WO1989009025A1 - Unite de collecte de sang et son emploi - Google Patents

Unite de collecte de sang et son emploi Download PDF

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Publication number
WO1989009025A1
WO1989009025A1 PCT/SE1989/000165 SE8900165W WO8909025A1 WO 1989009025 A1 WO1989009025 A1 WO 1989009025A1 SE 8900165 W SE8900165 W SE 8900165W WO 8909025 A1 WO8909025 A1 WO 8909025A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
tube
secondary tube
cannula
donor
Prior art date
Application number
PCT/SE1989/000165
Other languages
English (en)
Inventor
Maria Hansby
Original Assignee
Maria Hansby
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maria Hansby filed Critical Maria Hansby
Publication of WO1989009025A1 publication Critical patent/WO1989009025A1/fr
Priority to NO90904141A priority Critical patent/NO904141L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150732—Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150992—Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus

Definitions

  • the invention relates to improvements in sampling procedures performed when blood is collected from blood donors.
  • Blood collecting units basically comprise the following com ⁇ ponents: (i) a cannula to be inserted into the vein of a blood donor, (ii) a vessel for collecting the blood, and (iii) a tube connecting the cannula and vessel with each other so as to permit blood flow from the donor via the cannula system to thus provide the possibility that blood collected by means of said unit is stored for more than one 24-hr day.
  • the tube and vessel are usually made of plastics.
  • the collector vessel takes the form of an approximately 0.5 - 1 lit.
  • bag wich contains anticoagulants, generally in the form of a solution. Additional vessels (bags) may be connected to the blood collector vessel for the purpose of blood processing. It is a common practice to subject the blood to centrifugation so as to obtain erythrocytes, plasma and white blood cells in the form of individual phases which then can be separated from one another.
  • the US-A-3.523.530 discloses a blood collecting unit having a main tube provided with a cannula at one end and connected to a blood collecting vessel at its other end.
  • a branch tube or secondary tube is further provided for taking blood samples from the donor and is connected to the main tube by means of a Y- connector.
  • the free end of the secondary tube is provided with a needle assembly for penetrating a rubber stopper of a test tube.
  • Clamps are arranged on the main tube on both sides of the Y- connector for directing the blood flow to either the blood collecting vessel or the branch tube. With this device it is not possible to have anticoagulant solution in the main tube and at the same time prevent it from entering the secondary tube, from which the blood samples are collected.
  • the DE-A-2.203.858 discloses a plasmapherese unit with an infusion unit. There is no secondary tube for taking blood samples and one does not have the problem of an anticoagulant solution in the system.
  • the sampling has to be performed in a closed system where the blood will never contact the air and where the sampling vials are always closed - prior to, during and after the sampling procedure. In this manner it would be possible to avoid spilling and "splashing" of blood droplets. It is a further object to provide a device which permits the presence of anticoagulant solution in the main tube but preferably prevents the solution to enter the secondary tube and the blood sample.
  • a blood collecting unit comprising a first tube (main tube), said main tube having at one end thereof a cannula to be inserted into the vein of a blood donor and having at its other end a vessel for collecting blood from the donor, said main tube has a bifurcation situated between said cannula and vessel and provided with a second tube, so-called secondary tube, which at its outer end provides means for collecting minor amounts of blood (blood samples), which is characterized in that the secondary tube is equipped with a device preventing liquid flow through the secondary tube and constructed in such a manner that it can be opened up by being acted upon externally, so that then liquid is enabled to flow through the secondary tube.
  • a distinctive feature of the invention is that the tube (main tube) connecting the cannula with the collector vessel has a bifurcation situated between the cannula and the vessel and provided with a second tube (secondary tube) with means at its outer end for collecting minor amounts of blood (blood samples). Also according to this feature the secondary tube end is of a construction such that it can be opened up by being acted upon externally, so that liquid is then enabled to flow through the secondary tube.
  • the blood collecting unit of the invention may be composed of ordinary parts such as are available for blood drawing and sampling system.
  • an ordinary piece of bifurcate tubing made of plastics for practical reasons, the bifurcation is preferably Y-shaped, with the vertical stem of the Y being directed against the direction of blood flow, i.e. towards the blood donor.
  • the blocking device may be a so-called breakpin, that is, a tube or small pipe with a stop means lying inside the tube and destructible by being acted upon from the outside.
  • the outermost end of the secondary tube has a fitting by means of which the sample collector vessel can be sealingly connected to the secondary tube.
  • sampling procedures contemplated will often comprise/taking more than one sample it is suitable for the sample collector vessel to be replaceable in a manner such that no blood can leak from the secondary tube during the replacement operation.
  • Such systems are available commercially, although not meant for being coupled to blood collecting units. Examples of such systems are vacutainer/venoject vials consisting of glass tubes with, rubber stoppers. In the interior of the vial, the pressure is reduced as compared to ambient pressure (vacuum). Blood can be drawn into the vial in that the said stopper is perforated by means of a thin hollow needle (cannula) connected to a blood vessel.
  • cannula thin hollow needle
  • the interior channel or duct of the hollow needle should be of a dimension that does not permit blood flowing therethrough unless a vacuum is applied.
  • a cannula having these properties may be connected to the outermost end of the secondary tube.
  • the length of the main tube chosen should be in conformity with standard practice for blood collecting units. Of course other lengths may be chosen in the case of the present invention just as well as in the case of other blood collecting units in general.
  • the main principle for choosing the position of the bifurcation point is that it should be in the upper portion of the main tube (as seen starting from the cannula) as this will facilitate the sampling procedure.
  • the reason why the bifurcation must not be contiguous to the cannula is basically that this could all too easily cause an undesired displacement of the cannula. Therefore, in the case of most of the blood collecting units the bifurcation is to be positioned at a distance of about 22-25 cm from the cannula.
  • the same basic principle applies to the secondary tube: Its length should be such as to permit an easy sampling operation without displacement of the cannula. At the same time, the secondary tube should be such that it can readily be removed by welding or pinching after the sampling operation has been completed. The secondary tube should therefore have a length exceeding 10 cm; if its length exceeds 35 cm this will give rise to clearly noticeable practical problems. The preferred length of the secondary tube is 12-20 cm.
  • the position of the blocking device in the secondary tube this will depend on whether or not a noncoagulating (nonclotting) blood sample is acceptable. If the blocking device is placed at a great distance from the bifurcation the an ⁇ ticoagulant collecting between the blocking device and the bifurcation may prevent clotting of the first sample. If no such sample is required this means that an unnecessary waste sample is obtained. Therefore, in one of the most practical embodiments of the invention the distance between said blocking device and bifurcation is such that only clotting samples can be collected; so that in case a nonclotting sample is actually desired the sample collector vial is provided with anticoagulant.
  • the aforesaid distance should preferably be as short as possible, as a rule less than about 2 cm (e.g. 1 cm), but at the same time allowing for easy manipulation when the blocking device is to be opened up.
  • the most preferred embodiment of the blood collecting unit according to the invention is illustrated in Figure 1 where (1) is the cannula to be applied to the donor, (2) is the main tube, (3) is the blood collector vessel, (4) is the Y-shaped bifurca- tion provided with a blocking device (breakpin (5)), and (6) is the secondary tube provided with a fitting (7) for suitable sample receiving means.
  • the rest of the elements shown do not form indispensable parts of the equipment but may be of practical use.
  • (8) is a vacutainer/venoject unit comprising an adapter with a hollow needle and a vacuum tube having a rubber stopper.
  • (9) is a cap member which is removed when the vacutainer/venoject unit is attached.
  • (10) indicates that the main tube can be cut off by means of welding upon completion of the blood drawing operation.
  • the blood drawing procedure is started as according to current routine practice.
  • the cannula on the blood bag tube is inserted into one of the veins of the donor.
  • On any suitable occasion after having made sure that good blood flow and filling of the bag is being obtained one may proceed to performing the sampling operation in the following way:
  • An adapter e.g. of the type having a Luer fitting at one end thereof and a thin needle at the other end
  • the blocking device is opened up. A certain portion of the blood will then flow into this tube.
  • blood is drawn into the sampling vial; and this may then be followed by a desired number of additional such vials, one after the other.
  • the secondary tube is severed by welding or by being pinched off. The main blood withdrawing operation then proceeds further until it is completed.
  • the breakpin is positioned in the Y bifurcation.
  • the breakpin is located close to the outermost end of the secondary tube.
  • the blood bag tube initially contains an anticoagulant solution to prevent blood clotting in the bag.
  • blood collecting units In case blood is collected in type (2) blood collecting units the blood taken for sampling will be mixed with a small amount of the anticoagulant solution from the tube. This may thwart blood clotting and obtaining of serum samples.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • External Artificial Organs (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Unité de collecte de sang comprenant un tube, (tube principal), ledit tube présentant à une de ses extrémités une canule destinée à être insérée dans la veine d'un donneur de sang, et présentant à son autre extrémité un récipient pour recueillir le sang du donneur. Ladite unité est caractérisée en ce que le tube principal comprend une bifurcation située entre la canule et le récipient et pourvue d'un deuxième tube, dit tube secondaire, lequel (a) comporte à son extrémité extérieure des moyens pour recueillir de faibles quantités de sang (prises de sang) et (b) est muni d'un dispositif empêchant l'écoulement de liquide à travers le tube secondaire et conçu de manière à pouvoir s'ouvrir sous une action externe, afin que le liquide puisse alors s'écouler à travers le tube secondaire.
PCT/SE1989/000165 1988-03-31 1989-03-31 Unite de collecte de sang et son emploi WO1989009025A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO90904141A NO904141L (no) 1988-03-31 1990-09-24 Blodtappingsapparat og anvendelse av samme.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8801199A SE460697B (sv) 1988-03-31 1988-03-31 Blodtappningsanordning foer blodgivning samt anvaendning av anordningen
SE8801199-4 1988-03-31

Publications (1)

Publication Number Publication Date
WO1989009025A1 true WO1989009025A1 (fr) 1989-10-05

Family

ID=20371875

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1989/000165 WO1989009025A1 (fr) 1988-03-31 1989-03-31 Unite de collecte de sang et son emploi

Country Status (2)

Country Link
SE (1) SE460697B (fr)
WO (1) WO1989009025A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5069665A (en) * 1990-07-02 1991-12-03 Ng Raymond C Fluid aspiration needle
US5178157A (en) * 1992-01-14 1993-01-12 Fanlo Ramon G Phlebotomy device and method of use thereof
WO1993025143A1 (fr) * 1992-06-05 1993-12-23 Ulla Meirik Technique de collecte d'echantillons de sang combine avec des procedes de prelevement de sang
EP0801537A1 (fr) * 1995-01-13 1997-10-22 Migada, Inc. Appareil de prelevement sanguin
EP0930079A1 (fr) * 1998-01-16 1999-07-21 Terumo Kabushiki Kaisha Dispositif de collection de sang
EP0949946A1 (fr) * 1996-12-24 1999-10-20 Pall Corporation Traitement de liquides biologiques
US6592613B1 (en) * 1998-01-16 2003-07-15 Terumo Kabushiki Kaisha Blood collecting apparatus and blood collecting method using blood collecting apparatus
EP1048306A3 (fr) * 1999-04-30 2003-08-13 Enrique Arrontes Caballero Ensemble de dérivation pour poches à sang
WO2004058067A1 (fr) * 2002-12-18 2004-07-15 Lydall, Inc. Dispositif de prelevement sanguin a systeme ferme
DE202010016024U1 (de) 2010-11-30 2011-02-10 Stradis Med Gmbh Blutplasmasammelflasche mit einer Probenahmeeinrichtung
WO2019209713A1 (fr) * 2018-04-27 2019-10-31 Becton, Dickinson And Company Systèmes de collecte pour échantillons triés par cytométrie en flux et procédés les mettant en oeuvre

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3523530A (en) * 1967-11-24 1970-08-11 American Hospital Supply Corp Needle assembly for parenteral liquid container
DE2203858B2 (de) * 1971-11-05 1977-10-27 Immuno AG für chemisch-medizinische Produkte, Wien Blutabnahme- und reinfusionsgeraet
US4294249A (en) * 1979-10-18 1981-10-13 Cutter Laboratories, Inc. Swage-molded injection site

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3523530A (en) * 1967-11-24 1970-08-11 American Hospital Supply Corp Needle assembly for parenteral liquid container
DE2203858B2 (de) * 1971-11-05 1977-10-27 Immuno AG für chemisch-medizinische Produkte, Wien Blutabnahme- und reinfusionsgeraet
US4294249A (en) * 1979-10-18 1981-10-13 Cutter Laboratories, Inc. Swage-molded injection site

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5069665A (en) * 1990-07-02 1991-12-03 Ng Raymond C Fluid aspiration needle
US5178157A (en) * 1992-01-14 1993-01-12 Fanlo Ramon G Phlebotomy device and method of use thereof
WO1993025143A1 (fr) * 1992-06-05 1993-12-23 Ulla Meirik Technique de collecte d'echantillons de sang combine avec des procedes de prelevement de sang
EP0801537A1 (fr) * 1995-01-13 1997-10-22 Migada, Inc. Appareil de prelevement sanguin
EP0801537A4 (fr) * 1995-01-13 1999-07-28 Migada Inc Appareil de prelevement sanguin
EP0949946A4 (fr) * 1996-12-24 2001-02-14 Pall Corp Traitement de liquides biologiques
EP0949946A1 (fr) * 1996-12-24 1999-10-20 Pall Corporation Traitement de liquides biologiques
US6328726B1 (en) 1998-01-16 2001-12-11 Terumo Kabushiki Kaisha Blood collecting apparatus and blood-collecting method using blood collecting apparatus
EP0930079A1 (fr) * 1998-01-16 1999-07-21 Terumo Kabushiki Kaisha Dispositif de collection de sang
US6592613B1 (en) * 1998-01-16 2003-07-15 Terumo Kabushiki Kaisha Blood collecting apparatus and blood collecting method using blood collecting apparatus
EP1602385A1 (fr) * 1998-01-16 2005-12-07 Terumo Kabushiki Kaisha Dispositif de collection de sang
USRE43283E1 (en) 1998-01-16 2012-03-27 Terumo Kabushiki Kaisha Blood collecting apparatus and blood collecting method using blood collecting apparatus
USRE43310E1 (en) 1998-01-16 2012-04-10 Terumo Kabushiki Kaisha Blood collecting apparatus and blood collecting method using blood collecting apparatus
EP1048306A3 (fr) * 1999-04-30 2003-08-13 Enrique Arrontes Caballero Ensemble de dérivation pour poches à sang
WO2004058067A1 (fr) * 2002-12-18 2004-07-15 Lydall, Inc. Dispositif de prelevement sanguin a systeme ferme
DE202010016024U1 (de) 2010-11-30 2011-02-10 Stradis Med Gmbh Blutplasmasammelflasche mit einer Probenahmeeinrichtung
WO2019209713A1 (fr) * 2018-04-27 2019-10-31 Becton, Dickinson And Company Systèmes de collecte pour échantillons triés par cytométrie en flux et procédés les mettant en oeuvre
CN112136034A (zh) * 2018-04-27 2020-12-25 贝克顿·迪金森公司 用于流式细胞术分选样品的收集系统及其使用方法

Also Published As

Publication number Publication date
SE460697B (sv) 1989-11-13
SE8801199L (sv) 1989-10-01
SE8801199D0 (sv) 1988-03-31

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