UY28325A1 - Nuevos derivados de indol como inhibidores del factor xa - Google Patents

Nuevos derivados de indol como inhibidores del factor xa

Info

Publication number
UY28325A1
UY28325A1 UY28325A UY28325A UY28325A1 UY 28325 A1 UY28325 A1 UY 28325A1 UY 28325 A UY28325 A UY 28325A UY 28325 A UY28325 A UY 28325A UY 28325 A1 UY28325 A1 UY 28325A1
Authority
UY
Uruguay
Prior art keywords
factor
compounds
formula
inhibitors
factor viia
Prior art date
Application number
UY28325A
Other languages
English (en)
Inventor
Dr Marc Nazare
Dr Volkmar Wehner
Dr Kurt Ritter
Dr Volker Laux
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of UY28325A1 publication Critical patent/UY28325A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula I, en la que R0; R1; R2; R3; R4; R5; R6; R7; Q; V, G y M tienen los significados indicados en las reivindicaciones.Los compuestos de la fórmula I son compuestos farmacológicamente activos valiosos. Muestran un fuerte efecto antitrombótico y son adecuados, por ejemplo, para la terapia y profilaxis de trastornos cardiovasculares tales como enfermedades tromboembólicas o reestenosis. Son inhibidores reversibles de las enzimas de la coagulación sanguínea factor Xa (Fxa) y/o factor Vlla (FVLLA) y, en general, pueden aplicarse en situaciones en las que está presente una actividad indeseada del factor Cha ido del factor Vía o en situaciones para cuya curación o prevención se desea la inhibición del factor Xa y/o del factor Vlla. Además, la invención se refiere a procesos para la preparación de compuestos de la fórmula I, a su uso, en particular como ingredientes activos en productos farmacéuticos, y a preparaciones farmacéuticas que los contienen.
UY28325A 2003-05-19 2004-05-19 Nuevos derivados de indol como inhibidores del factor xa UY28325A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03011306A EP1479677A1 (en) 2003-05-19 2003-05-19 New indole derivatives as factor xa inhibitors

Publications (1)

Publication Number Publication Date
UY28325A1 true UY28325A1 (es) 2004-12-31

Family

ID=33040953

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28325A UY28325A1 (es) 2003-05-19 2004-05-19 Nuevos derivados de indol como inhibidores del factor xa

Country Status (15)

Country Link
US (1) US7196103B2 (es)
EP (2) EP1479677A1 (es)
JP (1) JP4676960B2 (es)
AT (1) ATE475659T1 (es)
AU (1) AU2004238495B2 (es)
BR (1) BRPI0410466A (es)
CA (1) CA2526066A1 (es)
CL (1) CL2004001074A1 (es)
DE (1) DE602004028367D1 (es)
MX (1) MXPA05012232A (es)
PA (1) PA8603601A1 (es)
PE (1) PE20050156A1 (es)
TW (1) TW200510393A (es)
UY (1) UY28325A1 (es)
WO (1) WO2004101554A1 (es)

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US7317027B2 (en) * 2003-05-19 2008-01-08 Sanofi-Aventis Deutschland Gmbh Azaindole-derivatives as factor Xa inhibitors
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US7223780B2 (en) * 2003-05-19 2007-05-29 Sanofi-Aventis Deutschland Gmbh Triazole-derivatives as blood clotting enzyme factor Xa inhibitors
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TW200920369A (en) 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
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SG190667A1 (en) 2008-05-23 2013-06-28 Panmira Pharmaceuticals Llc 5-lipoxygenase-activating protein inhibitor
MY198422A (en) 2009-04-29 2023-08-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
EP2448585B1 (en) * 2009-07-01 2014-01-01 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
US8618299B2 (en) * 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en) * 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US9073925B2 (en) * 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
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WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
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Also Published As

Publication number Publication date
PE20050156A1 (es) 2005-04-27
BRPI0410466A (pt) 2006-05-30
PA8603601A1 (es) 2004-11-26
JP4676960B2 (ja) 2011-04-27
DE602004028367D1 (de) 2010-09-09
WO2004101554A1 (en) 2004-11-25
US20050033049A1 (en) 2005-02-10
JP2006528940A (ja) 2006-12-28
US7196103B2 (en) 2007-03-27
TW200510393A (en) 2005-03-16
CA2526066A1 (en) 2004-11-25
AU2004238495B2 (en) 2010-07-22
CL2004001074A1 (es) 2005-03-28
EP1479677A1 (en) 2004-11-24
EP1633746B1 (en) 2010-07-28
MXPA05012232A (es) 2006-08-18
AU2004238495A1 (en) 2004-11-25
ATE475659T1 (de) 2010-08-15
EP1633746A1 (en) 2006-03-15

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