UY26505A1 - Derivados de piperazina sustituídos, su preparación y su empleo como medicamentos - Google Patents

Derivados de piperazina sustituídos, su preparación y su empleo como medicamentos

Info

Publication number
UY26505A1
UY26505A1 UY26505A UY26505A UY26505A1 UY 26505 A1 UY26505 A1 UY 26505A1 UY 26505 A UY26505 A UY 26505A UY 26505 A UY26505 A UY 26505A UY 26505 A1 UY26505 A1 UY 26505A1
Authority
UY
Uruguay
Prior art keywords
preparation
piperazine derivatives
substituted piperazine
medicines
salts
Prior art date
Application number
UY26505A
Other languages
English (en)
Inventor
Armin Heckel
Thorsten Lehmann-Lintz
Michael Mark
Leo Thomas
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of UY26505A1 publication Critical patent/UY26505A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Abstract

La presente invención se refiere a derivados de piperazina sustituidos de la fórmula general en la que Ra, Rb, Rc, Rf, X, m y n están definidos como en la reivindicación 1, a sus isómeros y a sus sales, en particular sus sales fisiológicamente compatibles, que representan valiosos inhibidores de la proteína de transferencia de triglicéridos microsomal (MTP), a medicamentos que contienen estos compuestos y a su empleo así como a su preparación.
UY26505A 1999-12-27 2000-12-26 Derivados de piperazina sustituídos, su preparación y su empleo como medicamentos UY26505A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19963234A DE19963234A1 (de) 1999-12-27 1999-12-27 Substituierte Piperazinderivate, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
UY26505A1 true UY26505A1 (es) 2001-07-31

Family

ID=7934664

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26505A UY26505A1 (es) 1999-12-27 2000-12-26 Derivados de piperazina sustituídos, su preparación y su empleo como medicamentos

Country Status (10)

Country Link
US (1) US6821967B2 (es)
EP (1) EP1255736A2 (es)
JP (1) JP4005362B2 (es)
AU (1) AU3364101A (es)
CA (1) CA2395249A1 (es)
CO (1) CO5251385A1 (es)
DE (1) DE19963234A1 (es)
MX (1) MXPA02006231A (es)
UY (1) UY26505A1 (es)
WO (1) WO2001047898A2 (es)

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* Cited by examiner, † Cited by third party
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OA12626A (en) 2001-06-28 2006-06-13 Pfizer Prod Inc triamide-substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (MTP)and/or apolipoprotein B(APO B) secretion.
US7456184B2 (en) 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
US7732451B2 (en) 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
EP1425029A4 (en) 2001-08-10 2006-06-07 Palatin Technologies Inc PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES
US7655658B2 (en) 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7625948B2 (en) 2002-02-28 2009-12-01 Japan Tobacco Inc. Ester compound and medicinal use thereof
WO2003082286A1 (en) * 2002-04-03 2003-10-09 Chemon Inc. Quinoline derivatives, their preparation and pharmaceutical compositions comprising the same
DE10232525A1 (de) * 2002-07-18 2004-01-29 Zentaris Ag Neue Anthracen-Derivate und deren Verwendung als Arzneimittel
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
WO2005021486A1 (ja) 2003-08-29 2005-03-10 Japan Tobacco Inc. エステル誘導体及びその医薬用途
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
JP2008503470A (ja) * 2004-06-17 2008-02-07 ワイス ゴナドトロピン放出ホルモン受容体アンタゴニストの製造法
WO2006009734A1 (en) 2004-06-17 2006-01-26 Wyeth Gonadotropin releasing hormone receptor antagonists
US8101774B2 (en) 2004-10-18 2012-01-24 Japan Tobacco Inc. Ester derivatives and medicinal use thereof
CA2587853A1 (en) * 2004-11-23 2006-06-01 Wyeth Gonadotropin releasing hormone receptor antagonists
US7534796B2 (en) * 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) * 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US20060189619A1 (en) * 2005-02-24 2006-08-24 Wyeth 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) * 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
US7803778B2 (en) 2006-05-23 2010-09-28 Theracos, Inc. Glucose transport inhibitors and methods of use
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
WO2008085842A1 (en) * 2007-01-04 2008-07-17 Interdigital Technology Corporation Node b based segmentation/concatenation
CN101790311B (zh) 2007-08-23 2014-04-23 泰拉科斯有限公司 苄基苯衍生物及使用方法
EP2312944B1 (en) * 2008-07-15 2018-09-05 Theracos, Inc. Deuterated benzylbenzene derivatives and methods of use
WO2011153712A1 (en) 2010-06-12 2011-12-15 Theracos, Inc. Crystalline form of benzylbenzene sglt2 inhibitor
WO2012018950A1 (en) 2010-08-03 2012-02-09 Beth Israel Deaconess Medical Center Methods and compositions for treatment of metabolic disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4397855A (en) 1981-06-26 1983-08-09 Warner-Lambert Company 4-(Substituted)-α, α-dimethyl-1-piperazine pentanoic acids and derivatives as anti-arteriosclerotic agents and method
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
PL328094A1 (en) * 1996-01-16 1999-01-04 Bristol Myers Squibb Co Conformingly restricted aromatic inhibitors triglycerides carrying chromosome protein and method of obtaining such inhibitors
EP1180514A4 (en) * 1999-04-09 2003-02-26 Meiji Seika Kaisha NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND BENAMID DERIVATIVES, AND THEIR MEDICINAL PRODUCTS
DE19945594A1 (de) * 1999-09-23 2001-03-29 Boehringer Ingelheim Pharma Substituierte Piperazinderivate, ihre Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
AU3364101A (en) 2001-07-09
MXPA02006231A (es) 2002-12-05
US20030166637A1 (en) 2003-09-04
JP4005362B2 (ja) 2007-11-07
WO2001047898A3 (de) 2002-04-04
DE19963234A1 (de) 2002-01-24
US6821967B2 (en) 2004-11-23
JP2003521484A (ja) 2003-07-15
EP1255736A2 (de) 2002-11-13
CO5251385A1 (es) 2003-02-28
WO2001047898A2 (de) 2001-07-05
CA2395249A1 (en) 2001-07-05

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20120524