PE20080150A1 - PYRIDINONE DERIVATIVES N-ARIL AND N-HETEROARYL SUBSTITUTED AS ANTAGONISTS OF THE MELANIN-CONCENTRATING HORMONE (MCH) RECEPTOR - Google Patents

PYRIDINONE DERIVATIVES N-ARIL AND N-HETEROARYL SUBSTITUTED AS ANTAGONISTS OF THE MELANIN-CONCENTRATING HORMONE (MCH) RECEPTOR

Info

Publication number
PE20080150A1
PE20080150A1 PE2007000677A PE2007000677A PE20080150A1 PE 20080150 A1 PE20080150 A1 PE 20080150A1 PE 2007000677 A PE2007000677 A PE 2007000677A PE 2007000677 A PE2007000677 A PE 2007000677A PE 20080150 A1 PE20080150 A1 PE 20080150A1
Authority
PE
Peru
Prior art keywords
aril
mch
antagonists
receptor
halo
Prior art date
Application number
PE2007000677A
Other languages
Spanish (es)
Inventor
Manuel Jesus Alcazar-Vaca
Jacqueline Macritchie
Jose Ignacio Andres-Gil
Santamarina Julen Oyarzabal
Frank Matthias Dautzenberg
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20080150A1 publication Critical patent/PE20080150A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRIDINONA N-ARIL Y N-HETEROARIL SUSTITUIDOS DE FORMULA (I) DONDE A ES FENILO O PIRIDINILO; R1 Y R2 SON CADA UNO H, ALQUILO(C1-C3), ALQUILCARBONILO(C1-C3), ALQUILOXI(C1-C3)-ALQUILO(C1-C3), ENTRE OTROS; R3 ES H, HALO, CN, OH, OXO, ENTRE OTROS; R4 Y R5 SON CADA UNO H, HALO, CN, OH, AMINO, ENTRE OTROS; k Y l SON CADA UNO DE 0 A 4; m ES DE 0 A 3; Y1 E Y3 SON CADA UNO UN ENLACE SIMPLE, NR7, O, S, SO O SO2, DONDE R7 ES H O ALQUILO(C1-C3); Y2 ES UN HIDROCARBURO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALO, CN, OH, AMINO, TIO, ENTRE OTROS; B ES UN ANILLO DE 6 MIEMBROS QUE TIENE HASTA 3 ATOMOS DE N OPCIONALMENTE SUSTITUIDO CON HALO, CN, OH, OXO, TIO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA (i), (ii), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE LA HORMONA CONCENTRADORA DE MELANINA (MCH) SIENDO UTILES EN EL TRATAMIENTO DE ANSIEDAD, DEPRESION, PSICOSISREFERS TO COMPOUNDS DERIVED FROM N-ARIL AND N-HETEROARIL PYRIDINONE SUBSTITUTED FROM FORMULA (I) WHERE A IS PHENYL OR PYRIDINYL; R1 AND R2 ARE EACH H, ALKYL (C1-C3), ALKYLCARBONyl (C1-C3), ALKYLOXY (C1-C3) -ALKYL (C1-C3), AMONG OTHERS; R3 IS H, HALO, CN, OH, OXO, AMONG OTHERS; R4 AND R5 ARE EACH H, HALO, CN, OH, AMINO, AMONG OTHERS; k AND l ARE EACH FROM 0 TO 4; m IS 0 TO 3; Y1 AND Y3 ARE EACH A SIMPLE LINK, NR7, O, S, SO OR SO2, WHERE R7 IS H OR ALKYL (C1-C3); Y2 IS A HYDROCARBON (C1-C6) OPTIONALLY SUBSTITUTED WITH HALO, CN, OH, AMINO, TIO, AMONG OTHERS; B IS A RING OF 6 MEMBERS THAT HAS UP TO 3 ATOMS OF N OPTIONALLY REPLACED WITH HALO, CN, OH, OXO, TIO, AMONG OTHERS. PREFERRED COMPOUNDS ARE THE COMPOUNDS OF FORMULA (i), (ii), AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE ANTAGONISTS OF THE MELANIN CONCENTRATING HORMONE (MCH) RECEPTOR, BEING USEFUL IN THE TREATMENT OF ANXIETY, DEPRESSION, PSYCHOSIS

PE2007000677A 2006-06-02 2007-05-31 PYRIDINONE DERIVATIVES N-ARIL AND N-HETEROARYL SUBSTITUTED AS ANTAGONISTS OF THE MELANIN-CONCENTRATING HORMONE (MCH) RECEPTOR PE20080150A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06114917 2006-06-02
EP06123263 2006-10-31

Publications (1)

Publication Number Publication Date
PE20080150A1 true PE20080150A1 (en) 2008-04-11

Family

ID=38266244

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000677A PE20080150A1 (en) 2006-06-02 2007-05-31 PYRIDINONE DERIVATIVES N-ARIL AND N-HETEROARYL SUBSTITUTED AS ANTAGONISTS OF THE MELANIN-CONCENTRATING HORMONE (MCH) RECEPTOR

Country Status (5)

Country Link
AR (1) AR061163A1 (en)
PE (1) PE20080150A1 (en)
TW (1) TW200811146A (en)
UY (1) UY30378A1 (en)
WO (1) WO2007141200A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008041090A1 (en) * 2006-10-06 2008-04-10 Pfizer Limited Malanin concentrating hormone receptor-1 antagonist pyridinones
JP5501251B2 (en) 2008-01-11 2014-05-21 アルバニー モレキュラー リサーチ， インコーポレイテッド (1-Azinone) substituted pyridoindoles as MCH antagonists
EP2406233B1 (en) * 2009-03-09 2013-11-13 Bristol-Myers Squibb Company Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists
EP2437601A4 (en) * 2009-06-03 2012-10-31 Glaxosmithkline Llc Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists
WO2010141539A1 (en) * 2009-06-03 2010-12-09 Glaxosmithkline Llc Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists
EP2448585B1 (en) 2009-07-01 2014-01-01 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011127643A1 (en) * 2010-04-12 2011-10-20 Merck Sharp & Dohme Corp. Pyridone derivatives
US20120316200A1 (en) * 2010-04-12 2012-12-13 Merck Sharp & Dohme Corp. Pyridone derivatives
US9359300B2 (en) 2010-12-06 2016-06-07 Confluence Life Sciences, Inc. Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
PT2648516T (en) 2010-12-06 2018-11-29 Aclaris Therapeutics Inc Substituted pyridinone-pyridinyl compounds
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
WO2013149362A1 (en) * 2012-04-06 2013-10-10 Glaxosmithkline Llc 1-(dihydronaphthalenyl)pyridones as melanin-concentrating hormone receptor 1 antagonists
WO2014012360A1 (en) 2012-07-18 2014-01-23 Sunshine Lake Pharma Co., Ltd. Nitrogenous heterocyclic derivatives and their application in drugs
RS61724B1 (en) 2013-06-07 2021-05-31 Aclaris Therapeutics Inc Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
EP3083584B1 (en) 2013-12-19 2018-02-21 Sunshine Lake Pharma Co., Ltd. Nitrogenous heterocyclic derivatives and their application in the treatment of tissue fibrosis
CN116082225A (en) * 2016-08-08 2023-05-09 北京康蒂尼药业股份有限公司 Preparation method of hydroxynisone
CN107698498A (en) * 2016-08-08 2018-02-16 罗楹 A kind of preparation method of oxycodone
WO2021142395A1 (en) * 2020-01-10 2021-07-15 Consynance Therapeutics, Inc. Therapeutic combinations of drugs and methods of using them
BR112022019349A2 (en) 2020-03-27 2022-11-16 Aclaris Therapeutics Inc CRYSTALLINE FORM, PHARMACEUTICAL COMPOSITION, TABLET AND METHOD FOR ISOLATING A COMPOUND

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20063937B (en) * 2002-02-14 2006-10-10 Pharmacia Corp Substituted pyridinones as modulators of p38 map kinase
CN1930126A (en) * 2004-03-05 2007-03-14 万有制药株式会社 Pyridone derivative
DE602006017712D1 (en) * 2005-08-24 2010-12-02 Banyu Pharma Co Ltd PHENYLPYRIDONDERIVAT

Also Published As

Publication number Publication date
UY30378A1 (en) 2008-01-02
WO2007141200A8 (en) 2008-03-27
AR061163A1 (en) 2008-08-06
TW200811146A (en) 2008-03-01
WO2007141200A1 (en) 2007-12-13

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