WO1991000729A3 - Bis-dioxopiperazines, et leur utilisation en tant qu'agents de protection - Google Patents
Bis-dioxopiperazines, et leur utilisation en tant qu'agents de protection Download PDFInfo
- Publication number
- WO1991000729A3 WO1991000729A3 PCT/GB1990/001079 GB9001079W WO9100729A3 WO 1991000729 A3 WO1991000729 A3 WO 1991000729A3 GB 9001079 W GB9001079 W GB 9001079W WO 9100729 A3 WO9100729 A3 WO 9100729A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydrogen
- group
- carbon atoms
- maximum
- aliphatic hydrocarbon
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention se rapporte à des composés représentés par la formule (II); où n est égal à 0, à 1 ou à 2; R1, R2, R3 et R4 sont chacun choisis séparément parmi l'hydrogène, des groupes d'hydrocarbures aliphatiques acycliques non substitués ayant un maximum de six atomes de carbone et des groupes alkyle de 1 à 6 atomes de carbone substitués par un groupe hydroxy ou un groupe alkoxy de 1 à 6 atomes de carbone, ou l'un des éléments R1 et R2 et l'un des éléments R3 et R4 représentent l'hydrogène et les autres représentent un groupe de liaison en pont triméthylène, tétraméthylène ou pentaméthylène; et R5 représente l'hydrogène ou un groupe d'hydrocarbure aliphatique acyclique non substitué ayant un maximum de six atomes de carbone; à condition, toutefois, que: (a) lorsque n est égal à 0, les combinaisons R1 = R2 = R3 = R4 = R5 = H et R1 = R2 = R3 = R5 = H, R4 = méthyle sont exclues, et (b) lorsque n est égal à 0, que R1, R3 et R5 représentent chacun l'hydrogène et chacun des éléments R2 R4 est autre que l'hydrogène, le composé présente une configuration autre que la configuration méso ou érythro; ou à un sel d'un tel composé formé avec un acide inorganique ou organique physiologiquement acceptable, ledit composé ou son sel ayant une utilité thérapeutique, notamment comme agents cardioprotecteurs.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8916072.5 | 1989-07-13 | ||
GB898916072A GB8916072D0 (en) | 1989-07-13 | 1989-07-13 | Pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1991000729A2 WO1991000729A2 (fr) | 1991-01-24 |
WO1991000729A3 true WO1991000729A3 (fr) | 1991-06-13 |
Family
ID=10660005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1990/001079 WO1991000729A2 (fr) | 1989-07-13 | 1990-07-13 | Bis-dioxopiperazines, et leur utilisation en tant qu'agents de protection |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0409499A3 (fr) |
JP (1) | JPH04500690A (fr) |
AU (1) | AU6047190A (fr) |
CA (1) | CA2033203A1 (fr) |
GB (2) | GB8916072D0 (fr) |
NZ (1) | NZ234459A (fr) |
WO (1) | WO1991000729A2 (fr) |
ZA (1) | ZA905511B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3050598B2 (ja) * | 1990-07-04 | 2000-06-12 | 全薬工業株式会社 | 水溶性ビスージオキソピペラジン誘導体 |
GB9015435D0 (en) * | 1990-07-13 | 1990-08-29 | Creighton Andrew M | Pharmaceutical compositions |
GB9115596D0 (en) * | 1991-07-12 | 1991-09-04 | Creighton Andrew M | Pharmaceutical compositions |
GB9122677D0 (en) * | 1991-10-25 | 1991-12-11 | Eurocetus Bv | Process for preparing(s)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione) |
US5760039A (en) * | 1991-10-25 | 1998-06-02 | Chiron Corporation | Lyophilized composition containing S(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione) |
GB9124483D0 (en) * | 1991-11-18 | 1992-01-08 | Windleshaw Enterprises Ltd | Bis(3,5-dioxoalkylpiperazine)derivatives for use in treating intracellular accumulation of metal ions |
AU7370594A (en) * | 1993-07-23 | 1995-02-20 | Lxr Biotechnology Inc. | Methods of treating apoptosis and associated conditions |
US6265385B1 (en) * | 1996-01-11 | 2001-07-24 | Topo Target Aps | Topoisomerase II poison and bis-dioxopiperazine derivative combination therapy |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3196153A (en) * | 1961-01-19 | 1965-07-20 | Geigy Chem Corp | Poly(3, 5-diketo-piperazinyl-1) compounds |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1234935A (en) * | 1967-07-03 | 1971-06-09 | Nat Res Dev | Piperazine derivatives |
GB1374979A (en) * | 1970-12-21 | 1974-11-20 | Nat Res Dev | 3,5-dioxopiperazine derivatives |
NL163957C (nl) * | 1968-07-02 | 1980-11-17 | Nat Res Dev | Werkwijze voor het bereiden van een geneesmiddel tegen kanker, alsmede werkwijze voor het bereiden van een 1,2-di(3,5-dioxopiperazinoalkaanverbinding. |
DE1967027C3 (de) * | 1968-07-02 | 1978-06-22 | National Research Development Corp., London | Bis-<33-dioxopiperazino)-alkanverbindungen und Verfahren zu ihrer Herstellung |
GB1236947A (en) * | 1968-08-15 | 1971-06-23 | Ici Ltd | Process for the preparation of piperazine derivatives |
FR2278324A1 (fr) * | 1974-07-18 | 1976-02-13 | Bottu | Nouveaux derives du paracetamol |
DE2511891A1 (de) * | 1975-03-19 | 1976-10-07 | Gruenenthal Chemie | Neue derivate des 2,6-dioxopiperazins, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel sowie verfahren zu deren herstellung |
DE2511892A1 (de) * | 1975-03-19 | 1976-10-07 | Gruenenthal Chemie | Arzneimittel |
-
1989
- 1989-07-13 GB GB898916072A patent/GB8916072D0/en active Pending
-
1990
- 1990-07-11 NZ NZ234459A patent/NZ234459A/en unknown
- 1990-07-13 ZA ZA905511A patent/ZA905511B/xx unknown
- 1990-07-13 WO PCT/GB1990/001079 patent/WO1991000729A2/fr active Application Filing
- 1990-07-13 CA CA002033203A patent/CA2033203A1/fr not_active Abandoned
- 1990-07-13 AU AU60471/90A patent/AU6047190A/en not_active Abandoned
- 1990-07-13 GB GB9015437A patent/GB2235874A/en not_active Withdrawn
- 1990-07-13 JP JP2510521A patent/JPH04500690A/ja active Pending
- 1990-07-13 EP EP19900307685 patent/EP0409499A3/en not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3196153A (en) * | 1961-01-19 | 1965-07-20 | Geigy Chem Corp | Poly(3, 5-diketo-piperazinyl-1) compounds |
Non-Patent Citations (6)
Title |
---|
Advances in Pharmacology and Chemotherapy, vol. 19, 1982, Academic Press, Inc., E.H. Herman et al.: "Biological properties of ICRF-159 and related bis(dioxopiperazine) compounds", pages 249-290 see the whole article; especially page 251, compounds 13,14; page 252, compound 17; page 253, compound 19 * |
Dev. Oncolog., vol. 53, 1988, V.J. Ferrans et al.: "Pretreatment with ICRF-187 protects against the chronic cardiac toxicity produced by very large cumulative dosis of doxorubicin in beagle dogs", pages 56-63 * |
Med. Chem. Proc. Int. Symp. 6th, 1978, A.M. Creighton et al.: "Bisdioxopiperazines", pages 281-288 * |
Research Communications in Chemical Pathology and Pharmacology, vol. 33, no. 3, September 1981, A.N. El-Hage et al.: "Reduction in the diabetogenic effect of alloxan in mice by treatment with the antineoplastic agent ICRF-187", pages 509-523 * |
Research communications in Chemical Pathology and Pharmacology, vol. 48, no. 1, April 1985, E.H. Herman et al.: "Comparison of the protective effect of ICRF-187 and structurally related analogues against acute daunorubicin toxicity in Syrian golden hamsters", pages 35-55 * |
Toxicology, vol. 28, 1983, Elsevier Scientific Publishers Ireland Ltd, (IE), A.N. El-Hage et al.: "Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminopheninduced hepatotoxicity in Syrian golden hamsters", pages 295-303 see summary; page 299, table II * |
Also Published As
Publication number | Publication date |
---|---|
GB2235874A (en) | 1991-03-20 |
GB8916072D0 (en) | 1989-08-31 |
AU6047190A (en) | 1991-02-06 |
ZA905511B (en) | 1992-03-25 |
EP0409499A2 (fr) | 1991-01-23 |
CA2033203A1 (fr) | 1991-01-14 |
GB9015437D0 (en) | 1990-08-29 |
JPH04500690A (ja) | 1992-02-06 |
NZ234459A (en) | 1992-04-28 |
WO1991000729A2 (fr) | 1991-01-24 |
EP0409499A3 (en) | 1991-03-27 |
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