WO1988006878A1 - Composition pharmaceutique contenant des esters d'acide benzoique et kit - Google Patents
Composition pharmaceutique contenant des esters d'acide benzoique et kit Download PDFInfo
- Publication number
- WO1988006878A1 WO1988006878A1 PCT/US1988/000682 US8800682W WO8806878A1 WO 1988006878 A1 WO1988006878 A1 WO 1988006878A1 US 8800682 W US8800682 W US 8800682W WO 8806878 A1 WO8806878 A1 WO 8806878A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hair growth
- enhancing agent
- weight
- percent
- growth enhancing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
Definitions
- the first aspect of the present invention involves a method for promoting hair growth which comprises topically applying to the scalp of a subject a hair growth enhancing agent comprising at least one benzoic acid ester of primary aliphatic alcohols having from 12 to 15 carbon atoms and a biologically acceptable excipient which does not substantially interfere with the hair growth promotion.
- the benzoic acid esters of the present invention can be prepared by reacting benzoic acid with the primary linear alcohol(s) under reaction conditions conducive to benzoate formation.
- the hair growth enhancing agents of the present invention may be produced as described in U.S. Patent No. 4,275,222 to Scala.
- additional active ingredients there are contemplated compounds which are also capable of promoting the growth of hair.
- additional ⁇ active ingredients there are contemplated any compounds capable of treating other scalp conditions. Exemplary of' such compounds are anti-seborrhea and anti-psoriasis agents such as chloroxine, sodium sulfacetamide/sulfur and anthralin.
- filler there is contemplated any pharmaceutically inert compound which is added to the composition to provide bulk.
- exemplary of such compounds are inert clay compounds and talc.
- the hair growth enhancing agent of this invention may be applied to the scalp of a patient or subject in any dosage form capable of permitting intimate contact of the hair growth enhancing agent with the scalp.
- the hair growth enhancing agent may be administered in lotion, cream or ointment dosage form.
- the disparate flow characteristics of dosage forms is a result of the properties of the compounds contained in the carrier or vehicle.
- acceptable excipients include water, stearic acid, stearic alcohol, propylparaben , methylparaben, glycerin, carbitol, microcrystalline cellulose, polyethylene glycol and the like.
- acceptable excipients include water, alkylaryl sulfonic acid salts, hydroxyethylcellulose, propylene glycol, silicon emulsions
- acceptable excipients include anhydrous lanolin, dimethicone, petrolatum, polyethylene glycol, white wax and the like.
- the benzoic acid ester hair growth enhancing agent is present in the dosage form in an amount sufficient to impart hair growth promoting activity to the dosage form at a reasonable dosage without disturbing the homogeneity of the dosage form.
- the present invention contemplates the presence of the benzoic acid ester hair growth enhancing agent in an amount from about 0.5 to about 25 percent by weight of the pharmaceutical topical agent.
- the hair growth enhancing agent is present in an amount ' from about 1.0 to about 10 percent by weight of the pharmaceutical topical agent.
- the hair growth enhancing agent is present in an amount from about 2.5 to about 5.0 percent of the pharmaceutical topical agent.
- the dosage form of the present invention is applied in such an amount as to provide a sufficient amount of the hair growth enhancing agent to the scalp area to promote the growth of hair.
- Dosages contemplated by the present invention range from about 0.05 to about 10 ml of the dosage form per day.
- Preferred dosages range from about 0.1 to about 1.0 ml of the dosage form per day.
- Such a dosage may be applied once daily or, if desired, in divided dosages.
- One preferred embodiment of the first aspect of the present invention provides a hair growth enhancing agent comprising from about 10 to about 35 percent by weight of the C ⁇ _2 alcohol benzoate. Another preferred embodiment of this aspect provides a hair growth enhancing agent comprising' from about 25 to about 45 percent by weight of the C 13 alcohol benzoate. A third preferred embodiment of this aspect provides a hair growth enhancing agent comprising from about 15 to about 30 percent by weight of the C 14 alcohol benzoate. Another preferred embodiment provides a hair growth enhancing agent comprising from about 15 to about 25 percent by weight of the C 15 alcohol benzoate.
- a further preferred embodiment of the first aspect of the present invention involves a method for promoting hair growth which comprises topically applying to the scalp of a subject a hair growth enhancing agent comprising at least two benzoic acid esters of primary alcohols having from 12 to 15 carbon atoms as said at least one benzoic acid ester.
- a hair growth enhancing agent comprising from about 10 to about 35 percent by weight of the C ⁇ alcohol benzoate.
- Another more preferred form of this embodiment provides a hair growth enhancing agent comprising from about 25 to about 45 percent by weight of the C ⁇ _ 3 alcohol benzoate.
- a third more preferred form provides a hair growth enhancing agent comprising from about 15 to about 30 percent by weight of the C 14 alcohol benzoate.
- Another more preferred form provides a hair growth enhancing agent comprising from about 15 to about 25 percent by weight of the C ⁇ alcohol benzoate.
- a further preferred embodiment of the present invention includes a method for promoting hair growth which comprises topically applying to the scalp of a subject a hair growth enhancing agent comprising at least three benzoic acid esters of primary alcohols having from 12 to 15 carbon atoms as said at least one benzoic acid ester.
- a more preferred form of this embodiment of the present invention provides a hair growth enhancing agent comprising from about 10 to about 35 percent by weight of the C 12 alcohol benzoate.
- Another more preferred form of this embodiment provides a hair growth enhancing agent comprising from about 25 to about 45 percent by weight of the C ⁇ _ 3 alcohol benzoate.
- a third more preferred form provides a hair growth enhancing agent comprising from about 15 to about 30 percent by weight of the C 14 alcohol benzoate.
- Another more preferred form provides a hair growth enhancing agent comprising from about 15 to about 25 percent by weight of the C ] _5 alcohol benzoate.
- the final embodiment of the first aspect of-the present invention provides a method for promoting hair growth which comprises topically applying to the scalp of a "subject a hair growth enhancing agent comprising all four benzoic acid esters of primary alcohols having from 12 to 15 carbon atoms as said at least one benzoic acid ester.
- a more preferred form of this embodiment of the present invention provides a hair growth enhancing agent comprising from about 10 to about 35 percent by weight of the C ⁇ alcohol benzoate.
- Another more preferred form of this embodiment provides a hair growth enhancing agent comprising from about 25 to about 45 percent by weight of the 0 ⁇ 3 alcohol benzoate.
- a third more preferred form provides a hair growth enhancing agent comprising from about 15 to about 30 percent by weight of the C ⁇ 4 alcohol benzoate.
- Another more preferred form provides a hair growth enhancing agent comprising from about 15 to about 25 percent by weight of the C 15 alcohol benzoate.
- the second aspect of the present invention provides a kit containing a topical medication suitable for promoting hair growth on the scalp of a subject which comprises a package containing: (a) a container including a topical medication comprising a hair growth enhancing agent comprising at least one benzoic acid ester of primary alcohols having from 12 to 15 carbon atoms and containing a biologically acceptable excipient which does not substantially interfere with the hair growth promotion for topical administration to the scalp of said subject; and (b) directions for administration of said topical medication to said scalp for the promotion of hair growth said topical medication upon continued application to said scalp promoting the growth of hair thereon.
- the container may be a standard pharmaceutical container such as a bottle, tube or jar.
- the topical medication contains benzoic acid ester(s) which constitute the active ingredient in the kit, and that the topical medication is to be topically administered to the scalp of a patient wishing to promote hair growth directly to those areas where growth is desired.
- Such directions are set forth on a label which is attached directly to the pharmaceutical container.
- the container may be a box or other cardboard, plastic or similar container having therein both a package insert with instructions on how to use the topical medication as a topical hair growth promoting agent together with an inner container housing the topical medication.
- One preferred embodiment of the second aspect of the present invention provides a hair growth enhancing agent comprising from about 10 to about 35 percent by weight of the C ⁇ alcohol benzoate. Another preferred embodiment of this aspect provides a hair growth enhancing agent comprising from about 25 to about 45 percent by weight of the C ] _ 3 alcohol benzoate. A third preferred embodiment of this aspect provides a hair growth enhancing agent comprising from about 15 to about 30 percent by weight of the C- j _ alcohol benzoate. Another preferred embodiment provides a hair growth enhancing agent comprising from about 15 to about 25 percent by weight of the C 15 alcohol benzoate.
- a hair growth enhancing agent comprising 25% by weight of the benzoic acid ester of the C 12 primary linear alcohol (1-dodecanol) ,. 40% by weight of the benzoic acid ester of the C 13 primary linear alcohol (tridecanol) , 20% by weight of the benzoic acid ester of the C 14 primary linear alcohol (tetradecanol) and 15% by weight of the benzoic acid ester of the C 15 primary linear alcohol (pentadecanol) is prepared according to the process disclosed in U.S. Patent 4,275,222. 10 ml of the resultant hair growth enhancing agent is admixed with 240 ml of si harmonyone and 50 ml of cyclomethicone to form a pharmaceutically acceptable lotion.
- EXAMPLE 2 A hair growth enhancing agent comprising 25% by weight of the benzoic acid ester of the C 12 primary linear alcohol (1-dodecanol) ,. 40% by weight of the benzoic acid ester of the C 13 primary linear alcohol (tridecan
- Example 1 0.30 ml of the lotion of Example 1 is applied to the exposed scalp of a patient once daily in a therapeutic program to promote hair growth.
- a hair growth enhancing agent comprising 30% by weight of the benzoic acid ester of the C 12 primary linear alcohol (1-dodecanol) , 35% by weight of the benzoic acid ester of the C 13 primary linear alcohol (tridecanol) , 20% by weight of the benzoic acid ester of the C 14 primary linear alcohol (tetradecanol) and 15% by weight of the benzoic acid ester of the C ] _5 primary linear alcohol (pentadecanol) is prepared according to the process disclosed in U.S. Patent 4,275,222.
- 10 ml of the resultant hair growth enhancing agent is admixed with 120 ml of anhydrous lanolin, 80 ml of polyethylene glycol, 30 ml of mineral oil and 20 ml of white wax to form a pharmaceutically acceptable ointment.
- EXAMPLE 4 0.35 ml of the ointment of Example 3 is applied to the exposed scalp of a patient once daily in a therapeutic program to promote hair growth.
- a hair growth enhancing agent comprising 25% by weight of the benzoic acid ester of the C 12 primary linear alcohol (1-dodecanol) , 30% by weight of the benzoic acid ester of the C ⁇ 3 primary linear alcohol (tridecanol) , 25% by weight of the benzoic acid ester of the C ⁇ 4 primary linear alcohol (tetradecanol) and 20% by weight of the benzoic acid ester of the C 15 primary linear alcohol (pentadecanol) is prepared according to the process disclosed in U.S. Patent 4,275,222.
- Example 5 0.25 ml of the cream of Example 5 is applied to the exposed scalp of a patient once daily in a therapeutic program to promote hair growth.
- EXAMPLE 7 250 ml of the lotion of Example 1 is placed in a bottle having affixed thereto a label stating directions explaining that the bottle contains a topical medication which includes benzoic acid ester compounds as the active ingredient, and that the topical medication is to be topically administered to the scalp of a patient to promote hair growth of the patient.
- a topical medication which includes benzoic acid ester compounds as the active ingredient
- EXAMPLE 8 250 ml of the lotion of Example 1 is placed in a bottle which is housed inside a box.
- a package insert stating directions explaining that the bottle contains a topical medication which includes benzoic acid ester compounds as the active ingredient, and that the topical medication is to be topically administered to the scalp of a patient to promote hair growth of the patient is also placed inside a box to complete the pharmaceutical kit.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procédé favorisant la croissance capillaire par application topique, sur le cuir chevelu d'un sujet, d'un agent augmentant la croissance des cheveux, se composant d'au moins un ester d'acide benzoïque d'alcools primaires ayant de 12 à 15 atomes de carbone. Des kits pharmaceutiques contenant une composition renfermant l'agent augementant la croissance des cheveux sont également envisagés.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2512087A | 1987-03-12 | 1987-03-12 | |
US025,120 | 1987-03-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1988006878A1 true WO1988006878A1 (fr) | 1988-09-22 |
Family
ID=21824144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1988/000682 WO1988006878A1 (fr) | 1987-03-12 | 1988-03-11 | Composition pharmaceutique contenant des esters d'acide benzoique et kit |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1988006878A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1097701A1 (fr) * | 1999-11-03 | 2001-05-09 | Beiersdorf AG | Compositions cosmétiques capillaires à base d'un mélange de polymères cationiques et d'éthers de cellulose et de polyéthylène glycols et de tensioactifs siliconiques |
US6635775B1 (en) * | 2000-02-04 | 2003-10-21 | Finetex, Inc. | Reduced odor esters and process for producing same |
WO2009083736A1 (fr) * | 2007-12-28 | 2009-07-09 | Innospec Limited | Compositions et leurs utilisations |
WO2016057505A1 (fr) * | 2014-10-07 | 2016-04-14 | Therakine | Conservation de bioactivité par des matrices hydrophobes |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4293544A (en) * | 1979-03-07 | 1981-10-06 | Finetex Incorporated | Fluid and semi-fluid compositions including benzoate esters |
US4322545A (en) * | 1979-09-14 | 1982-03-30 | Finetex, Inc. | Benzoic acid esters |
WO1982004189A1 (fr) * | 1981-05-27 | 1982-12-09 | Moeller Hinrich | Derives d'acide arene-carboxylique en tant qu'agents a effet anti- seborrhee entrant dans des compositions cosmetiques |
-
1988
- 1988-03-11 WO PCT/US1988/000682 patent/WO1988006878A1/fr unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4293544A (en) * | 1979-03-07 | 1981-10-06 | Finetex Incorporated | Fluid and semi-fluid compositions including benzoate esters |
US4322545A (en) * | 1979-09-14 | 1982-03-30 | Finetex, Inc. | Benzoic acid esters |
WO1982004189A1 (fr) * | 1981-05-27 | 1982-12-09 | Moeller Hinrich | Derives d'acide arene-carboxylique en tant qu'agents a effet anti- seborrhee entrant dans des compositions cosmetiques |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1097701A1 (fr) * | 1999-11-03 | 2001-05-09 | Beiersdorf AG | Compositions cosmétiques capillaires à base d'un mélange de polymères cationiques et d'éthers de cellulose et de polyéthylène glycols et de tensioactifs siliconiques |
US6635775B1 (en) * | 2000-02-04 | 2003-10-21 | Finetex, Inc. | Reduced odor esters and process for producing same |
WO2009083736A1 (fr) * | 2007-12-28 | 2009-07-09 | Innospec Limited | Compositions et leurs utilisations |
WO2016057505A1 (fr) * | 2014-10-07 | 2016-04-14 | Therakine | Conservation de bioactivité par des matrices hydrophobes |
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