UY31079A1 - Derivados de fenilaminobenceno sustituidos de utilidad para el tratamiento de trastornos y enfermedades hiperproliferativos asociados con actividad quinasa extracelular mediada por mitógenos - Google Patents

Derivados de fenilaminobenceno sustituidos de utilidad para el tratamiento de trastornos y enfermedades hiperproliferativos asociados con actividad quinasa extracelular mediada por mitógenos

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Publication number
UY31079A1
UY31079A1 UY31079A UY31079A UY31079A1 UY 31079 A1 UY31079 A1 UY 31079A1 UY 31079 A UY31079 A UY 31079A UY 31079 A UY31079 A UY 31079A UY 31079 A1 UY31079 A1 UY 31079A1
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UY
Uruguay
Prior art keywords
treatment
phenylaminobencene
mythogens
meditated
hyperproliferative disorders
Prior art date
Application number
UY31079A
Other languages
English (en)
Inventor
Guenther Judit
Petersen Kristin
Puehler Florian
Brittain Dominic
Koppitz Marcus
Hitchcock Ingo
Lobell Mario
Acualair Daniel
Dumas Jacques
Rudolph Joachim
Li Yinguf
Original Assignee
Bayer Schering Pharma Ag
Bayer Healthcare Ag
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39666034&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY31079(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag, Bayer Healthcare Ag filed Critical Bayer Schering Pharma Ag
Publication of UY31079A1 publication Critical patent/UY31079A1/es

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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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Abstract

Nuevos compuestos de fenilaminobenceno sustituidos, composiciones farmacéuticas que contienen dichos compuestos y el uso de tales compuestos o composiciones para el tratamiento de trastornos hiperproliferativos y/o de angiogcnesis, como un agente único o en combinación con otros ingredintes activos
UY31079A 2007-05-11 2008-05-09 Derivados de fenilaminobenceno sustituidos de utilidad para el tratamiento de trastornos y enfermedades hiperproliferativos asociados con actividad quinasa extracelular mediada por mitógenos UY31079A1 (es)

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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
CL2009000949A1 (es) * 2008-04-21 2010-12-24 Novartis Ag Compuestos derivados de 1,2,3,5-tetrahidro-indolizina, 6,7,8,9-tetrahidro-4h-quinolizina sustituidos, inhibidores de la actividad de cinasa de mek; su composicion farmaceutica; su uso para el tratamiento de enfermedades hiperproliferativas, tal como cancer e inflamaciones.
EP2279166A1 (en) * 2008-04-22 2011-02-02 Bayer Schering Pharma Aktiengesellschaft Substituted phenoxybenzamides
RU2579897C2 (ru) 2008-09-26 2016-04-10 Онкомед Фармасьютикалс, Инк. Агенты, связывающие рецептор "frizzled", и их применение
WO2010051933A2 (en) * 2008-11-10 2010-05-14 Bayer Schering Pharma Aktiengesellschaft Substituted sulphonamido phenoxybenzamides
US20110237592A1 (en) * 2008-11-10 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Substituted amido phenoxybenzamides
WO2011047796A1 (en) 2009-10-21 2011-04-28 Bayer Schering Pharma Aktiengesellschaft Substituted halophenoxybenzamide derivatives
JP2013508318A (ja) * 2009-10-21 2013-03-07 バイエル・ファルマ・アクチェンゲゼルシャフト 置換されたベンゾスルホンアミド誘導体
CA2777430A1 (en) 2009-10-21 2011-04-28 Bayer Pharma Aktiengesellschaft Substituted benzosulphonamides
PE20121471A1 (es) * 2009-11-04 2012-11-01 Novartis Ag Derivados de sulfonamida heterociclicos utiles como inhibidores de mek
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
WO2012055953A1 (en) 2010-10-29 2012-05-03 Bayer Pharma Aktiengesellschaft Substituted phenoxypyridines
EP2788378A4 (en) * 2011-12-09 2015-09-09 Oncomed Pharm Inc ASSOCIATION THERAPY FOR THE TREATMENT OF CANCER
CA2890003A1 (en) * 2012-10-31 2014-05-08 Toyama Chemical Co., Ltd. Amine derivatives or salt thereof as tnf"alpha"inhibitors
CN105073195A (zh) 2013-02-04 2015-11-18 昂科梅德制药有限公司 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测
JP6863742B2 (ja) * 2013-09-11 2021-04-21 ジ・アドミニストレーターズ・オブ・ザ・チューレーン・エデュケーショナル・ファンド 新規アントラニルアミドとその使用
MA55141A (fr) 2018-11-20 2021-09-29 Nflection Therapeutics Inc Composés cyanoaryl-aniline pour le traitement d'affections de la peau
MA55143A (fr) * 2018-11-20 2021-09-29 H Lee Moffitt Cancer Center & Res Institute Inc Composés aryl-aniline et hétéroaryl-aniline pour le traitement de cancers de la peau
AR121078A1 (es) 2020-01-22 2022-04-13 Chugai Pharmaceutical Co Ltd Derivados de arilamida con actividad antitumoral

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4817267B1 (es) * 1970-06-09 1973-05-28
JPH0283376A (ja) * 1988-09-19 1990-03-23 Pfizer Pharmaceut Co Ltd ベンゾオキサゾロン誘導体および抗アレルギー又は抗炎症組成物
US6310060B1 (en) * 1998-06-24 2001-10-30 Warner-Lambert Company 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
NZ518726A (en) * 2001-05-09 2004-06-25 Warner Lambert Co Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
WO2005051302A2 (en) * 2003-11-19 2005-06-09 Array Biopharma Inc. Bicyclic inhibitors of mek and methods of use thereof
CA2618218C (en) * 2005-07-21 2015-06-30 Ardea Biosciences, Inc. N-(arylamino)-sulfonamide inhibitors of mek
WO2007121269A2 (en) * 2006-04-11 2007-10-25 Ardea Biosciences, Inc. N-aryl-n'alkyl sulfamides as mek inhibitors

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US20090082328A1 (en) 2009-03-26
AR066505A1 (es) 2009-08-26
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JP5592253B2 (ja) 2014-09-17
PE20090286A1 (es) 2009-03-27

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