UY26045A1 - "comuestos de 1,2,3,4-tetrahidro-1-naftalenamina útiles en terapia." - Google Patents

"comuestos de 1,2,3,4-tetrahidro-1-naftalenamina útiles en terapia."

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Publication number
UY26045A1
UY26045A1 UY26045A UY26045A UY26045A1 UY 26045 A1 UY26045 A1 UY 26045A1 UY 26045 A UY26045 A UY 26045A UY 26045 A UY26045 A UY 26045A UY 26045 A1 UY26045 A1 UY 26045A1
Authority
UY
Uruguay
Prior art keywords
alkyl
optionally substituted
independently represent
represent
naphthalenamine
Prior art date
Application number
UY26045A
Other languages
English (en)
Inventor
Donald Stuart Middleton
Alan Stoibe
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9904691.4A external-priority patent/GB9904691D0/en
Priority claimed from GBGB9921314.2A external-priority patent/GB9921314D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of UY26045A1 publication Critical patent/UY26045A1/es

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    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
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    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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Abstract

La invención proporciona compuestos de fórmula (i), en la que r1 y r2 representan independientemente h o alquilo c1-6; r3 representa fenilo sustituido con al menos un grupo seleccionado de entre halo, cf3,ocf3,cn,oh, alquilo c1-6 y alcoxi c1-6 y r4,r5,y r11 representan independientemente h o -(ch2)n-a, representando n 0, 1o 2, con la condición de que al menos uno de r4,r5 y r11 sea distinto de h; a representa conr6r7 o so2nr6r7, en los que r6 y r7 representan independientemente h, cicloalquilo c3-6 o alquilo c1-6, estando el grupo alquilo c1-6 opcionalmente sustituido, y además, r6 y r7, junto con el átomo de n al que están unidos representan un anillo que está opcionalmente sustituido; c02r8, en el que r8 representa h o alquilo c1-6; nr9r10, en el que r9 y r10 representan independientemente h, alquilo c1-6 (opcionalmente sustituido),(alquilo c1-6)so2-, (alquilo c1-6)concedida-, h2nso2- o h2nco-; un anillo heterocíclico de 5 o 6 miembros que contiene 1, 2 o 3 heteroátomos seleccionados entre n, s y o, que está opcionalmente sustituido; S(o)x (alquilo c1-6), el que x representa 0, 1o2;oh;Cn;no2 o alcoxi c1-6 que está opcionalmente sustituido; con la condición de que cuando nr1r2 representa n(h)metilo, r4 representa h y r3 representa 4-clorofenilo, entonces r5 no representa metoxi; y sales farmacéuticamente aceptables del mismo. Los compuestos de la invención son útiles en el tratamiento o prevención de una diversidad de trastornos, incluyendo aquellos en los que está implicada la regulación de la función del transportador de monoamina.
UY26045A 1999-03-01 2000-02-29 "comuestos de 1,2,3,4-tetrahidro-1-naftalenamina útiles en terapia." UY26045A1 (es)

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US4940731A (en) * 1989-08-30 1990-07-10 Pfizer Inc. Method of treating premature ejaculation using sertraline
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DE60021859D1 (de) 2005-09-15
CO5170504A1 (es) 2002-06-27
BR0009238A (pt) 2001-11-20
AU2315400A (en) 2000-09-21
JP2002538134A (ja) 2002-11-12

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