WO1992008458A1 - Use of temocillin or carbenicillin for the treatment or prophylaxis of bacterial infections in fish - Google Patents
Use of temocillin or carbenicillin for the treatment or prophylaxis of bacterial infections in fish Download PDFInfo
- Publication number
- WO1992008458A1 WO1992008458A1 PCT/GB1991/001980 GB9101980W WO9208458A1 WO 1992008458 A1 WO1992008458 A1 WO 1992008458A1 GB 9101980 W GB9101980 W GB 9101980W WO 9208458 A1 WO9208458 A1 WO 9208458A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fish
- treatment
- temocillin
- carbenicillin
- prophylaxis
- Prior art date
Links
- 241000251468 Actinopterygii Species 0.000 title claims abstract description 17
- 238000011282 treatment Methods 0.000 title claims abstract description 17
- 238000011321 prophylaxis Methods 0.000 title claims abstract description 5
- 208000035143 Bacterial infection Diseases 0.000 title claims abstract 4
- 208000022362 bacterial infectious disease Diseases 0.000 title claims abstract 4
- 229960003669 carbenicillin Drugs 0.000 title claims description 6
- FPPNZSSZRUTDAP-UWFZAAFLSA-N carbenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)C(C(O)=O)C1=CC=CC=C1 FPPNZSSZRUTDAP-UWFZAAFLSA-N 0.000 title claims description 6
- 229960001114 temocillin Drugs 0.000 title claims description 6
- BVCKFLJARNKCSS-DWPRYXJFSA-N temocillin Chemical compound N([C@]1(OC)C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(C(O)=O)C=1C=CSC=1 BVCKFLJARNKCSS-DWPRYXJFSA-N 0.000 title claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229960004659 ticarcillin Drugs 0.000 claims description 5
- OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 claims description 5
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 206010017553 Furuncle Diseases 0.000 claims description 2
- 241000277331 Salmonidae Species 0.000 claims description 2
- 206010047400 Vibrio infections Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000002778 food additive Substances 0.000 claims description 2
- 235000013373 food additive Nutrition 0.000 claims description 2
- 208000003512 furunculosis Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 abstract description 2
- 150000002960 penicillins Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 description 11
- 244000052769 pathogen Species 0.000 description 4
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 241000607525 Aeromonas salmonicida Species 0.000 description 1
- 241001148129 Yersinia ruckeri Species 0.000 description 1
- 230000000895 acaricidal effect Effects 0.000 description 1
- 239000000642 acaricide Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 230000000507 anthelmentic effect Effects 0.000 description 1
- 229940124339 anthelmintic agent Drugs 0.000 description 1
- 239000000921 anthelmintic agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000010824 fish disease Diseases 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
Definitions
- This invention relates to the treatment of fish pathogens using antibacterial agents .
- the present invention provides a method of treatment of bacterial pathogens in fish which comprises 20 administering to the fish an effective amount of ticarcillin, temocillin or carbenicillin, or a veterinarily acceptable derivative thereof.
- the present invention provides the use of 25 ticarcillin, temocillin or carbenicillin, or a veterinary acceptable derivative thereof, in the manufacture of a medicament for the treatment of bacterial pathogens in fish.
- the treatment may be carried out prophylatically or to fish 30 infested with pathogens.
- the compounds have been found to be especially effective in the treatment of fin-fish such as salmonids, and against bacterial pathogens associated with furunculosis. They are 35 also effective against bacterial strains associated with vibriosis .
- the compounds may be administered orally, for example as a paste, tablet or capsule, but typically as a food additive, for example granules, pellets or powder, which are blended with the feed.
- the compounds may also be administered topically, for example in sprays or baths, typically by dipping or holding the fish in a solution or suspension of the compound, or by addition o_f the compound to a stock pool or holding tank. Additionally, the compound may be administered by injection or intubation.
- the compounds may be formulated with veterinarily acceptable carriers appropriate to the mode of administration.
- Such formulations may include conventional additives and other pharmacologically active agents such as anthelmintics and acaricides.
- the compounds are administered in quantities sufficient to provide a dose of from 0.001 to 100 mg of active ingredient per kg of fish weight, more suitably 0.1 to 50 mg/kg.
- a formulation incorporating the compounds may suitably contain from 0.1% by weight, preferably from 1 to 60% by weight of the compound, depending on the mode of administration.
- the effectiveness of the compounds in this invention are illustrated by the following test results showing minimum inhibitory concentrations (MIC) against variants of Aeromonas salmonicida and Yersinia ruckeri.
- MIC minimum inhibitory concentrations
- the results were obtained using an agar plate doubling dilation method based on that of the U.S. National Committee for Laboratory Standards. Oxoid sensitivity broth was used to prepare the inocula and oxoid sensi-test agar was used as the test medium. Incubation was for 20 hours at 22°C.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Certain penicillins are useful in the treatment or prophylaxis of bacterial infections in fish.
Description
Use of te oci l l in or carbenici l l in for the treatment or prophylaxis of bacterial i nfections in fish .
This invention relates to the treatment of fish pathogens using antibacterial agents .
5
Λ A paper entitled "Treatment of Fish Disease" by N.C. Stuart in Veterinary Record (1983) 112, pages 173-177 indicates that various antibiotics including penicillin G and ampicillin have been used in the treatment of fish. ιo Subsequently, T. Kitao has disclosed in Gyobokenkyu (Fish Pathology) Vol. 24, No. 2 pp. 83-87 (1989) that amoxicillin shows in vitro activity against various fish pathogens.
We have now discovered that certain other penicillin 15 derivatives are effective in the treatment of fish pathogens.
In one aspect the present invention provides a method of treatment of bacterial pathogens in fish which comprises 20 administering to the fish an effective amount of ticarcillin, temocillin or carbenicillin, or a veterinarily acceptable derivative thereof.
In a second aspect the present invention provides the use of 25 ticarcillin, temocillin or carbenicillin, or a veterinary acceptable derivative thereof, in the manufacture of a medicament for the treatment of bacterial pathogens in fish.
The treatment may be carried out prophylatically or to fish 30 infested with pathogens. ^
The compounds have been found to be especially effective in the treatment of fin-fish such as salmonids, and against bacterial pathogens associated with furunculosis. They are 35 also effective against bacterial strains associated with
vibriosis .
The compounds may be administered orally, for example as a paste, tablet or capsule, but typically as a food additive, for example granules, pellets or powder, which are blended with the feed.
The compounds may also be administered topically, for example in sprays or baths, typically by dipping or holding the fish in a solution or suspension of the compound, or by addition o_f the compound to a stock pool or holding tank. Additionally, the compound may be administered by injection or intubation.
The compounds may be formulated with veterinarily acceptable carriers appropriate to the mode of administration. Such formulations may include conventional additives and other pharmacologically active agents such as anthelmintics and acaricides.
Suitably the compounds are administered in quantities sufficient to provide a dose of from 0.001 to 100 mg of active ingredient per kg of fish weight, more suitably 0.1 to 50 mg/kg.
A formulation incorporating the compounds may suitably contain from 0.1% by weight, preferably from 1 to 60% by weight of the compound, depending on the mode of administration.
It will be appreciated that it may be advisable to repeat the dose in accordance with conventional prophylatic or treatment regimes.
The effectiveness of the compounds in this invention are illustrated by the following test results showing minimum inhibitory concentrations (MIC) against variants of Aeromonas salmonicida and Yersinia ruckeri.
The results were obtained using an agar plate doubling dilation method based on that of the U.S. National Committee for Laboratory Standards. Oxoid sensitivity broth was used to prepare the inocula and oxoid sensi-test agar was used as the test medium. Incubation was for 20 hours at 22°C.
Claims
1. Use of ticarcillin, temocillin or carbenicillin, or a veterinarily acceptable derivative thereof, in the
5 manufacture of a medicament for the treatment or prophylaxis of bacterial infections in fish.
2. Use according to claim 1, for the treatment of salmonids.
10
3. Use according to claim 1 or 2, for the treatment of furunculosis or vibriosis.
4. A method of treatment or prophylaxis of bacterial
15 infections in fish which comprises administering to the fish an effective amount of ticarcillin, temocillin or carbenicillin, or a veterinarily acceptable derivative thereof.
205. A pharmaceutical composition for use in the treatment of bacterial infections in fish which comprises ticarcillin, temocillin, carbenicillin, or a veterinarily acceptable derivative thereof, and a pharmaceutically acceptable carrier.
25
6. A composition according to claim 5, in the form of a food additive.
7. A composition according to claim 5, in the form of a 30 spray or dip.
8. A composition according to claim 6, wherein the carrier is water and the composition is a stock pool or holding tank.
35
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9024925.1 | 1990-11-16 | ||
| GB909024925A GB9024925D0 (en) | 1990-11-16 | 1990-11-16 | Novel treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1992008458A1 true WO1992008458A1 (en) | 1992-05-29 |
Family
ID=10685473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB1991/001980 WO1992008458A1 (en) | 1990-11-16 | 1991-11-11 | Use of temocillin or carbenicillin for the treatment or prophylaxis of bacterial infections in fish |
Country Status (5)
| Country | Link |
|---|---|
| AU (1) | AU8870791A (en) |
| GB (1) | GB9024925D0 (en) |
| IE (1) | IE913969A1 (en) |
| WO (1) | WO1992008458A1 (en) |
| ZA (1) | ZA919023B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999027786A1 (en) * | 1997-12-04 | 1999-06-10 | The University Of Nottingham | Control of biofilm formation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05234936A (en) * | 1992-02-26 | 1993-09-10 | Fujitsu Ltd | Manufacture of semiconductor device |
-
1990
- 1990-11-16 GB GB909024925A patent/GB9024925D0/en active Pending
-
1991
- 1991-11-11 AU AU88707/91A patent/AU8870791A/en not_active Abandoned
- 1991-11-11 WO PCT/GB1991/001980 patent/WO1992008458A1/en active Application Filing
- 1991-11-14 IE IE396991A patent/IE913969A1/en not_active Application Discontinuation
- 1991-11-14 ZA ZA919023A patent/ZA919023B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05234936A (en) * | 1992-02-26 | 1993-09-10 | Fujitsu Ltd | Manufacture of semiconductor device |
Non-Patent Citations (7)
| Title |
|---|
| Antimicrobial Agents and Chemotherapy, vol. 27, no. 6, June 1985, American Soc. for Microbiology (US), S.A. de Grandis et al.: "Antimicrobial susceptibility patterns and R plasmid-mediated resistance of the fish pathogen Yersinia ruckeri", pages 938-942, see the whole article * |
| Diseases of Aquatic Organisms, vol. 2, no. 1, 31 December 1986, C. Michel et al.: "Biochemical identification of Lactobacillus piscicola strains from France and Belgium", pages 27-30, see the whole article * |
| Fish Pathology, vol. 24, no. 2, 1989, T. Kitao et al.: "In vitro studies of amoxicillin on antibacterial activity for some fish pathogens", pages 83-87, see the abstract (cited in the application) * |
| J.E.F. Reynolds: "Martindale, The Extra Pharmacopoeia", 1989, 29th Ed. The Pharmaceutical Press, London (GB), see abstract 24-f "Carbenicillin Sodium", pages 139-141, 312-313 and 324-326 * |
| Journal of Fish Biology, vol. 23, no. 5, November 1983, Academic Press, J.F. Davis et al.: "Pathogenic bacteria associated with cultured American eels, Anguilla rostrata Le Sueur", pages 557-564, see the whole article * |
| Systematic and Applied Microbiology, vol. 13, no. 4, October 1990, Gustav Fischer Verlag, D. McIntosh et al.: "Recovery of cell wall deficient forms (L-forms) of the fish pathogens Aeromonas salmonicida and Yersinia ruckeri", pages 378-381, see the whole article * |
| The Veterinary Record, vol. 112, no. 8, 19 February 1983, N.C. Stuart: "Treatment of fish disease", pages 173-177, see the whole article (cited in the application) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999027786A1 (en) * | 1997-12-04 | 1999-06-10 | The University Of Nottingham | Control of biofilm formation |
Also Published As
| Publication number | Publication date |
|---|---|
| AU8870791A (en) | 1992-06-11 |
| ZA919023B (en) | 1992-09-30 |
| IE913969A1 (en) | 1992-05-20 |
| GB9024925D0 (en) | 1991-01-02 |
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