UY27767A1 - BICYCLIC HETEROCICLES, MEDICATIONS CONTAINING THESE COMPOUNDS, THEIR EMPLOYMENT, AND PROCEDURES FOR THEIR PREPARATION. - Google Patents
BICYCLIC HETEROCICLES, MEDICATIONS CONTAINING THESE COMPOUNDS, THEIR EMPLOYMENT, AND PROCEDURES FOR THEIR PREPARATION.Info
- Publication number
- UY27767A1 UY27767A1 UY27767A UY27767A UY27767A1 UY 27767 A1 UY27767 A1 UY 27767A1 UY 27767 A UY27767 A UY 27767A UY 27767 A UY27767 A UY 27767A UY 27767 A1 UY27767 A1 UY 27767A1
- Authority
- UY
- Uruguay
- Prior art keywords
- preparation
- bicyclic
- diseases
- heterocicles
- employment
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Abstract
La presente invención se refiere a heterociclos bicíclicos de fórmula general (I) en la cual Ra, Rb, Rc, A, B, C, D, E, y X están definidos como en la reivindicación 1, sus tautómeros, sus estereoisómeros, sus mezclas y sus sales, en especial sus sales fisiológicamente tolerables con ácidos inorgánicos u orgánicos, que presentan valiosas propiedades farmacológicas, en especial una acción inhibidora sobre la transducción de senal mediada por tirosincinasas, a su empleo en el tratamiento de enfermedades, en especial enfermedades tumorales e hiperplasia benigna de próstata (BPH), enfermedades de los pulmones y de las vías respiratorias, y a su preparación.The present invention relates to bicyclic heterocycles of general formula (I) in which Ra, Rb, Rc, A, B, C, D, E, and X are defined as in claim 1, their tautomers, their stereoisomers, their mixtures and their salts, especially their physiologically tolerable salts with inorganic or organic acids, which have valuable pharmacological properties, especially an inhibitory action on the transduction of signal mediated by tyrosine kinase, for use in the treatment of diseases, especially tumor diseases and benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract, and their preparation.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10217689A DE10217689A1 (en) | 2002-04-19 | 2002-04-19 | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
UY27767A1 true UY27767A1 (en) | 2003-11-28 |
Family
ID=29224623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY27767A UY27767A1 (en) | 2002-04-19 | 2003-04-16 | BICYCLIC HETEROCICLES, MEDICATIONS CONTAINING THESE COMPOUNDS, THEIR EMPLOYMENT, AND PROCEDURES FOR THEIR PREPARATION. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1499619A1 (en) |
JP (1) | JP4527406B2 (en) |
AR (1) | AR039571A1 (en) |
AU (1) | AU2003226806A1 (en) |
CA (1) | CA2484395C (en) |
DE (1) | DE10217689A1 (en) |
PE (1) | PE20040171A1 (en) |
TW (1) | TW200408643A (en) |
UY (1) | UY27767A1 (en) |
WO (1) | WO2003089439A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE04748B1 (en) | 1999-06-21 | 2006-12-15 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocyclic compounds, drugs containing these compounds, their use and methods for their preparation |
US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
US20040044014A1 (en) | 2002-04-19 | 2004-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
WO2004006846A2 (en) | 2002-07-15 | 2004-01-22 | Exelixis, Inc. | Receptor-type kinase modulators and methods of use |
WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
CA2537812C (en) | 2003-09-26 | 2013-01-22 | Exelixis, Inc. | C-met modulators and method of use |
SI1746999T1 (en) * | 2004-05-06 | 2012-01-31 | Warner Lambert Co | 4-phenylamino-quinazolin-6-yl-amides |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
KR100832594B1 (en) * | 2005-11-08 | 2008-05-27 | 한미약품 주식회사 | Quinazoline derivatives as an multiplex inhibitor and method for the preparation thereof |
EP3173084B1 (en) | 2005-11-11 | 2019-10-23 | Boehringer Ingelheim International GmbH | Quinazoline derivatives for the treatment of cancer diseases |
AU2007299080B2 (en) | 2006-09-18 | 2013-04-18 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring EGFR mutations |
EA019959B1 (en) | 2009-01-16 | 2014-07-30 | Экселиксис, Инк. | Malate salt of n-(4-{[6,7-bis(methyloxy)quin0lin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer |
KR20120090025A (en) | 2009-07-02 | 2012-08-16 | 뉴젠 세러퓨틱스 인코포레이티드 | Phosphorus containing quinazoline compounds and methods of use |
JP5963672B2 (en) | 2009-07-06 | 2016-08-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | BIBW2992, a salt thereof and a method for drying a solid pharmaceutical preparation comprising this active ingredient |
UA108618C2 (en) | 2009-08-07 | 2015-05-25 | APPLICATION OF C-MET-MODULATORS IN COMBINATION WITH THEMOSOLOMID AND / OR RADIATION THERAPY FOR CANCER TREATMENT | |
CN102020639A (en) | 2009-09-14 | 2011-04-20 | 上海恒瑞医药有限公司 | 6-amido quinazoline or 3-cyano quinoline derivative, preparation method thereof and application of derivative to medicament |
HUE033575T2 (en) | 2011-05-26 | 2017-12-28 | Xuanzhu Pharma Co Ltd | Quinazoline derivative as tyrosine-kinase inhibitor, preparation method therefor and application thereof |
JP2014532063A (en) * | 2011-10-12 | 2014-12-04 | テリジェン リミテッドTeligene Ltd | Quinazoline derivatives as kinase inhibitors and methods of use thereof |
US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
AU2019346550A1 (en) | 2018-09-25 | 2021-04-22 | Black Diamond Therapeutics, Inc. | Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2174250T5 (en) * | 1996-04-12 | 2010-04-21 | Warner-Lambert Company Llc | IRREVERSIBLE THYROSINE KINASE INHIBITORS. |
TW436485B (en) * | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
EP2896612A1 (en) * | 1998-09-29 | 2015-07-22 | Wyeth Holdings LLC | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
CN1341104A (en) * | 1999-02-27 | 2002-03-20 | 贝林格尔英格海姆法玛公司 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases |
DE19908567A1 (en) * | 1999-02-27 | 2000-08-31 | Boehringer Ingelheim Pharma | New 4-amino-quinazoline or quinoline derivatives, are tyrosine kinase-mediated signal transduction inhibitors useful e.g. for treating tumors, polyps or respiratory or gastrointestinal diseases |
EE04748B1 (en) * | 1999-06-21 | 2006-12-15 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocyclic compounds, drugs containing these compounds, their use and methods for their preparation |
ES2280375T3 (en) * | 2000-04-08 | 2007-09-16 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | BICYCLE HETEROCICLES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCEDURE FOR PREPARATION. |
DE10017539A1 (en) * | 2000-04-08 | 2001-10-11 | Boehringer Ingelheim Pharma | New 6-acylamino-4-amino-quinazoline or quinoline derivatives, are tyrosine kinase-mediated signal transduction inhibitors useful e.g. for treating tumors or respiratory or gastrointestinal diseases |
DE10042062A1 (en) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclic heterocycles, medicaments containing these compounds, their use and methods of preparation |
DE10042061A1 (en) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
-
2002
- 2002-04-19 DE DE10217689A patent/DE10217689A1/en not_active Withdrawn
-
2003
- 2003-04-14 EP EP03746824A patent/EP1499619A1/en not_active Withdrawn
- 2003-04-14 JP JP2003586159A patent/JP4527406B2/en not_active Expired - Fee Related
- 2003-04-14 AU AU2003226806A patent/AU2003226806A1/en not_active Abandoned
- 2003-04-14 WO PCT/EP2003/003828 patent/WO2003089439A1/en active Application Filing
- 2003-04-14 CA CA2484395A patent/CA2484395C/en not_active Expired - Fee Related
- 2003-04-15 PE PE2003000384A patent/PE20040171A1/en not_active Application Discontinuation
- 2003-04-16 TW TW092108807A patent/TW200408643A/en unknown
- 2003-04-16 UY UY27767A patent/UY27767A1/en not_active Application Discontinuation
- 2003-04-16 AR ARP030101330A patent/AR039571A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AR039571A1 (en) | 2005-02-23 |
DE10217689A1 (en) | 2003-11-13 |
WO2003089439A1 (en) | 2003-10-30 |
CA2484395C (en) | 2011-11-22 |
CA2484395A1 (en) | 2003-10-30 |
EP1499619A1 (en) | 2005-01-26 |
TW200408643A (en) | 2004-06-01 |
AU2003226806A1 (en) | 2003-11-03 |
JP4527406B2 (en) | 2010-08-18 |
PE20040171A1 (en) | 2004-06-02 |
JP2005526837A (en) | 2005-09-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20150224 |