WO1991015199A1 - Composition et procede antidiarrheique - Google Patents

Composition et procede antidiarrheique Download PDF

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Publication number
WO1991015199A1
WO1991015199A1 PCT/US1991/002445 US9102445W WO9115199A1 WO 1991015199 A1 WO1991015199 A1 WO 1991015199A1 US 9102445 W US9102445 W US 9102445W WO 9115199 A1 WO9115199 A1 WO 9115199A1
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WO
WIPO (PCT)
Prior art keywords
composition
antidiarrheal
present
diarrhea
lactobacillus
Prior art date
Application number
PCT/US1991/002445
Other languages
English (en)
Inventor
Jonah Shacknai
John W. Holaday
Sherwood L. Gorbach
Original Assignee
Medicis Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicis Corporation filed Critical Medicis Corporation
Priority to JP91507880A priority Critical patent/JPH05506228A/ja
Publication of WO1991015199A1 publication Critical patent/WO1991015199A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Definitions

  • the present invention relates to an antidiarrheal composition and a method for treating diarrhea and related conditions. More particularly, the present invention provides a palatable composition for treating diarrhea in a human or an animal comprising one or more nutritional substances, a synthetic fiber, and an electrolyte admixture. Optionally, a Lactobacillus sp. can be added to the antidiarrheal composition.
  • the term "diarrhea” is an increase in stool frequency with a concomitant decrease in stool consistency.
  • secretory diarrhea is an increase in the volume of water in the stools due mainly to increased secretion of electrolytes and consequently water.
  • the term "nutritional substance” as used herein includes, but is not limited to, carrots, maize, millet, sorghum, carob, rice, rice flour, rice water, mashed potatoes, and short-chain glucose polymers or admixtures thereof.
  • Diarrhea is a common and often debilitating disease in children and adults. In developing countries, diarrheal diseases are the largest single cause of death among infants and children. In developed countries, diarrheal disease causes significant morbidity and unnecessary mortality. In the United States, for example, acute gastroenteritis ranks second only to the common cold in frequency, accounting for more than 3 million (3%) of pediatric office visits. Acute diarrheas are caused by, among other tilings, viruses, bacteria, and parasites. The onset of acute diarrhea is usually within 2-3 days of infection but can be immediate and its clinical features are fluid diarrhea, sometimes with blood and mucus, and acute weight loss. Diarrhea can cause dehydration, electrolyte imbalances, acid-base disturbances and, in severe cases, can result in death.
  • Diarrhea occurs when there is an imbalance between the processes for intestinal absorption and secretion of water. This imbalance may be caused by either decreased absorption or increased secretion or a combination of both.
  • solutes Because the transfer of water across the intestinal mucosa is a passive consequence of movements of solutes, both decreased absorption and increased secretion of water are associated with changes in transfer of solutes, which can be either organic substrates or electrolytes.
  • agents are capable of stimulating intestinal secretion. These agents include bacterial enterotoxins, intralumenal metabolites, hormones, neurotransmitters, and other endogenous substances.
  • Acute gastroenteritis which may be regarded as an acute infection of the gastrointestinal tract, is usually a self- limiting, short illness, lasting up to a week or ten days. The majority of cases are managed by oral rehydration therapy and only those with severe dehydration require intravenous fluids to supplement body water.
  • oral rehydration salt solution can correct and prevent the progress of the dehydration that can occur in acute childhood diarrhea.
  • Oral rehydrating solutions can be regarded as an effective means of restoring the fluid and electrolyte losses in diarrheas of various etiologies.
  • Glucose- linked enhanced sodium and water absorption from the small intestinal lumen is largely intact during acute diarrhea of diverse etiology and form the scientific basis of oral rehydration therapy.
  • Conventional oral replacement therapy consists of glucose, salts, and water.
  • Cereal base oral replacement therapy has been used to improve home therapy of diarrhea to decrease the number of referrals to treatment centers. Constraints of cereal based oral replacement therapies include need for cooking prior to use, fermentation and bacterial overgrowth, and difficulty in making a ready to use packaged product.
  • Glucose polymers are useful for increasing available glucose without increasing significantly osmotic activity in the intestinal lumen.
  • short chain glucose polymers are superior to D-glucose in correcting abnormal water and electrolyte transport
  • Short-chain glucose polymers of rice comprising two to nine glucose units are hydrolyzed and absorbed in the small intestine faster than isocaloric D-glucose.
  • Other sources of glucose polymers include, among others, corn, sorghum, and tapioca.
  • Lactobacillus acidophilus is a therapeutically beneficial strain of bacteria which is a component of the normal intestinal flora of most healthy human beings. Generally, the normal intestinal flora contains in excess of 10 11 colony forming units (CFU) of lactobacilli.
  • CFU colony forming units
  • Certain strains of Lactobacillus acidophilus, when ingested by humans or animals produce beneficial effects on gastrointestinal function and provide resistance to gastrointestinal colonization by pathogenic microorganisms.
  • the GG strain of Lactobacillus acidophilus (Lactobacillus GG) is the subject of United States Patent No. 4,839,282 to Gorbach et al., which is incorporated herein by reference. The strain of Lactobacillus that is described in U.S.
  • Patent No. 4,839,282 has been renamed Lactobacillus casei rhamorum, strain GG.
  • Lactobacillus GG shall mean the strain of Lactobacillus described in U.S. Patent No. 4,839,282.
  • the Lactobacillus GG promotes carbohydrate digestion and aids in protein digestion.
  • the sugars, amino acids, and peptides produced by the action of the Lactobacillus GG provide nutrition and promote rehydration via the sodium-solute intestinal epithelial cell transporter.
  • diarrhea may alter the intestinal microflora.
  • Lactobacillus GG is able to colonize the human intestine and to produce antimicrobial substances which control proliferation of gram-negative and gram-positive organisms. For these reasons, Lactobacillus GG, administered as a component of an oral replacement regimen can accelerate recovery from diarrhea.
  • Polycarbophil is a polyacrylic acid cross-linked with di-vinyl glycol. It is a pharmacologically inert substance which has the capacity to bind free fecal water. It acts to reduce stool frequency and stool volume. Orally administered, polycarbophil exerts its most marked hydrosorptive action only on reaching the slightly acid or alkaline medium of the small intestine and colon.
  • U.S. Patent No. 2,798,053 to Brown, entitled “Carboxylic Polymers” suggests the usefulness of carboxylic polymers in the treatment of various disorders of the human and animal gastrointestinal tract (Column 1, lines 70-71) including their use as bulk laxatives (Column 1 , lines 68-69). This patent is directed to the polymerization of carboxylic-type monomers and the production of carboxylic polymers.
  • Mill KK entitled “Composition for Preventing and Treating Diarrhea in Animals” discloses the use of sodium polyacrylate and an insoluble mineral adsorbent to remedy diarrhea in animals. What is needed is an effective oral replacement therapy based on ingredients which reduce stool frequency and stool volume and, at the same time, are nutritionally valuable.
  • the oral replacement should be palatable, and be easy to administer in unit dosage form.
  • the oral replacement therapy for treating diarrhea should be acceptable for use outside the hospital or doctor's office without the need for trained medical personnel.
  • the present invention provides a composition and method for treating diarrhea and related conditions in humans or animals.
  • the present invention can be used to treat adults or children.
  • the antidiarrheal composition of the present invention comprises an admixture of one or more nutritional substances, a synthetic fiber, and an electrolyte admixture so the electrolyte requirements for rehydration are met in an orally palatable formulation.
  • This admixture can be prepared as a sterile composition.
  • an effective concentration of Lactobacillus acidophilus can be added to the antidiarrheal composition of the present invention.
  • the antidiarrheal composition can be stored conveniently until used and can be administered in unit dosage form which is more convenient and safer than currently used methods.
  • the present invention can be premixed and dehydrated either by desiccation or lyophilization.
  • the dehydrated composition When used, the dehydrated composition need only be rehydrated and administered to the patient orally.
  • an object of the present invention to provide an antidiarrheal composition useful in the treatment of diarrhea, particularly but not exclusively in children. It is another object of the present invention to reduce stool output.
  • the present invention provides a composition and method for treating diarrhea and related conditions.
  • the antidiarrheal composition of the present invention comprises one or more nutritional substances, a synthetic fiber, and an electrolyte admixture so the electrolyte requirements for rehydration are met in an orally palatable formulation.
  • the present invention can be prepared as a sterile composition.
  • the therapeutically useful bacteria Lactobacillus acidophilus can be included in the antidiarrheal composition of the present invention.
  • the present invention can be stored conveniently until used and can be administered in unit dosage form which is more convenient and safer than currently used methods.
  • the present invention is also useful for oral rehydration.
  • the nutritional substance that is a component of the composition of the present invention includes, but is not limited to, carrots, maize, millet, wheat, sorghum, rice flour, rice water and mashed potatoes or admixtures thereof. Of these, the preferred nutritional substance is rice flour or mashed carrots.
  • the quantity of these nutritional substances that is preferred in the composition of the present invention is between 1 g/100 ml and 20 g/100 ml. The preferred quantity is between 3 g/100 ml and 10 g/100 ml.
  • the synthetic fibers that can be used in the antidiarrheal composition of the present invention includes, but is not limited to, acrylates and, more particularly, polycarbophil.
  • the quantity of the synthetic fibers that is preferred in the composition of the present invention is between 0.05 g/100 ml and 0.3 g/100 ml.
  • the preferred quantity is between 0.08 g/100 ml and 0.2 g/100 ml with the most preferred concentration of synthetic fiber being approximately 0.1 g/100 ml.
  • the electrolyte composition of the antidiarrheal composition of the present invention comprises an admixture of sodium salt, chloride, citrate, potassium salt and bicarbonate.
  • the salts can be either chloride or citrate.
  • zinc salt can be added to the electrolyte admixture. It is to be understood that the exact concentration of each electrolyte is not critical to the present invention.
  • Another nutritional substance that optionally can be included in the composition of the present invention is short-chain glucose polymers derived from controlled hydrolysis of starches including, among others, rice, sorghum, corn, and tapioca.
  • the preferred quantity of short-chain glucose polymers is between 0.5 g/100 ml and 25 g/100 ml.
  • the most preferred quantity is between 2.5 g/100 ml and 5 g/100 ml.
  • Lactobacillus Another component that can be included in the composition of the present invention is Lactobacillus.
  • the preferred strain of Lactobacillus is the Lactobacillus casei rhamorum, strain GG, although it is to be understood that other strains of Lactobacillus can be used in the present invention.
  • the preferred concentration of Lactobacillus is between 10 6 CFU/100 ml and 10 12 CFU/100 ml. The most preferred concentration is between 109 CFU/100 ml and 10*0 CFU/100 ml.
  • glucose can optionally be added to the antidiarrheal composition of the present invention.
  • the preferred concentration of glucose in the antidiarrheal composition of the present invention is between approximately 10 and 100 mM/L, with the more preferred concentration between approximately 20 and 75 mM/L.
  • the most preferred concentration of glucose in the antidiarrheal composition of the present invention is approximately 40 mM/L.
  • the antidiarrheal composition of the present invention can be dehydrated to provide an easily stored and transported composition.
  • the antidiarrheal composition of the present invention can be dehydrated either by submitting the liquid composition to lyophilization procedures which are well known to those of ordinary skill in the art or by desiccating the composition.
  • the Lactobacillus acidophilus in the antidiarrheal composition of the present invention can be freeze dried by methods known to those of ordinary skill in the art before being added to the lyophilized ingredients of the present invention.
  • To use the dehydrated composition one only needs to add the proper amount of water to the dehydrated composition. For example, if the original dose contained 330 ml of water before dehydration, then one would add 330 ml of water to the dehydrated composition before administering it to the patient.
  • the antidiarrheal composition of the present invention has the general composition shown in Table 1.
  • electrolyte concentrations shown in the above Table 1 are final concentrations.
  • concentrations of the exogenously added electrolytes can be adjusted accordingly. Analysis of the electrolyte composition of the nutritional substance can be performed by procedures well-known to those of ordinary skill in the art.
  • the nutritional substance in the antidiarrheal composition of the present invention can be mashed carrots.
  • 500 g. of young carrots are boiled slowly in 1 liter water for about 90 minutes. If necessary, water can be added during the boiling. Thereafter, the carrots are transformed into a puree either by rubbing them through a sieve or with a blender-mixer. Water is added to the puree to bring the total volume to 1 liter.
  • the carrot puree is then dehydrated either by desiccation or lyophilization and ground into a fine powder.
  • the dehydrated carrot powder is used in preparing the antidiarrheal composition of the present invention.
  • Example 2 The antidiarrheal composition is prepared using the ingredients and amounts shown in Table 2.
  • the ingredients in Table 2 are admixed to form a smooth textured composition suitable for oral administration to a human or animal with diarrhea. It is to be understood that non- dehydrated carrot puree could be used to prepare the antidiarrheal composition of the present invention. The amount of water would have to be appropriately adjusted.
  • Example 2 The composition of Example 2 wherein the composition is lyophilized to form a ready-to-use composition that can be reconstituted by adding water and mixing.
  • Example 2 For children between approximately 3 and 6 years of age the oral dosage of the composition described in Example 2 is approximately 0.33 L. to 0.5 L. three times a day or as needed. The dosage should not exceed 1.5 L. in twenty four hours.
  • Example 5 The antidiarrheal composition is prepared using the ingredients and amounts shown in Table 3.
  • the ingredients in Table 3 are admixed to form a smooth textured composition suitable for oral administration to a human or animal with diarrhea.
  • Example 5 The composition of Example 5 wherein the composition is lyophilized to form a ready-to-use composition that can be reconstituted by adding water and mixing.
  • Example 8 For children between approximately 3 and 6 years of age the oral dosage of the composition described in Example 5 is approximately 0.33 L. to 0.5 L. three times a day or as needed. The dosage should not exceed 1.5 L. in twenty four hours.
  • Example 8 For children between approximately 3 and 6 years of age the oral dosage of the composition described in Example 5 is approximately 0.33 L. to 0.5 L. three times a day or as needed. The dosage should not exceed 1.5 L. in twenty four hours.
  • the antidiarrheal composition is prepared using the ingredients and amounts shown in Table 3 except rice flour is substituted for carrot powder.
  • the antidiarrheal composition is prepared using the ingredients and amounts shown in Table 3 except approximately 5x109 CFU to 5x1010 CFU of Lactobacillus GG are added to the mixture.
  • the antidiarrheal composition is prepared using the ingredients and amounts shown in Table 3 except rice flour is substituted for carrot powder and approximately 5xl0 9 CFU to 5x10 10 CFU of Lactobacillus GG are added to the mixture.
  • Example 11 The antidiarrheal composition is prepared using the ingredients and amounts shown in Table 4.
  • the antidiarrheal composition is prepared using the ingredients and amounts shown in Table 4 except approximately 5x109 CFU to 5x1010 CFU of Lactobacillus GG are added to the mixture.
  • the antidiarrheal composition is prepared using the ingredients and amounts shown in Table 4 wherein the short- chain glucose polymers are two to nine glucose units long, and derived from the controlled hydrolysis of rice.
  • Example 11 For children between approximately 2 weeks and 3 years of age the oral dosage of the composition described in Example 11 is approximately 0.1 to 0.5 L three times a day or as needed. It should be understood that the foregoing relates only to a preferred embodiment of the present invention and that numerous modifications or alterations may be made without departing from the spirit and scope of the invention as set forth in the appended claims.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract

Composition et procédé de traitement de la diarrhée et d'états apparentés. La composition antidiarrhéique de l'invention comprend un mélange d'une ou de plusieurs substances nutritionnelles, d'une fibre synthétique et d'électrolytes, de manière que les conditions électrolytiques de la réhydratation soient remplies dans une formulation orale d'un goût agréable. On peut facultativement ajouter un Lactobacillus sp. à ladite composition antidiarrhéique.
PCT/US1991/002445 1990-04-09 1991-04-09 Composition et procede antidiarrheique WO1991015199A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP91507880A JPH05506228A (ja) 1990-04-09 1991-04-09 止痢薬組成物及び方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50675090A 1990-04-09 1990-04-09
US506,750 1990-04-09
US67837291A 1991-04-04 1991-04-04
US678,372 1991-04-04

Publications (1)

Publication Number Publication Date
WO1991015199A1 true WO1991015199A1 (fr) 1991-10-17

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PCT/US1991/002445 WO1991015199A1 (fr) 1990-04-09 1991-04-09 Composition et procede antidiarrheique

Country Status (4)

Country Link
JP (1) JPH05506228A (fr)
AU (1) AU7687091A (fr)
CA (1) CA2081388A1 (fr)
WO (1) WO1991015199A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994007506A1 (fr) * 1992-09-25 1994-04-14 Boehringer Ingelheim Gmbh Preparations galeniques de polycarbophyle calcique permettant l'ingestion de doses elevees de principe actif
US5489440A (en) * 1995-03-06 1996-02-06 Abbott Laboratories Rice flour-based oral rehydration solution
US5498408A (en) * 1992-09-21 1996-03-12 Sandoz Nutrition Ltd. Oral rehydration composition
WO1996037206A1 (fr) * 1995-05-26 1996-11-28 Virbac Laboratories (Nz) Limited Compositions orales de rehydratation a base de farine de riz pour animaux de ferme
WO1997034599A2 (fr) * 1996-03-20 1997-09-25 Children's Medical Center Corporation Utilisation de clotrimazole et de composes apparentes dans le traitement de la diarrhee
WO1998006411A2 (fr) * 1996-08-09 1998-02-19 Dicofarm S.P.A. Traitement de la diarrhee infantile aigue et prevention des reactions allergiques a des aliments ingeres dans la phase suivant l'administration de lactobacillus gg dans la solution de rehydratation orale
WO1998009669A1 (fr) * 1996-09-03 1998-03-12 The Royal Children's Hospital Foundation Solution rehydratante per os a base de riz
EP0852503A1 (fr) * 1995-02-22 1998-07-15 Medhat Abu-Shaaban Composition pour le traitement de la diarrhee, son utilisation et sa preparation
AU709607B2 (en) * 1996-09-03 1999-09-02 Royal Children's Hospital Foundation, The Rice-based oral rehydration solution
ES2277550A1 (es) * 2005-12-21 2007-07-01 Laboratorios Casen-Fleet, S.L. Kit farmaceutico para la preparacion de una sal de hidratacion con un probiotico para bebes.
US7374753B1 (en) * 1997-06-03 2008-05-20 Ganeden Biotech, Inc. Probiotic lactic acid bacterium to treat bacterial infections associated with SIDS
CN110122852A (zh) * 2019-05-07 2019-08-16 天津晶然科技有限公司 一种食物组合物、辅食添加和腹泻喂养方法及用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5965016A (ja) * 1982-10-06 1984-04-13 Nisshin Flour Milling Co Ltd 動物の下痢予防および治療用組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5965016A (ja) * 1982-10-06 1984-04-13 Nisshin Flour Milling Co Ltd 動物の下痢予防および治療用組成物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Volume 101, No. 22, issued 30 November 1984, (Columbus, Ohio, USA), Nisshin Flour Milling Co., "Antidiarrhea Compositions Containing Minerals and Sodium Acrylate Polymers", see page 378, column 2, the abstract No. 198189; & JP,A,59 065 016, 13 April 1984. *
HANDBOOK OF NONPRESCIPTION DRUGS, 14 June 1977, AMERICAN PHARMACEUTICAL ASSOCIATION, 5th Edition, pages 26, 31 and 33-35. *
THE LANCET, 19 August 1989, (MOLLA et al.), "Food- Based Oral Rehydration Salt Solution for Acute Childhood Diarrhoea", pages 429-431. *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498408A (en) * 1992-09-21 1996-03-12 Sandoz Nutrition Ltd. Oral rehydration composition
WO1994007506A1 (fr) * 1992-09-25 1994-04-14 Boehringer Ingelheim Gmbh Preparations galeniques de polycarbophyle calcique permettant l'ingestion de doses elevees de principe actif
EP0852503A1 (fr) * 1995-02-22 1998-07-15 Medhat Abu-Shaaban Composition pour le traitement de la diarrhee, son utilisation et sa preparation
EP0852503A4 (fr) * 1995-02-22 1999-02-10 Abu Shaaban Medhat Composition pour le traitement de la diarrhee, son utilisation et sa preparation
US5489440A (en) * 1995-03-06 1996-02-06 Abbott Laboratories Rice flour-based oral rehydration solution
WO1996037206A1 (fr) * 1995-05-26 1996-11-28 Virbac Laboratories (Nz) Limited Compositions orales de rehydratation a base de farine de riz pour animaux de ferme
WO1997034599A2 (fr) * 1996-03-20 1997-09-25 Children's Medical Center Corporation Utilisation de clotrimazole et de composes apparentes dans le traitement de la diarrhee
WO1997034599A3 (fr) * 1996-03-20 1998-02-12 Childrens Medical Center Utilisation de clotrimazole et de composes apparentes dans le traitement de la diarrhee
US5889038A (en) * 1996-03-20 1999-03-30 Children's Hospital Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
WO1998006411A3 (fr) * 1996-08-09 1998-05-07 Dicofarm Spa Traitement de la diarrhee infantile aigue et prevention des reactions allergiques a des aliments ingeres dans la phase suivant l'administration de lactobacillus gg dans la solution de rehydratation orale
WO1998006411A2 (fr) * 1996-08-09 1998-02-19 Dicofarm S.P.A. Traitement de la diarrhee infantile aigue et prevention des reactions allergiques a des aliments ingeres dans la phase suivant l'administration de lactobacillus gg dans la solution de rehydratation orale
WO1998009669A1 (fr) * 1996-09-03 1998-03-12 The Royal Children's Hospital Foundation Solution rehydratante per os a base de riz
AU709607B2 (en) * 1996-09-03 1999-09-02 Royal Children's Hospital Foundation, The Rice-based oral rehydration solution
US7374753B1 (en) * 1997-06-03 2008-05-20 Ganeden Biotech, Inc. Probiotic lactic acid bacterium to treat bacterial infections associated with SIDS
ES2277550A1 (es) * 2005-12-21 2007-07-01 Laboratorios Casen-Fleet, S.L. Kit farmaceutico para la preparacion de una sal de hidratacion con un probiotico para bebes.
CN110122852A (zh) * 2019-05-07 2019-08-16 天津晶然科技有限公司 一种食物组合物、辅食添加和腹泻喂养方法及用途

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Publication number Publication date
AU7687091A (en) 1991-10-30
CA2081388A1 (fr) 1991-10-10
JPH05506228A (ja) 1993-09-16

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