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Single-use biosensor for detecting antigen/antibody bonds in whole blood for use as an anti-hiv confirmatory test with verbal result on a liquid crystal display

Info

Publication number
WO1991006855A3
WO1991006855A3 PCT/DE1990/000816 DE9000816W WO1991006855A3 WO 1991006855 A3 WO1991006855 A3 WO 1991006855A3 DE 9000816 W DE9000816 W DE 9000816W WO 1991006855 A3 WO1991006855 A3 WO 1991006855A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
result
means
liquid
confirmatory
ear
Prior art date
Application number
PCT/DE1990/000816
Other languages
German (de)
French (fr)
Other versions
WO1991006855A2 (en )
Inventor
Falko Volkhardt Erich Tittel
Original Assignee
Falko Volkhardt Erich Tittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay
    • G01N33/569Immunoassay; Biospecific binding assay for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • G01N33/56988AIDS or HTLV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/150022Source of blood for capillary blood or interstitial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150412Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101Details
    • A61B5/15103Piercing procedure
    • A61B5/15107Piercing being assisted by a triggering mechanism
    • A61B5/15109Fully automatically triggered, i.e. the triggering does not require a deliberate action by the user, e.g. by contact with the patient's skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101Details
    • A61B5/15115Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15117Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142Devices intended for single use, i.e. disposable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/157Devices characterised by integrated means for measuring characteristics of blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18Liquid substances or solutions comprising solids or dissolved gases
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55Specular reflectivity
    • G01N21/552Attenuated total reflection
    • G01N21/553Attenuated total reflection and using surface plasmons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay
    • G01N33/543Immunoassay; Biospecific binding assay with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02Operational features
    • A61B2560/0266Operational features for monitoring or limiting apparatus function
    • A61B2560/028Arrangements to prevent overuse, e.g. by counting the number of uses
    • A61B2560/0285Apparatus for single use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233Special features of optical sensors or probes classified in A61B5/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12Manufacturing methods specially adapted for producing sensors for in-vivo measurements

Abstract

A confirmatory test on a silicon chip is based on the ELISA and WB method. The result, which has traditionally been obtained by chemical means, is obtained in this case by physical means using ultrasound (PZ) (approximately 500-fold acceleration) and the surface plasmon resonance effect. The 9 measurement points (M) are scanned by means of fibre optics (LB) and photodiodes (A). The final result is displayed via a logical circuit on a liquid crystal display (L). In an unambiguous case, the result is displayed verbally (e.g., antiHIV-negative), otherwise only as a code number which can be looked up in an accompanying diagnostic booklet. The assembled device is less than half the size of a matchbox. It also possesses a simple punching device which when used as an ear clip with clasp (for puncturing the ear lobe) displays the result automatically after 3 minutes. To prevent possible infection, the partial antigens (M) immobilized in the chip are destroyed with a disinfectant liquid (after 10 minutes).
PCT/DE1990/000816 1989-11-02 1990-10-26 Single-use biosensor for detecting antigen/antibody bonds in whole blood for use as an anti-hiv confirmatory test with verbal result on a liquid crystal display WO1991006855A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE3936442 1989-11-02
DEP3936442.9 1989-11-02

Publications (2)

Publication Number Publication Date
WO1991006855A2 true WO1991006855A2 (en) 1991-05-16
WO1991006855A3 true true WO1991006855A3 (en) 1991-06-27

Family

ID=6392702

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1990/000816 WO1991006855A3 (en) 1989-11-02 1990-10-26 Single-use biosensor for detecting antigen/antibody bonds in whole blood for use as an anti-hiv confirmatory test with verbal result on a liquid crystal display

Country Status (4)

Country Link
JP (1) JPH04502671A (en)
DE (1) DE4033741C2 (en)
EP (1) EP0452439A1 (en)
WO (1) WO1991006855A3 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8690798B2 (en) 1996-05-17 2014-04-08 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US9445756B2 (en) 2005-03-02 2016-09-20 Roche Diabetes Care, Inc. Dynamic integrated lancing test strip with sterility cover

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US5623070A (en) * 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
CA2102884A1 (en) * 1993-03-04 1994-09-05 James J. Wynne Dental procedures and apparatus using ultraviolet radiation
DE4315211A1 (en) * 1993-05-07 1994-02-03 Gunnar Brink Specific molecule detector using near-infrared surface plasmon resonance - has small cover plate of glass, silicon, metal or plastic having same size as precious metal layer carrying specific receptor mols.
US20020010406A1 (en) 1996-05-17 2002-01-24 Douglas Joel S. Methods and apparatus for expressing body fluid from an incision
EP1189281B1 (en) * 1998-06-30 2007-08-22 Micronas GmbH Chip-arrangement
DE19836110C2 (en) * 1998-08-10 2002-07-11 Jandratek Gmbh Sensor device with a mixing device
DE19836109A1 (en) * 1998-08-10 2000-03-02 Biotul Bio Instr Gmbh Apparatus and method for near the interface of the sample mixture in biosensor
WO2001069248A3 (en) * 2000-03-15 2002-01-03 Gil Zilber An immunoassay diagnostic probe and its use
DE10134650B4 (en) 2001-07-20 2009-12-03 Roche Diagnostics Gmbh System for withdrawing small amounts of body fluid
EP1730524A4 (en) * 2004-03-19 2008-05-21 Ind Res Ltd Biosensors for detecting bond rupture
EP1659404A1 (en) * 2004-11-17 2006-05-24 Valtronic S.A. Autonomes miniaturisiertes Diagnosegerät
US8585627B2 (en) 2008-12-04 2013-11-19 The Invention Science Fund I, Llc Systems, devices, and methods including catheters configured to monitor biofilm formation having biofilm spectral information configured as a data structure
US8706211B2 (en) 2007-08-17 2014-04-22 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having self-cleaning surfaces
US8647292B2 (en) 2007-08-17 2014-02-11 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having components that are actively controllable between two or more wettability states
US8366652B2 (en) 2007-08-17 2013-02-05 The Invention Science Fund I, Llc Systems, devices, and methods including infection-fighting and monitoring shunts
US8460229B2 (en) 2007-08-17 2013-06-11 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having components that are actively controllable between transmissive and reflective states
US8753304B2 (en) 2007-08-17 2014-06-17 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter
US8114346B2 (en) 2007-08-17 2012-02-14 The Invention Science Fund I, Llc Event-triggered ultraviolet light sterilization of surfaces
US8162924B2 (en) 2007-08-17 2012-04-24 The Invention Science Fund I, Llc System, devices, and methods including actively-controllable superoxide water generating systems
EP2384168B1 (en) 2008-12-04 2014-10-08 Searete LLC Actively-controllable sterilizing excitation delivery implants
US8702640B2 (en) 2007-08-17 2014-04-22 The Invention Science Fund I, Llc System, devices, and methods including catheters configured to monitor and inhibit biofilm formation
US20120041285A1 (en) 2008-12-04 2012-02-16 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, and methods including implantable devices with anti-microbial properties
US20090048648A1 (en) * 2007-08-17 2009-02-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Self-sterilizing device
US8734718B2 (en) 2007-08-17 2014-05-27 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component
EP2274593A4 (en) * 2008-04-23 2014-07-23 Société De Commercialisation Des Produits De La Rech Appliquée Socpra Sciences Et Génie S E C Integrated shear-vertical surface acoustic wave and surface plasmon resonance sensing device and method
US8029740B2 (en) 2008-07-11 2011-10-04 The Invention Science Fund I, Llc Event-triggered self-sterilization of article surfaces
US7931149B2 (en) 2009-05-27 2011-04-26 Given Imaging Ltd. System for storing and activating an in vivo imaging capsule
DE102010011560A1 (en) * 2010-03-16 2011-09-22 Gilupi Gmbh biodetector
US9101678B2 (en) 2011-11-03 2015-08-11 Elwha Llc Heat-sanitization of surfaces

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8690798B2 (en) 1996-05-17 2014-04-08 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US9445756B2 (en) 2005-03-02 2016-09-20 Roche Diabetes Care, Inc. Dynamic integrated lancing test strip with sterility cover

Also Published As

Publication number Publication date Type
DE4033741C2 (en) 1994-03-31 grant
JPH04502671A (en) 1992-05-14 application
WO1991006855A2 (en) 1991-05-16 application
DE4033741A1 (en) 1991-05-08 application
EP0452439A1 (en) 1991-10-23 application

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