WO1988007371A3 - Prevention et traitement des effets nocifs de l'exposition de la peau au soleil, et compositions a cet effet - Google Patents

Prevention et traitement des effets nocifs de l'exposition de la peau au soleil, et compositions a cet effet Download PDF

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Publication number
WO1988007371A3
WO1988007371A3 PCT/US1988/001036 US8801036W WO8807371A3 WO 1988007371 A3 WO1988007371 A3 WO 1988007371A3 US 8801036 W US8801036 W US 8801036W WO 8807371 A3 WO8807371 A3 WO 8807371A3
Authority
WO
WIPO (PCT)
Prior art keywords
sun
prevention
treatment
deleterious effects
compositions therefor
Prior art date
Application number
PCT/US1988/001036
Other languages
English (en)
Other versions
WO1988007371A2 (fr
Inventor
Peter M Ross
Leon H Bradlow
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Publication of WO1988007371A2 publication Critical patent/WO1988007371A2/fr
Publication of WO1988007371A3 publication Critical patent/WO1988007371A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Un méthyle ester de l'acide 21-nonanoïque de triamcinolone acétonide, d'autres composés affectant la cascade d'acides arachidoniques et d'autres inhibiteurs de synthèse connus, ainsi que des compositions topiques et pharmaceutiques de ceux-ci sont utilisés dans un procédé pour traiter la peau exposée au rayonnement ultraviolet en vue d'inhiber la suppression par ce dernier de l'hypersensibilité retardée de l'épiderme et ainsi de réduire ou de prévenir les effets carcinogènes du coup de soleil. Des formulations du méthyle ester de l'acide 21-nonanoïque de triamcinolone acétonide contiennent de préférence environ 0,005 à 1,0 pourcent en poids du principe actif.
PCT/US1988/001036 1987-03-25 1988-03-25 Prevention et traitement des effets nocifs de l'exposition de la peau au soleil, et compositions a cet effet WO1988007371A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3076487A 1987-03-25 1987-03-25
US16154288A 1988-02-29 1988-02-29
US161,542 1988-02-29
US030,764 1993-03-12

Publications (2)

Publication Number Publication Date
WO1988007371A2 WO1988007371A2 (fr) 1988-10-06
WO1988007371A3 true WO1988007371A3 (fr) 1988-12-01

Family

ID=26706437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/001036 WO1988007371A2 (fr) 1987-03-25 1988-03-25 Prevention et traitement des effets nocifs de l'exposition de la peau au soleil, et compositions a cet effet

Country Status (4)

Country Link
EP (1) EP0307468A1 (fr)
AU (1) AU613370B2 (fr)
CA (1) CA1316827C (fr)
WO (1) WO1988007371A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897260A (en) * 1987-05-22 1990-01-30 The Rockefeller University Compositions that affect suppression of cutaneous delayed hypersensitivity and products including same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2264003A1 (de) * 1972-12-22 1974-07-04 Schering Ag Neue pregnansaeure-derivate
US4282216A (en) * 1977-04-20 1981-08-04 Johnson & Johnson Topical anti-inflammatory drug therapy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4185100A (en) * 1976-05-13 1980-01-22 Johnson & Johnson Topical anti-inflammatory drug therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2264003A1 (de) * 1972-12-22 1974-07-04 Schering Ag Neue pregnansaeure-derivate
US4282216A (en) * 1977-04-20 1981-08-04 Johnson & Johnson Topical anti-inflammatory drug therapy

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
British Journal of Dermatology, vol. 115, no. 4, 1986, P.M. Farr et al.: "A quantitative study of the effect of topical indomethacin on cutaneous erythema induced by UVB and UVC radiation", pages 453-466 *
Cancer Research, vol. 42, no. 10, October 1982, N.J. Lowe et al.: "Inhibition of ultraviolet-B epidermal ornithine decarboxylase induction and skin carcinogenesis in hairless mice by topical indomethacin and triamcinolone acetonide" pages 3941-3943 *
Drug Intelligence and Clinical Pharmacy, vol. 20, no. 6, June 1986, P. Tan et al.: "Effect of topically applied flurbiprofen on ultraviolet-induced erythema", pages 496-499 *
Endocrinology, vol. 116, no. 1, 1985, The Endocrine Society (US), J. Gorsline et al.: "Triamcinolone acetonide 21-oic acid methyl ester: a potent local antiinflammatory steroid without detectable systemic effects", pages 263-273 *
The Journal of Investigative Dermatology, vol. 64, no. 5, 1975, The William & Wilkins Co. (US), D.S. Snyder: "Cutaneous effects of topical indomethacin, an inhibitor of prostaglandin synthesis, on UV-damaged skin", pages 322-325 *
The Journal of Investigative Dermatology, vol. 77, no. 1, 1981, The William & Wilkens Co. (US), N.J. Lowe: "Ultraviolet light and epidermal polyamines", pages 147-153 *
The Journal of Investigative Dermatology, vol. 90, no. 3, 1988, The Society for Investigative Dermatology, Inc., P.M. Ross et al.: "Glucocorticoid effects on contact hypersensitivity and on cutaneous response to ultraviolet light in the mouse", pages 366-371 *
The Merck Manual of Diagnosis and Therapy, 14th edition, 1982, edited by R. Berkow, published by Merck Sharp & Dohme Research Laboratories (Rahway, New Jersey, US), pages 312 *
Z. Hautkr., vol. 56, no. 22, 27 May 1981, Grosse Verlag (Berlin, DE), K.P. Jablonski et al.: "Der Einfluss von Azetylsalizylsaure auf die biologische Wirksamkeit von UV-A-Strahlen", pages 1437-1446 *

Also Published As

Publication number Publication date
AU613370B2 (en) 1991-08-01
EP0307468A1 (fr) 1989-03-22
AU1707788A (en) 1988-11-02
CA1316827C (fr) 1993-04-27
WO1988007371A2 (fr) 1988-10-06

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