WO1991005561A1 - Traitement contre les poux de tete - Google Patents
Traitement contre les poux de tete Download PDFInfo
- Publication number
- WO1991005561A1 WO1991005561A1 PCT/AU1990/000487 AU9000487W WO9105561A1 WO 1991005561 A1 WO1991005561 A1 WO 1991005561A1 AU 9000487 W AU9000487 W AU 9000487W WO 9105561 A1 WO9105561 A1 WO 9105561A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- azadirachtin
- solution
- solvent
- composition
- humans
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/26—Meliaceae [Chinaberry or Mahogany family], e.g. mahogany, langsat or neem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
Definitions
- HEAD LICE TREATMENT TECHNICAL FIELD relates to a treatment composition for humans, and it relates particularly to a novel composition containing neem extract to repel and/or treat head lice in humans.
- Neem trees - Azadirachta indica - are known to grow in many countries around the world, including Kenya, Mauritius- India- Thailand, Indonesia and Australia. There may be slight variations in trees from one location to another, but they all have one thing in common - they all produce a naturally occurring insecticide called azadirachtin. Most of the azadirachtin is produced in the seeds of the tree, although some is contained in the bark and leaves. Whilst neem seed extract is used as an insecticide and repellant in farm animals, its application to humans has not been fully explored. In Australian Patent Application No. 26320/88, reference is made to application of azadirachtin to humans.
- the azadirachtin is applied to humans as an ointment for the hair and scalp. Ointments are generally not acceptable to users who do not wish to have them in their hair for abnormally long periods of time. Accordingly, investigations were carried out with the principal object of developing a composition which could be regularly applied to the hair and scalp of a human, not be greasy and its presence being generally understated by other humans. To have the best possible chance of success, the composition should be capable of being sprayed directly onto the scalp using a volatile solvent that would not be an irritant to the scalp and would evaporate away, leaving the active ingredient behind to do its intended job. The criteria selected for success were that the composition should be -
- a composition comprising a solution of azadirachtin including up to about 1% of azadirachtin and the balance substantially all solvent suitable for permitting application of the solution to the human head.
- the solution includes at least 80% of an alcoholic or spirit solvent.
- azadirachtin is present in amounts of about 200-2000 parts per million (ppm) . Whilst acting as a repellent, azadirachtin is typically present in amounts of 10-1000 ppm.
- any solvent that lends itself to providing a suitable vehicle to deliver the neem extract to the head by means of spraying would be acceptable in the formula, the solvent properties required being that it must dissolve the neem extract, must produce a fine mist when sprayed, and must be acceptable to use on a human scalp.
- alcohols are suitable solvents.
- the type of alcohol used may be of any variety such as isopropyl alcohol or ethyl alcohol.
- Other additives may be in the solution, such as perfumes, conditioners and colours, as referred to hereinafter.
- the solution may comprise neem seed extract (5%) to 1.00 parts and mixed fruit perfume to 0.5 parts, the balance to 100 parts being industrial methylated spirits.
- the application of the spray was carried out only after the hair and scalp had been thoroughly dried should the participant have washed or wet his/her head.
- the hair was parted to expose the scalp and the repellant sprayed onto the scalp itself.
- One spray was applied to the front of the head, and one to the back of the head, and massaged into the scalp. The participants were advised that washing of the hair washed out the active ingredient.
- the trial results were also assessed to establish effectiveness for two purposes: (1) to kill and eradicate the lice, and (2) to repel lice and thereby avoid further re-infestation.
- ethyl alcohol was used as the carrier solvent for several reasons - (a) It is an effective solvent of azadirachtin;
- Test solutions was made containing various strengths of azadirachtin content. Strengths used varied from 200 parts per million (ppm) to 1000 ppm of azadirachtin. Solvents used were light liquid paraffin and 90% ethyl alcohol. It was found that as soon as water was added to the alcoholic solution, the azadirachtin started to "throw out” of solution. Any dilution of the alcohol base below 80% alcohol content rendered it useless as a solvent for azadirachtin. A simple pump top spray bottle was used to deliver the product to the scalp.
- the test solution was spirit based containing 800 ppm azadirachtin. From day 1 the test repelled lice. Whereas in the past, the participant was susceptible to be re- infested every three or four weeks, the participant became lice free for the term of the test (approximately three months) notwithstanding being exposed to lice. The participant's parents reported that the participant's hair condition had improved as well. The participant was happy to use the composition. Participant 2
- the solution supplied was paraffin oil based, with 500ppm of azadirachtin. The participant reported results consistent with the experiences of Participant 1. Participant 3 The solution was spirit based and contained 500 ppm of azadirachtin. The participant reported results consistent with the experiences of Participant 1. Participant 4
- This household was made up of two women, each with two children, living together, with a never ending problem of head lice infestation.
- One of the women and her children had very thick wavy long hair, which is very difficult to treat.
- the woman and child with wavy hair also had oily hair and so were treated with a spirit based composition containing 400 ppm of azadirachtin in 90% ethyl alcohol.
- the other woman and her children had dry hair, and so were treated with an oil based composition containing 400 ppm in light liquid paraffin. For the first two weeks no lice were evident. However, subsequently one of the daughter's hair was heavily infested.
- the light liquid paraffin was only given to two participants to try, as it was considered to be likely to be less successful than the spirit base due to its oiliness on the scalp and less effective vaporisation when sprayed from a pump spray. Of the two participants supplied with the oil based test samples, only one persisted with it. That participant, however, reported complete success.
- the ethyl alcohol used as the spirit base needs to be at least 80% alcohol content.
- Other alcohols such as isopropyl alcohol may be suitable as a solvent base to deliver the azadirachtin to the scalp.
- Perfume may be added to hide the rather offensive smell of the neem extract, but since the neem extract is required in such low concentrations, it is not difficult to hide the smell.
- the solution is easily dispersed in a pump top spray, which makes the product easy to use for the parents and is readily acceptable by the children. Aerosol spray application would have equal acceptance.
- the important aspect of the invention is that the solution allows the neem extract to be delivered directly to the hair and scalp by a solvent that thereafter evaporates away, leaving the active ingredient - the neem extract.
- the solution according to the invention is effective as both a repellant and a treatment for the killing and eradicating of head lice and their eggs from the human head. Any perfume that hides the bad smell of the neem extract would be acceptable.
- One unexpected additional advantage of use of the neem extract is apparently its effect as a hair conditioner, so it would not be necessary to add extra conditioners to the formula,such as lanoline, in order to condition the hair.
- neem extract on its own has proven to be completely effective for the purposes outlined above, it is extremely expensive. Accordingly, it is also envisaged that activity enhancers, such as pyrethrums, may be added to the formula in order that the strength of the neem extract may be reduced without detracting from the efficacy of the product.
- activity enhancers such as pyrethrums
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Agronomy & Crop Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Pest Control & Pesticides (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Nouvelle composition contenant de l'extrait de neem comme traitement préventif ou actif contre les poux de tête chez les humains. La composition peut être appliquée régulièrement sur les cheveux ou le cuir chevelu d'un être humain sans graisser et sans que sa présence soit, en général, remarquée par les autres. La composition, dans l'ensemble, comprend une solution d'azadirachtine incluant jusqu'à 1 % environ d'azadirachtine et le reste pouvant être constitué de pratiquement tous les solvants permettant l'application de la solution sur le cuir chevelu. La solution peut comprendre au moins 80 % d'un solvant alcoolisé, cependant des solvants non alcoolisés peuvent s'utiliser comme support adéquat pour appliquer l'extrait de neem sur la tête, de préférence, en le pulvérisant. Le solvant doit être capable de dissoudre l'extrait de neem pour produire un fin brouillard quand il est pulvérisé et être compatible à l'utilisation sur le cuir chevelu.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPJ677389 | 1989-10-10 | ||
AUPJ6773 | 1989-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991005561A1 true WO1991005561A1 (fr) | 1991-05-02 |
Family
ID=3774264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU1990/000487 WO1991005561A1 (fr) | 1989-10-10 | 1990-10-10 | Traitement contre les poux de tete |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1991005561A1 (fr) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19532447A1 (de) * | 1995-09-04 | 1997-03-06 | Heinz Prof Dr Rembold | Repellens zur Schädlingsbekämpfung |
WO2000042982A1 (fr) * | 1999-01-26 | 2000-07-27 | Pearlman Dale L | Procedes et kits pour l'elimination, le traitement ou la prevention, en cas d'infestation par les poux, au moyen d'agents pediculostatiques sechables |
WO2001060163A2 (fr) | 2000-02-17 | 2001-08-23 | Ecosmart Technologies, Inc. | Compositions pesticides dirigees contre les poux du corps humain et contenant des huiles essentielles de plantes |
WO2003057231A1 (fr) * | 2002-01-10 | 2003-07-17 | Natural Science.Com Limited | Compose pediculicide |
DE102004054143A1 (de) * | 2004-11-08 | 2006-05-11 | Alpha-Biocare Gmbh | Herstellung von pflanzlichen Wirkstoffen gegen Krankheitserreger und Schädlinge mit Dicarbonsäurealkylestern |
WO2010108680A1 (fr) * | 2009-03-27 | 2010-09-30 | Uwe Andresen | Composition répulsive pour application topique sur des êtres vivants |
US8178116B2 (en) | 2002-04-29 | 2012-05-15 | Piedmont Pharmaceuticals, Llc | Methods and compositions for treating ectoparasite infestation |
US20130253450A1 (en) * | 2012-03-21 | 2013-09-26 | Laura Marie Shelton | System and method for the treatment of lice with a liquid solution |
US8877219B2 (en) | 1998-07-28 | 2014-11-04 | Ecosmart Technologies, Inc. | Pesticidal compositions containing rosemary oil and wintergreen oil |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556562A (en) * | 1984-03-19 | 1985-12-03 | Vikwood, Ltd. | Stable anti-pest neem seed extract |
AU1122088A (en) * | 1987-07-14 | 1989-01-19 | Vincent Henry Guerrini | Improvements in the inhibition of lice |
AU2632088A (en) * | 1987-11-30 | 1989-06-01 | University Of Queensland, The | Improvements in the inhibition of lice |
US4946681A (en) * | 1989-06-26 | 1990-08-07 | W. R. Grace & Co.-Conn. | Method to prepare an improved storage stable neem seed extract |
-
1990
- 1990-10-10 WO PCT/AU1990/000487 patent/WO1991005561A1/fr unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556562A (en) * | 1984-03-19 | 1985-12-03 | Vikwood, Ltd. | Stable anti-pest neem seed extract |
AU1122088A (en) * | 1987-07-14 | 1989-01-19 | Vincent Henry Guerrini | Improvements in the inhibition of lice |
AU2632088A (en) * | 1987-11-30 | 1989-06-01 | University Of Queensland, The | Improvements in the inhibition of lice |
US4946681A (en) * | 1989-06-26 | 1990-08-07 | W. R. Grace & Co.-Conn. | Method to prepare an improved storage stable neem seed extract |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19532447A1 (de) * | 1995-09-04 | 1997-03-06 | Heinz Prof Dr Rembold | Repellens zur Schädlingsbekämpfung |
US9497974B2 (en) | 1998-07-28 | 2016-11-22 | Kittrich Corporation | Pesticidal compositions and methods for using same |
US9247751B2 (en) | 1998-07-28 | 2016-02-02 | Kittrich Corporation | Pesticidal compositions containing rosemary oil and wintergreen oil |
US8877219B2 (en) | 1998-07-28 | 2014-11-04 | Ecosmart Technologies, Inc. | Pesticidal compositions containing rosemary oil and wintergreen oil |
WO2000042982A1 (fr) * | 1999-01-26 | 2000-07-27 | Pearlman Dale L | Procedes et kits pour l'elimination, le traitement ou la prevention, en cas d'infestation par les poux, au moyen d'agents pediculostatiques sechables |
US6265384B1 (en) | 1999-01-26 | 2001-07-24 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
US6303581B2 (en) | 1999-01-26 | 2001-10-16 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pedicul ostatic agents |
US6350734B1 (en) | 1999-01-26 | 2002-02-26 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
US6541455B2 (en) | 1999-01-26 | 2003-04-01 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
US6974584B2 (en) | 2000-02-17 | 2005-12-13 | Ecosmart Technologies, Inc. | Pesticidal compositions containing plant essential oils against human body louse |
US6969522B2 (en) | 2000-02-17 | 2005-11-29 | Ecosmart Technologies, Inc. | Pesticidal compositions containing plant essential oils against human body louse |
WO2001060163A3 (fr) * | 2000-02-17 | 2002-02-07 | Ecosmart Technologies Inc | Compositions pesticides dirigees contre les poux du corps humain et contenant des huiles essentielles de plantes |
WO2001060163A2 (fr) | 2000-02-17 | 2001-08-23 | Ecosmart Technologies, Inc. | Compositions pesticides dirigees contre les poux du corps humain et contenant des huiles essentielles de plantes |
WO2003057231A1 (fr) * | 2002-01-10 | 2003-07-17 | Natural Science.Com Limited | Compose pediculicide |
US8178116B2 (en) | 2002-04-29 | 2012-05-15 | Piedmont Pharmaceuticals, Llc | Methods and compositions for treating ectoparasite infestation |
US8815270B2 (en) | 2002-04-29 | 2014-08-26 | Piedmont Pharmaceuticals, Llc | Methods and compositions for treating ectoparasite infestation |
DE102004054143A1 (de) * | 2004-11-08 | 2006-05-11 | Alpha-Biocare Gmbh | Herstellung von pflanzlichen Wirkstoffen gegen Krankheitserreger und Schädlinge mit Dicarbonsäurealkylestern |
DE102004054143B4 (de) * | 2004-11-08 | 2010-09-09 | Alpha-Biocare Gmbh | Mittel, enthaltend aus Neemsamen, Neemöl, getrockneten Blättern oder Rinde von Neembaum gewonnene Wirkstoffe und Dicarbonsäurealkylester, zur Bekämpfung von tierischen oder pflanzlichen Schädlingen oder Krankheitserregern |
WO2010108680A1 (fr) * | 2009-03-27 | 2010-09-30 | Uwe Andresen | Composition répulsive pour application topique sur des êtres vivants |
US20130253450A1 (en) * | 2012-03-21 | 2013-09-26 | Laura Marie Shelton | System and method for the treatment of lice with a liquid solution |
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