux-ci et présentant des propriétés antivirales et antitumorales.
PCT/EP1991/002220 1990-11-22 1991-11-20 Derives polyaminopyrrolecarboxamido, leurs procedes de preparation et compositions pharmaceutiques les contenant WO1992009574A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22154A/90 1990-11-22
IT02215490A IT1243389B (it) 1990-11-22 1990-11-22 Derivati poliaminopirrolcarbossiamidici, processi di preparazione e composizioni farmaceutiche che li contengono.

Publications (2)

Publication Number Publication Date
WO1992009574A2 WO1992009574A2 (fr) 1992-06-11
WO1992009574A3 true WO1992009574A3 (fr) 1992-08-06

Family

ID=11192305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/002220 WO1992009574A2 (fr) 1990-11-22 1991-11-20 Derives polyaminopyrrolecarboxamido, leurs procedes de preparation et compositions pharmaceutiques les contenant

Country Status (3)

Country Link
AU (1) AU8917891A (fr)
IT (1) IT1243389B (fr)
WO (1) WO1992009574A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1263089B (it) * 1993-04-26 1996-07-24 Menarini Farma Ind Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono.
WO1998045284A1 (fr) 1996-02-26 1998-10-15 California Institute Of Technology Regulation stereochimique de l'affinite de fixation a l'adn, specificite de sequence, et preferences d'orientation de polyamides en epingle a cheveux chiraux dans le sillon mineur
US6506906B1 (en) 1996-02-26 2003-01-14 California Institute Of Technology Preparation and use of bifunctional molecules having DNA sequence binding specificity
US6090947A (en) 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
US6555692B1 (en) 1996-02-26 2003-04-29 California Institute Of Technology Preparation and use of bifunctional molecules having DNA sequence binding specificity
AU734715B2 (en) 1996-02-26 2001-06-21 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded DNA
US6143901A (en) * 1996-07-31 2000-11-07 Genesoft, Inc. Complex formation between dsDNA and pyrrole imidazole polyamides
US5998140A (en) * 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
US8188109B2 (en) 2009-07-20 2012-05-29 Naxospharma S.R.L. Benzoquinolizinium salt derivatives as anticancer agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2178036A (en) * 1985-07-16 1987-02-04 Erba Farmitalia Poly-4-aminopyrrole-2-carboxamido derivatives and process for their preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2178036A (en) * 1985-07-16 1987-02-04 Erba Farmitalia Poly-4-aminopyrrole-2-carboxamido derivatives and process for their preparation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Bulletin de la Société Chimique de France, no. 11, 1967, M. JULIA et al.: "Amidines et guanidines apparentées à la congocidine. I. - Structure de la congocidine", pages 4348-4356, see compounds 9,13 on page 4350 *
Chemical Abstracts, vol. 112, 1990, (Columbus, Ohio, US), K.L. KISSINGER et al.: "Molecular recognition between oligopeptides and nucleic acids: DNA binding specificity of a series of bisnetropsin analogs deduced from footprinting analysis", see page 28, abstract no. 191480v, & CHEM. RES. TOXICOL. 1990, 3(2), 162-8, see compound with RN 126501-80-2 *
J. Med Chem., vol. 26, 1983, American Chemical Society, L. GREHN et al.: "Synthesis and antiviral activity of distamycin A analogues: Substitutions on the different pyrrole nitrogens and in the amidine function", pages 1042-1049, see entire publication; compounds with RN 77716-18-8 *

Also Published As

Publication number Publication date
AU8917891A (en) 1992-06-25
WO1992009574A2 (fr) 1992-06-11
IT9022154A1 (it) 1992-05-23
IT9022154A0 (it) 1990-11-22
IT1243389B (it) 1994-06-10

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