WO1988006439A3 - Liposomes resistants a la phospholipase a2 - Google Patents

Liposomes resistants a la phospholipase a2 Download PDF

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Publication number
WO1988006439A3
WO1988006439A3 PCT/US1988/000508 US8800508W WO8806439A3 WO 1988006439 A3 WO1988006439 A3 WO 1988006439A3 US 8800508 W US8800508 W US 8800508W WO 8806439 A3 WO8806439 A3 WO 8806439A3
Authority
WO
WIPO (PCT)
Prior art keywords
phospholipase
mol
formula
liposome
resistant liposomes
Prior art date
Application number
PCT/US1988/000508
Other languages
English (en)
Other versions
WO1988006439A2 (fr
Inventor
Wolfgang J Baumann
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Publication of WO1988006439A2 publication Critical patent/WO1988006439A2/fr
Publication of WO1988006439A3 publication Critical patent/WO1988006439A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Abstract

Un procédé de prévention de la dégradation hydrolytique de membranes de liposomes du type provoquée par la phospholipase A2 comprend la formation d'un liposome ayant une membrane à double couche qui comprend (i) entre 67,5 et 85 moles % environ d'un phospholipide ayant la formule (I) et (ii) entre 15,0 et 32,5 moles % environ d'un lysophospholipide ayant la formule (II), dans lesquelles R1, R2 et R3 représentent individuellement des groupes (C10-C30)alkanoyl comprenant entre 0 et 4 liaisons doubles.
PCT/US1988/000508 1987-02-24 1988-02-19 Liposomes resistants a la phospholipase a2 WO1988006439A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1736987A 1987-02-24 1987-02-24
US017,369 1987-02-24

Publications (2)

Publication Number Publication Date
WO1988006439A2 WO1988006439A2 (fr) 1988-09-07
WO1988006439A3 true WO1988006439A3 (fr) 1988-11-03

Family

ID=21782196

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/000508 WO1988006439A2 (fr) 1987-02-24 1988-02-19 Liposomes resistants a la phospholipase a2

Country Status (1)

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WO (1) WO1988006439A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10148065A1 (de) * 2001-09-28 2003-04-17 Max Planck Gesellschaft (Ester)-Lysolecithine in Liposomen
AR036316A1 (es) * 2002-08-29 2004-08-25 Monte Verde S A Una composicion farmaceutica de liposomas de tamano pequeno y metodo de preparacion
ATE418966T1 (de) * 2004-11-03 2009-01-15 Liplasome Pharma As Arzneimittelabgabesysteme auf lipidbasis mit unnatürlichen phospholipase-a2-abbaubaren lipid- derivaten und ihre therapeutische verwendung

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61129191A (ja) * 1984-11-27 1986-06-17 Nippon Oil & Fats Co Ltd ドコサヘキサエン酸含有グリセロリン脂質

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61129191A (ja) * 1984-11-27 1986-06-17 Nippon Oil & Fats Co Ltd ドコサヘキサエン酸含有グリセロリン脂質

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Biochemistry, volume 26, no. 23, 17 November 1987, American Chemical Society, N. Elise Gabriel et al.: "Enzymatic hydrolysis of short-chain lecithin/long chain phospholipid unilamellar vesicles: "Sensitivity of phospholipases to matrix phase state", pages 7409-7418 *
Chemical Abstracts, volume 100, no. 13, 26 March 1984, (Columbus, Ohio, US), M.K. Jain et al.: "Activation of phospolipase A2 by freshly added lysophospholipids", see page 274 *
Chemical Abstracts, volume 107, no. 23, 7 December 1987, (Columbus, Ohio, US), see page 631, abstract 218004d, & JP-A-61129191 (NIPPON OILS AND FATS CO., LTD) 17 June 1986 *
Chemical Abstracts, volume 93, no. 1, 7 July 1980, (Columbus, Ohio, US), C. Vigo et al.: "Mechanisms of inhibition of phospholipase A2", see page 402 *
Chemical Abstracts, volume 94, no. 19, 11 May 1981, (Columbus, Ohio, US), C.M. Gupta et al.: "Carbamyl analogs of phosphatidylcholines. Synthesis, interaction with phospholipases and permeability behaviour of their liposomes", see page 253 *
Chemical Abstracts, volume 97, no. 23, 6 December 1982, (Columbus, Ohio, US), E. Okimasu et al.: "Inhibitory effect of glycyrrhizin on the phospholipase A2 activity", see page 270 *

Also Published As

Publication number Publication date
WO1988006439A2 (fr) 1988-09-07

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