UY30378A1 - NEW DERIVATIVES OF PIRIDINONA N-ARIL AND N-HETEROARIL SUBSTITUTED FOR USE IN DISEASES MEDIATED BY MCH-1 - Google Patents

NEW DERIVATIVES OF PIRIDINONA N-ARIL AND N-HETEROARIL SUBSTITUTED FOR USE IN DISEASES MEDIATED BY MCH-1

Info

Publication number
UY30378A1
UY30378A1 UY30378A UY30378A UY30378A1 UY 30378 A1 UY30378 A1 UY 30378A1 UY 30378 A UY30378 A UY 30378A UY 30378 A UY30378 A UY 30378A UY 30378 A1 UY30378 A1 UY 30378A1
Authority
UY
Uruguay
Prior art keywords
mch
substituted
piridinona
heteroaril
aril
Prior art date
Application number
UY30378A
Other languages
Spanish (es)
Inventor
Oyarzabal Santamarina Julen
Macritchie Jacqueline
Dautzenberg Frank Matthias
Andres-Gil Jose Ignacio
Alcazar-Vaca Manuel Jesus
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of UY30378A1 publication Critical patent/UY30378A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invencion se refiere a derivados de piridinona de N-arilo y de N-heteroarilo sustituídos que tienen actividad antagonística hormonal concentradora de melanina (MCH), en particular MCH-1 de acuerdo con la formula general (I) una sal de adicion de base o ácida farmacéuticamente aceptable del mismo, una forma de N-oxido del mismo o una sal de amonio cuaternario del mismo. Las bondades de la invencion se describen en "descripcion de la invencion"The present invention relates to substituted N-aryl and N-heteroaryl pyridinone derivatives having melanin concentrating hormonal antagonistic activity (MCH), in particular MCH-1 according to general formula (I) an addition salt of pharmaceutically acceptable base or acid thereof, an N-oxide form thereof or a quaternary ammonium salt thereof. The benefits of the invention are described in "description of the invention"

UY30378A 2006-06-02 2007-05-31 NEW DERIVATIVES OF PIRIDINONA N-ARIL AND N-HETEROARIL SUBSTITUTED FOR USE IN DISEASES MEDIATED BY MCH-1 UY30378A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06114917 2006-06-02
EP06123263 2006-10-31

Publications (1)

Publication Number Publication Date
UY30378A1 true UY30378A1 (en) 2008-01-02

Family

ID=38266244

Family Applications (1)

Application Number Title Priority Date Filing Date
UY30378A UY30378A1 (en) 2006-06-02 2007-05-31 NEW DERIVATIVES OF PIRIDINONA N-ARIL AND N-HETEROARIL SUBSTITUTED FOR USE IN DISEASES MEDIATED BY MCH-1

Country Status (5)

Country Link
AR (1) AR061163A1 (en)
PE (1) PE20080150A1 (en)
TW (1) TW200811146A (en)
UY (1) UY30378A1 (en)
WO (1) WO2007141200A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008041090A1 (en) * 2006-10-06 2008-04-10 Pfizer Limited Malanin concentrating hormone receptor-1 antagonist pyridinones
EP2240481A1 (en) 2008-01-11 2010-10-20 Albany Molecular Research, Inc. (1-azinone) -substituted pyridoindoles as mch antagonists
US8278316B2 (en) 2009-03-09 2012-10-02 Bristol-Myers Squibb Company Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists
WO2010141539A1 (en) * 2009-06-03 2010-12-09 Glaxosmithkline Llc Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists
EP2437601A4 (en) * 2009-06-03 2012-10-31 Glaxosmithkline Llc Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2011003005A1 (en) * 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011127643A1 (en) * 2010-04-12 2011-10-20 Merck Sharp & Dohme Corp. Pyridone derivatives
WO2011130086A1 (en) * 2010-04-12 2011-10-20 Merck Sharp & Dohme Corp. Pyridone derivatives
SI2648516T1 (en) 2010-12-06 2019-01-31 Aclaris Therapeutics, Inc. Substituted pyridinone-pyridinyl compounds
US9359300B2 (en) 2010-12-06 2016-06-07 Confluence Life Sciences, Inc. Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
WO2013149362A1 (en) * 2012-04-06 2013-10-10 Glaxosmithkline Llc 1-(dihydronaphthalenyl)pyridones as melanin-concentrating hormone receptor 1 antagonists
US9434695B2 (en) 2012-07-18 2016-09-06 Sunshine Lake Pharma Co., Ltd Nitrogenous heterocyclic derivatives and their application in drugs
PL3003039T3 (en) 2013-06-07 2021-10-25 Aclaris Therapeutics, Inc. Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
US9902712B2 (en) 2013-12-19 2018-02-27 Sunshine Lake Pharma Co., Ltd. Nitrogenous heterocyclic derivatives and their application in drugs
CN107698498A (en) * 2016-08-08 2018-02-16 罗楹 A kind of preparation method of oxycodone
CN116082225A (en) * 2016-08-08 2023-05-09 北京康蒂尼药业股份有限公司 Preparation method of hydroxynisone
EP4076527A4 (en) * 2020-01-10 2024-05-15 Consynance Therapeutics, Inc. Therapeutic combinations of drugs and methods of using them
CN115484952A (en) 2020-03-27 2022-12-16 阿克拉瑞斯治疗股份有限公司 Methods, compositions, and crystalline forms of substituted pyridone-pyridyl compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2334990T3 (en) * 2002-02-14 2010-03-18 Pharmacia Corporation PIRIDINONES REPLACED AS MODULATORS OF P38 MAP QUINASA.
JPWO2005085200A1 (en) * 2004-03-05 2008-01-17 萬有製薬株式会社 Pyridone derivative
CA2619770A1 (en) * 2005-08-24 2007-03-01 Banyu Pharmaceutical Co., Ltd. Phenylpyridone derivative

Also Published As

Publication number Publication date
WO2007141200A1 (en) 2007-12-13
WO2007141200A8 (en) 2008-03-27
AR061163A1 (en) 2008-08-06
PE20080150A1 (en) 2008-04-11
TW200811146A (en) 2008-03-01

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