ECSP19058009A - Proceso industrial para preparar la sal sódica de 6-perdesoxi-6-per(2-carboxietil)tio-gamma-ciclodextrina (sugammadex sodio) - Google Patents

Proceso industrial para preparar la sal sódica de 6-perdesoxi-6-per(2-carboxietil)tio-gamma-ciclodextrina (sugammadex sodio)

Info

Publication number
ECSP19058009A
ECSP19058009A ECSENADI201958009A ECDI201958009A ECSP19058009A EC SP19058009 A ECSP19058009 A EC SP19058009A EC SENADI201958009 A ECSENADI201958009 A EC SENADI201958009A EC DI201958009 A ECDI201958009 A EC DI201958009A EC SP19058009 A ECSP19058009 A EC SP19058009A
Authority
EC
Ecuador
Prior art keywords
cyclodextrin
gamma
sodium
sugammadex
carboxyethyl
Prior art date
Application number
ECSENADI201958009A
Other languages
English (en)
Inventor
Barry James Coyle
Brant De Carvalho Guilherme Savoi
Gustavo Ariel Revelli
Original Assignee
Triquim S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Triquim S A filed Critical Triquim S A
Publication of ECSP19058009A publication Critical patent/ECSP19058009A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un proceso industrial para preparar la sal sódica de 6-perdesoxi-6-per(2-carboxietil)tio-gamma-ciclodextrina (Sugammadex sodio), que comprende: a) hacer reaccionar gamma-ciclodextrina con trifosgeno en presencia de dimetilformamida (DMF) para obtener el compuesto intermediario 6-perdesoxi-6-percloro-gamma-ciclodextrina; y b) hacer reaccionar el compuesto intemediario 6-perdesoxi-6-percloro-gamma-ciclodextrina con ácido 3-mercaptopropiónico en presencia de la base hidróxido de sodio para obtener Sugammadex sodio crudo. Accesoriamente, el compuesto intermediario 6-perdesoxi-6-percloro-gamma-ciclodextrina crudo obtenido se purifica. Adicionalmente, el proceso comprende el paso c) de purificar el Sugammadex sodio crudo por recristalización para obtener Sugammadex sodio puro. El Sugammadex sodio obtenido tiene una pureza del orden de 96-98 %.
ECSENADI201958009A 2018-11-14 2019-08-13 Proceso industrial para preparar la sal sódica de 6-perdesoxi-6-per(2-carboxietil)tio-gamma-ciclodextrina (sugammadex sodio) ECSP19058009A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP180103323A AR113880A1 (es) 2018-11-14 2018-11-14 PROCESO INDUSTRIAL PARA PREPARAR LA SAL SÓDICA DE 6-PERDESOXI-6-PER(2-CARBOXIETIL)TIO-g-CICLODEXTRINA (SUGAMMADEX SODIO)

Publications (1)

Publication Number Publication Date
ECSP19058009A true ECSP19058009A (es) 2021-02-26

Family

ID=68343555

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201958009A ECSP19058009A (es) 2018-11-14 2019-08-13 Proceso industrial para preparar la sal sódica de 6-perdesoxi-6-per(2-carboxietil)tio-gamma-ciclodextrina (sugammadex sodio)

Country Status (8)

Country Link
AR (1) AR113880A1 (es)
BR (1) BR102019005482A2 (es)
CL (1) CL2019001808A1 (es)
CR (1) CR20190335A (es)
EC (1) ECSP19058009A (es)
NI (1) NI201900071A (es)
RU (1) RU2019118270A (es)
UY (1) UY38277A (es)

Also Published As

Publication number Publication date
NI201900071A (es) 2020-01-06
RU2019118270A (ru) 2020-12-14
BR102019005482A2 (pt) 2020-06-02
CL2019001808A1 (es) 2020-08-07
RU2019118270A3 (es) 2021-09-17
CR20190335A (es) 2019-09-04
AR113880A1 (es) 2020-06-24
UY38277A (es) 2020-05-29

Similar Documents

Publication Publication Date Title
AR118960A1 (es) Formas sólidas de ácido (2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6-(((4ar,10ar)-7-hidroxi-1-propil-1,2,3,4,4a,5,10,10a-octahidrobenzo[g]quinolin-6-il)oxi)tetrahidro-2h-piran-2-carboxílico
PE20161243A1 (es) Compuesto heterociclico fusionado
BR112022006052A2 (pt) Processo para a preparação de protioconazol
AR103230A1 (es) Procesos para la preparación de un compuesto de diariltiohidantoína
MX2020006306A (es) Método novedoso para producir 4,5-dihidroisoxazol 5,5-disustituido.
AR118647A1 (es) Proceso de preparación de 2-(3,5-diclorofenil)-6-benzoxazolcarboxilato de 1-deoxi-1-metilamino-d-glucitol
WO2020016847A3 (en) Purification process for preparation of eribulin and intermediates thereof
BR112019025195A8 (pt) análogos do peptídeo gip de ação prolongada
AR107494A1 (es) Proceso para la preparación de osimertinib (azd9291) o una sal del mismo, y “azd9291 anilina” o una sal de la misma
CL2019000016A1 (es) Procesos novedosos para preparar estimuladores de guanilato ciclasa soluble.
AR094054A1 (es) 6-cloro-3-(fenil-d₅)-inden-1-ona y uso de la misma
BR112021018733A2 (pt) Composições de d-metirosina e métodos para preparar as mesmas
MX2021006220A (es) Procesos para producir trifluoroyodometano de alta pureza.
ECSP19058009A (es) Proceso industrial para preparar la sal sódica de 6-perdesoxi-6-per(2-carboxietil)tio-gamma-ciclodextrina (sugammadex sodio)
MA20150407A1 (fr) Procédé de production d'acide peracétique à l'équilibre et acide peracétique à l'équilibre pouvant être obtenu par ce procédé
GT201100241A (es) Proceso para preparar compuestos antivirales
BR112022017283A2 (pt) Cristalização de 2?-fl
MX2021002896A (es) Proceso para preparar 1-(3,5-diclorofenil)-2,2,2-trifluoroetanona y sus derivados.
EA201990236A1 (ru) Новые способы получения стимуляторов растворимой гуанилатциклазы
BR112018067299A2 (pt) método para produção de derivado de sulfóxido
MX2019005785A (es) Proceso para la purificacion de 1-(4-clorofenil)pirazol-3-ol.
MX2018016270A (es) Produccion de anhidrido de sulfonilazida.
FR3041658B1 (fr) Procede de production de l-methionine
AR122564A1 (es) Proceso para la preparación de antranilamidas
MX2017004787A (es) Proceso para preparar trifluoroacetofenonas sustituidas con un grupo de tipo halo.