JO2467B1 - New indole derivatives as factor Xa inhibitors - Google Patents
New indole derivatives as factor Xa inhibitorsInfo
- Publication number
- JO2467B1 JO2467B1 JO200339A JOP20030039A JO2467B1 JO 2467 B1 JO2467 B1 JO 2467B1 JO 200339 A JO200339 A JO 200339A JO P20030039 A JOP20030039 A JO P20030039A JO 2467 B1 JO2467 B1 JO 2467B1
- Authority
- JO
- Jordan
- Prior art keywords
- factor
- compounds
- formula
- inhibitors
- factor viia
- Prior art date
Links
- 229940123583 Factor Xa inhibitor Drugs 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 108010054265 Factor VIIa Proteins 0.000 abstract 4
- 108010074860 Factor Xa Proteins 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229940012414 factor viia Drugs 0.000 abstract 4
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000001435 Thromboembolism Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to compounds of the formula I, in which R0;R1;R2 ;R3 ; R4 ; R5; R6;R7;Q; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JO200339A JO2467B1 (en) | 2003-04-08 | 2003-04-08 | New indole derivatives as factor Xa inhibitors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JO200339A JO2467B1 (en) | 2003-04-08 | 2003-04-08 | New indole derivatives as factor Xa inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO2467B1 true JO2467B1 (en) | 2009-01-20 |
Family
ID=48040990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JO200339A JO2467B1 (en) | 2003-04-08 | 2003-04-08 | New indole derivatives as factor Xa inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| JO (1) | JO2467B1 (en) |
-
2003
- 2003-04-08 JO JO200339A patent/JO2467B1/en active
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