Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds

Definitions

• the invention relates to disinfectant compositions.
• Hydrogen peroxide has been known for more than a century for its oxidizing power, which makes it a bleaching agent, a disinfectant and an antiseptic.
• the hydrogen peroxide found are used in an industrial environment, for example in the bleaching of textiles, paper pulp, and in a medical environment in disinfection and antisepsis.
• Hydrogen peroxide is notably used with success in bleaching textiles, however the case of hospital laundries is particular, because, it is advisable to clean the linen by an appropriate detergent, to bleach it with a bleaching agent, to disinfect or sterilize it .
• Formaldehyde and certain formaldehyde generators studied for about fifty years for their germicidal properties are well known in the pharmacopoeia and also used in the mechanical industry, in the treatment of cutting fluids, in cosmetology etc for their bacteriostatic or fungistatic power which make good preservatives from perishable media.
• the present invention therefore relates to disinfectant compositions characterized by the combination of a formaldehyde generator and hydrogen peroxide.
• formaldehyde generator is meant the compounds capable of forming in situ at least one free or masked formaldehyde molecule.
• masked formaldehyde molecule is meant any chemical species in chemical equilibrium with formaldehyde, such as hydrates, hemiacetals and ketals, as well as its polymers.
• formaldehyde generators mention may be made of formaldehyde oligomers, in particular those represented by the general formula HO- (CH 2 O) n -H, ethers or esters derivatives of organic acids or corresponding minerals, of formula RO- (CH 2 O) n -R 'and the cyclic oligomers of general formula (OCH 2 ) n.
• this formaldehyde generator of formula HO- (CH 2 O) n -H, the compounds in the formula of which n is between 1 and 8 may be of interest, for example methylene glycol to octaoxymethylene glycol, likewise paraformaldehyde in which n is between 8 and 100.
• R ' can be the same or different, and represent C 1-20 carbon chains, linear, branched or cyclic, saturated or unsaturated, n being between 1 and 100.
• R - (CH 2 O) n -R ', R and R' which may be identical or different, may also represent the radical COR 1 where R 1 is a linear, branched carbon chain C 1 -20 or cyclic, saturated or unsaturated.
• R 2 and R 2 which may be identical or different, may represent a carbon chain of the R type as defined above, a hydrogen atom or Y.
• Synergy appears in an alkaline medium, between pH8 and pH12, and more particularly between pH9 and pH11.
• the disinfecting action of hydrogen peroxide is strongly reinforced by the association with one of the formaldehyde generators mentioned above, in particular for weight ratios of the two constituents from 10/1 to 1/10, preferably 5/1 to 1 / 5, and in particular from 2/1 to 1/2.
• the bactericidal synergistic effect was appreciated from the lowering of a bacterial population.
• a mixture of hydrogen peroxide and formaldehyde generator allows a reduction of 99% of the bacterial population.
• the residual population is approximately 50 times lower than at the end of a treatment with hydrogen peroxide, tris-hydroxymethylnitromethane or ⁇ -polyoxymethylene. alone.
• the disinfectant compositions according to the intention find their applications in terminal disinfection in a hospital environment, disinfection by soaking of medical, dental, veterinary, thermo-sensitive instruments and materials, disinfection of household and hospital linen and disinfection by spraying of media. contaminated.
• the Streptococcus faecalis CNCM 5855 strain was chosen as the tracer most representative of the bactericidal effect.
• the strains are prepared and tested according to the protocols of the AFNGR NFT 72150 standard, except for the following modifications: at the end of the contact time, generally between 0 and 60 minutes, or even four hours in certain cases, the enumeration of the bacterial population Survivor is done by assay of bacterial adenosine triphosphate (ATP) in bioluminescence. All living bacteria contain adenosine triphosphate which is involved in the light-producing enzymatic reaction between luciferin and luciferase.
• ATP bacterial adenosine triphosphate
• the amount of light being proportional to the amount of ATP present for constant doses of luciferin and luciferase, it is proportional to the number of surviving bacteria in the test.
• the device used is equipment sold under the brand name "Lumac / 3M Biocounter M2010A"
• the falls of bacterial germs are indicated in log decimal log 10 corresponding to the ratio of the number of initial germs to the numbers of final germs after disinfection at the end of the contact time. Comparative tests were carried out under the conditions previously described with hydrogen peroxide alone, tris-hydroxymethylnitromethane, sold under the brand "TN 100", and with the combination of the two compounds. These association tests were conducted at room temperature, in this case no temperature is specified, or at 40 ° C. The tests were carried out at different pH and contact time in minutes, the bactericidal effect is indicated in germ drop in log 10, and the results recorded in the tables; the figures indicated correspond to the germ losses in log 10 of the initial germs / final germs ratio after disinfection.
• Bacillus cereus spores of Bacillus cereus CNCM 7803 were chosen as a tracer representative of the germicidal effect. Bacillus cereus spores are prepared and tested according to the protocols of the AFNOR standard of the 72000 series.
• Bacillus cereus CNCM 7803 spores are brought into contact for 12 minutes at 60 ° C with the product to be tested in the presence of detergent (4g / l). After neutralizing the disinfectant, the suspension is counted on agar in a petri dish. The initial spore concentration is 10 spores per ml (revivable units).
• Detergent indicator alkaline washing at 60 ° C drops the initial population by about 10 times.

Landscapes

• Life Sciences & Earth Sciences (AREA)
• Dentistry (AREA)
• Wood Science & Technology (AREA)
• Inorganic Chemistry (AREA)
• Pest Control & Pesticides (AREA)
• Plant Pathology (AREA)
• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Chemical & Material Sciences (AREA)
• Agronomy & Crop Science (AREA)
• Zoology (AREA)
• General Health & Medical Sciences (AREA)
• Environmental Sciences (AREA)
• Agricultural Chemicals And Associated Chemicals (AREA)
• Apparatus For Disinfection Or Sterilisation (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
• Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
• Cosmetics (AREA)

Applications Claiming Priority (2)

Publications (1)

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Citations (1)

• 1988
  • 1988-02-19 FR FR8801985A patent/FR2627389B1/fr not_active Expired - Fee Related
• 1989
  • 1989-02-17 ES ES89400437T patent/ES2052940T3/es not_active Expired - Lifetime
  • 1989-02-17 DE DE8989400437T patent/DE68903510T2/de not_active Expired - Fee Related
  • 1989-02-17 AT AT89400437T patent/ATE82464T1/de not_active IP Right Cessation
  • 1989-02-17 WO PCT/FR1989/000059 patent/WO1989007396A1/fr not_active Ceased
  • 1989-02-17 EP EP89400437A patent/EP0329556B1/fr not_active Expired - Lifetime
• 1992
  • 1992-11-20 GR GR920402611T patent/GR3006312T3/el unknown

Patent Citations (1)

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