UY25702A1 - Desnaturalizantes para las sales aminas simpaticomiméticas - Google Patents
Desnaturalizantes para las sales aminas simpaticomiméticasInfo
- Publication number
- UY25702A1 UY25702A1 UY25702A UY25702A UY25702A1 UY 25702 A1 UY25702 A1 UY 25702A1 UY 25702 A UY25702 A UY 25702A UY 25702 A UY25702 A UY 25702A UY 25702 A1 UY25702 A1 UY 25702A1
- Authority
- UY
- Uruguay
- Prior art keywords
- hydrochloride
- inhibitor
- water
- sympathomimetic amine
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Composiciones farmacéuticas que comprenden una sal amina simpaticomimética (particularmente seleccionada del grupo compuesto por clorhidrato de pseudoefedrina, sulfato de pseudoefedrina, clorhidrato de efedrina, y clorhidrato de fenilpropanilamina) y al menos un inhibidor de combinación (particularmente seleccionado de sales de metal de transición y polímeros amino), donde dicho inhibidor de combinación en cantidades suficientes actúa tanto para interferir con el aislamiento de la amina simpaticomimética de la composición en otros compuestos farmacológicamente activos (especialmente seleccionados del grupo que consta de matanfetamina, anfetamina, metcatinona, y catinona) sin alterar significativamente la liberación de dicha composición farmacéutica en comparación con la composición no desnaturalizada; que además puede comprender un inhibidor de reacción (como por ejemplo compuestos polihidroxi insolubles en agua, compuestos polihidroxino no poliméricos solubles en agua y compuestos de éster solubles en éster) y/o un inhibidor de separación (seleccionado de celulosa soluble en agua, gomas polisacáridas, polímeros de óxido de polietileno, pólimeros de ácido acrílico, almidones, silicatos de aluminio y magnesio, polivinilpirrolidonas y arcillas). Por ejemplo las sales ácidas de las aminas simpatiocoiméticas, como el clorhidrato de la pseudoefedrina, actúan causando que las terminaciones nerviosas adrenérgicas liberan norepinefrina, estimulando los receptores alfa y beta de la norepinefrina, especialmente del tracto respiratorio superior.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9971298P | 1998-09-10 | 1998-09-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25702A1 true UY25702A1 (es) | 1999-11-17 |
Family
ID=22276270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25702A UY25702A1 (es) | 1998-09-10 | 1999-09-09 | Desnaturalizantes para las sales aminas simpaticomiméticas |
Country Status (22)
Country | Link |
---|---|
US (4) | US6359011B1 (es) |
EP (1) | EP1112089A1 (es) |
JP (1) | JP2002524534A (es) |
KR (1) | KR20010075021A (es) |
CN (1) | CN1201822C (es) |
AR (1) | AR032730A1 (es) |
AU (2) | AU771194B2 (es) |
BR (1) | BR9913575A (es) |
CA (1) | CA2339354A1 (es) |
CO (1) | CO5280050A1 (es) |
CR (1) | CR6106A (es) |
GT (1) | GT199900148A (es) |
HK (1) | HK1039898A1 (es) |
HN (1) | HN1999000156A (es) |
MY (1) | MY117971A (es) |
NZ (1) | NZ510012A (es) |
PA (1) | PA8481601A1 (es) |
PE (1) | PE20001034A1 (es) |
SV (1) | SV1999000148A (es) |
TW (1) | TW550071B (es) |
UY (1) | UY25702A1 (es) |
WO (1) | WO2000015261A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GT199900148A (es) * | 1998-09-10 | 2001-02-28 | Desnaturalizantes para las sales aminas simpaticomimeticas. | |
AU7105501A (en) * | 2000-07-17 | 2002-01-30 | Yamanouchi Pharma Co Ltd | Pharmaceutical composition improved in peroral absorbability |
US7736670B2 (en) * | 2000-11-30 | 2010-06-15 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
ITMI20021074A1 (it) * | 2002-05-20 | 2003-11-20 | Actimex S R L | Composizione ternaria comprendente una sostanza attiva e processo di comacinazione per la sua preparazione |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
US20050220877A1 (en) * | 2004-03-31 | 2005-10-06 | Patel Ashish A | Bilayer tablet comprising an antihistamine and a decongestant |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102004045037A1 (de) * | 2004-09-15 | 2006-03-16 | Basf Ag | Pharmazeutische Darreichungsformen mit erschwerter Extrahierbarkeit eines Sympathomimetikums aus der Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
ATE493118T1 (de) * | 2006-01-19 | 2011-01-15 | Dow Global Technologies Inc | Biologisch wirksame zusammensetzung mit ethylcellulose |
US9238073B2 (en) | 2006-04-12 | 2016-01-19 | Wyeth Llc | Pharmaceutical composition containing sympathomimetic amine salt and co-distillable additive |
US8273798B2 (en) * | 2007-06-04 | 2012-09-25 | Shear Kershman Laboratories | Tamper resistant lipid-based oral dosage form for opioid agonists |
AU2008280801B2 (en) * | 2007-07-23 | 2014-03-06 | Kingsway Pharmaceuticals Inc. | Therapeutic formulations for the treatment of cold and flu-like symptoms |
MX2010004178A (es) | 2007-10-19 | 2010-05-03 | Otsuka Pharma Co Ltd | Preparacion farmaceutica solida de tipo matriz. |
BR112012001466A2 (pt) | 2009-07-22 | 2020-08-11 | Grünenthal GmbH | forma de dosagem resistente à falsificação para opioides sensíveis à oxidação, seu processo de fabricação, e embalagem |
US8901113B2 (en) * | 2009-09-30 | 2014-12-02 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
CA2839123A1 (en) | 2011-07-29 | 2013-02-07 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
MX348054B (es) | 2011-07-29 | 2017-05-25 | Gruenenthal Gmbh | Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco. |
WO2013036567A2 (en) * | 2011-09-07 | 2013-03-14 | Johnson Brent A | Methods, compositions, and compounds for the reduction of illegal methamphetamine production |
WO2013089986A1 (en) * | 2011-12-12 | 2013-06-20 | Product And Technology Partners Llc | Improved denaturants for sympathomimetic amines |
CA2880163A1 (en) * | 2012-08-01 | 2014-02-06 | Acura Pharmaceuticals, Inc. | Stabilization of one-pot methamphetamine synthesis systems |
AU2013352162B2 (en) | 2012-11-30 | 2018-08-16 | Acura Pharmaceuticals, Inc. | Self-regulated release of active pharmaceutical ingredient |
AU2014284333B2 (en) * | 2013-07-03 | 2017-03-16 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
KR20160031526A (ko) | 2013-07-12 | 2016-03-22 | 그뤼넨탈 게엠베하 | 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형 |
BR112016010482B1 (pt) | 2013-11-26 | 2022-11-16 | Grünenthal GmbH | Preparação de uma composição farmacêutica em pó por meio de criomoagem |
AU2015237721B2 (en) | 2014-03-26 | 2018-04-26 | Sun Pharma Advanced Research Company Ltd. | Abuse deterrent immediate release coated reservoir solid dosage form |
WO2017040607A1 (en) | 2015-08-31 | 2017-03-09 | Acura Pharmaceuticals, Inc. | Methods and compositions for self-regulated release of active pharmaceutical ingredient |
US10842750B2 (en) * | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
TW202002957A (zh) | 2018-02-09 | 2020-01-16 | 德商歌林達有限公司 | 包含轉化抑制劑之麻黃素及其衍生物之抗損壞調配物 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3169092A (en) | 1963-09-26 | 1965-02-09 | Richardson Merrell Inc | Stabilization of amines by tartrazine and bisulfite |
US3546142A (en) * | 1967-01-19 | 1970-12-08 | Amicon Corp | Polyelectrolyte structures |
US3773920A (en) * | 1971-07-14 | 1973-11-20 | Nikken Chemicals Co Ltd | Sustained release medicinal composition |
GB1593261A (en) | 1976-07-23 | 1981-07-15 | Inveresk Res Int | Controlled release suppository |
RO68771A2 (ro) * | 1976-08-25 | 1980-08-15 | Intreprinderea De Medicamente,Ro | Unguent antipruriginos si sicativ |
SU1146046A1 (ru) | 1983-11-11 | 1985-03-23 | Центральный Ордена Ленина Институт Усовершенствования Врачей | Состав дл ретракции десны |
US4493827A (en) | 1983-11-14 | 1985-01-15 | Ronald Valle | Method of inducing sleep |
US4601894A (en) * | 1985-03-29 | 1986-07-22 | Schering Corporation | Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate |
US4657757A (en) | 1985-03-29 | 1987-04-14 | Schering Corporation | Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate |
US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
US5026560A (en) * | 1987-01-29 | 1991-06-25 | Takeda Chemical Industries, Ltd. | Spherical granules having core and their production |
US4894239A (en) | 1987-06-02 | 1990-01-16 | Takeda Chemical Industries, Ltd. | Sustained-release preparation and production thereof |
ZA904021B (en) | 1989-11-24 | 1991-02-27 | Van Der Linde Leon | Slimming preparations |
CA2068402C (en) | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
US5407686A (en) | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
US5518730A (en) * | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
EP1166801A1 (en) | 1993-06-04 | 2002-01-02 | Warner-Lambert Company | Preparations containing silicon dioxide to improve the taste thereof |
US5543405A (en) * | 1993-10-22 | 1996-08-06 | Keown; Wendy J. | Composition and method for weight reduction and long term management of obesity |
AUPM814994A0 (en) | 1994-09-14 | 1994-10-06 | Sterling Winthrop Inc. | Codeine-containing formulations |
US5529783A (en) | 1994-12-19 | 1996-06-25 | Mcneil-Ppc, Inc. | Rotor granulation and coating of acetaminophen, pseudoephedrine, chlorpheniramine, and, optionally dextromethorphan |
US5626878A (en) | 1995-01-10 | 1997-05-06 | Warner Lambert Company | Reduction of electrostatic forces between magnesium trisilicate adsorbates |
CA2250010C (en) | 1996-04-10 | 2008-06-10 | Warner-Lambert Company | Denaturants for sympathomimetic amine salts |
GT199900148A (es) * | 1998-09-10 | 2001-02-28 | Desnaturalizantes para las sales aminas simpaticomimeticas. |
-
1999
- 1999-09-07 GT GT199900148A patent/GT199900148A/es unknown
- 1999-09-08 US US09/391,739 patent/US6359011B1/en not_active Expired - Lifetime
- 1999-09-08 MY MYPI99003873A patent/MY117971A/en unknown
- 1999-09-09 AU AU59157/99A patent/AU771194B2/en not_active Ceased
- 1999-09-09 HN HN1999000156A patent/HN1999000156A/es unknown
- 1999-09-09 CR CR6106A patent/CR6106A/es not_active Application Discontinuation
- 1999-09-09 CN CNB998107565A patent/CN1201822C/zh not_active Expired - Fee Related
- 1999-09-09 PE PE1999000908A patent/PE20001034A1/es not_active Application Discontinuation
- 1999-09-09 SV SV1999000148A patent/SV1999000148A/es not_active Application Discontinuation
- 1999-09-09 CA CA002339354A patent/CA2339354A1/en not_active Abandoned
- 1999-09-09 CO CO99057123A patent/CO5280050A1/es not_active Application Discontinuation
- 1999-09-09 PA PA19998481601A patent/PA8481601A1/es unknown
- 1999-09-09 BR BR9913575-2A patent/BR9913575A/pt not_active Application Discontinuation
- 1999-09-09 KR KR1020017003081A patent/KR20010075021A/ko not_active Application Discontinuation
- 1999-09-09 JP JP2000569845A patent/JP2002524534A/ja active Pending
- 1999-09-09 AR ARP990104527A patent/AR032730A1/es unknown
- 1999-09-09 EP EP99946837A patent/EP1112089A1/en not_active Withdrawn
- 1999-09-09 WO PCT/US1999/020708 patent/WO2000015261A1/en not_active Application Discontinuation
- 1999-09-09 UY UY25702A patent/UY25702A1/es not_active Application Discontinuation
- 1999-09-09 NZ NZ510012A patent/NZ510012A/xx unknown
- 1999-09-10 TW TW088115613A patent/TW550071B/zh not_active IP Right Cessation
-
2001
- 2001-11-20 US US09/996,438 patent/US20020082304A1/en not_active Abandoned
-
2002
- 2002-02-26 HK HK02101442.0A patent/HK1039898A1/zh unknown
-
2004
- 2004-06-18 AU AU2004202702A patent/AU2004202702B2/en not_active Ceased
-
2005
- 2005-07-20 US US11/186,681 patent/US20050256194A1/en not_active Abandoned
-
2006
- 2006-06-02 US US11/445,967 patent/US20060216268A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ510012A (en) | 2002-11-26 |
US20020082304A1 (en) | 2002-06-27 |
WO2000015261A1 (en) | 2000-03-23 |
HN1999000156A (es) | 2003-08-01 |
CA2339354A1 (en) | 2000-03-23 |
PE20001034A1 (es) | 2000-10-18 |
KR20010075021A (ko) | 2001-08-09 |
HK1039898A1 (zh) | 2002-05-17 |
US20050256194A1 (en) | 2005-11-17 |
JP2002524534A (ja) | 2002-08-06 |
TW550071B (en) | 2003-09-01 |
US6359011B1 (en) | 2002-03-19 |
AU5915799A (en) | 2000-04-03 |
CO5280050A1 (es) | 2003-05-30 |
CN1316911A (zh) | 2001-10-10 |
AR032730A1 (es) | 2003-11-26 |
PA8481601A1 (es) | 2001-04-30 |
US20060216268A1 (en) | 2006-09-28 |
MY117971A (en) | 2004-08-30 |
CR6106A (es) | 2003-12-05 |
CN1201822C (zh) | 2005-05-18 |
BR9913575A (pt) | 2001-05-22 |
GT199900148A (es) | 2001-02-28 |
SV1999000148A (es) | 2000-09-11 |
AU2004202702B2 (en) | 2007-11-22 |
EP1112089A1 (en) | 2001-07-04 |
AU2004202702A1 (en) | 2004-07-15 |
AU771194B2 (en) | 2004-03-18 |
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