WO1989007953A1 - Cartouche d'injection par compression sous vide amelioree - Google Patents

Cartouche d'injection par compression sous vide amelioree Download PDF

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Publication number
WO1989007953A1
WO1989007953A1 PCT/US1988/002373 US8802373W WO8907953A1 WO 1989007953 A1 WO1989007953 A1 WO 1989007953A1 US 8802373 W US8802373 W US 8802373W WO 8907953 A1 WO8907953 A1 WO 8907953A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
medicament
collar
injector
nozzle
Prior art date
Application number
PCT/US1988/002373
Other languages
English (en)
Inventor
Gasper L. Zuppardo
Original Assignee
Vci Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vci Corporation filed Critical Vci Corporation
Publication of WO1989007953A1 publication Critical patent/WO1989007953A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Definitions

  • This invention is in the field of needleless hypodermic and hyporucosal injectors using a vacuum to stabilize a nozzle of the device over the tissue to be penetrated.
  • the present invention relates to an improved disposable medicament insert cartridge for use in such injectors; thusly simplifying use and manufacture, as well as facilitating disposability of the cartridge and its housing components and alignment of replacement cartridges within housings.
  • the present invention satisfies the above- indicated need for easy disposability, low cost, and reliable and easy replacement and alignment capabilities of medicament insert cartridges for vacuum-compression injectors by providing a low-cost disposable and replaceable cartridge that incorporates alignment features obviating the need for comparatively complex and expensive manufacturing alignment structures with tight tolerances within the housing, thusly further facil ⁇ itating low cost and disposability of such housing components.
  • the cartridge of the present invention incorporates a perforated alignment collar which serves to seat it, during replacement, within a mating conical alignment bore of its housing, and which holds the cartridge concentrically and in correct alignment within such housing particularly during actuation of the injector and pressurization of cartridge contents.
  • Perforations in the collar provide conduits for the vacuum-creating air flow from the annular gap between the cartridge and its housing to further conduits within the injector apparatus and eventually to the vacuum pump of the injector equipment.
  • the cartridge of the present invention incorporates a laser- drilled nozzle orifice of appropriately small diametrical size suited dimensionally and economically for the purposes of its function as well as its intended disposability.
  • FIG. 1 is a schematic sectional view of a medicament cartridge according to the principles of the present invention
  • FIG. 2 is a schematic end view of the cartridge shown in FIG. 1, as seen from the cartridge tip end; and, FIG. 3 is an enlarged schematic partial cross- section of a portion of the cartridge shown in FIGS.l and 2 depicted within adjacent portions of the injector as such injector components are assembled ready for use. DESCRIPTION OF THE ILLUSTRATED EMBODIMENTS
  • the medicament cartridge 100 comprises a cartridge body 103 of a generally elongated hollow cylindrical shape and a sealing plunger plug 105 which is tightly slidably inserted within the bore 107.
  • Cartridge body 103 comprises a cylindrical portion and includes barrel 123, a tip 113 at one end, and a collar 115 at the other end.
  • a small-diameter orifice nozzle 111 is formed at one end of the cartridge body 103 within its tip 113 as appropriate for vacuum-compression injectors.
  • a flange ⁇ like generally circular collar 115 is formed on the other end of cartridge body 103.
  • Collar 115 is provided with one or more perforations 117, shown here as four annular sector-shaped openings communicating between the two faces of the collar, but which may be of any number and any variety of appropriate shapes including peripheral cut-outs in collar 115. Collar 115 is further provided with two or more ribs 119, shown here as four circumferentially-eguispaced and ra ially-oriented, parallel-sided gussets, whose outermost surfaces 121 are formed to fall substantially on an imaginary frusto- conical surface with its cone axis coinciding with the centerline of cartridge body 103.
  • Outermost surfaces 121 of ribs 119 extend from the periphery of collar 115 to -4- the periphery of barrel 123 of cartridge body 103 in inclined manner, as shown.
  • Ribs 119 may be of any number larger than one and may take the shape of axially oriented vanes, as shown, or of any other suitable form, such as for instance helical, spiral, etc., provided that at least portions of the ribs' outermost surfaces 121 fall on the described imaginary frusto-conical surface.
  • FIG. 3 shows the portion of the medicament cartridge 100 that includes collar 115 mounted within the vacuum-compression injector 30 which is, for simplicity's sake, indicated only by portions of those injector components which are adjacent and which serve the mounting and actuation of the medicament cartridge when it is assembled within the injector.
  • FIG. 3 is thusly representative of and includes portions of the general structure of the injectors shown in FIGS. 1 of the referenced U.S. Patents to Cohen (4,403,609 and 4,421,508), which are incorporated herein -,y reference.
  • FIGS. 1 of Cohen's above patents will utilize the same numerals as used in FIGS. 1 of Cohen's above patents to designate those Injector components with similar functions, even though such components may be modified in design to suit the purposes of the cartridge of the present invention.
  • medicament cartridge 100 is mounted in the vacuum-compression injector in the bore of a generally cylindrical nozzle housing 41 that is provided with a threaded tapered base 39.
  • the injector's exterior cylindrical housing 13 has interior threads 38 for threadably joining the tapered base 39 of nozzle housing 41.
  • the right-hand end of a vacuum feed coupler 125 which is one of the internal injector components, is provided with a vacuum feed flange 129 that incorporates a face-sealing vacuum 'O'-ring 127 in an appropriate groove in its right-hand face.
  • '0' ring 127 serves as a face seal between flange 129 and sealing face 131 of the tapered base 39 of the nozzle housing 41, as illus- trated.
  • the vacuum feed coupler 125 is provided with a generally cylindrical coupler bore 137 on its axis and this bore is provided with an enlarged conical entry at its right-hand face which forms vacuum chamber 15. From the injector, which is otherwise not shown here, a piston rod plunger 23 protrudes toward the right through coupler bore 137 some small distance into the bore 107 of medicament cartridge 100 wherein it impinges on the left face of plunger plug 105.
  • the described assembled components provide conduits for passage of vacuum-creating air flow from the region surrounding tip 113 (shown in FIGS. 1 and 2) of the cartridge body 103 through annular passageway 45 between cartridge body 103 and nozzle housing 41, past spaces between ribs 119 of cartridge body 103, through perforations 117 in collar 115 of cartridge body 103, through vacuum chamber 15 and second annular passageway 51 formed between piston rod plunger 23 and coupler bore 137 in the vacuum feed coupler 125, and from there on into and through further conduits in the injector apparatus and eventually to the vacuum pump of the injector equipment.
  • This passage of vacuum-creating air flow is indicated in FIG. 3 by schematic flow lines provided with directional arrows.
  • Cartridge 100 prefilled with medicament, is assembled, as shown in FIG. 3 within cylindrical nozzle housing 41 and within its tapered base 39 and is retained therein by the threaded engagement between tapered base 39 and exterior cylindrical housing 13 of the injector apparatus, whereby the injector's vacuum feed coupler 125 abuts and seals with its face seal vacuum 'O'-ring 127 -6- onto the sealing face 131 of tapered base 39.
  • the right- hand face of vacuum feed flange 129 retains cartridge 100 in place.
  • the injector's piston rod plunger 23 enters into bore entry 109 of bore 107 and impinges on or reaches close to the left face of plunger plug 105.
  • a vacuum pump draws air through the conduits described above and, on actuation of the injection mechanism, piston rod plunger 23 is driven toward the right-hand side into bore 107 of cartridge body 103 and pushes plunger plug 105 toward the right to pressurize and expel the cartridge's medicament content through nozzle 111 in tip 113 of cartridge body 103. It can be visualized that the motion and force of piston rod plunger 23 exerts a force toward the right onto cartridge 100 and thusly assists in seating it tightly with its collar 115 and ribs 119 seating within the mating counterbore 133 and within the mating taper bore 135 in tapered base 39.
  • the cartridge 100 of the present invention incorporating perforations 117 in its collar 115 as conduits for passage of vacuum-creating air flow, provides-for a significant reduction in tooling and parts complexity and thusly manufacturing cost in comparison with components providing similar functions in hitherto known vacuum-compression injectors.
  • Known injectors have incorporated such vacuum-conduit facilities with housing structures, necessitating undercuts and various tooling coring measures which are costly in manufacturing.
  • Such conventional housing structures are liable to jamming and lack non-jamming self-aligning capabilities when used in combination with conventional cartridges, particularly when desirable loose-tolerance manufacturing processes are applied.
  • Medicament cartridge 100 may be manufactured, for instance, by molding from a variety of plastic suited to medical uses as wella s from glass and other appro ⁇ priate materials. Mass production, for example by injection molding, has posed particular problems in the past in regard- to the manufacture of the small diameter orifice nozzle 111, as the small orifices, which are needed to be of the order of one to thirteen thousandths of an inch in diameter and in lengths between approx ⁇ imately twenty and sixty thousandths of an inch, are impractical if not impossible to mold reliably and economically.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Une cartouche d'injection de médicament par compression sous vide amélorée (100) utilisée dans des dispositifs d'injection hypomucosiques et hypodermiques sans aiguille (30) comprend une structure à collier (115) qui est auto-alignée dans l'enceinte (41) de l'ajutage contenant la cartouche du dispositif d'injection et présente des perforations (117) qui conduisent un écoulement d'air créant un vide, cet écoulement d'air passant via un espace annulaire (45) entre le corps (103) de la cartouche et l'enceinte (41), naissant au niveau d'une région de vide entourant l'ajutage (113) de la cartouche, et présentant un orifice d'ajutage percé au laser (111) pour l'injection du médicament.
PCT/US1988/002373 1988-02-26 1988-07-19 Cartouche d'injection par compression sous vide amelioree WO1989007953A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16080688A 1988-02-26 1988-02-26
US160,806 1988-02-26

Publications (1)

Publication Number Publication Date
WO1989007953A1 true WO1989007953A1 (fr) 1989-09-08

Family

ID=22578533

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/002373 WO1989007953A1 (fr) 1988-02-26 1988-07-19 Cartouche d'injection par compression sous vide amelioree

Country Status (2)

Country Link
ES (1) ES2011127A6 (fr)
WO (1) WO1989007953A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073165A (en) * 1988-02-05 1991-12-17 Marpam International, Inc. Hypodermic jet injector and cartridge therefor
WO2001058638A1 (fr) * 2000-02-11 2001-08-16 Weston Medical Limited Procede et appareil de fabrication d'une gelule de medicament destinee a un injecteur sans aiguille
WO2004014467A1 (fr) * 2002-08-09 2004-02-19 Chang-Ming Yang Seringue

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4403609A (en) * 1981-02-24 1983-09-13 Cohen Edgar C Vacuum-compression injector
US4421508A (en) * 1981-02-24 1983-12-20 Cohen Edgar C Vacuum-compression injector

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4403609A (en) * 1981-02-24 1983-09-13 Cohen Edgar C Vacuum-compression injector
US4421508A (en) * 1981-02-24 1983-12-20 Cohen Edgar C Vacuum-compression injector

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073165A (en) * 1988-02-05 1991-12-17 Marpam International, Inc. Hypodermic jet injector and cartridge therefor
WO2001058638A1 (fr) * 2000-02-11 2001-08-16 Weston Medical Limited Procede et appareil de fabrication d'une gelule de medicament destinee a un injecteur sans aiguille
WO2004014467A1 (fr) * 2002-08-09 2004-02-19 Chang-Ming Yang Seringue

Also Published As

Publication number Publication date
ES2011127A6 (es) 1989-12-16

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