WO1991015583A1 - Famille de proteines apparentee a une proteine precoce immediate exprimee par des cellules endotheliales humaines durant la differenciation - Google Patents

Famille de proteines apparentee a une proteine precoce immediate exprimee par des cellules endotheliales humaines durant la differenciation Download PDF

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Publication number
WO1991015583A1
WO1991015583A1 PCT/US1991/002344 US9102344W WO9115583A1 WO 1991015583 A1 WO1991015583 A1 WO 1991015583A1 US 9102344 W US9102344 W US 9102344W WO 9115583 A1 WO9115583 A1 WO 9115583A1
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WIPO (PCT)
Prior art keywords
protein
edg
endothelial cells
receptor
cells
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PCT/US1991/002344
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English (en)
Inventor
Timothy Tun Hla
Thomas Maciag
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The American National Red Cross
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Application filed by The American National Red Cross filed Critical The American National Red Cross
Publication of WO1991015583A1 publication Critical patent/WO1991015583A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Nouvelle famille de gènes et de protéines spécifiques tissulaires qui sont apparentés à un gène récepteur couplé à une protéine G, et à la protéine réceptrice. Le gène est un gène intermédiaire précoce qui est exprimé dans des cellules endothéliales différenciatrices. La présente invention décrit notamment un gène, edg-1, qui est un gène précoce immédiat qui encode un récepteur couplé à une protéine G dans des cellules endothéliales. Elle décrit aussi la protéine réceptrice couplée à une protéine G, qui est encodée par edg-1.
PCT/US1991/002344 1990-04-05 1991-04-04 Famille de proteines apparentee a une proteine precoce immediate exprimee par des cellules endotheliales humaines durant la differenciation WO1991015583A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50480090A 1990-04-05 1990-04-05
US504,800 1990-04-05

Publications (1)

Publication Number Publication Date
WO1991015583A1 true WO1991015583A1 (fr) 1991-10-17

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PCT/US1991/002344 WO1991015583A1 (fr) 1990-04-05 1991-04-04 Famille de proteines apparentee a une proteine precoce immediate exprimee par des cellules endotheliales humaines durant la differenciation

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AU (1) AU7686891A (fr)
WO (1) WO1991015583A1 (fr)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000952A2 (fr) * 1995-06-20 1997-01-09 Incyte Pharmaceuticals, Inc. Homologue du recepteur de edg-2 de l'homme
US5739029A (en) * 1990-09-13 1998-04-14 Duke University Vectors for expression of G protein coupled receptors in yeast
EP1070080A1 (fr) * 1998-03-09 2001-01-24 Smithkline Beecham Corporation POLYNUCLEOTIDES ET POLYPEPTIDES D'EDG-1c HUMAIN ET LEURS PROCEDES D'UTILISATION
WO2001011022A1 (fr) * 1999-08-05 2001-02-15 Smithkline Beecham Corporation Recepteur edg3 couple a la proteine g des souris
GB2379880A (en) * 1998-01-08 2003-03-26 Microsense Cardiovascular Sys A method for protecting a remotely monitorable sensor during deployment into a bodily lumen.
EP1369430A2 (fr) * 1997-05-07 2003-12-10 Human Genome Sciences, Inc. Deux récepteurs couplés par des protéines G: GPCR2 induit par VEB (EBI-2) et GPCR de type GDE-1
WO2004058149A2 (fr) 2002-12-20 2004-07-15 Merck & Co., Inc. 1-(amino)indanes et (1,2-dihydro-3-amino)-benzofuranes, benzothiophenes et indoles utilises en tant qu'agonistes du recepteur edg
US7521192B2 (en) 2001-04-18 2009-04-21 Rigel Pharmaceuticals, Inc. EDG: modulators of lymphocyte activation and migration
US7605269B2 (en) 2005-03-23 2009-10-20 Actelion Pharmaceuticals Ltd. Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists
US7723378B2 (en) 2005-03-23 2010-05-25 Actelion Pharmaceuticals Ltd. Hydrogenated benzo (C) thiophene derivatives as immunomodulators
US7750040B2 (en) 2004-07-29 2010-07-06 Actelion Pharmaceuticals Ltd Thiophene derivatives
US7846964B2 (en) 2005-03-23 2010-12-07 Actelion Pharmaceuticals Ltd. Thiophene derivatives as spingosine-1-phosphate-1 receptor agonists
WO2011007324A1 (fr) 2009-07-16 2011-01-20 Actelion Pharmaceuticals Ltd Dérivés pyridin-4-yliques
US7951794B2 (en) 2005-06-24 2011-05-31 Actelion Pharmaceuticals Ltd. Thiophene derivatives
US7981924B2 (en) 2005-11-23 2011-07-19 Actelion Pharmaceuticals Ltd. Thiophene derivatives
US8003800B2 (en) 2006-01-11 2011-08-23 Actelion Pharmaceuticals Ltd. Thiophene derivatives as S1P1/EDG1 receptor agonists
US8044076B2 (en) 2006-09-21 2011-10-25 Actelion Pharmaceuticals Ltd. Phenyl derivatives and their use as immunomodulators
US8133910B2 (en) 2006-09-07 2012-03-13 Actelion Pharmaceuticals Ltd. Thiophene derivatives as S1P1/EDGE1 receptor agonists
US8148410B2 (en) 2007-12-10 2012-04-03 Actelion Pharmaceuticals Ltd. Thiophene derivatives as agonists of S1P1/EDG1
US8178562B2 (en) 2006-01-24 2012-05-15 Actelion Pharmaceuticals, Ltd. Pyridine derivatives
WO2012098505A1 (fr) 2011-01-19 2012-07-26 Actelion Pharmaceuticals Ltd Dérivés de 2-methoxy-pyridin-4-yl
US8288554B2 (en) 2006-09-08 2012-10-16 Actelion Pharmaceuticals Ltd. Pyridin-3-yl derivatives as immunomodulating agents
US8299086B2 (en) 2007-11-01 2012-10-30 Actelion Pharmaceuticals Ltd. Pyrimidine derivatives
US8410151B2 (en) 2008-03-07 2013-04-02 Actelion Pharmaceuticals Ltd Aminomethyl benzene derivatives
US8580824B2 (en) 2006-09-07 2013-11-12 Actelion Pharmaceuticals Ltd. Pyridin-4-yl derivatives as immunomodulating agents
US8592460B2 (en) 2007-03-16 2013-11-26 Actelion Pharmaceuticals Ltd. Amino-pyridine derivatives as S1P1 /EDG1 receptor agonists
US8598208B2 (en) 2007-08-17 2013-12-03 Actelion Pharmaceuticals Ltd. Pyridine derivatives as S1P1/EDG1 receptor modulators
US8791100B2 (en) 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds
WO2014141171A1 (fr) 2013-03-15 2014-09-18 Actelion Pharmaceuticals Ltd Dérivés de pyridin-4-yle
US10385043B2 (en) 2015-05-20 2019-08-20 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (S)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 265, No. 16, issued 05 June 1990, HLA et al., "An Abundant Transcript Induced in Differentiating Human Endothelial Cells Encodes a Polypeptide with Structural Similarities to G-Protein-Coupled Receptors", pages 9308-9313. *
SCIENCE, Vol. 241, issued 16 September 1988, KLEIN et al., "A Chemoattractant Recepteor Controls Development in Dictvostelium Discoideum", pages 1467-1472. *
SCIENCE, Vol. 245, issued 08 September 1989, DEVREOTES, "Dictvostelium Discoideum: a Model Sytem for Cell-Cell Interactions in Development", pages 1054-1058. *

Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739029A (en) * 1990-09-13 1998-04-14 Duke University Vectors for expression of G protein coupled receptors in yeast
US6168927B1 (en) 1990-09-13 2001-01-02 Duke University Expression of G protein coupled receptors in yeast
US7413876B2 (en) 1990-09-13 2008-08-19 Duke University Office Of Science And Technology Expression of G protein coupled receptors in yeast
US6855550B2 (en) 1990-09-13 2005-02-15 Duke University Expression of G protein coupled receptors in yeast
WO1997000952A2 (fr) * 1995-06-20 1997-01-09 Incyte Pharmaceuticals, Inc. Homologue du recepteur de edg-2 de l'homme
WO1997000952A3 (fr) * 1995-06-20 1997-03-20 Incyte Pharma Inc Homologue du recepteur de edg-2 de l'homme
EP1369430A3 (fr) * 1997-05-07 2004-01-28 Human Genome Sciences, Inc. Deux récepteurs couplés par des protéines G: GPCR2 induit par VEB (EBI-2) et GPCR de type GDE-1
US6887683B1 (en) 1997-05-07 2005-05-03 Human Genome Sciences, Inc. Human G-protein coupled receptors
EP1369430A2 (fr) * 1997-05-07 2003-12-10 Human Genome Sciences, Inc. Deux récepteurs couplés par des protéines G: GPCR2 induit par VEB (EBI-2) et GPCR de type GDE-1
GB2379880B (en) * 1998-01-08 2003-05-07 Microsense Cardiovascular Sys Method for protecting a remotely monitorable sensor during deployment in a bodily lumen.
GB2379880A (en) * 1998-01-08 2003-03-26 Microsense Cardiovascular Sys A method for protecting a remotely monitorable sensor during deployment into a bodily lumen.
US6423508B1 (en) 1998-03-09 2002-07-23 Smithkline Beecham Corporation Polynucleotide sequences of human EDG-1c
EP1070080A1 (fr) * 1998-03-09 2001-01-24 Smithkline Beecham Corporation POLYNUCLEOTIDES ET POLYPEPTIDES D'EDG-1c HUMAIN ET LEURS PROCEDES D'UTILISATION
EP1070080A4 (fr) * 1998-03-09 2004-12-29 Smithkline Beecham Corp POLYNUCLEOTIDES ET POLYPEPTIDES D'EDG-1c HUMAIN ET LEURS PROCEDES D'UTILISATION
WO2001011022A1 (fr) * 1999-08-05 2001-02-15 Smithkline Beecham Corporation Recepteur edg3 couple a la proteine g des souris
US7521192B2 (en) 2001-04-18 2009-04-21 Rigel Pharmaceuticals, Inc. EDG: modulators of lymphocyte activation and migration
WO2004058149A2 (fr) 2002-12-20 2004-07-15 Merck & Co., Inc. 1-(amino)indanes et (1,2-dihydro-3-amino)-benzofuranes, benzothiophenes et indoles utilises en tant qu'agonistes du recepteur edg
US7750040B2 (en) 2004-07-29 2010-07-06 Actelion Pharmaceuticals Ltd Thiophene derivatives
US7605269B2 (en) 2005-03-23 2009-10-20 Actelion Pharmaceuticals Ltd. Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists
US7723378B2 (en) 2005-03-23 2010-05-25 Actelion Pharmaceuticals Ltd. Hydrogenated benzo (C) thiophene derivatives as immunomodulators
US7846964B2 (en) 2005-03-23 2010-12-07 Actelion Pharmaceuticals Ltd. Thiophene derivatives as spingosine-1-phosphate-1 receptor agonists
US8039644B2 (en) 2005-03-23 2011-10-18 Actelion Pharmaceuticals Ltd. Hydrogenated benzo (C) thiophene derivatives as immunomodulators
US7951794B2 (en) 2005-06-24 2011-05-31 Actelion Pharmaceuticals Ltd. Thiophene derivatives
US7981924B2 (en) 2005-11-23 2011-07-19 Actelion Pharmaceuticals Ltd. Thiophene derivatives
US8003800B2 (en) 2006-01-11 2011-08-23 Actelion Pharmaceuticals Ltd. Thiophene derivatives as S1P1/EDG1 receptor agonists
US8697732B2 (en) 2006-01-24 2014-04-15 Actelion Pharmaceuticals Ltd. Pyridine derivatives
US8178562B2 (en) 2006-01-24 2012-05-15 Actelion Pharmaceuticals, Ltd. Pyridine derivatives
US8133910B2 (en) 2006-09-07 2012-03-13 Actelion Pharmaceuticals Ltd. Thiophene derivatives as S1P1/EDGE1 receptor agonists
US8580824B2 (en) 2006-09-07 2013-11-12 Actelion Pharmaceuticals Ltd. Pyridin-4-yl derivatives as immunomodulating agents
US8288554B2 (en) 2006-09-08 2012-10-16 Actelion Pharmaceuticals Ltd. Pyridin-3-yl derivatives as immunomodulating agents
US8044076B2 (en) 2006-09-21 2011-10-25 Actelion Pharmaceuticals Ltd. Phenyl derivatives and their use as immunomodulators
US8592460B2 (en) 2007-03-16 2013-11-26 Actelion Pharmaceuticals Ltd. Amino-pyridine derivatives as S1P1 /EDG1 receptor agonists
US8598208B2 (en) 2007-08-17 2013-12-03 Actelion Pharmaceuticals Ltd. Pyridine derivatives as S1P1/EDG1 receptor modulators
US8299086B2 (en) 2007-11-01 2012-10-30 Actelion Pharmaceuticals Ltd. Pyrimidine derivatives
US8148410B2 (en) 2007-12-10 2012-04-03 Actelion Pharmaceuticals Ltd. Thiophene derivatives as agonists of S1P1/EDG1
US8410151B2 (en) 2008-03-07 2013-04-02 Actelion Pharmaceuticals Ltd Aminomethyl benzene derivatives
WO2011007324A1 (fr) 2009-07-16 2011-01-20 Actelion Pharmaceuticals Ltd Dérivés pyridin-4-yliques
US8658675B2 (en) 2009-07-16 2014-02-25 Actelion Pharmaceuticals Ltd. Pyridin-4-yl derivatives
US8791100B2 (en) 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds
WO2012098505A1 (fr) 2011-01-19 2012-07-26 Actelion Pharmaceuticals Ltd Dérivés de 2-methoxy-pyridin-4-yl
US9133179B2 (en) 2011-01-19 2015-09-15 Actelion Pharmaceuticals Ltd. 2-methoxy-pyridin-4-yl-derivatives
WO2014141171A1 (fr) 2013-03-15 2014-09-18 Actelion Pharmaceuticals Ltd Dérivés de pyridin-4-yle
US9617250B2 (en) 2013-03-15 2017-04-11 Actelion Pharmaceuticals Ltd. Pyridin-4-yl derivatives
US10385043B2 (en) 2015-05-20 2019-08-20 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (S)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol
US10836754B2 (en) 2015-05-20 2020-11-17 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (S)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol
US11390615B2 (en) 2015-05-20 2022-07-19 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (S)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenox
US11834443B2 (en) 2015-05-20 2023-12-05 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol

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