WO1990000420A1 - Systeme d'amenee de lumiere - Google Patents

Systeme d'amenee de lumiere Download PDF

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Publication number
WO1990000420A1
WO1990000420A1 PCT/GB1989/000796 GB8900796W WO9000420A1 WO 1990000420 A1 WO1990000420 A1 WO 1990000420A1 GB 8900796 W GB8900796 W GB 8900796W WO 9000420 A1 WO9000420 A1 WO 9000420A1
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WO
WIPO (PCT)
Prior art keywords
light
area
light source
shell
diffusely
Prior art date
Application number
PCT/GB1989/000796
Other languages
English (en)
Inventor
Adrian Charles Rowland
James Todd Allardice
Original Assignee
Adrian Charles Rowland
James Todd Allardice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adrian Charles Rowland, James Todd Allardice filed Critical Adrian Charles Rowland
Publication of WO1990000420A1 publication Critical patent/WO1990000420A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/0001—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
    • G02B6/0005—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type
    • G02B6/0008—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type the light being emitted at the end of the fibre
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A61B2017/22057—Optical properties
    • A61B2017/22058—Optical properties reflective
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0644—Handheld applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0664—Details
    • A61N2005/0665—Reflectors
    • A61N2005/0666—Reflectors for redirecting light to the treatment area

Definitions

  • This invention relates to an apparatus and method for illuminating an area of an object and in particular to a device in which the total amount of luminant energy delivered to the area can be accurately determined. It is particularly applicable to medical treatment techniques which rely on the illumination of body tissue in order to achieve desired effects . e.g. photodynamic therapy and bio-stimulation.
  • HpD haematoporphyrin derivative
  • the area of the body with the tumour is irradiated with laser light having wavelength of about 630 nm from an argon dye laser.
  • the effect of the laser light on the HpD is to cause oxygen radicals to be released which destroy the surrounding tumour tissue.
  • the illumination stage of the treatment is usually given twenty-four to seventy-two hours after administration of the HpD agent, though with skin cancer, laser treatment can be delivered up to three or four weeks after the administration of the HpD.
  • the treatment area has been illuminated using laser light directed down an optical fibre, the tip of the fibre being moved over the treatment area.
  • the illumination consists of an intense centre spot with the intensity falling away gradually from the centre of the spot. This means that it is difficult to give an even dosage of light to a large area. Furthermore, it is very easy to apply too much light to some areas.
  • Another proposal is to control the intensity profile of the beam emerging from an optical fibre by interposing an oblique glass plate between the laser and the optical fibre.
  • a further problem, which also occurs with the improved techniques mentioned above, is, however, that since the surface of the body being illuminated is to some extent reflective, it is difficult to determine exactly how much light is absorbed to act on the HpD.
  • the reflectivity of different parts of the treatment area may vary and so even dosage estimates based on an estimated or measured reflectivity are not particularly good.
  • a typical dosage estimate with one of the techniques above was that 30-400
  • laser light has also been proposed to use in other medical treatments, e.g. bio-stimulation in which tissue is irradiated with low power laser light. It has been suggested that this irradiation has certain beneficial effects and has been used to speed-up the healing of wounds, as a beauty treatment and in physiotherapy.
  • Laser illumination has also been used in the treatment of vascular abnormalities such as port wine stain and the removal of tattoos.
  • Other types of light have also been used, for instance, infra red or ultra violet for treating various conditions e.g. the treatment of skin disorders e.g. psoriasis. In some of these agents which render the skin sensitive to the particular light being used have been administered to the patient.
  • similar problems with achieving a uniform illumination and calculating the amount of light delivered to the surface have been found.
  • the present invention provides a device to deliver a defined quantity of light to a surface comprising a light source for illuminating the surface and means for scattering light reflected from the surface so that it can be directed back onto the surface.
  • the scattering means are adapted to provide a substantially uniform illumination of the surface.
  • the present invention provides apparatus for illuminating an area of an object, comprising a delivery device including a light source for illuminating the area and a concave diffusely reflecting surface, wherein the diffuse reflecting surface is adapted to define the area to be illuminated when the device is held in contact with the object and to collect light reflected from the surface of the object and scatter it back towards the area.
  • the light source which conveniently is the tip of an optical, fibre, is arranged to illuminate the diffusely reflective surface so that light from the light source is reflected towards the treatment area.
  • This can be achieved by diffusing the light with, for example, a ceramic reflector or possibly a p.t.f.e. or etched diffuser on the optical fibre.
  • the present invention also provides a method of illuminating an area of an object comprising the steps of: illuminating the area of the object with light from a light source illuminating a concave diffusely reflective surface maintained confronting the area, positioning the diffusely reflecting surface with its edges in contact with the object so that it collects light reflected from the surface of the object and scatters it back towards the area and so that the edges of the concave diffusely reflecting surface define the area being illuminated.
  • the light used may be laser light as in the conventional PDT techniques or may be non-coherent light for some applications.
  • the diffusely reflective surface may be the inner, concave surface of a part-spherical,e.g. hemispherical, shell-like structure with the optical fibre and diffusing device attached in its top. In use, the shell is held with its edges in contact with the object under illumination so that any light reflected off the illuminated area is collected and scattered back thereto by the diffusely reflective surface.
  • a reflectivity of 99% can be achieved by coating the concave surface with reflective paint, or any suitable highly reflective coating, e.g. a ceramic.
  • the area to be illuminated is smaller than the base area of the hemisphere then parts of the area which do not require illumination can be masked with a highly reflective surface. This means that light striking the reflective surface is not lost but is reflected back towards the diffusely reflective surface and eventually onto the area to be illuminated.
  • the amount of light delivered to the treatment area can be accurately determined since none of the light delivered to the area is allowed to escape. This is because almost all of the light reflected from the illuminated area is scattered back towards it by the diffuse reflective surface and since the reflective surface is held in contact with the object, no light can escape under the edges.
  • the use of a diffusing device on the end of the optical fibre delivering the laser light and the use of the diffusely reflective surface mean that the intensity of the illumination is substantially uniform over the whole of the treatment area.
  • the invention also has benefits for the safety of the operator and, if it is being used in medical treatment, for the patient, as once the reflective surface is in contact with the body the laser system is closed and there is very little risk of accidental injury to the operator or to the patient caused by escaping laser light. It is possible to arrange for the laser or other light source only to be switched on when the reflective surface is placed in contact with the body - e.g. by a pressure sensitive or temperature sensitive switch or by some other switching means.
  • the target to be illuminated may be treated with an agent to absorb the light, e.g. a photodegradable or photocensitizing agent.
  • an agent to absorb the light e.g. a photodegradable or photocensitizing agent.
  • a suitable agent which might be preferentially absorbed by certain cells e.g. cancerous cells, e.g. HpD can be administered to the patient some hours before the laser treatment.
  • An accurate amount of light can then be delivered to the treatment area and this allows the operator to calculate more accurately what depth of tissue may be destroyed. This not only allows better treatment of an individual patient but also allows a better correlation- of results to treatment conditions and so the best conditions for the treatment of the cancer and different types of cancer may be determined more easily.
  • the invention is also useful for the treatment of port wine stains, homeopathic processes and bio-stimulation where the fact that the illumination is uniform and defined allow better control of the treatment process.
  • the invention has been described above in relation to use in medical treatment, e.g. for photodynamic therapy. It is, however, useful in any process where it is desirable to uniformly illuminate an area and to avoid loosing light by reflection from that area.
  • types of electromagnetic radiation other than optical laser light might be appropriate.
  • the device may also be useful for promoting biological growth of animals o.r particularly plants, where again the fact that the illumination is accurately defined and no radiation is allowed to escape can improve the efficiency and economy of the process.
  • the shape of the reflective surface is not thought to be particularly critical, the preferred embodiment in this specification uses a hemisphere but other concave shapes can be used.
  • the size of shell is chosen to be close to the size of the area to be illuminated.
  • a typical size of shell used for medical purposes would be a few inches in diameter, but larger or smaller shells, e.g. large enough to cover the complete pelvic area, may also be used where appropriate. It is also possible for the reflective surface to be formed on a flexible member so that it can be shaped to match the shape of the area to be treated. These allow the operator to avoid treating areas which do not need treatment.
  • the fibre may be mounted to direct light onto a diffuse reflector, made from, e.g. a reflective ceramic, mounted in front of the diffusely reflective surface to reflect the light back onto it.
  • a diffuse reflector made from, e.g. a reflective ceramic
  • the apparatus may further comprise a deformable sheet of material across the open end of the concave surface, e.g. a sheet of white rubber or synthetic rubber, and which has a high reflectivity, appreciable transmission and low-absorption.
  • a deformable sheet of material across the open end of the concave surface e.g. a sheet of white rubber or synthetic rubber, and which has a high reflectivity, appreciable transmission and low-absorption.
  • the absorption should be low enough to prevent undesirable light loss, e.g. about 1%, and the transmission high enough to allow sufficient illumination of the target surface. For medical applications about 9% is acceptable.
  • the reflectivity should be, for such applications, about 90%.
  • Figure 2 is a partially cutaway view of the embodiment of Fig 1 in use
  • Figure 3 is a schematic view of a second embodiment of the invention in use
  • Figure 4 shows a third embodiment of the present invention.
  • Figure 5 shows a fourth embodiment of the invention
  • the apparatus comprises a light delivery device 1 which consists of a hemispherical relatively rigid, plastics shell 3 whose inside, concave surface is coated with a reflective coating 5.
  • the coating is a reflective paint or ceramic which provides a diffuse reflective surface. It is possible to achieve a reflectivity as high as 99% or more with such a coating.
  • the shell, intended for medical use in PDT is about 5-15cm in diameter and about l-2mm thick.
  • Laser light is supplied to the device along an optical fibre 7, which may be a single fibre or a bundle of fibres.
  • the fibres are teflon coated and retained within a p.t.f.e. sheath 9.
  • the fibres terminate at a diffusing element 11, which is in this embodiment a p.t.f.e. cylinder or, alternatively, a ceramic or etched fibre diffuser (formed by exposure to hydrofluoric acid) mounted in the hemispherical shell.
  • the fibre is connected to the shell by a two-part block 13 having a bore down the r centre through which the fibre and sheath pass. The fibre is trapped in an interference fit between the two parts of the block 13.
  • the diffuser 11 is positioned about 2cm below the top of the shell.
  • Light transmitted down the fibre passes into the diffuser 11 and is emitted from the end of the diffuser in a number of directions. Some light will be transmitted directly to the treatment surface, but some light will also be transmitted towards the diffusely reflective surface 5.
  • Various light paths are shown in the diagram. Light striking the diffusely reflective surface will be scattered therefrom, partly towards the treatment area and part towards opposing regions of the reflector. It will be appreciated, therefore, that a fairly uniform illumination is achieved within the region defined by the edges of the reflective shell.
  • the shell may be provided with a sensor and switch so that the laser supplying light to the optical fibre 9 is only switched on when the shell is pressed into contact with the surface which is to be illuminated. This results in less chance of the patient or operator being accidentally exposed to laser light and thus improves the safety of the apparatus.
  • Fig. 2 the device is shown schematically in use on part of a patient 15. This shows the device used in a situation where the area 17 which is? to be illuminated is smaller than the base area of the reflector. The parts of skin which would undesirably be exposed to the light have therefore been masked using a reflective tape 19, for example, aluminium tape. This means that light supplied to the delivery device 1 which misses the exposed treatment area and hits the tape is reflected back up to the diffusely reflective surface and scattered back towards the treatment area.
  • Figure 3 shows a second embodiment of the invention in use.
  • the reflective shell 22 is formed from a flexible plastics material so that it may be deformed to cover a desired treatment area more accurately.
  • a further feature of this embodiment which can also be used in the other embodiments of the invention, is that light is supplied to the device by several optical fibres 27 each connected to a diffusing device 11 and spaced over the surface of the shell. This enables a greater amount of light to be delivered per unit time if necessary and helps in maintaining a substantially uniform light distribution particularly in the case where the shell is deformed.
  • the above embodiments have been described as being supplied with laser light by an optical fibre.
  • the invention is also usable in other applications in which e.g. ultra violet or infra red light or any electromagnetic wave radiation are used.
  • the light may be delivered to the delivery device using a light guide e.g. liquid or fibre light guide or other types of radiation guides or the light source may be mounted in or on the shell.
  • Figure 4 shows schematically a third embodiment of the invention in which light delivered to the device by an optical fibre 9 is directed onto a reflector 30 in this case spherical, though other shapes may be used, which reflects light back upon to the diffusely reflective surface which, in turn, scatters it onto the treatment area.
  • the reflector 30, which may be a highly reflective ceramic, is mounted on the shell 1 by a mounting 32.
  • Figure 5 shows disgrammatically a fourth embodiment of the invention which uses a reflector 1 and light delivery system 9 and 30 as in the previous embodiments, but also includes a deformable partly reflective partly transmissive sheet 50 across the open end of the reflector which, in use, covers the target area.
  • the sheet 50 may be a sheet of white rubber or synthetic rubber and has a high reflectance preferably greater than 17% and more preferably still greater than 77% , very low absorttion preferably less than 5% and appreciable transmission. Typical values which have - 14 - been effective in practice are, for instance, 90% reflection, 9% transmission and 1% absorption. This sheet 50 is particularly useful when the device is used to illuminate an uneven surface as it conforms or partly confirms to that surface and improves the uniformity of the light delivered to the target.
  • the invention it is possible to calculate the amount of light supplied to the treatment area much more accurately than with the prior art devices. This is because substantially all of the light supplied to the device is eventually absorbed by the treatment surface. None is allowed to escape - because the reflector shell is placed in contact with the object being illuminated and any light reflected from the treatment surface is eventually scattered back by the diffuse reflector towards the treatment surface. Furthermore, the fact, that virtually none of the light supplied to the device is allowed to escape means that the device is particularly safe to use.

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

On a mis au point un dispositif permettant de soumettre à un rayonnement de manière uniforme une aire d'une surface, définissant avec précision l'aire se trouvant sous le rayonnement, collectant la lumière réfléchie par l'aire et la rediffusant vers la surface. Le dispositif comprend un boîtier (3) dont la surface intérieure est recouverte d'un réflecteur diffus, et une source de lumière (11) montée dans le boîtier. La source de lumière peut être un dispositif diffusant relié à un laser éloigné du boîtier (3), via une fibre optique (7). En utilisation on place le boîtier (3) contre la surface illuminée de sorte que les bords du boîtier (3) définissent l'aire soumise à l'illumination, et que l'utilisation de la surface réfléchissante diffuse dudit boîtier empêche toute fuite de lumière. On peut placer une feuille déformable de matériau partiellement réflecteur et partiellement transmetteur sur la bouche ouverte de l'hémisphère afin de couvrir l'aire cible pour augmenter l'uniformité de l'illumination, lorsque l'on emploie ledit dispositif sur des surfaces inégales. Ledit dispositif est particulièrement utile en thérapie photodynamique.
PCT/GB1989/000796 1988-07-13 1989-07-13 Systeme d'amenee de lumiere WO1990000420A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8816648.3 1988-07-13
GB888816648A GB8816648D0 (en) 1988-07-13 1988-07-13 Light delivery system

Publications (1)

Publication Number Publication Date
WO1990000420A1 true WO1990000420A1 (fr) 1990-01-25

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AU (1) AU3977389A (fr)
GB (1) GB8816648D0 (fr)
WO (1) WO1990000420A1 (fr)

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2644699A1 (fr) * 1989-03-25 1990-09-28 Strahlen Umweltforsch Gmbh Procede et dispositif d'irradiation de cavites a partir de l'interieur
EP0448004A2 (fr) * 1990-03-19 1991-09-25 Andreas Dr. Weikl Cathéter de traitement médical
WO1995032441A1 (fr) * 1994-05-25 1995-11-30 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Accessoire de rayonnement pour une fibre optique permettant d'obtenir un niveau uniforme d'illumination sur un plan
US5474528A (en) * 1994-03-21 1995-12-12 Dusa Pharmaceuticals, Inc. Combination controller and patch for the photodynamic therapy of dermal lesion
WO1998043704A1 (fr) * 1997-04-02 1998-10-08 Wound Healing Of Oklahoma, Inc. Procede et systeme de diffusion de lumiere laser
US5849027A (en) * 1996-09-04 1998-12-15 Mbg Technologies, Inc. Photodynamic therapy method and apparatus
WO1999046005A1 (fr) * 1998-03-12 1999-09-16 Palomar Medical Technologies, Inc. Systeme d'application de rayonnement electromagnetique sur la peau
EP0955884A1 (fr) * 1995-10-12 1999-11-17 The General Hospital Corporation Dispositif emetteur de rayonnement
US6013053A (en) * 1996-05-17 2000-01-11 Qlt Photo Therapeutics Inc. Balloon catheter for photodynamic therapy
AT406122B (de) * 1997-12-30 2000-02-25 Prinz Reinhold Adaptierung von laserdioden für zoomeffektstrahlung
US6146409A (en) * 1996-05-20 2000-11-14 Bergein F. Overholt Therapeutic methods and devices for irradiating columnar environments
WO2001036869A1 (fr) * 1999-11-19 2001-05-25 Julian Douglas Fairman Dispositif d'apport de lumiere
EP1109599A1 (fr) * 1998-09-11 2001-06-27 Light Sciences Corporation Timbre conforme pour phototherapie de tumeurs sous-cutanees
EP1118311A3 (fr) * 2000-01-06 2002-07-17 S.L.T. Japan Co., Ltd. Appareil pour l'irradiation au laser du corps
FR2830074A1 (fr) * 2001-09-27 2003-03-28 Valeo Vision Systeme optique pour la formation d'un faisceaux lumineux comportant une serie de fibres optiques
WO2003047693A3 (fr) * 2001-11-14 2003-07-31 Healing Machines Inc Systeme et procede de photoactivation des mecanismes de guerison
US6635054B2 (en) 2000-07-13 2003-10-21 Transurgical, Inc. Thermal treatment methods and apparatus with focused energy application
US6755820B1 (en) * 1999-09-20 2004-06-29 Susanne Johansson Laser probe for medical treatment
US7979121B2 (en) 2002-06-14 2011-07-12 Lazure Scientific, Inc. Method and apparatus for physiological treatment with electromagnetic energy
US20120238939A1 (en) * 2011-03-17 2012-09-20 Jk-Holding Gmbh Device for irradiating actinic radiation of different wavelengths
US8915948B2 (en) 2002-06-19 2014-12-23 Palomar Medical Technologies, Llc Method and apparatus for photothermal treatment of tissue at depth
US8974445B2 (en) 2009-01-09 2015-03-10 Recor Medical, Inc. Methods and apparatus for treatment of cardiac valve insufficiency
US9028536B2 (en) 2006-08-02 2015-05-12 Cynosure, Inc. Picosecond laser apparatus and methods for its operation and use
US9700372B2 (en) 2002-07-01 2017-07-11 Recor Medical, Inc. Intraluminal methods of ablating nerve tissue
US9780518B2 (en) 2012-04-18 2017-10-03 Cynosure, Inc. Picosecond laser apparatus and methods for treating target tissues with same
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
US10245107B2 (en) 2013-03-15 2019-04-02 Cynosure, Inc. Picosecond optical radiation systems and methods of use
US10350440B2 (en) 2013-03-14 2019-07-16 Recor Medical, Inc. Ultrasound-based neuromodulation system
US10434324B2 (en) 2005-04-22 2019-10-08 Cynosure, Llc Methods and systems for laser treatment using non-uniform output beam
US10499937B2 (en) 2006-05-19 2019-12-10 Recor Medical, Inc. Ablation device with optimized input power profile and method of using the same
US11185662B2 (en) 2009-10-30 2021-11-30 Recor Medical, Inc. Method and apparatus for treatment of hypertension through percutaneous ultrasound renal denervation
US11418000B2 (en) 2018-02-26 2022-08-16 Cynosure, Llc Q-switched cavity dumped sub-nanosecond laser

Citations (2)

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Publication number Priority date Publication date Assignee Title
DE3300517A1 (de) * 1982-01-09 1984-07-26 Ludger 5445 Kottenheim Mersmann Therapiegeraet als lasertherapiegeraet und/oder phototherapiegeraet und/oder als haematogenes lasertherapiegeraet und/oder als autooszillationstherapiegeraet und/oder als stromtherapiegeraet und/oder als magnetfeldtherapiegeraet und/oder als rauschtherapiegeraet und/oder als wahlweise kombination dieser verschiedenen therapiegeraete fuer den therapeutischen einsatz in der veterinaer- human- oder phytomedizin
FR2591902A1 (fr) * 1985-12-23 1987-06-26 Collin Yvon Appareil de lasertherapie externe comportant une ou plusieurs diodes laser dans des ventouses

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3300517A1 (de) * 1982-01-09 1984-07-26 Ludger 5445 Kottenheim Mersmann Therapiegeraet als lasertherapiegeraet und/oder phototherapiegeraet und/oder als haematogenes lasertherapiegeraet und/oder als autooszillationstherapiegeraet und/oder als stromtherapiegeraet und/oder als magnetfeldtherapiegeraet und/oder als rauschtherapiegeraet und/oder als wahlweise kombination dieser verschiedenen therapiegeraete fuer den therapeutischen einsatz in der veterinaer- human- oder phytomedizin
FR2591902A1 (fr) * 1985-12-23 1987-06-26 Collin Yvon Appareil de lasertherapie externe comportant une ou plusieurs diodes laser dans des ventouses

Cited By (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2644699A1 (fr) * 1989-03-25 1990-09-28 Strahlen Umweltforsch Gmbh Procede et dispositif d'irradiation de cavites a partir de l'interieur
EP0448004A2 (fr) * 1990-03-19 1991-09-25 Andreas Dr. Weikl Cathéter de traitement médical
EP0448004A3 (en) * 1990-03-19 1991-12-04 Andreas Dr. Weikl Catheter for medical treatment
US5474528A (en) * 1994-03-21 1995-12-12 Dusa Pharmaceuticals, Inc. Combination controller and patch for the photodynamic therapy of dermal lesion
WO1995032441A1 (fr) * 1994-05-25 1995-11-30 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Accessoire de rayonnement pour une fibre optique permettant d'obtenir un niveau uniforme d'illumination sur un plan
US5519534A (en) * 1994-05-25 1996-05-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane
EP0955884A4 (fr) * 1995-10-12 2001-02-07 Gen Hospital Corp Dispositif emetteur de rayonnement
EP0955884A1 (fr) * 1995-10-12 1999-11-17 The General Hospital Corporation Dispositif emetteur de rayonnement
US6086558A (en) * 1996-05-17 2000-07-11 Qlt Phototherapeutics, Inc. Balloon catheter for photodynamic therapy
EP1563871A1 (fr) 1996-05-17 2005-08-17 QLT Inc. Cathéter à ballonnet pour la thérapie photodynamique
US6013053A (en) * 1996-05-17 2000-01-11 Qlt Photo Therapeutics Inc. Balloon catheter for photodynamic therapy
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