WO1985000369A1 - Synthese a l'aide d'adn hybride du facteur de croissance epidermique - Google Patents

Synthese a l'aide d'adn hybride du facteur de croissance epidermique Download PDF

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Publication number
WO1985000369A1
WO1985000369A1 PCT/US1984/001050 US8401050W WO8500369A1 WO 1985000369 A1 WO1985000369 A1 WO 1985000369A1 US 8401050 W US8401050 W US 8401050W WO 8500369 A1 WO8500369 A1 WO 8500369A1
Authority
WO
WIPO (PCT)
Prior art keywords
egf
dna
encoding
dna sequence
sequence
Prior art date
Application number
PCT/US1984/001050
Other languages
English (en)
Inventor
Graeme I. Bell
Original Assignee
Chiron Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corporation filed Critical Chiron Corporation
Priority to DE1984902750 priority Critical patent/DE148922T1/de
Priority to JP84502699A priority patent/JPS60501737A/ja
Publication of WO1985000369A1 publication Critical patent/WO1985000369A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF] (urogastrone)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Séquences d'ADN et procédés permettant d'obtenir des séquences d'ADN comprenant une séquence de codage du facteur de croissance épidermique chez les mammifères. Les séquences d'ADN peuvent être utilisées dans des vecteurs de clonage et d'expression pour la production d'ADN et d'ARN, afin de produire des polypeptides comprenant le facteur de croissance épidermique chez les mammifères.
PCT/US1984/001050 1983-07-05 1984-07-02 Synthese a l'aide d'adn hybride du facteur de croissance epidermique WO1985000369A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE1984902750 DE148922T1 (de) 1983-07-05 1984-07-02 Hybride dns-synthese des epidermwachstumsfaktors.
JP84502699A JPS60501737A (ja) 1983-07-05 1984-07-02 上皮成長因子のハイブリドｄｎａ合成

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51137283A 1983-07-05 1983-07-05
US511,372 1983-07-05

Publications (1)

Publication Number Publication Date
WO1985000369A1 true WO1985000369A1 (fr) 1985-01-31

Family

ID=24034614

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1984/001050 WO1985000369A1 (fr) 1983-07-05 1984-07-02 Synthese a l'aide d'adn hybride du facteur de croissance epidermique

Country Status (3)

Country Link
EP (1) EP0148922A4 (fr)
JP (1) JPS60501737A (fr)
WO (1) WO1985000369A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717717A (en) * 1986-11-05 1988-01-05 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
WO1989001489A1 (fr) * 1987-08-10 1989-02-23 Commonwealth Scientific And Industrial Research Or Regulation de l'angiogenese et compositions et procedes prevus a cet effet
EP0438200A1 (fr) * 1990-01-16 1991-07-24 Centro De Ingenieria Genetica Y Biotecnologia Méthode d'expression de gènes hétérologues dans la levure Pichia pastoris, vecteurs d'expression et microorganismes transformés
US5087616A (en) * 1986-08-07 1992-02-11 Battelle Memorial Institute Cytotoxic drug conjugates and their delivery to tumor cells
US5102789A (en) * 1989-03-15 1992-04-07 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of epideramal growth factor in pichia pastoris yeast cells
US5208144A (en) * 1988-08-23 1993-05-04 The General Hospital Corporation Method for detection of human dna containing the gene encoding low density lipoprotein receptor
US5366081A (en) * 1987-08-26 1994-11-22 United States Surgical Corporation Packaged synthetic absorbable surgical elements
US5472702A (en) * 1987-08-26 1995-12-05 United States Surgical Corporation Sterilization of growth factors
EP0910569A1 (fr) * 1996-04-10 1999-04-28 Human Genome Sciences, Inc. Proteine extracellulaire/epidermique de type facteur de croissance
US5904716A (en) * 1995-04-26 1999-05-18 Gendler; El Method for reconstituting cartilage tissue using demineralized bone and product thereof
WO2001036632A2 (fr) * 1999-11-17 2001-05-25 Compugen Ltd. Variants d'epissage alternatif
US6852506B1 (en) 1996-04-10 2005-02-08 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein
EP2093241A2 (fr) 2008-01-29 2009-08-26 Confluent Surgical Inc. Copolymère séquence bioabsorbable

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046039A1 (fr) * 1980-08-05 1982-02-17 G.D. Searle & Co. Gène synthétique d'urogastrone, plasmide recombinant correspondant, cellules transformées, production de celles-ci, et expression d'urogastrone
US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046039A1 (fr) * 1980-08-05 1982-02-17 G.D. Searle & Co. Gène synthétique d'urogastrone, plasmide recombinant correspondant, cellules transformées, production de celles-ci, et expression d'urogastrone
US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
GRAY et al., Nature, Volume 303, 1983, pages 722-725 *
HOUGHTON et al., Nucleic Acids Research Volume 8, 1980, pages 2885-2894 *
RUTTER et al., CHEMICAL ABSTRACTS, Volume 101, 1984, Abstract No. 18357k, Biochem. Clin. Aspects Neuropept., Synth., Process, Gene Struct., 1983, KOCH et al., (ED.), Academic Press, Orlando, FL, pages 293-308 *
SAVAGE et al., CHEMICAL ABSTRACTS, Volume 78, 1973, Abstract No. 39662c, J. Biol. Chem., Vol 247, 1972, pages 7612-7621 *
SCOTT et al., Science, Volume 221, 1983 pages 236-240 *
See also references of EP0148922A4 *
ULLRICH et al., CHEMICAL ABSTRACTS, Volume 101, 1984, Abstract No. 18356j, Biochem. Clin. Aspects Neuropept., Synth., Process, Gene Struct., 1983, KOCH et al., (ED.), Academic Press, Orlando, FL, pages 277-291 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
AU595290B2 (en) * 1986-02-24 1990-03-29 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
US5004686A (en) * 1986-02-24 1991-04-02 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
US5087616A (en) * 1986-08-07 1992-02-11 Battelle Memorial Institute Cytotoxic drug conjugates and their delivery to tumor cells
US4717717A (en) * 1986-11-05 1988-01-05 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
WO1989001489A1 (fr) * 1987-08-10 1989-02-23 Commonwealth Scientific And Industrial Research Or Regulation de l'angiogenese et compositions et procedes prevus a cet effet
US5472702A (en) * 1987-08-26 1995-12-05 United States Surgical Corporation Sterilization of growth factors
US5366081A (en) * 1987-08-26 1994-11-22 United States Surgical Corporation Packaged synthetic absorbable surgical elements
US5208144A (en) * 1988-08-23 1993-05-04 The General Hospital Corporation Method for detection of human dna containing the gene encoding low density lipoprotein receptor
US5102789A (en) * 1989-03-15 1992-04-07 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of epideramal growth factor in pichia pastoris yeast cells
EP0438200A1 (fr) * 1990-01-16 1991-07-24 Centro De Ingenieria Genetica Y Biotecnologia Méthode d'expression de gènes hétérologues dans la levure Pichia pastoris, vecteurs d'expression et microorganismes transformés
US5904716A (en) * 1995-04-26 1999-05-18 Gendler; El Method for reconstituting cartilage tissue using demineralized bone and product thereof
EP0910569A1 (fr) * 1996-04-10 1999-04-28 Human Genome Sciences, Inc. Proteine extracellulaire/epidermique de type facteur de croissance
EP0910569A4 (fr) * 1996-04-10 2002-05-08 Human Genome Sciences Inc Proteine extracellulaire/epidermique de type facteur de croissance
US6852506B1 (en) 1996-04-10 2005-02-08 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein
WO2001036632A2 (fr) * 1999-11-17 2001-05-25 Compugen Ltd. Variants d'epissage alternatif
WO2001036632A3 (fr) * 1999-11-17 2002-01-03 Compugen Ltd Variants d'epissage alternatif
EP2093241A2 (fr) 2008-01-29 2009-08-26 Confluent Surgical Inc. Copolymère séquence bioabsorbable

Also Published As

Publication number Publication date
EP0148922A1 (fr) 1985-07-24
EP0148922A4 (fr) 1987-06-15
JPS60501737A (ja) 1985-10-17

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