WO1988006439A3 - Phospholipase a2-resistant liposomes - Google Patents

Phospholipase a2-resistant liposomes Download PDF

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Publication number
WO1988006439A3
WO1988006439A3 PCT/US1988/000508 US8800508W WO8806439A3 WO 1988006439 A3 WO1988006439 A3 WO 1988006439A3 US 8800508 W US8800508 W US 8800508W WO 8806439 A3 WO8806439 A3 WO 8806439A3
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WO
WIPO (PCT)
Prior art keywords
phospholipase
mol
formula
liposome
resistant liposomes
Prior art date
Application number
PCT/US1988/000508
Other languages
French (fr)
Other versions
WO1988006439A2 (en
Inventor
Wolfgang J Baumann
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Publication of WO1988006439A2 publication Critical patent/WO1988006439A2/en
Publication of WO1988006439A3 publication Critical patent/WO1988006439A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method to inhibit phospholipase A2-type hydrolytic degradation of liposome membranes is disclosed comprising forming a liposome having a bilayer membrane comprising (i) between about 67.5-85 mol-% of a phospholipid of formula (I), and (ii) between about 15.0-32.5 mol-% of a lysophospholipid of formula (II), wherein R2, R1 and R3 are individually (C10-C30) alkanoyl groups including from about 0-4 double bonds.
PCT/US1988/000508 1987-02-24 1988-02-19 Phospholipase a2-resistant liposomes WO1988006439A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1736987A 1987-02-24 1987-02-24
US017,369 1987-02-24

Publications (2)

Publication Number Publication Date
WO1988006439A2 WO1988006439A2 (en) 1988-09-07
WO1988006439A3 true WO1988006439A3 (en) 1988-11-03

Family

ID=21782196

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/000508 WO1988006439A2 (en) 1987-02-24 1988-02-19 Phospholipase a2-resistant liposomes

Country Status (1)

Country Link
WO (1) WO1988006439A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10148065A1 (en) * 2001-09-28 2003-04-17 Max Planck Gesellschaft (Ester) -lysolecithins in liposomes
AR036316A1 (en) * 2002-08-29 2004-08-25 Monte Verde S A A PHARMACEUTICAL COMPOSITION OF SMALL SIZE LIPOSOMES AND PREPARATION METHOD
DE602005012155D1 (en) * 2004-11-03 2009-02-12 Liplasome Pharma As LIPID BASED DRUG DISPOSAL SYSTEMS USING UNSATURATIVE PHOSPHOLIPASE-A2 ABBAUBARANT LIPID DERIVATIVES AND THEIR THERAPEUTIC USE

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61129191A (en) * 1984-11-27 1986-06-17 Nippon Oil & Fats Co Ltd Glycerophospholipid containing decosahexaenoic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61129191A (en) * 1984-11-27 1986-06-17 Nippon Oil & Fats Co Ltd Glycerophospholipid containing decosahexaenoic acid

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Biochemistry, volume 26, no. 23, 17 November 1987, American Chemical Society, N. Elise Gabriel et al.: "Enzymatic hydrolysis of short-chain lecithin/long chain phospholipid unilamellar vesicles: "Sensitivity of phospholipases to matrix phase state", pages 7409-7418 *
Chemical Abstracts, volume 100, no. 13, 26 March 1984, (Columbus, Ohio, US), M.K. Jain et al.: "Activation of phospolipase A2 by freshly added lysophospholipids", see page 274 *
Chemical Abstracts, volume 107, no. 23, 7 December 1987, (Columbus, Ohio, US), see page 631, abstract 218004d, & JP-A-61129191 (NIPPON OILS AND FATS CO., LTD) 17 June 1986 *
Chemical Abstracts, volume 93, no. 1, 7 July 1980, (Columbus, Ohio, US), C. Vigo et al.: "Mechanisms of inhibition of phospholipase A2", see page 402 *
Chemical Abstracts, volume 94, no. 19, 11 May 1981, (Columbus, Ohio, US), C.M. Gupta et al.: "Carbamyl analogs of phosphatidylcholines. Synthesis, interaction with phospholipases and permeability behaviour of their liposomes", see page 253 *
Chemical Abstracts, volume 97, no. 23, 6 December 1982, (Columbus, Ohio, US), E. Okimasu et al.: "Inhibitory effect of glycyrrhizin on the phospholipase A2 activity", see page 270 *

Also Published As

Publication number Publication date
WO1988006439A2 (en) 1988-09-07

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