WO1990010058A3 - Procede de production et de purification d'un vaccin pour l'hepatite b - Google Patents
Procede de production et de purification d'un vaccin pour l'hepatite b Download PDFInfo
- Publication number
- WO1990010058A3 WO1990010058A3 PCT/US1990/000747 US9000747W WO9010058A3 WO 1990010058 A3 WO1990010058 A3 WO 1990010058A3 US 9000747 W US9000747 W US 9000747W WO 9010058 A3 WO9010058 A3 WO 9010058A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- molecular weight
- hepatitis
- high molecular
- purification
- contaminant proteins
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90907882A EP0408742B1 (fr) | 1989-02-07 | 1990-02-07 | Procede de production et de purification d'un vaccin pour l'hepatite b |
DE69012903T DE69012903T2 (de) | 1989-02-07 | 1990-02-07 | Verfahren zur herstellung und reinigung von hepatitis b-impfstoff. |
KR1019900702244A KR0148119B1 (ko) | 1989-02-07 | 1990-02-07 | B형 간염백신의 제조방법 및 정제법 |
CA002026570A CA2026570C (fr) | 1989-02-07 | 1990-02-07 | Methode de production et de purification de vaccin contre l'hepatite b |
SU4831850/13A RU2080876C1 (ru) | 1989-02-07 | 1990-02-07 | Способ получения очищенных частиц поверхностного антигена гепатита в, очищенная частица поверхностного антигена гепатита в человека и вакцина против гепатита в |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30777789A | 1989-02-07 | 1989-02-07 | |
US307,777 | 1989-02-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1990010058A2 WO1990010058A2 (fr) | 1990-09-07 |
WO1990010058A3 true WO1990010058A3 (fr) | 1990-11-01 |
Family
ID=23191134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1990/000747 WO1990010058A2 (fr) | 1989-02-07 | 1990-02-07 | Procede de production et de purification d'un vaccin pour l'hepatite b |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0408742B1 (fr) |
JP (1) | JP2825647B2 (fr) |
KR (1) | KR0148119B1 (fr) |
AT (1) | ATE112170T1 (fr) |
AU (1) | AU632575B2 (fr) |
CA (1) | CA2026570C (fr) |
DE (1) | DE69012903T2 (fr) |
DK (1) | DK0408742T3 (fr) |
ES (1) | ES2061040T3 (fr) |
HK (1) | HK183395A (fr) |
IL (1) | IL93304A (fr) |
RU (1) | RU2080876C1 (fr) |
WO (1) | WO1990010058A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW570803B (en) * | 1997-04-09 | 2004-01-11 | Duphar Int Res | Influenza vaccine |
CN103319572B (zh) * | 2012-03-20 | 2015-06-24 | 北京天坛生物制品股份有限公司 | 一种乙型肝炎表面抗原的纯化方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4442205A (en) * | 1981-09-22 | 1984-04-10 | The United States Of America As Represented By The Department Of Health And Human Services | Simian virus recombinant that directs the synthesis of hepatitis B surface antigen |
US4612283A (en) * | 1983-10-05 | 1986-09-16 | 501 Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute | Method for purification of HBs antigen |
EP0257507A1 (fr) * | 1986-08-17 | 1988-03-02 | Yeda Research And Development Ltd. | Vaccin de l'hépatite |
US4741901A (en) * | 1981-12-03 | 1988-05-03 | Genentech, Inc. | Preparation of polypeptides in vertebrate cell culture |
US4742158A (en) * | 1986-04-25 | 1988-05-03 | Merck & Co., Inc. | Purification of hepatitis pre-S antigens by polymerized serum albumin affinity binding |
WO1988006185A1 (fr) * | 1987-02-11 | 1988-08-25 | Scripps Clinic And Research Foundation | Vecteurs retroviraux d'expression et procedes de production d'antigenes du virus d'hepatite b |
US4883865A (en) * | 1987-09-30 | 1989-11-28 | Merck & Co. Inc. | Recovery of pres2+s antigen |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI861417A0 (fi) * | 1985-04-15 | 1986-04-01 | Endotronics Inc | Hepatitis b ytantigen framstaelld med rekombinant-dna-teknik, vaccin, diagnostiskt medel och cellinjer samt foerfaranden foer framstaellning daerav. |
JPS63230639A (ja) * | 1987-03-19 | 1988-09-27 | Nippon Chem Res Kk | 新規なb型肝炎ウイルス表面抗原粒子とその製法 |
JPH0216975A (ja) * | 1988-02-09 | 1990-01-19 | Eugene Tech Internatl Inc | 異成分混交性のプレーsに富んだb型肝炎表面抗原 |
-
1990
- 1990-02-07 CA CA002026570A patent/CA2026570C/fr not_active Expired - Lifetime
- 1990-02-07 RU SU4831850/13A patent/RU2080876C1/ru active
- 1990-02-07 DE DE69012903T patent/DE69012903T2/de not_active Expired - Lifetime
- 1990-02-07 JP JP2507455A patent/JP2825647B2/ja not_active Expired - Lifetime
- 1990-02-07 AU AU56485/90A patent/AU632575B2/en not_active Expired
- 1990-02-07 KR KR1019900702244A patent/KR0148119B1/ko not_active IP Right Cessation
- 1990-02-07 EP EP90907882A patent/EP0408742B1/fr not_active Expired - Lifetime
- 1990-02-07 IL IL93304A patent/IL93304A/xx not_active IP Right Cessation
- 1990-02-07 WO PCT/US1990/000747 patent/WO1990010058A2/fr active IP Right Grant
- 1990-02-07 AT AT90907882T patent/ATE112170T1/de not_active IP Right Cessation
- 1990-02-07 DK DK90907882.6T patent/DK0408742T3/da active
- 1990-02-07 ES ES90907882T patent/ES2061040T3/es not_active Expired - Lifetime
-
1995
- 1995-11-30 HK HK183395A patent/HK183395A/xx not_active IP Right Cessation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4442205A (en) * | 1981-09-22 | 1984-04-10 | The United States Of America As Represented By The Department Of Health And Human Services | Simian virus recombinant that directs the synthesis of hepatitis B surface antigen |
US4741901A (en) * | 1981-12-03 | 1988-05-03 | Genentech, Inc. | Preparation of polypeptides in vertebrate cell culture |
US4612283A (en) * | 1983-10-05 | 1986-09-16 | 501 Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute | Method for purification of HBs antigen |
US4742158A (en) * | 1986-04-25 | 1988-05-03 | Merck & Co., Inc. | Purification of hepatitis pre-S antigens by polymerized serum albumin affinity binding |
EP0257507A1 (fr) * | 1986-08-17 | 1988-03-02 | Yeda Research And Development Ltd. | Vaccin de l'hépatite |
WO1988006185A1 (fr) * | 1987-02-11 | 1988-08-25 | Scripps Clinic And Research Foundation | Vecteurs retroviraux d'expression et procedes de production d'antigenes du virus d'hepatite b |
US4883865A (en) * | 1987-09-30 | 1989-11-28 | Merck & Co. Inc. | Recovery of pres2+s antigen |
Non-Patent Citations (4)
Title |
---|
BIO/TECHNOLOGY, Published February 1987, Vol. 5, BRUNT, "Hepatitis B Vaccine Makers Multiply", pages 103-104. * |
CHEMICAL ABSTRACTS, No. 106:28525f; & EP,A,198 474 (SALSTROM et al.), 22 October 1986. * |
DERWENT ABSTRACT, No. 88-312212/44; & JP,A,63 230 639 (27-09-88). * |
NATURE, Published 1985, Vol. 315, NEURETH et al., "Hepatitis B Virus Contains Pre-S Gene-Encoded Domains", pages 154-156. * |
Also Published As
Publication number | Publication date |
---|---|
EP0408742B1 (fr) | 1994-09-28 |
DK0408742T3 (da) | 1995-03-20 |
KR910700071A (ko) | 1991-03-13 |
RU2080876C1 (ru) | 1997-06-10 |
ATE112170T1 (de) | 1994-10-15 |
AU632575B2 (en) | 1993-01-07 |
AU5648590A (en) | 1990-09-26 |
DE69012903T2 (de) | 1995-05-11 |
DE69012903D1 (de) | 1994-11-03 |
EP0408742A4 (en) | 1992-12-09 |
JPH03503847A (ja) | 1991-08-29 |
JP2825647B2 (ja) | 1998-11-18 |
EP0408742A1 (fr) | 1991-01-23 |
CA2026570C (fr) | 2000-05-30 |
ES2061040T3 (es) | 1994-12-01 |
WO1990010058A2 (fr) | 1990-09-07 |
CA2026570A1 (fr) | 1991-01-08 |
HK183395A (en) | 1995-12-08 |
IL93304A0 (en) | 1990-11-29 |
IL93304A (en) | 1992-09-06 |
KR0148119B1 (ko) | 1998-08-17 |
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