WO1989012469A1 - Antimicrobial composition containing aluminium acetotartrate and a diol - Google Patents
Antimicrobial composition containing aluminium acetotartrate and a diol Download PDFInfo
- Publication number
- WO1989012469A1 WO1989012469A1 PCT/SE1989/000341 SE8900341W WO8912469A1 WO 1989012469 A1 WO1989012469 A1 WO 1989012469A1 SE 8900341 W SE8900341 W SE 8900341W WO 8912469 A1 WO8912469 A1 WO 8912469A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acetotartrate
- aluminium
- diol
- solution
- use according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 28
- 229940016389 aluminium acetotartrate Drugs 0.000 title claims abstract description 23
- KQVRYPWCDUCYPZ-OLXYHTOASA-K aluminum;(2r,3r)-2,3-dihydroxybutanedioate;acetate Chemical compound [Al+3].CC([O-])=O.[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O KQVRYPWCDUCYPZ-OLXYHTOASA-K 0.000 title claims abstract description 23
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 11
- 150000002009 diols Chemical class 0.000 title claims abstract description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000000243 solution Substances 0.000 claims abstract description 20
- 206010040880 Skin irritation Diseases 0.000 claims abstract description 11
- 230000036556 skin irritation Effects 0.000 claims abstract description 11
- 231100000475 skin irritation Toxicity 0.000 claims abstract description 11
- 239000007864 aqueous solution Substances 0.000 claims abstract description 6
- 239000002904 solvent Substances 0.000 claims description 3
- 239000002304 perfume Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims 1
- 229960004063 propylene glycol Drugs 0.000 description 10
- 235000013772 propylene glycol Nutrition 0.000 description 10
- 244000005700 microbiome Species 0.000 description 9
- 210000002700 urine Anatomy 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 230000002147 killing effect Effects 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 4
- 241000233866 Fungi Species 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Chemical class 0.000 description 3
- 239000004411 aluminium Chemical class 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical class [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000007857 degradation product Substances 0.000 description 2
- 230000001408 fungistatic effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- NSMXQKNUPPXBRG-SECBINFHSA-N (R)-lisofylline Chemical compound O=C1N(CCCC[C@H](O)C)C(=O)N(C)C2=C1N(C)C=N2 NSMXQKNUPPXBRG-SECBINFHSA-N 0.000 description 1
- 235000007173 Abies balsamea Nutrition 0.000 description 1
- 239000004857 Balsam Substances 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012444 Dermatitis diaper Diseases 0.000 description 1
- 208000003105 Diaper Rash Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- SLZWEMYSYKOWCG-UHFFFAOYSA-N Etacelasil Chemical compound COCCO[Si](CCCl)(OCCOC)OCCOC SLZWEMYSYKOWCG-UHFFFAOYSA-N 0.000 description 1
- 244000018716 Impatiens biflora Species 0.000 description 1
- 239000004146 Propane-1,2-diol Substances 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- DMGNPLVEZUUCBT-UHFFFAOYSA-K aluminum;propanoate Chemical class [Al+3].CCC([O-])=O.CCC([O-])=O.CCC([O-])=O DMGNPLVEZUUCBT-UHFFFAOYSA-K 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000002289 effect on microbe Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
Definitions
- Antimicrobial composition containing aluminium acetotartrate and a diol.
- the present invention refers to a antimicrobial composition intended to reduce skin irritations especially under napkins.
- Skin irritations under napkins are often a big problem.
- the problem occur e.g. during diarrhoea periods, with children and adults having eczema or other skin diseases or if the napkins are not changed often enough.
- the problems are often impaired by infections of different microorganisms.
- it is important on one hand to reduce the effect of skin irritations caused by degradation products from urine and faecal, and on the other hand to inhibit the growth of fungi and bacteria.
- compositions with double salts of aluminium propionate and aluminium subpropionate i.a. for treating infantile diaper rash.
- This composition is stated to inhibit enzymatic cleavage of urea to ammonia. There is no state ⁇ ment about any antimicrobial effect.
- SE-B-432 438 there is described a skin cleaning composition containing one or more synthetic tensides and to which aluminium acetotartrate is added in order to inhibit irritations and skin problems. Admixture of some other substances such as propylene glycol or glycerol is also mentioned, but not for what purpose and it is assumed that these substances are intended as solvents.
- SE-A-8305839-6 there is disclosed a skin treating preparation in the form of a lotion or balsam and in which 0,4 - 2% alsol (aluminium acetotartrate) is included as an adstringent, protec ⁇ ting and restorative component.
- the object of the present invention is to provide a composition having an antimicrobial effect and which besides inhibits and prevents skin irritations especially under napkins.
- This has been provided through use of a composition containing aluminium acetotartrate and at least one diol with antimicrobial proper ⁇ ties, said composition being in a solution, preferably aqueous solution.
- Aluminium acetotart ⁇ rate is used in treatment of discharging skin diseases.
- the solution has a draining and cooling effect.
- the solution is acid which reduces the effect of tissue-injurious enzymes in faecal and urine.
- Propylene glycol has known antimicrobial properties. Previous examinations have proved that it effectively inhibits the growth of many different bacteria and fungi in concentrations of 5-15%.
- aluminium acetotartrate By mixing aluminium acetotartrate and propylene glycol in aqueous solution there is provieded a mixture having both a draining and cooling effect and an effective inhibition of the growth of many microorganisms.
- the components form a stable aqueous solution.
- aluminium acetotartrate has a pH-stabilizing effect on the solutio .
- Propylene glycol can be present in the solution at a concentra- tion of 5-40% by weight, at which 10-30% by weight is a preferred interval.
- Aluminium acetotartrate can be present at a concentration of 0,1-50% by weight, at which 0,25-15% by weight is a preferred interval.
- a solution containing C_ albicans (10 4 cells ml ⁇ l) was applie on a 5 x 5 cm area on the volar aspect of the arm.
- 40% means that there in the test medium is 40% of the exami and 60% medium.
- the mixture of 1% aluminium acetotartrate and 20% propylene glycol can preferably be applied on the napkin in the form of a spray.
- the solution is evenly applied on the napkin before this is applied to the skin.
- the composition can be applied directly on the skin. It is also possible that the napki at the manufacturer is provided with a layer impregnated with the composition, at which the solvent has been allowed to evaporate.
- the layer is preferably arranged inside the surface layer of th napkin.
- the killing effect on microorganisms is potentiated by the combination porpylene glycol and aluminium acetotartrate. It is as far as we known not previously known that aluminium acetotart ⁇ rate can have a certain inhibitory effect on microorganisms. It is also unexpected that a product is obtained that is both mild to the skin, pH-stabilizing and besides have a killing effect on microorganisms.
- the main field of application for the composition according to the invention is in napkins for inhibiting and reduce the effect of skin irritations caused by degradation products from urine and faecal and to inhibit the growth of fungi and bacteria. It can however also be used in connection with other skin irritations, e.g. blisters.
- Propylene glycol in the composition can be substituted by other diols with antimicrobial properties, e.g. butane diol.
- composition can besides contain other admixtures such as perfume and the like.
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Materials Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Antimicrobial composition intended to reduce skin irritations especially under napkins. The composition consists of a solution, preferably an aqueous solution, of aluminium acetotartrate and a diol with antimicrobial properties, e.g. propylene glycol.
Description
Antimicrobial composition containing aluminium acetotartrate and a diol.
The present invention refers to a antimicrobial composition intended to reduce skin irritations especially under napkins.
Skin irritations under napkins are often a big problem. The problem occur e.g. during diarrhoea periods, with children and adults having eczema or other skin diseases or if the napkins are not changed often enough. The problems are often impaired by infections of different microorganisms. In order to prevent these problems it is important on one hand to reduce the effect of skin irritations caused by degradation products from urine and faecal, and on the other hand to inhibit the growth of fungi and bacteria.
In GB-A-1.024.193 there is described compositions with double salts of aluminium propionate and aluminium subpropionate, i.a. for treating infantile diaper rash. This composition is stated to inhibit enzymatic cleavage of urea to ammonia. There is no state¬ ment about any antimicrobial effect.
In SE-B-432 438 there is described a skin cleaning composition containing one or more synthetic tensides and to which aluminium acetotartrate is added in order to inhibit irritations and skin problems. Admixture of some other substances such as propylene glycol or glycerol is also mentioned, but not for what purpose and it is assumed that these substances are intended as solvents.
In SE-A-8305839-6 there is disclosed a skin treating preparation in the form of a lotion or balsam and in which 0,4 - 2% alsol (aluminium acetotartrate) is included as an adstringent, protec¬ ting and restorative component.
The purpose and most important feature of the invention
The object of the present invention is to provide a composition having an antimicrobial effect and which besides inhibits and prevents skin irritations especially under napkins. This has been
provided through use of a composition containing aluminium acetotartrate and at least one diol with antimicrobial proper¬ ties, said composition being in a solution, preferably aqueous solution.
Description of the invention
A mixture of 1% aluminium acetotartrate and 20% propylene glycol in water has been tested, concerning possible skin irritations and effect on different fungi and bacteria. Aluminium acetotart¬ rate is used in treatment of discharging skin diseases. The solution has a draining and cooling effect. The solution is acid which reduces the effect of tissue-injurious enzymes in faecal and urine.
Propylene glycol has known antimicrobial properties. Previous examinations have proved that it effectively inhibits the growth of many different bacteria and fungi in concentrations of 5-15%.
By mixing aluminium acetotartrate and propylene glycol in aqueous solution there is provieded a mixture having both a draining and cooling effect and an effective inhibition of the growth of many microorganisms. The components form a stable aqueous solution. As far as known to the applicants it is not previously known to combine these components in a stable aqueous solution. Besides aluminium acetotartrate has a pH-stabilizing effect on the solutio .
Propylene glycol can be present in the solution at a concentra- tion of 5-40% by weight, at which 10-30% by weight is a preferred interval. Aluminium acetotartrate can be present at a concentration of 0,1-50% by weight, at which 0,25-15% by weight is a preferred interval.
Tests have been performed with a water solution of:
- 1% aluminium acetotartrate
- 1% aluminium acetotartrate and 1% Nacl
- 1% aluminium acetotartrate and 10% propylene glycol
- 1% aluminium acetotartrate and 20% propylene glycol
Skin irritation test
A napkin wetted with 50 ml of one of these mixtures applied o the under side of the forearm on 2 volunteers during 24 hours. N skin irritations accurred for any of the mixtures.
Effect on microorganisms
The killing effect of these mixtures in vitro (in the laboratory against Staphylococcus aureus, S. epidermidis, Streptococcu faecalis, Escherichia coli and Candida albicans was examined. Th mixtures were incorporated in a solid test medium in the concen trations 12,25 and 40%. The test medium was DST (Oxoid, England) The killing effect was read as the lowest concentration (MIC) a which there was a total inhibition of the growth of the micro organism. The results can be seen in Table 1. In many cases w saw an inhibition of the growth of the microorganism with the 40 - mixtures, but no total killing except for the cases that ar seen from Table 1.
Below three experiments performed on two volunteers will b described. 1. The aluminiumacetotartrate - propane-l,2-diol solution wa applied on the volar aspect of the arm (5 x 5 cm). Candid albicans (104 cells ml~l, 0.2 ml) was applied on the test area. piece of diaper (5 x 5 cm) containing 8 ml of urine was applie on the test area. The diaper was covered with plast adhesive fo 8 hrs.
2. A solution containing C^_ albicans (104 cells ml ~1) wa applied on a 5 x 5 cm area on the volar aspect of the arm. Th area was covered with a piece of diaper (5 x 5 cm) containing mixture of urine and 25% of the test solution for 8hrs (8 ml).
3. A solution containing C_ albicans (104 cells ml~l) was applie on a 5 x 5 cm area on the volar aspect of the arm. The area wa
covered with a 5 x 5 cm piece of diaper containing 8 ml of urine for 8 hrs.
RESULTS: The results are in Table 2. A 10 fold reduction in the amount of C^ albicans was seen with both of the methods tested. The solution is fungistatic and not fungicidic. No growth of microorganisms will occur when the solution is applied on the skin before the diaper containting urine is placed on the area. The same is seen when the solution is applied on the diaper.
Table 1. The killing effect of different aluminium acetotartrate mixtures on different microorganisms.
C. albicans S.aureus S.epiderm. St. faecal E.c 1% alumin.ac. > 40% > 40% > 40% > 40 % 40%
1%
1% Nacl > 40% > 40% > 40% > 40% 40%
1% alumin.ac.
10% prop.glyc. > 40% > 40% > 40% > 40% 40%
1% alumin.ac.
20% prop.glyc. 40% 40% 40% 40% 25%
a: 40% means that there in the test medium is 40% of the exami and 60% medium.
Table 2. The fungistatic effect of a solution containing 1% aluminiumacetotartrate and 20% propane-1, 2-diol on Candida albicans in vivo.
vol no method control 1 3
1 6.8 x 103 6.0 x 10^ 5.9 x 104
3.0 x 103 2.0 x 10 4.2 x 104
Application
The mixture of 1% aluminium acetotartrate and 20% propylene glycol can preferably be applied on the napkin in the form of a spray. The solution is evenly applied on the napkin before this is applied to the skin. Altematievely the composition can be applied directly on the skin. It is also possible that the napki at the manufacturer is provided with a layer impregnated with the composition, at which the solvent has been allowed to evaporate. The layer is preferably arranged inside the surface layer of th napkin.
The killing effect on microorganisms is potentiated by the combination porpylene glycol and aluminium acetotartrate. It is as far as we known not previously known that aluminium acetotart¬ rate can have a certain inhibitory effect on microorganisms. It is also unexpected that a product is obtained that is both mild to the skin, pH-stabilizing and besides have a killing effect on microorganisms.
The main field of application for the composition according to the invention is in napkins for inhibiting and reduce the effect of skin irritations caused by degradation products from urine and faecal and to inhibit the growth of fungi and bacteria. It can however also be used in connection with other skin irritations, e.g. blisters.
Propylene glycol in the composition can be substituted by other diols with antimicrobial properties, e.g. butane diol.
The composition can besides contain other admixtures such as perfume and the like.
Claims
1. Use of a composition containting aluminium acetotartrate and at least one diol with antimicrobial properties for making a preparation intended to reduce skin irritations especially under napkins, at which the aluminium acetotartrate and the diol are in a solution preferably aqueous solution.
2. Use according to claim 1, c h a r a c t e r i z e d i n, that said diol is propylene glycol.
3. Use according to claim 1 or 2, c h a r a c t e r i z e d t h e r e i n, that the solution contains 5-40% by weight of the diol and 0,25- 15% by weight of aluminium acetotartrate.
4. Use according to claim 3, c h a r a c t e r i z e d t h e r e i n, that the solution contains 10-30% by weight of diol and 0,25-15% by weight of aluminium acetotartrate.
5. Use according to any of claims 1-4, c h a r a c t e r i z e d t h e r e i n, that it contains additives like perfume and the like.
6. Use according to any of the preceding claims, c h a r a c t e r i z e d t h e r e i n, that the solution is intended to be applied on a napkin, bandage or the like.
7. Use according to any of the preceding claims, c h a r a c t e r i z e d t h e r e n, that the solution is intended to be applied directly on the skin.
8. Use according to claim 6 or 7, c h a r a c t e r i z e d t h e r e i n, that the solution is intended to be • applied in the form of spray.
9. Napkin, c h a r a c t e r i z e d t h e r e i n, that it has a layer impregnated with a composition according t any of claims 1-5, at which the solvent has allowed to evaporate
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8802257A SE461315B (en) | 1988-06-16 | 1988-06-16 | APPLICATION OF A COMPOSITION CONTAINING ALUMINUM ACETOTAR TARGET AND A DIOL TO REDUCE SKIN IRRITATIONS CAUSED BY URINE OR DRAINAGE, AND BLOW IMPREGNATED WITH THE COMPOSITION |
| SE8802257-9 | 1988-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1989012469A1 true WO1989012469A1 (en) | 1989-12-28 |
Family
ID=20372638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/SE1989/000341 WO1989012469A1 (en) | 1988-06-16 | 1989-06-16 | Antimicrobial composition containing aluminium acetotartrate and a diol |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0420927A1 (en) |
| SE (1) | SE461315B (en) |
| WO (1) | WO1989012469A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506134A (en) * | 1990-10-22 | 1996-04-09 | Corvas International, Inc. | Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex |
| WO2009099419A3 (en) * | 2008-01-30 | 2010-05-06 | Taylor Fresh Foods, Inc | Antimicrobial compositions and methods of use thereof |
| DE202008017939U1 (en) | 2008-10-02 | 2011-08-22 | Taylor Fresh Foods, Inc. | Antimicrobial composition |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1024193A (en) * | 1962-12-24 | 1966-03-30 | Mundipharma Ag | Aluminium organic acid salt compositions |
| US3608086A (en) * | 1968-11-01 | 1971-09-21 | Synergistics | Treatment of dermatologic diseases employing aluminum propionate aluminum dipropionate and certain double acid salts thereof |
| SE432438B (en) * | 1982-07-19 | 1984-04-02 | Ake Gillners | Detergent composition |
| SE453568B (en) * | 1983-10-21 | 1988-02-15 | Nobel Consumer Goods Ab | Skin care compsns. contg. silicone oil |
-
1988
- 1988-06-16 SE SE8802257A patent/SE461315B/en not_active IP Right Cessation
-
1989
- 1989-06-16 WO PCT/SE1989/000341 patent/WO1989012469A1/en not_active Application Discontinuation
- 1989-06-16 EP EP89907861A patent/EP0420927A1/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1024193A (en) * | 1962-12-24 | 1966-03-30 | Mundipharma Ag | Aluminium organic acid salt compositions |
| US3608086A (en) * | 1968-11-01 | 1971-09-21 | Synergistics | Treatment of dermatologic diseases employing aluminum propionate aluminum dipropionate and certain double acid salts thereof |
| SE432438B (en) * | 1982-07-19 | 1984-04-02 | Ake Gillners | Detergent composition |
| SE453568B (en) * | 1983-10-21 | 1988-02-15 | Nobel Consumer Goods Ab | Skin care compsns. contg. silicone oil |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506134A (en) * | 1990-10-22 | 1996-04-09 | Corvas International, Inc. | Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex |
| WO2009099419A3 (en) * | 2008-01-30 | 2010-05-06 | Taylor Fresh Foods, Inc | Antimicrobial compositions and methods of use thereof |
| GB2469245A (en) * | 2008-01-30 | 2010-10-06 | Taylor Fresh Foods Inc | Antimicrobial compositions and methods of use thereof |
| DE112008003663T5 (en) | 2008-01-30 | 2010-12-30 | Taylor Fresh Foods, Inc., Salinas | Antimicrobial compositions and methods for their use |
| GB2469245B (en) * | 2008-01-30 | 2013-04-24 | New Leaf Food Safety Solutions Llc | Antimicrobial compositions and methods of use thereof |
| US9259006B2 (en) | 2008-01-30 | 2016-02-16 | Smartwash Solutions, Llc | Antimicrobial compositions and methods of use thereof |
| DE202008017939U1 (en) | 2008-10-02 | 2011-08-22 | Taylor Fresh Foods, Inc. | Antimicrobial composition |
Also Published As
| Publication number | Publication date |
|---|---|
| SE8802257D0 (en) | 1988-06-16 |
| SE8802257L (en) | 1989-12-17 |
| EP0420927A1 (en) | 1991-04-10 |
| SE461315B (en) | 1990-02-05 |
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