WO1989010746A2 - Produit de remplacement du sang - Google Patents

Produit de remplacement du sang Download PDF

Info

Publication number
WO1989010746A2
WO1989010746A2 PCT/US1989/001761 US8901761W WO8910746A2 WO 1989010746 A2 WO1989010746 A2 WO 1989010746A2 US 8901761 W US8901761 W US 8901761W WO 8910746 A2 WO8910746 A2 WO 8910746A2
Authority
WO
WIPO (PCT)
Prior art keywords
subject
concentration
blood
blood substitute
solution
Prior art date
Application number
PCT/US1989/001761
Other languages
English (en)
Other versions
WO1989010746A3 (fr
Inventor
Paul E. Segall
Harold D. Waitz
Hal Sternberg
Original Assignee
Cryomedical Sciences Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryomedical Sciences Inc. filed Critical Cryomedical Sciences Inc.
Priority to KR1019900700020A priority Critical patent/KR900701286A/ko
Publication of WO1989010746A2 publication Critical patent/WO1989010746A2/fr
Publication of WO1989010746A3 publication Critical patent/WO1989010746A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un produit de remplacement du sang pouvant remplacer le sang chez les mammifères lorsque l'on procède à des interventions chirurgicales à des températures hypothermiques. Ledit produit de remplacement comprend de l'eau, des électrolytes en concentrations physiologiques, du dextran 40 en concentration suffisante pour que le produit de remplacement du sang produise une supension colloïdale dont la pression osmotique fluidique est généralement équivalente à celle du plasma humain, un tampon HEPES à pH physiologique, de la dextrose, l'ion magnésium en concentration d'environ 0,01 M et l'ion potassium en concentration supérieure à 10 mEq par litre, suffisant à prévenir ou à arrêter la fibrillation cardiaque. Dans un des modes de réalisation, le produit de remplacement du sang est un système multisolution dont les solutions comprennent différents taux des composantes mentionnées ci-dessus et sont administrées séquentiellement de manière à remplacer entièrement la circulation sanguine d'un patient.
PCT/US1989/001761 1988-05-02 1989-04-26 Produit de remplacement du sang WO1989010746A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019900700020A KR900701286A (ko) 1988-05-02 1989-04-26 혈액 대용품

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18901188A 1988-05-02 1988-05-02
US189,011 1988-05-02

Publications (2)

Publication Number Publication Date
WO1989010746A2 true WO1989010746A2 (fr) 1989-11-16
WO1989010746A3 WO1989010746A3 (fr) 1989-12-14

Family

ID=22695537

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/001761 WO1989010746A2 (fr) 1988-05-02 1989-04-26 Produit de remplacement du sang

Country Status (5)

Country Link
EP (1) EP0414815A1 (fr)
JP (1) JPH04500505A (fr)
KR (1) KR900701286A (fr)
AU (1) AU3843289A (fr)
WO (1) WO1989010746A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994009797A1 (fr) * 1992-10-30 1994-05-11 Gennady Alexandrovich Markov Compose de stimulation et de correction biologiques du phenotype d'un organisme et son procede de production
WO1999022746A1 (fr) * 1997-10-31 1999-05-14 Biotime, Inc. Solutions aqueuses physiologiquement acceptables et procedes d'utilisation desdites solutions
US6300322B1 (en) 1993-06-04 2001-10-09 Biotime, Inc. Plasma-like solution
US6680305B1 (en) 1993-06-04 2004-01-20 Biotime, Inc. Physiologically acceptable aqueous solutions and methods for their use

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7500843B2 (en) 2004-09-08 2009-03-10 Crain Enterprises, Inc. Mold system kit
GB0712833D0 (en) * 2007-07-03 2007-08-08 Aqix Ltd Body Fluid Expander

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3585368D1 (de) * 1984-06-22 1992-03-19 Richard L Veech Polyanionische materialien enthaltende elektrolytloesungen.

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994009797A1 (fr) * 1992-10-30 1994-05-11 Gennady Alexandrovich Markov Compose de stimulation et de correction biologiques du phenotype d'un organisme et son procede de production
US6300322B1 (en) 1993-06-04 2001-10-09 Biotime, Inc. Plasma-like solution
US6680305B1 (en) 1993-06-04 2004-01-20 Biotime, Inc. Physiologically acceptable aqueous solutions and methods for their use
US7943292B2 (en) 1993-06-04 2011-05-17 Biotime, Inc. Physiologically acceptable aqueous solutions and methods for their use
WO1999022746A1 (fr) * 1997-10-31 1999-05-14 Biotime, Inc. Solutions aqueuses physiologiquement acceptables et procedes d'utilisation desdites solutions

Also Published As

Publication number Publication date
AU3843289A (en) 1989-11-29
JPH04500505A (ja) 1992-01-30
EP0414815A1 (fr) 1991-03-06
KR900701286A (ko) 1990-12-01
WO1989010746A3 (fr) 1989-12-14

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WO1989010746A2 (fr) Produit de remplacement du sang
Leaf et al. A Mannitol-Based Perfusate for Reversible 5-Hour Asanguineous Ultraprofound Hypothermia in Canines

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