WO1987004167A3 - Steroides d'aminoglycoside, leur procede de production, leur utilisation et des compositions pharmaceutiques les contenant - Google Patents

Steroides d'aminoglycoside, leur procede de production, leur utilisation et des compositions pharmaceutiques les contenant Download PDF

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Publication number
WO1987004167A3
WO1987004167A3 PCT/EP1987/000004 EP8700004W WO8704167A3 WO 1987004167 A3 WO1987004167 A3 WO 1987004167A3 EP 8700004 W EP8700004 W EP 8700004W WO 8704167 A3 WO8704167 A3 WO 8704167A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
aminoglycoside
steroids
Prior art date
Application number
PCT/EP1987/000004
Other languages
English (en)
Other versions
WO1987004167A2 (fr
WO1987004167A1 (fr
Inventor
Laura Chiodini
Mauro Gobbini
Sergio Mantegani
Daniela Ruggieri
Aldemio Temperilli
Gabriella Traquandi
Patrizia Ferrari
Original Assignee
Erba Farmitalia
Laura Chiodini
Mauro Gobbini
Sergio Mantegani
Daniela Ruggieri
Aldemio Temperilli
Gabriella Traquandi
Patrizia Ferrari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia, Laura Chiodini, Mauro Gobbini, Sergio Mantegani, Daniela Ruggieri, Aldemio Temperilli, Gabriella Traquandi, Patrizia Ferrari filed Critical Erba Farmitalia
Priority to AT87902073T priority Critical patent/ATE56726T1/de
Priority to HU871920A priority patent/HU198740B/hu
Priority to DE8787902073T priority patent/DE3765049D1/de
Publication of WO1987004167A2 publication Critical patent/WO1987004167A2/fr
Publication of WO1987004167A1 publication Critical patent/WO1987004167A1/fr
Publication of WO1987004167A3 publication Critical patent/WO1987004167A3/fr
Priority to FI873798A priority patent/FI873798A/fi
Priority to KR870700814A priority patent/KR880700814A/ko
Priority to DK468387A priority patent/DK468387D0/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Les composés de la formule I (où soit R1 = OH, C1-C4 alkoxy et R2 = H, C1-C4 alkyle, soit R1+R2 = une liaison chimique; R3 = un résidu de sucre aminodésoxy ou aminodidésoxy ou aminotridésoxy de la série D et L, la liaison glycosidique étant alpha ou beta) et leurs sels pharmaceutiquement acceptables sont utiles comme agents anti-hypertensifs. On décrit également leurs préparation et utilisation ainsi que des compositions pharmaceutiques les contenant.
PCT/EP1987/000004 1986-01-09 1987-01-07 Steroides d'aminoglycoside, leur procede de production, leur utilisation et des compositions pharmaceutiques les contenant WO1987004167A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AT87902073T ATE56726T1 (de) 1986-01-09 1987-01-07 Aminoglykoside steroide, deren herstellungsverfahren, verwendung und arzneimittelzubereitungen, die diese enthalten.
HU871920A HU198740B (en) 1986-01-09 1987-01-07 Process for producing aminoglycoside steroids and pharmaceutical compositions comprising these compounds as active ingredients
DE8787902073T DE3765049D1 (de) 1986-01-09 1987-01-07 Aminoglykoside steroide, deren herstellungsverfahren, verwendung und arzneimittelzubereitungen, die diese enthalten.
FI873798A FI873798A (fi) 1986-01-09 1987-09-01 Aminoglykosidsteroider, foerfarande foer deras framstaellning, deras anvaendning samt farmaceutiska kompositioner innehaollande desamma.
KR870700814A KR880700814A (ko) 1986-01-09 1987-09-08 아미노글리코사이드 스테로이드, 이의 제조방법, 이의 용도 및 이를 함유하는 약제학적 조성물
DK468387A DK468387D0 (da) 1986-01-09 1987-09-08 Aminoglycosidsteroider, fremgangsmaade til deres fremstilling, deres anvendelse samt farmaceutiske praeparater, der indeholder dem

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8600489 1986-01-09
GB868600489A GB8600489D0 (en) 1986-01-09 1986-01-09 Aminoglycoside steroids

Publications (3)

Publication Number Publication Date
WO1987004167A2 WO1987004167A2 (fr) 1987-07-16
WO1987004167A1 WO1987004167A1 (fr) 1987-07-16
WO1987004167A3 true WO1987004167A3 (fr) 1987-08-13

Family

ID=

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Vol. 102, No. 21, 27 May 1985 (Columbus, Ohio, USA), I.F. MAKEREVICH et al., "Side Reactions During Saponification of Acyl Cardenolides with Ammonia", see page 607, Abstract No. 185349m, Khim. Prir. Soedin. 1984, (3), 394-5 *
CHEMICAL ABSTRACTS, Vol. 78, Nr. 19, 14 May 1973 (Columbus, Ohio, USA), J.N. DAVISSON et al., "Inhibition and Potentiation of Ouabain Inotropism by Modified Cardenolides", see page 16, Abstract No. 119146c, Proc. West. Pharmacol. Soc. 1972, 15, 31-4 *
Helvetica Chimica Acta, Vol. 55, No. 5, 1972 (Basel, CH), A.F. KRASSO et al., "Zur Stereochemie der Epoxycardanolide (Isogenine)", pages 1352-1371, see pages 1354; 1364-1371 *
Journal of the Chemical Society, Chemical Communications, 1967 (London, GB), T.R. KASTURI et al., "Synthesis of Isobufalin Methyl Ester", see pages 644-646 *

Also Published As

Publication number Publication date
US4882315A (en) 1989-11-21
ZA87114B (en) 1987-09-30
HUT46930A (en) 1988-12-28
NZ218856A (en) 1989-05-29
FI873798A0 (fi) 1987-09-01
HU198740B (en) 1989-11-28
PT84072A (en) 1987-02-01
KR880700814A (ko) 1988-04-12
AU590409B2 (en) 1989-11-02
IL81164A (en) 1990-12-23
ES2003200A6 (es) 1988-10-16
GB8600489D0 (en) 1986-02-12
WO1987004167A2 (fr) 1987-07-16
AU7161187A (en) 1987-07-28
DK468387A (da) 1987-09-08
IL81164A0 (en) 1987-08-31
EP0254744B1 (fr) 1990-09-19
PT84072B (pt) 1989-07-31
EP0254744A1 (fr) 1988-02-03
FI873798A (fi) 1987-09-01
GR870014B (en) 1987-05-08
DK468387D0 (da) 1987-09-08
JPS63502436A (ja) 1988-09-14

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