WO1988007371A3 - Prevention and treatment of the deleterious effects of exposing skin to the sun, and compositions therefor - Google Patents

Prevention and treatment of the deleterious effects of exposing skin to the sun, and compositions therefor Download PDF

Info

Publication number
WO1988007371A3
WO1988007371A3 PCT/US1988/001036 US8801036W WO8807371A3 WO 1988007371 A3 WO1988007371 A3 WO 1988007371A3 US 8801036 W US8801036 W US 8801036W WO 8807371 A3 WO8807371 A3 WO 8807371A3
Authority
WO
WIPO (PCT)
Prior art keywords
sun
prevention
treatment
deleterious effects
compositions therefor
Prior art date
Application number
PCT/US1988/001036
Other languages
French (fr)
Other versions
WO1988007371A2 (en
Inventor
Peter M Ross
Leon H Bradlow
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Publication of WO1988007371A2 publication Critical patent/WO1988007371A2/en
Publication of WO1988007371A3 publication Critical patent/WO1988007371A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Triamcinolone acetonide 21-ennoic acid methyl ester, other compounds affecting the arachidionic acid cascade and other known synthesis inhibitors, and topical and pharmaceutical compositions thereof are utilized in a method of treating ultraviolet radiation exposed skin to inhibit ultraviolet radiation suppresion of delayed hypersensitivity in the epidermis thereby reducing or obviating the carcinogenic effects of the sunburn. Formulations of the triamcionolone acetonide 21-ennoic acid methyl ester preferably contain about 0.005 to 1.0 percent by weight of the active ingredient.
PCT/US1988/001036 1987-03-25 1988-03-25 Prevention and treatment of the deleterious effects of exposing skin to the sun, and compositions therefor WO1988007371A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3076487A 1987-03-25 1987-03-25
US16154288A 1988-02-29 1988-02-29
US161,542 1988-02-29
US030,764 1993-03-12

Publications (2)

Publication Number Publication Date
WO1988007371A2 WO1988007371A2 (en) 1988-10-06
WO1988007371A3 true WO1988007371A3 (en) 1988-12-01

Family

ID=26706437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/001036 WO1988007371A2 (en) 1987-03-25 1988-03-25 Prevention and treatment of the deleterious effects of exposing skin to the sun, and compositions therefor

Country Status (4)

Country Link
EP (1) EP0307468A1 (en)
AU (1) AU613370B2 (en)
CA (1) CA1316827C (en)
WO (1) WO1988007371A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897260A (en) * 1987-05-22 1990-01-30 The Rockefeller University Compositions that affect suppression of cutaneous delayed hypersensitivity and products including same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2264003A1 (en) * 1972-12-22 1974-07-04 Schering Ag Pregnane-21-carboxylic acid derivs. - with local (not systemic) anti-inflammatory activity
US4282216A (en) * 1977-04-20 1981-08-04 Johnson & Johnson Topical anti-inflammatory drug therapy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4185100A (en) * 1976-05-13 1980-01-22 Johnson & Johnson Topical anti-inflammatory drug therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2264003A1 (en) * 1972-12-22 1974-07-04 Schering Ag Pregnane-21-carboxylic acid derivs. - with local (not systemic) anti-inflammatory activity
US4282216A (en) * 1977-04-20 1981-08-04 Johnson & Johnson Topical anti-inflammatory drug therapy

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
British Journal of Dermatology, vol. 115, no. 4, 1986, P.M. Farr et al.: "A quantitative study of the effect of topical indomethacin on cutaneous erythema induced by UVB and UVC radiation", pages 453-466 *
Cancer Research, vol. 42, no. 10, October 1982, N.J. Lowe et al.: "Inhibition of ultraviolet-B epidermal ornithine decarboxylase induction and skin carcinogenesis in hairless mice by topical indomethacin and triamcinolone acetonide" pages 3941-3943 *
Drug Intelligence and Clinical Pharmacy, vol. 20, no. 6, June 1986, P. Tan et al.: "Effect of topically applied flurbiprofen on ultraviolet-induced erythema", pages 496-499 *
Endocrinology, vol. 116, no. 1, 1985, The Endocrine Society (US), J. Gorsline et al.: "Triamcinolone acetonide 21-oic acid methyl ester: a potent local antiinflammatory steroid without detectable systemic effects", pages 263-273 *
The Journal of Investigative Dermatology, vol. 64, no. 5, 1975, The William & Wilkins Co. (US), D.S. Snyder: "Cutaneous effects of topical indomethacin, an inhibitor of prostaglandin synthesis, on UV-damaged skin", pages 322-325 *
The Journal of Investigative Dermatology, vol. 77, no. 1, 1981, The William & Wilkens Co. (US), N.J. Lowe: "Ultraviolet light and epidermal polyamines", pages 147-153 *
The Journal of Investigative Dermatology, vol. 90, no. 3, 1988, The Society for Investigative Dermatology, Inc., P.M. Ross et al.: "Glucocorticoid effects on contact hypersensitivity and on cutaneous response to ultraviolet light in the mouse", pages 366-371 *
The Merck Manual of Diagnosis and Therapy, 14th edition, 1982, edited by R. Berkow, published by Merck Sharp & Dohme Research Laboratories (Rahway, New Jersey, US), pages 312 *
Z. Hautkr., vol. 56, no. 22, 27 May 1981, Grosse Verlag (Berlin, DE), K.P. Jablonski et al.: "Der Einfluss von Azetylsalizylsaure auf die biologische Wirksamkeit von UV-A-Strahlen", pages 1437-1446 *

Also Published As

Publication number Publication date
AU1707788A (en) 1988-11-02
WO1988007371A2 (en) 1988-10-06
EP0307468A1 (en) 1989-03-22
CA1316827C (en) 1993-04-27
AU613370B2 (en) 1991-08-01

Similar Documents

Publication Publication Date Title
IE940583L (en) Topical antimicrobial pharmaceutical compositions
NZ295303A (en) Sunscreen composition comprising a sunscreen agent, an anti-inflammatory agent and a composition for healing wounds
EP1690534A3 (en) Lipoic acid in topical compositions
CA2209167A1 (en) Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof
AU598020B2 (en) Cosmetic composition
EP0382066A3 (en) Use of dihydroliponic acid as an analgetic, antiphlogistic and/or cytoprotective agent
MX9307509A (en) Method and pharmaceutical preparation to reduce cell activity.
CA2015838A1 (en) Method of topically treating acne vulgaris
IT1170214B (en) PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PERIPHERAL ARTERIOPATHIES
ZA911728B (en) Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors
ES8206974A1 (en) Non-yellowing topical pharmaceutical composition.
IE800406L (en) Pharmaceutical composition
CA2173147A1 (en) Anti-obesity agent
DK165903C (en) PHARMACEUTICAL PREPARATION AGAINST ACNE
IE781032L (en) Pharmaceutical compositions
JPS56120611A (en) Beautifying cosmetic
US6159450A (en) Use of Ginkgo biloba flavonoidic extract substantially devoid of terpenes for oral hygiene and composition containing such extract
US4404198A (en) Phenyl Salicylate as a topical anti-inflammatory
WO1987000432A3 (en) Use of melatonin or related compounds for the treatment of psoriasis
KR930703252A (en) Use of coucurbitin used in the manufacture of anti-allergic cosmetics or pharmaceutical, especially dermatological compositions, and methods of using the same
WO1988007371A3 (en) Prevention and treatment of the deleterious effects of exposing skin to the sun, and compositions therefor
DE69314463T2 (en) SKIN REGENERATING COSMETIC COMPOSITION
US20070141167A1 (en) Use of Benzyl Nicotinate for Pain Relief
WO1993003720A3 (en) Methods and compositions for treating sunburns
IE43994L (en) Diphenylmethanes.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE FR GB IT LU NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT LU NL SE

WWE Wipo information: entry into national phase

Ref document number: 1988904039

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1988904039

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1988904039

Country of ref document: EP