UY35159A - UK-2 BIOSYNTHETIC GEN AND METHOD FOR IMPROVING THE PRODUCTIVITY OF UK-2 USING SUCH GEN - Google Patents

UK-2 BIOSYNTHETIC GEN AND METHOD FOR IMPROVING THE PRODUCTIVITY OF UK-2 USING SUCH GEN

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Publication number
UY35159A
UY35159A UY0001035159A UY35159A UY35159A UY 35159 A UY35159 A UY 35159A UY 0001035159 A UY0001035159 A UY 0001035159A UY 35159 A UY35159 A UY 35159A UY 35159 A UY35159 A UY 35159A
Authority
UY
Uruguay
Prior art keywords
gen
biosynthetic
productivity
cluster
improving
Prior art date
Application number
UY0001035159A
Other languages
Spanish (es)
Inventor
Kobayashi Koei
Sumida Naomi
Yanai Koji
Original Assignee
Meiji Seika Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Pharma Co Ltd filed Critical Meiji Seika Pharma Co Ltd
Priority to UY0001035159A priority Critical patent/UY35159A/en
Publication of UY35159A publication Critical patent/UY35159A/en

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Método de producción de UK-2 a bajo costo. En el ADN genómico del Streptoverticillium sp. 3-7, que produce UK-2, se identificó una región que es un racimo de genes biosintéticos UK-2. Mediante hibridación, se aisló ADNs en la región, que se usó para preparar una cepa con genes interrumpidos. Se transformó el Streptoverticillium sp. 3-7 mediante un vector que contiene el racimo de genes biosintéticos UK-2 aislados, logrando mejorar su productividad entre 10 y 60 veces o más, en comparación con la de la cepa parenteral. Cada célula de los transformantes poseen 2 copias del racimo de genes biosintéticos de UK-2.UK-2 production method at low cost. In the genomic DNA of Streptoverticillium sp. 3-7, which produces UK-2, a region that is a cluster of UK-2 biosynthetic genes was identified. By hybridization, DNAs were isolated in the region, which was used to prepare a strain with interrupted genes. Streptoverticillium sp. 3-7 using a vector containing the cluster of isolated UK-2 biosynthetic genes, managing to improve their productivity between 10 and 60 times or more, compared to that of the parenteral strain. Each cell of the transformants possess 2 copies of the cluster of biosynthetic genes of UK-2.

UY0001035159A 2013-11-29 2013-11-29 UK-2 BIOSYNTHETIC GEN AND METHOD FOR IMPROVING THE PRODUCTIVITY OF UK-2 USING SUCH GEN UY35159A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
UY0001035159A UY35159A (en) 2013-11-29 2013-11-29 UK-2 BIOSYNTHETIC GEN AND METHOD FOR IMPROVING THE PRODUCTIVITY OF UK-2 USING SUCH GEN

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UY0001035159A UY35159A (en) 2013-11-29 2013-11-29 UK-2 BIOSYNTHETIC GEN AND METHOD FOR IMPROVING THE PRODUCTIVITY OF UK-2 USING SUCH GEN

Publications (1)

Publication Number Publication Date
UY35159A true UY35159A (en) 2015-05-29

Family

ID=53491696

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035159A UY35159A (en) 2013-11-29 2013-11-29 UK-2 BIOSYNTHETIC GEN AND METHOD FOR IMPROVING THE PRODUCTIVITY OF UK-2 USING SUCH GEN

Country Status (1)

Country Link
UY (1) UY35159A (en)
  • 2013

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Date Code Title Description
104 Application deemed to be withdrawn (no substantive examination fee paid)

Effective date: 20201204