UY33738A - Compuesto 8-oxo-9-[3-(1H-bencimidazol-2-iloxi)-fenil]-4,5,6,7,8,9-hexahidro-2H-pirrolo[3,4-b]quinolina-3-carboxilato de etilo, sus sales y métodos de preparación. - Google Patents

Compuesto 8-oxo-9-[3-(1H-bencimidazol-2-iloxi)-fenil]-4,5,6,7,8,9-hexahidro-2H-pirrolo[3,4-b]quinolina-3-carboxilato de etilo, sus sales y métodos de preparación.

Info

Publication number
UY33738A
UY33738A UY0001033738A UY33738A UY33738A UY 33738 A UY33738 A UY 33738A UY 0001033738 A UY0001033738 A UY 0001033738A UY 33738 A UY33738 A UY 33738A UY 33738 A UY33738 A UY 33738A
Authority
UY
Uruguay
Prior art keywords
benzimidazol
pyrrolo
hexahydro
yloxy
oxo
Prior art date
Application number
UY0001033738A
Other languages
English (en)
Inventor
Pascal Billot
Carry Jean-Christophe
Nathalie Arokiassamy
Patrick Clavieres
Clerc Francois
Crocq-Stuerga Veronique
Sylvette Lachaud
Philippe Lienard
Menegotto Jerome
Laurent Schio
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of UY33738A publication Critical patent/UY33738A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere más precisamente a una nueva sal, co-cristal y formulaciones de 8-oxo-9-[3-(1H-bencimidazol-2-iloxi)-fenil]-4,5,6,7,8,9-hexahidro-2H-pirrolo[3,4-b]quinolina-3-carboxilato de etilo de fórmula (F) a sus preparaciones y a su utilización en terapéutica, principalmente como inhibidores selectivos de las quinasas Aurora A y B, y para su utilización como anticancerosos.
UY0001033738A 2010-11-17 2011-11-17 Compuesto 8-oxo-9-[3-(1H-bencimidazol-2-iloxi)-fenil]-4,5,6,7,8,9-hexahidro-2H-pirrolo[3,4-b]quinolina-3-carboxilato de etilo, sus sales y métodos de preparación. UY33738A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1059456A FR2967413A1 (fr) 2010-11-17 2010-11-17 Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora.

Publications (1)

Publication Number Publication Date
UY33738A true UY33738A (es) 2012-06-29

Family

ID=43759999

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001033738A UY33738A (es) 2010-11-17 2011-11-17 Compuesto 8-oxo-9-[3-(1H-bencimidazol-2-iloxi)-fenil]-4,5,6,7,8,9-hexahidro-2H-pirrolo[3,4-b]quinolina-3-carboxilato de etilo, sus sales y métodos de preparación.

Country Status (5)

Country Link
AR (1) AR083901A1 (es)
FR (1) FR2967413A1 (es)
TW (1) TW201307339A (es)
UY (1) UY33738A (es)
WO (1) WO2012066486A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005018911D1 (de) * 2005-07-20 2010-03-04 Aventis Pharma Sa 1,4-Dihydropyridine-kondensierte Heterocyclen Verfahren zu deren Herstellung sowie Verwendung und Zusammensetzungen dergleichen
FR2945535B1 (fr) * 2009-05-18 2011-06-10 Sanofi Aventis Compose anticancereux et composition pharmaceutique le contenant

Also Published As

Publication number Publication date
WO2012066486A1 (en) 2012-05-24
TW201307339A (zh) 2013-02-16
AR083901A1 (es) 2013-04-10
FR2967413A1 (fr) 2012-05-18

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