WO1990005135A3 - Process for the specific synthesis of new dithiocarbamic acid esters by substituting hydroxylated sites on mono- or polyhydroxylated molecules; products obtained by this process and their application - Google Patents

Process for the specific synthesis of new dithiocarbamic acid esters by substituting hydroxylated sites on mono- or polyhydroxylated molecules; products obtained by this process and their application Download PDF

Info

Publication number
WO1990005135A3
WO1990005135A3 PCT/FR1989/000569 FR8900569W WO9005135A3 WO 1990005135 A3 WO1990005135 A3 WO 1990005135A3 FR 8900569 W FR8900569 W FR 8900569W WO 9005135 A3 WO9005135 A3 WO 9005135A3
Authority
WO
WIPO (PCT)
Prior art keywords
mono
substituting
acid esters
products obtained
specific synthesis
Prior art date
Application number
PCT/FR1989/000569
Other languages
French (fr)
Other versions
WO1990005135A2 (en
Inventor
Denis Ghislain Postel
Gino Lino Ronco
Pierre Joseph Villa
Guy Andre Ville
Robert Plan
Original Assignee
Merieux Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merieux Inst filed Critical Merieux Inst
Priority to JP1511665A priority Critical patent/JPH04500677A/en
Publication of WO1990005135A2 publication Critical patent/WO1990005135A2/en
Priority to DK156690A priority patent/DK156690A/en
Publication of WO1990005135A3 publication Critical patent/WO1990005135A3/en
Priority to KR1019900701410A priority patent/KR900701773A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14—Dithiocarbamic acids; Derivatives thereof
    • C07C333/18—Esters of dithiocarbamic acids
    • C07C333/20—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Process for the specific synthesis of dithiocarbamic acid esters by substituting hydroxylated sites on mono- or polyhydroxylated molecules; products obtained by this process and their applications. Process for preparing esters of dithiocarbamic acids having the formula (I), in which R1 and R2 are saturated or unsaturated alkyl radicals, substituted or not with carbon-containing groups or heteroatoms or else forming with the nitrogen atom a saturated or unsaturated cycle with or without heteroatoms from alcohols or polyols; said process is characterized in that at least one hydroxylated group of the mono- or polyhydroxylated molecule is transformed, at a preliminary stage, into a leaving group (Y) such as an iodide, tosylate, brosylate, triflate or imidazol sulphonate and in that the leaving group (Y) is displaced by the anion (II), R1 and R2 having the above-mentioned meaning, introduced in the form of salt, preferably lithium, in the appropriate medium. The newly-obtained derivates may be used as drugs, notably as immunomodulators.
PCT/FR1989/000569 1988-11-02 1989-11-02 Process for the specific synthesis of new dithiocarbamic acid esters by substituting hydroxylated sites on mono- or polyhydroxylated molecules; products obtained by this process and their application WO1990005135A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP1511665A JPH04500677A (en) 1988-11-02 1989-11-02 A special method for the synthesis of novel dithiocarbamate esters by replacing the hydroxylated sites of mono- or polyhydroxylated molecules, the products obtained by this method and their applications.
DK156690A DK156690A (en) 1988-11-02 1990-06-28 PROCEDURE FOR SPECIFIC SYNTHESIS OF DITHIOCARBAMIC ACID ESTERS BY SUBSTITUTION OF HYDROXYLERED POSITIONS ON MONO- OR POLYHYDROXYLERED MOLECULES, PRODUCTS OBTAINED BY THE METHOD AND USE OF THE PROCEDURE
KR1019900701410A KR900701773A (en) 1988-11-02 1990-07-02 Method for specifically synthesizing dithio carbamic acid ester by substituting a hydroxylated site on a mono- or polyhydroxylated molecule, product obtained by the method, and application thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8814276A FR2638457B1 (en) 1988-11-02 1988-11-02 PROCESS FOR THE SPECIFIC SYNTHESIS OF DITHIOCARBAMIC ACID ESTERS BY SUBSTITUTION OF HYDROXYL SITES ON MONO- OR POLYHYDROXYLATED MOLECULES, PRODUCTS OBTAINED BY THIS PROCESS AND THEIR APPLICATIONS
FR88/14276 1988-11-02

Publications (2)

Publication Number Publication Date
WO1990005135A2 WO1990005135A2 (en) 1990-05-17
WO1990005135A3 true WO1990005135A3 (en) 1990-06-28

Family

ID=9371489

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1989/000569 WO1990005135A2 (en) 1988-11-02 1989-11-02 Process for the specific synthesis of new dithiocarbamic acid esters by substituting hydroxylated sites on mono- or polyhydroxylated molecules; products obtained by this process and their application

Country Status (8)

Country Link
EP (1) EP0371837A3 (en)
JP (1) JPH04500677A (en)
KR (1) KR900701773A (en)
AU (1) AU639669B2 (en)
CA (1) CA2002048A1 (en)
DK (1) DK156690A (en)
FR (1) FR2638457B1 (en)
WO (1) WO1990005135A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5000796A (en) * 1996-01-05 1997-08-01 CESA, Clean Energy SA Process for the deactivation of hiv and other viruses
US6043389A (en) * 1997-03-11 2000-03-28 Mor Research Applications, Ltd. Hydroxy and ether-containing oxyalkylene esters and uses thereof
US5939455A (en) * 1997-03-11 1999-08-17 Beacon Laboratories, Inc. Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives
DE19735120A1 (en) * 1997-08-13 1999-02-18 Peter Hans Prof D Hofschneider Use of thiol-compositions for inactivating virus in cell-free environments

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0179694A2 (en) * 1984-10-26 1986-04-30 Institut Merieux International Immunity-modulating medicament and process for its preparation
EP0288871A2 (en) * 1987-04-22 1988-11-02 PROTER S.p.A. Pharmaceutical compositions containing thio-dioxolane derivatives having mucolytic activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2892760A (en) * 1954-10-28 1959-06-30 Dehydag Gmbh Production of metal electrodeposits
JPS5449324A (en) * 1977-09-26 1979-04-18 Tokyo Yuuki Kagaku Kougiyou Kk Application and use of bactericide with low residue for agriculture and horticulture
DE3901706A1 (en) * 1988-05-17 1989-11-30 Bayer Ag HALOGEN-SUBSTITUTED PHENOXYBENZYL (THI) OL DERIVATIVES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0179694A2 (en) * 1984-10-26 1986-04-30 Institut Merieux International Immunity-modulating medicament and process for its preparation
EP0288871A2 (en) * 1987-04-22 1988-11-02 PROTER S.p.A. Pharmaceutical compositions containing thio-dioxolane derivatives having mucolytic activity

Also Published As

Publication number Publication date
AU639669B2 (en) 1993-08-05
DK156690A (en) 1990-08-15
JPH04500677A (en) 1992-02-06
CA2002048A1 (en) 1990-05-02
KR900701773A (en) 1990-12-04
EP0371837A3 (en) 1990-09-05
EP0371837A2 (en) 1990-06-06
FR2638457A1 (en) 1990-05-04
DK156690D0 (en) 1990-06-28
AU4522889A (en) 1990-05-28
FR2638457B1 (en) 1994-05-06
WO1990005135A2 (en) 1990-05-17

Similar Documents

Publication Publication Date Title
CA921035A (en) Process for the preparation of unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylic acid
ATE66950T1 (en) INTERNAL MOLD RELEASE AGENTS, THEIR USE FOR THE PRODUCTION OF MOLDINGS BY THE POLYISOCYANATE-POLYADDITION PROCESS AND PROCESS FOR THE MANUFACTURE OF THE MOLDINGS.
HU9302528D0 (en) Method for producing substituted cyclohexane derivatives and another one for preparing medical preparatives containing said compounds
PT71773A (en) PROCESS FOR THE PRODUCTION OF SUBSTITUTED OXIRANCARBONIC ACIDS
WO1990005135A3 (en) Process for the specific synthesis of new dithiocarbamic acid esters by substituting hydroxylated sites on mono- or polyhydroxylated molecules; products obtained by this process and their application
JPS5227721A (en) Process for preparation of substituted phosphonic acid derivatives
JPS5232999A (en) Process for preparing unsaturated epoxy esters having improved curabil ity
BR7408315D0 (en) PROCESS IMPROVEMENT FOR THE SYNTHESIS OF A C1-C7 ALIFACTIC HYDROCARBILE ESTER OF AN N- (2,6-DI (C1-C7 ALKYL) FENIL) ALPHA-AMINOCARBOXYLIC ACID
GB1389217A (en) Phenylglycine derivatives
ES449817A1 (en) Substituted 2-phenylimino-thiazolines a process for their preparation and their use as ectoparasiticides
DE3751149D1 (en) In position 3 2,2-dimethylcyclopropanecarboxylic acid derivatives substituted by a halogenated saturated chain, process for their preparation and their use for the production of pesticidal products.
DE3069765D1 (en) Process for preparing 2,3,5-trichloropyridine and ammonium salts of the methyl ester of methane phosphonic acid, and their preparation
HUT47091A (en) Process for producing tetrahydrobenzthiazols
JPS55111105A (en) Raw magnetic material
IT1012464B (en) PROCESS FOR THE PREPARATION OF 5 OXOCARBOXYLIC ACID ESTERS
ES439030A1 (en) N-dithiophosphoryl-carbamic acid esters
ATE118773T1 (en) METHOD FOR PRODUCING 2-(3-PYRIDYL)-TETRAHYDROTHIOPYRAN-2-CARBONIC ACID THIOAMIDE-1-(1R,2R)OXIDES, THE SO OBTAINED 2-(3-PYRIDYL)-TETRAHYDROTHIOPYRAN-2-CARBOTHIOPYRAN-2-CARBOTHIOPYRAN-1-(1R,2R )OXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.
ES527241A0 (en) A PROCEDURE FOR PREPARING 1-AROIL-5-OXO-2-PIRROLIDIN-PROPANOIC ACID DERIVATIVES
YU39743B (en) Process for preparing nitrosourea derivatives
JPS51149240A (en) Process for preparing new 3-substituted aminophenylacetic acid derivat ives
EP0109817A3 (en) Process for preparing oxazolinoazetidinones
ES504915A0 (en) PROCEDURE FOR PREPARING FURANIL AND TENYL ACIDS ACRYLIC ACRYLICS
GB774463A (en) Alkaloid derivatives and process for their manufacture
EP0237918A3 (en) N-substituted amino-alcanoic acids, process for their preparation, their use and pharmaceutical preparations based on these compounds
NL173398C (en) PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS AND PROCEDURE FOR THE PREPARATION OF A PETROL-SUBSTITUTED 1-METHYL-4- (10,11-DIHYDRO-5H-DIBENZO (A, D) CYCLOHEPTEN-5-YYLIDES) -PIPLIDEEN.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU DK JP KR US

AK Designated states

Kind code of ref document: A3

Designated state(s): AU DK JP KR US