UY26045A1 - "comuestos de 1,2,3,4-tetrahidro-1-naftalenamina útiles en terapia." - Google Patents

"comuestos de 1,2,3,4-tetrahidro-1-naftalenamina útiles en terapia."

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Publication number
UY26045A1
UY26045A1 UY26045A UY26045A UY26045A1 UY 26045 A1 UY26045 A1 UY 26045A1 UY 26045 A UY26045 A UY 26045A UY 26045 A UY26045 A UY 26045A UY 26045 A1 UY26045 A1 UY 26045A1
Authority
UY
Uruguay
Prior art keywords
alkyl
optionally substituted
independently represent
represent
naphthalenamine
Prior art date
Application number
UY26045A
Other languages
English (en)
Inventor
Donald Stuart Middleton
Alan Stoibe
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9904691.4A external-priority patent/GB9904691D0/en
Priority claimed from GBGB9921314.2A external-priority patent/GB9921314D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of UY26045A1 publication Critical patent/UY26045A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
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    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
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Abstract

La invención proporciona compuestos de fórmula (i), en la que r1 y r2 representan independientemente h o alquilo c1-6; r3 representa fenilo sustituido con al menos un grupo seleccionado de entre halo, cf3,ocf3,cn,oh, alquilo c1-6 y alcoxi c1-6 y r4,r5,y r11 representan independientemente h o -(ch2)n-a, representando n 0, 1o 2, con la condición de que al menos uno de r4,r5 y r11 sea distinto de h; a representa conr6r7 o so2nr6r7, en los que r6 y r7 representan independientemente h, cicloalquilo c3-6 o alquilo c1-6, estando el grupo alquilo c1-6 opcionalmente sustituido, y además, r6 y r7, junto con el átomo de n al que están unidos representan un anillo que está opcionalmente sustituido; c02r8, en el que r8 representa h o alquilo c1-6; nr9r10, en el que r9 y r10 representan independientemente h, alquilo c1-6 (opcionalmente sustituido),(alquilo c1-6)so2-, (alquilo c1-6)concedida-, h2nso2- o h2nco-; un anillo heterocíclico de 5 o 6 miembros que contiene 1, 2 o 3 heteroátomos seleccionados entre n, s y o, que está opcionalmente sustituido; S(o)x (alquilo c1-6), el que x representa 0, 1o2;oh;Cn;no2 o alcoxi c1-6 que está opcionalmente sustituido; con la condición de que cuando nr1r2 representa n(h)metilo, r4 representa h y r3 representa 4-clorofenilo, entonces r5 no representa metoxi; y sales farmacéuticamente aceptables del mismo. Los compuestos de la invención son útiles en el tratamiento o prevención de una diversidad de trastornos, incluyendo aquellos en los que está implicada la regulación de la función del transportador de monoamina.
UY26045A 1999-03-01 2000-02-29 "comuestos de 1,2,3,4-tetrahidro-1-naftalenamina útiles en terapia." UY26045A1 (es)

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ATE301636T1 (de) 2005-08-15
TNSN00037A1 (fr) 2005-11-10
CA2365032A1 (en) 2000-09-08
WO2000051972A8 (en) 2001-03-15
PA8491601A1 (es) 2001-04-30
PE20001497A1 (es) 2001-01-03
EP1157002A1 (en) 2001-11-28
ES2245639T3 (es) 2006-01-16
WO2000051972A1 (en) 2000-09-08
EP1157002B1 (en) 2005-08-10
DE60021859T2 (de) 2006-06-01
MA26724A1 (fr) 2004-12-20
GT200000024A (es) 2001-08-22
DE60021859D1 (de) 2005-09-15
CO5170504A1 (es) 2002-06-27
BR0009238A (pt) 2001-11-20
AU2315400A (en) 2000-09-21
JP2002538134A (ja) 2002-11-12

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