UY38277A - Proceso industrial para preparar la sal sódica de 6-perdesoxi-6-per(2-carboxietil)tio-gamma-ciclodextrina (sugammadex sodio) - Google Patents
Proceso industrial para preparar la sal sódica de 6-perdesoxi-6-per(2-carboxietil)tio-gamma-ciclodextrina (sugammadex sodio)Info
- Publication number
- UY38277A UY38277A UY0001038277A UY38277A UY38277A UY 38277 A UY38277 A UY 38277A UY 0001038277 A UY0001038277 A UY 0001038277A UY 38277 A UY38277 A UY 38277A UY 38277 A UY38277 A UY 38277A
- Authority
- UY
- Uruguay
- Prior art keywords
- cyclodextrin
- gamma
- sodium
- sugammadex
- carboxyethyl
- Prior art date
Links
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 6
- 229940080345 gamma-cyclodextrin Drugs 0.000 title abstract 6
- KMGKABOMYQLLDJ-VKHHSAQNSA-F sugammadex sodium Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O([C@@H]([C@@H]([C@H]1O)O)O[C@H]2[C@H](O)[C@H]([C@@H](O[C@@H]3[C@@H](CSCCC([O-])=O)O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]3[C@@H](CSCCC([O-])=O)O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]3[C@@H](CSCCC([O-])=O)O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]3[C@@H](CSCCC([O-])=O)O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]3[C@@H](CSCCC([O-])=O)O[C@@H]([C@@H]([C@H]3O)O)O3)O[C@@H]2CSCCC([O-])=O)O)[C@H](CSCCC([O-])=O)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H]3[C@@H](CSCCC([O-])=O)O1 KMGKABOMYQLLDJ-VKHHSAQNSA-F 0.000 title abstract 6
- 229940041622 sugammadex sodium Drugs 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- -1 2-CARBOXYETHYL Chemical class 0.000 title 1
- NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 abstract 1
- DKIDEFUBRARXTE-UHFFFAOYSA-N 3-mercaptopropanoic acid Chemical compound OC(=O)CCS DKIDEFUBRARXTE-UHFFFAOYSA-N 0.000 abstract 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C68/00—Preparation of esters of carbonic or haloformic acids
- C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un proceso industrial para preparar la sal sódica de 6-perdesoxi-6-per(2-carboxietil)tio-gamma-ciclodextrina (Sugammadex sodio), que comprende: a) hacer reaccionar gamma-ciclodextrina con trifosgeno en presencia de dimetilformamida (DMF) para obtener el compuesto intermediario 6-perdesoxi-6-percloro-gamma-ciclodextrina; y b) hacer reaccionar el compuesto intemediario 6-perdesoxi-6-percloro-gamma-ciclodextrina con ácido 3-mercaptopropiónico en presencia de la base hidróxido de sodio para obtener Sugammadex sodio crudo. Accesoriamente, el compuesto intermediario 6-perdesoxi-6-percloro-gamma-ciclodextrina crudo obtenido se purifica. Adicionalmente, el proceso comprende el paso c) de purificar el Sugammadex sodio crudo por recristalización para obtener Sugammadex sodio puro. El Sugammadex sodio obtenido tiene una pureza del orden de 96-98 %.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP180103323A AR113880A1 (es) | 2018-11-14 | 2018-11-14 | PROCESO INDUSTRIAL PARA PREPARAR LA SAL SÓDICA DE 6-PERDESOXI-6-PER(2-CARBOXIETIL)TIO-g-CICLODEXTRINA (SUGAMMADEX SODIO) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY38277A true UY38277A (es) | 2020-05-29 |
Family
ID=68343555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001038277A UY38277A (es) | 2018-11-14 | 2019-06-25 | Proceso industrial para preparar la sal sódica de 6-perdesoxi-6-per(2-carboxietil)tio-gamma-ciclodextrina (sugammadex sodio) |
Country Status (8)
| Country | Link |
|---|---|
| AR (1) | AR113880A1 (es) |
| BR (1) | BR102019005482A2 (es) |
| CL (1) | CL2019001808A1 (es) |
| CR (1) | CR20190335A (es) |
| EC (1) | ECSP19058009A (es) |
| NI (1) | NI201900071A (es) |
| RU (1) | RU2019118270A (es) |
| UY (1) | UY38277A (es) |
-
2018
- 2018-11-14 AR ARP180103323A patent/AR113880A1/es unknown
-
2019
- 2019-03-20 BR BR102019005482-4A patent/BR102019005482A2/pt active Search and Examination
- 2019-06-13 RU RU2019118270A patent/RU2019118270A/ru unknown
- 2019-06-25 UY UY0001038277A patent/UY38277A/es not_active Application Discontinuation
- 2019-06-26 NI NI201900071A patent/NI201900071A/es unknown
- 2019-06-27 CL CL2019001808A patent/CL2019001808A1/es unknown
- 2019-07-18 CR CR20190335A patent/CR20190335A/es unknown
- 2019-08-13 EC ECSENADI201958009A patent/ECSP19058009A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR102019005482A2 (pt) | 2020-06-02 |
| CL2019001808A1 (es) | 2020-08-07 |
| CR20190335A (es) | 2019-09-04 |
| RU2019118270A (ru) | 2020-12-14 |
| ECSP19058009A (es) | 2021-02-26 |
| RU2019118270A3 (es) | 2021-09-17 |
| NI201900071A (es) | 2020-01-06 |
| AR113880A1 (es) | 2020-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20240522 |