USRE46208E1 - Method for cryogenically treating tissue below the skin surface - Google Patents
Method for cryogenically treating tissue below the skin surface Download PDFInfo
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- USRE46208E1 USRE46208E1 US13/165,181 US201113165181A USRE46208E US RE46208 E1 USRE46208 E1 US RE46208E1 US 201113165181 A US201113165181 A US 201113165181A US RE46208 E USRE46208 E US RE46208E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B18/0218—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques with open-end cryogenic probe, e.g. for spraying fluid directly on tissue or via a tissue-contacting porous tip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
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- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
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- A—HUMAN NECESSITIES
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- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
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- A—HUMAN NECESSITIES
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- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00084—Temperature
- A61B2017/00092—Temperature using thermocouples
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- A61B2017/00681—Aspects not otherwise provided for
- A61B2017/00734—Aspects not otherwise provided for battery operated
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- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
- A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
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- A61B2018/00452—Skin
- A61B2018/00458—Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
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- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0237—Characteristics of handpieces or probes with a thermoelectric element in the probe for cooling purposes
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- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/06—Measuring instruments not otherwise provided for
- A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
- A61B2090/065—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension for measuring contact or contact pressure
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A61N2005/002—Cooling systems
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- A—HUMAN NECESSITIES
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- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0644—Handheld applicators
Definitions
- 11/250,139 is hereby incorporated by reference herein in its entirely for all purposes. Notice: More than one reissue application has been filed for the reissue of U.S. Pat. No. 6,632,219.
- the reissue applications are Reissue application Ser. No. 11/250,139 (now U.S. Pat. No. Re. 42,594), continuation Reissue application Ser. No. 13/165,153 (now U.S. Pat. No. Re. 43,881), and continuation Reissue application Ser. No. 13,165,181 (the present application), all of which are reissues of U.S. Pat. No. 6,632,219.
- Cryogenic spray directly to the skin may reduce a skin temperature below 0 C but can freeze the skin and cause significant damage to it.
- Typical cold contacting windows of the prior art utilize ice water at 0 C can cool the surface of the skin to as low as about 4 C. But prior art ice water cooled cold contact window devices are inadequate to remove enough heat to prevent unwanted surface tissue damage in many applications.
- the present invention provides a laser treatment device and process with controlled cooling.
- the device contains a cooling element with high heat conduction properties, which is transparent to the laser beam.
- a surface of the cooling element is held in contact with the tissue being treated while at least one other surface of the cooling element is cooled by the evaporation of a cryogenic fluid.
- the cooling is coordinated with the application of the laser beam so as to control the temperatures of all affected layers of tissues.
- the cooling element is a sapphire plate.
- a cryogenic spray cools the top surface of the plate and the bottom surface of the plate is in contact with the skin.
- the wavelength of the laser beam is chosen so that absorption in targeted tissue is low enough so that substantial absorption occurs throughout the targeted tissue.
- Applicants use an Er:Glass laser with a wavelength of 1.54 microns.
- a cooling rod is used. A first surface is in contact with the skin surface being treated and an opposite surface is contained in an anticondensation oil chamber that is optically connected to a laser beam delivering fiber optic cable.
- the temperature of the rod is monitored with a thermocouple which provides a feedback signal to a processor which controls the cooling and the laser power to provide proper regulation of temperatures at all affected tissue layers.
- the device may be used for treating port wine stains especially those stains involving relatively deep larger blood vessels which as indicated in the Background section are not well treated with photothermalyses techniques using highly preferentially absorbed wavelengths of about 530 nm and 575 to 590 nm.
- FIG. 1 is a drawing of the cooling rod hand piece for the subsurface light energy delivery with circumferential cooling of the cooling rod.
- FIG. 1A shows the device being used to coagulate a large blood vessel.
- FIGS. 2 is a time graph showing temperature changes below the skin surface.
- FIGS. 3A and 3B show a partially masked cooling rod.
- FIG. 4 shows a rod with the lens-type tip surface.
- FIGS. 5A and 5B is a second preferred embodiment.
- FIG. 6A and 6B show a drawing of the horizontally positioned cooling rod.
- FIGS. 7 A 1 - 7 and 7 B 1 - 7 are temperature profile charts.
- FIGS. 8A and 8B show the effect of two different wavelength beams on a blood vessel.
- FIG. 8C shows blood vessel coagulation
- FIG. 9 is a drawing of a preferred embodiment using a plate-type cooling element with non-circumferential cooling of the cooling element.
- FIGS. 10A and 10B show a preferred embodiment of the present invention.
- the laser beam is provided by an Er:Glass pulse laser producing 25 Joule 2 ms pulses at a wavelength of 1.54 microns and at pulse rates of 1 Hz or 0.5 Hz.
- the spot size is about 7 mm2.
- the laser output is adjusted to provide energy fluence on the skin surface of about 25J/cm2 per pulse. With a spot size of 7 mm2, the energy per pulse is about 1.7J.
- a thermocouple 8 is insulated from rod 16 and senses the temperature of the skin surface and provides a feedback signal to processor 30 which controls delivery of the cryogen spray via actuator 5 and the laser pulses through the laser controls (not shown). Also shown on FIG. 1 is “ready” light 7 and battery 6 which powers the light and the thermocouple.
- FIG. 1 also shows a section of human skin including epidermis E, dermis D and a subcutaneous fat SCF.
- the section of skin is first cleaned with alcohol to remove moisture to prevent a condensation on the contacting surface of the rod and in order to dehydrate the skin surface to reduce the epidermal damage from the light interaction with water.
- the valve of the nozzle is opened the cryogen coolant is sprayed micro drops into the cooling chamber.
- the cryogenic mist flows around the sapphire.
- the micro drops contact the rod and vaporize from the surface of the rod by the rod heat reducing the rod temperature dramatically fast.
- the whole rod becomes cold almost instantly because of the high thermoconductivity of sapphire.
- the sapphire rod cools the surface of the skin by heat exchange.
- a preferred application of the device shown in FIG. 1 is for spider vein removal.
- the operator presses the tip of the device against the skin as shown in FIG. 1 and presses the on button.
- the processor opens valve 12 permitting cryogen flow.
- the processor 30 monitors the skin temperature via thermocouple 8 and assures that the skin temperature is not below 0 C for more than 1 second.
- processor 30 determines that the temperature of the surface has dropped to a desired low temperature at a desired rate, such as ⁇ 15 C in a time period of 0.30 to 0.40 seconds, the “lasing” light indicator is switched-on and the processor will direct the laser to fire a pulse.
- the energy of the 1.7J pulse is dissipated in a distance of about 1.0 mm.
- FIG. 2 shows graphs of the temperature of the skin at points 100 microns below the skin surface (near the bottom boundary of the epidermis) and 400 microns below the surface of the skin (at the center of a 200 micron diameter spider vein) during the above described process.
- the reader should note that the tissue at a depth of 100 microns is below 0 C for about 100 milliseconds and that the tissue at 400 microns is above 70 C for about 100 milliseconds. It is well known that tissue is not adversely affected by subfreezing temperatures in this range until the time periods are more than about 500 ms. On the other hand, however temperatures in excess of 70 degrees for about 10 ms will coagulate the tissue.
- thermocouple 8 indicates an excessive temperature which in this procedure would be about 60 C.
- the thermocouple 8 is preferably calibrated to the temperature of the skin located in one millimeter from the rod edge. The difference between the temperature of the skin under the rod and in 1 mm from the rod edge is varied from 10 C to 20 C and depending upon the rod design. Applicant has performed computer simulations to determine temperature profiles in the case of laser treatments, at wavelengths of 585 nm, 632 nm, 1064 nm, 1340 nm, and 1540 nm, with and without surface cooling. FIGS.
- FIGS. 7 A 1 - 7 show the effects of a 20J/cm 2 , 0.54 mm diameter blood vessel, and 0.5 mm below the skin surface, with no surface cooling.
- FIGS. 7 B 1 - 7 represent similar conditions with surface cooling with a ⁇ 15° C. sapphire glass rod for 0.5 sec. These simulations show the advantages of the Nd:YAG at 1064 nm, the Nd:YAP at 1340 nm and the Er:Glass at 1540 nm as compared to the shorter wavelength lasers that are more highly absorptive in blood. This effect is seen clearly by comparing FIG. 8A to FIG. 8B . As shown in FIG.
- FIG. 8A shows the 585 nm pulse coagulates blood at the top of the vessel but does not penetrate sufficiently to coagulate blood deeper in the vessel.
- the 1540 nm pulse provides substantially uniform heating and coagulation of the vessel.
- FIG. 8C shows zones of cooling and coagulation in skin tissue.
- the time delay circuit can be used to trigger the time delay circuit after the cold rod touches the skin for the definite time.
- the time delay is defined by the procedure and by the anatomical structure of the skin and blood vessel.
- the laser device used in this preferred embodiment is a free running mode Er:Glass pulse laser that has the spike in the range of 1.54 microns. Light in this range has minimal scattering losses in the skin tissue and is readily absorbed in the skin fluids. Laser parameters such as pulse width, energy density, repetition rate can be selected to best fit the skin and the treated lesion of the patients. The parameters for two specific examples which have been utilized with good results for wrinkle removal and leg vein treatment are shown in Table 1:
- Each point on the skin receives a high energy density illumination for about 2 milliseconds. Some of the light is reflected. Of the light which is not reflected a significant portion of the energy of each pulse penetrates to the depth up to 1-1.5 mm and is absorbed by the skin fluids.
- the Nd:YAG laser is used.
- the wavelength of the beam is at 1.06 microns.
- Light at this wavelength has a very low absorption in skin tissue and in interstitial fluids. Absorption in blood is also low but is about twice that of general skin tissue and interstitial fluids. Therefore, this wavelength is very good for treating telagiactasia with dimensions in the range of 1 mm and greater and large spider veins in the range of 1.5 mm.
- Table 2 gives some preferred parameters for treating a 1 mm telagiactasia and a 1.5 mm-spjider vein.
- a long pulse Nd:YAG with a pulse width of about 100-200ms Pulses in this range have been utilized with good results for destruction of skin tumor angiogenesis and coagulation of hair follicular blood vessels at depths of up to 5.0 mm.
- Some preferred parameters are given in Table 3.
- cooling is provided for a period of about 1 to 2 seconds prior to the illumination.
- Angiogenic Follicular Plesus 0.8 mm Plexus 1 mm Pulse Width 100 ms 150 ms Repetition Rate 1 Hz 1 Hz Sapphire Rod Diameter 10 mm 12 mm Spot Size 78.5 mm 2 113 mm 2 Energy Fluence 120 J/cm 2 140 J/cm 2
- Estimation of temperature rise in skin can be made by calculating laser light fluence in skin and estimating energy deposition per unit volume of skin. Effect of contact skin surface cooling was accounted based on the solution of heat transfer equations.
- FIGS. 7 A 1 - 7 and 7 B 1 - 7 which were discussed above. Cooling experiments have been performed by using different configurations of the cooling element for the different applications. For these applications, one of the alternative embodiments is recommended.
- test station could be constructed using a plastic material having thermal properties similar to human skin and equipping it with fast response thermocouples located at various depths and positions below the surface. The thermocouples should be connected to the real time monitors so that the technician and the patient can see the thermal effects produced by the device prior to actual use on the patient.
- a second embodiment involves the use of a cryogenically cooled diamond cooling element as shown in FIGS. 5A and 5B .
- the device consists of copper holder 24 , which has a cryogenic container 21 .
- Synthetic diamond cooling element 23 is in the shape of a flattened cylinder and contains a circular groove through which cryogenic mist flows. The mist exits at the exit port 26 .
- the flattened diamond rod is transparent to the laser beam. It is applied to the part of the cleaned skin to be treated.
- the nozzle valve opens the shutter and the cryogenic spray flows to the chamber around this window. When the window is cold the “ready” light will be switched-on. The energy delivery procedure can be started.
- This device is good for the large area irradiation such as subsurface tumor interstitial thermotherapy with a high frequency electromagnetic radiation.
- a third embodiment for practicing this invention is to use a patterned rod to the surface of the skin in order to have damaged and healthy areas under the skin surface.
- FIGS. 3A and 3B show rod 31 with the perpendicular grooves 32 filled with copper stripes 33 .
- a laser light is sent through the cooled rod to the surface of the skin does not penetrate through the copper stripes. But the contacting surface of the rod has an almost uniform temperature distribution. It means that the surface of the skin is cooled uniformly. But under skin damage is not uniform having irradiated and not irradiated healthy spots. The reason to have these healthy untouched spots around the damaged tissue is to use the capacity of healthy spot tissue and cells for the fast immune response and wound healing process.
- FIG. 4 shows a cooling element with the lens-type tip surface. For such an element, it does not require a collimated lens and can be replaced by the transparent disk-type window in the oil chamber.
- This embodiment is essentially the same as the first one described above except that the cylindrical element is placed in the cooling chamber horizontally (see FIGS. 6A and 6B ).
- the rod could be of different shapes to provide desired beam profiles on the skin surface or to focus the beam.
- the focal point (or focal line) could be under the skin to help concentrate the beam energy in target locations.
- the device disclosed herein can be used in reverse. That is, surface tissue destruction can be provided by the very cold surface of the tip of the sapphire rod.
- the skin is pre-warmed with a low energy laser pulse of about one-half the values specified above which should cause no damage but will provide warmth which will minimize tissue destruction caused below the surface. This process is good for freezing of warts and certain types of surface skin cancers.
- pre and post cooling is provided by transparent circular part 20 as shown in FIG. 9 preferably comprised of sapphire.
- the exhaust from chamber 17 flows through port 21 onto the surface of the circular sapphire part 20 to cool it.
- This cool surface which will be at a temperature above 0 C prevents the epidermis from being overheated from the hotter lower dermis. This permits the technician to move the laser beam rapidly across the skin surface.
- the illuminated portion of the skin is both pre-cooled and post-cooled.
- FIGS. 10A and B Another preferred embodiment is shown in FIGS. 10A and B.
- Solenoid valve 50 is controlled by microprocessor 52 to provide a controlled spray from cryogen can 53 on sapphire plate 54 which cools skin surface 565 .
- the temperature of plate 54 is monitored using thermocouple 58 . Temperature data is displayed on display 60 .
- the operator has manual control of the spray with switch 62 as desired or the spray can be automatically controlled with processor 52 based on temperature data from thermocouple 58 .
- the operator holds a laser device in one hand and the cooling device in the other. He moves the cooling device in the direction of arrow 64 and the laser beam is directed as shown at 66 .
- sapphire plate 54 provides both pre and post cooling as the cooling device is moved along the skin surface.
- FIG. 10B shows a bottom view of plate 54 .
- the laser beam applicator (not shown specifically) and the cooling device are handled separately, but they could be mounted together as one unit.
- the cooling rod has a very high thermoconductivity coefficient and low absorption of the irradiating light.
- the substance used for the cryogenic cooling can be chosen based on the particular application. The important thing is to use a proper time of cooling in order to reach a required low temperature of the tissue at the required depth. Persons skilled in the art will recognize that certain material and configuration of the rod, container, coolant and connector will be preferred for different skin type, different lesions and different applications.
- the preferred embodiment of this invention can be used without this laser to provide cryogenic treatment to surface skin lesions.
- the same skin cooling can be provided with about 1/10 the cryogen as direct open spray.
- An important application of the device for cryogenic treatment is to promote lymphatic drainage by cold therapy.
- Skin rejuvenation begins with flushing of the lymphatic system to remove dead proteins and other debris.
- Thermal receptors in the lymphatic system are effectively stimulated by the presence of cold applied to the skin surface.
- Current techniques for lymphatic drainage by cold therapy include spray and ice, both of which are messy and offer poor control of the skin temperature.
- the device shown in FIGS. 10A and B is useful for lymphatic drainage due to its compact hand held design, disposable canisters and accurate control of the skin temperature.
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Abstract
Description
TABLE 1 |
Parameters Preferred. |
Wrinkles | Spider | |||
Pulse Width |
2 | |
2 | | ||
Repetition Rate | |||||
1 | Hz | 0.5 | Hz | ||
Sapphire Rod Diameter | 3 | |
2 | mm | |
Spot Size | 7.2 | mm2 | 3.14 | mm2 | |
Energy Fluence | 25 | J/cm2 | 25 | J/cm2 | |
TABLE 2 |
Parameters Preferred. |
|
Spider Veins 1.5 | |
Pulse Width |
25 | |
50 | | |
Repetition Rate | ||||
1 | Hz | 2 | Hz | |
Sapphire Rod Diameter | 3 | |
10 | mm |
Spot Size | 7.2 | mm2 | 78.5 | mm2 |
Energy Fluence | 40 | J/cm2 | 60 | J/cm2 |
TABLE 3 |
Parameters Preferred. |
Angiogenic | Follicular | ||
Plesus 0.8 | Plexus | 1 | |
Pulse Width |
100 | |
150 | | |
Repetition Rate | ||||
1 | Hz | 1 | Hz | |
|
10 | |
12 | mm |
Spot Size | 78.5 | mm2 | 113 | mm2 |
Energy Fluence | 120 | J/cm2 | 140 | J/cm2 |
Scattering | Refr. | ||||
Absorption | coef | Asymmetry | Index | ||
coef (1/cm) | (1/cm) | Factor (g) | | Thickness | |
Epidermis |
5 | 300 | 0.8 | 1.4 | 100 | |
Dermis | |||||
5 | 100 | 0.85 | 1.4 | | |
Blood | |||||
10 | 300 | 0.98 | 1.4 | N/A | |
ΔT=Q/mc
where skin density is about 1.15 g/cm3 and specific heat of skin about 3.8J/Cgm.
T(z,t)=37*erf(z/2 αct),
where erf refers to the Gausian error function, and z is the depth into the tissue, t is time lapse in seconds from the start of the contact skin cooling and α=10−4(cm2/sec) is thermal diffusivity of skin dermis. Skin temperature was found by superposition of laser heating and surface cooling effects.
Claims (67)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/165,181 USRE46208E1 (en) | 1998-10-16 | 2011-06-21 | Method for cryogenically treating tissue below the skin surface |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/174,065 US6059820A (en) | 1998-10-16 | 1998-10-16 | Tissue cooling rod for laser surgery |
US09/523,225 US6632219B1 (en) | 1998-10-16 | 2000-03-10 | Tissue cooling rod for laser surgery |
US11/250,139 USRE42594E1 (en) | 1998-10-16 | 2005-10-13 | Tissue cooling rod for laser surgery |
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Families Citing this family (171)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7473251B2 (en) * | 1996-01-05 | 2009-01-06 | Thermage, Inc. | Methods for creating tissue effect utilizing electromagnetic energy and a reverse thermal gradient |
US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US8182473B2 (en) | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
US6653618B2 (en) | 2000-04-28 | 2003-11-25 | Palomar Medical Technologies, Inc. | Contact detecting method and apparatus for an optical radiation handpiece |
KR100553297B1 (en) * | 1997-04-25 | 2006-02-20 | 스뜨리케르 프랑스 | Two-Part Intersomatic Implant |
WO1998051235A1 (en) | 1997-05-15 | 1998-11-19 | Palomar Medical Technologies, Inc. | Method and apparatus for dermatology treatment |
EP1062001B1 (en) | 1998-03-12 | 2005-07-27 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation of the skin |
EP2263749B1 (en) * | 1998-03-27 | 2017-06-21 | The General Hospital Corporation | Method for the selective targeting of sebaceous glands |
US6059820A (en) * | 1998-10-16 | 2000-05-09 | Paradigm Medical Corporation | Tissue cooling rod for laser surgery |
US6514242B1 (en) * | 1998-12-03 | 2003-02-04 | David Vasily | Method and apparatus for laser removal of hair |
US6402739B1 (en) * | 1998-12-08 | 2002-06-11 | Y-Beam Technologies, Inc. | Energy application with cooling |
US7041094B2 (en) * | 1999-03-15 | 2006-05-09 | Cutera, Inc. | Tissue treatment device and method |
US6733492B2 (en) * | 1999-05-31 | 2004-05-11 | Nidek Co., Ltd. | Laser treatment apparatus |
US6451007B1 (en) * | 1999-07-29 | 2002-09-17 | Dale E. Koop | Thermal quenching of tissue |
US6743222B2 (en) | 1999-12-10 | 2004-06-01 | Candela Corporation | Method of treating disorders associated with sebaceous follicles |
US20030036749A1 (en) * | 1999-12-10 | 2003-02-20 | Durkin Anthony J. | Method of treating disorders associated with sebaceous follicles |
EP2316372A1 (en) * | 2000-01-25 | 2011-05-04 | Palomar Medical Technologies, Inc. | Method and apparatus for medical treatment utilizing long duration electromagnetic radiation |
US6669688B2 (en) * | 2000-01-25 | 2003-12-30 | The Regents Of The University Of California | Method and apparatus for measuring the heat transfer coefficient during cryogen spray cooling of tissue |
US6436094B1 (en) * | 2000-03-16 | 2002-08-20 | Laserscope, Inc. | Electromagnetic and laser treatment and cooling device |
US6503268B1 (en) * | 2000-04-03 | 2003-01-07 | Ceramoptec Industries, Inc. | Therapeutic laser system operating between 1000nm and 1300nm and its use |
ES2167253B2 (en) * | 2000-07-13 | 2003-05-01 | Arcusa Villacampa Francisco Ja | SKIN PROTECTION DEVICE FOR LASER TREATMENTS AND PULSED LIGHT. |
ITPR20000067A1 (en) * | 2000-12-19 | 2002-06-19 | Irene Cantoni | LIPOLYSIS EQUIPMENT FOR AESTHETIC TREATMENT. |
CN1239131C (en) * | 2000-12-28 | 2006-02-01 | 帕洛玛医疗技术有限公司 | Method and apparatus for therapeutic EMR treatment of the skin |
JP4027049B2 (en) | 2001-02-28 | 2007-12-26 | 株式会社ニデック | Laser therapy device |
US6888319B2 (en) * | 2001-03-01 | 2005-05-03 | Palomar Medical Technologies, Inc. | Flashlamp drive circuit |
CA2439882A1 (en) * | 2001-03-02 | 2002-09-12 | Palomar Medical Technologies, Inc. | Apparatus and method for photocosmetic and photodermatological treatment |
ATE521296T1 (en) * | 2001-05-23 | 2011-09-15 | Palomar Medical Tech Inc | COOLING SYSTEM FOR A PHOTOCOSMETIC DEVICE |
WO2002094116A1 (en) * | 2001-05-23 | 2002-11-28 | Palomar Medical Technologies, Inc. | Cooling system for a photocosmetic device |
US6638272B2 (en) * | 2001-06-04 | 2003-10-28 | Cynosure, Inc | Cooling delivery guide attachment for a laser scanner apparatus |
US6723090B2 (en) | 2001-07-02 | 2004-04-20 | Palomar Medical Technologies, Inc. | Fiber laser device for medical/cosmetic procedures |
US7094252B2 (en) * | 2001-08-21 | 2006-08-22 | Cooltouch Incorporated | Enhanced noninvasive collagen remodeling |
US7303578B2 (en) * | 2001-11-01 | 2007-12-04 | Photothera, Inc. | Device and method for providing phototherapy to the brain |
US20030216719A1 (en) * | 2001-12-12 | 2003-11-20 | Len Debenedictis | Method and apparatus for treating skin using patterns of optical energy |
US20040082940A1 (en) * | 2002-10-22 | 2004-04-29 | Michael Black | Dermatological apparatus and method |
US20030109860A1 (en) * | 2001-12-12 | 2003-06-12 | Michael Black | Multiple laser treatment |
US20030109787A1 (en) * | 2001-12-12 | 2003-06-12 | Michael Black | Multiple laser diagnostics |
US10695577B2 (en) * | 2001-12-21 | 2020-06-30 | Photothera, Inc. | Device and method for providing phototherapy to the heart |
WO2003077783A1 (en) * | 2002-03-12 | 2003-09-25 | Palomar Medical Technologies, Inc. | Method and apparatus for hair growth management |
US7056318B2 (en) * | 2002-04-12 | 2006-06-06 | Reliant Technologies, Inc. | Temperature controlled heating device and method to heat a selected area of a biological body |
EP1539013A4 (en) | 2002-06-19 | 2005-09-21 | Palomar Medical Tech Inc | Method and apparatus for treatment of cutaneous and subcutaneous conditions |
IL151486A0 (en) * | 2002-08-26 | 2003-04-10 | Levin Alexander | Cryosurgical instrument and its accessory system |
US20040048842A1 (en) * | 2002-09-10 | 2004-03-11 | Mcmillan Kathleen | Method of treating skin disorders |
US20070213792A1 (en) * | 2002-10-07 | 2007-09-13 | Palomar Medical Technologies, Inc. | Treatment Of Tissue Volume With Radiant Energy |
EP1558339A1 (en) * | 2002-10-07 | 2005-08-03 | Palomar Medical Technologies, Inc. | Apparatus for performing photobiostimulation |
KR20050071618A (en) | 2002-10-23 | 2005-07-07 | 팔로마 메디칼 테크놀로지스, 인코포레이티드 | Phototreatment device for use with coolants and topical substances |
US20040147985A1 (en) * | 2003-01-27 | 2004-07-29 | Altus Medical, Inc. | Dermatological treatment flashlamp device and method |
US20050177141A1 (en) * | 2003-01-27 | 2005-08-11 | Davenport Scott A. | System and method for dermatological treatment gas discharge lamp with controllable current density |
EP2316373B9 (en) * | 2003-03-27 | 2014-02-26 | The General Hospital Corporation | Apparatus for dermatological treatment and fractional skin resurfacing |
US20060189965A1 (en) * | 2003-04-01 | 2006-08-24 | Emil Litvak | System,apparatus and method for large area tissue ablation |
US20050010271A1 (en) * | 2003-07-07 | 2005-01-13 | Merchant Robert F. | Method of using radiation to treat cutaneous and sub-cutaneous conditions |
EP1653876A1 (en) * | 2003-07-11 | 2006-05-10 | Reliant Technologies, Inc. | Method and apparatus for fractional photo therapy of skin |
US7282060B2 (en) * | 2003-12-23 | 2007-10-16 | Reliant Technologies, Inc. | Method and apparatus for monitoring and controlling laser-induced tissue treatment |
US7184184B2 (en) * | 2003-12-31 | 2007-02-27 | Reliant Technologies, Inc. | High speed, high efficiency optical pattern generator using rotating optical elements |
US7196831B2 (en) * | 2003-12-31 | 2007-03-27 | Reliant Technologies, Inc. | Two-dimensional optical scan system using a counter-rotating disk scanner |
US7372606B2 (en) | 2003-12-31 | 2008-05-13 | Reliant Technologies, Inc. | Optical pattern generator using a single rotating component |
US7309335B2 (en) * | 2003-12-31 | 2007-12-18 | Palomar Medical Technologies, Inc. | Dermatological treatment with visualization |
US7090670B2 (en) * | 2003-12-31 | 2006-08-15 | Reliant Technologies, Inc. | Multi-spot laser surgical apparatus and method |
JP5065005B2 (en) | 2004-04-01 | 2012-10-31 | ザ ジェネラル ホスピタル コーポレイション | Method and apparatus for dermatological treatment and tissue remodeling |
US7413572B2 (en) * | 2004-06-14 | 2008-08-19 | Reliant Technologies, Inc. | Adaptive control of optical pulses for laser medicine |
US20060217788A1 (en) * | 2004-07-09 | 2006-09-28 | Herron G S | Method of using laser induced injury to activate topical prodrugs |
US7837675B2 (en) * | 2004-07-22 | 2010-11-23 | Shaser, Inc. | Method and device for skin treatment with replaceable photosensitive window |
WO2006036968A2 (en) * | 2004-09-28 | 2006-04-06 | Reliant Technologies, Inc. | Methods and apparatus for modulation of the immune response using light-based fractional treatment |
US20060122584A1 (en) * | 2004-10-27 | 2006-06-08 | Bommannan D B | Apparatus and method to treat heart disease using lasers to form microchannels |
US7780656B2 (en) * | 2004-12-10 | 2010-08-24 | Reliant Technologies, Inc. | Patterned thermal treatment using patterned cryogen spray and irradiation by light |
US8277495B2 (en) | 2005-01-13 | 2012-10-02 | Candela Corporation | Method and apparatus for treating a diseased nail |
US7856985B2 (en) | 2005-04-22 | 2010-12-28 | Cynosure, Inc. | Method of treatment body tissue using a non-uniform laser beam |
EP2656809A1 (en) | 2005-08-12 | 2013-10-30 | Board Of Regents, The University Of Texas System | Systems, devices, and methods for optically clearing tissue |
US20070049996A1 (en) * | 2005-08-29 | 2007-03-01 | Reliant Technologies, Inc. | Monitoring Method and Apparatus for Fractional Photo-Therapy Treatment |
US20070093798A1 (en) * | 2005-08-29 | 2007-04-26 | Reliant Technologies, Inc. | Method and Apparatus for Monitoring and Controlling Thermally Induced Tissue Treatment |
CN101309631A (en) | 2005-09-15 | 2008-11-19 | 帕洛玛医疗技术公司 | Skin optical characterization device |
WO2007038567A1 (en) | 2005-09-28 | 2007-04-05 | Candela Corporation | Treating cellulite |
WO2007044840A2 (en) * | 2005-10-10 | 2007-04-19 | Reliant Technologies, Inc. | Laser-induced transepidermal elimination of content by fractional photothermolysis |
US7891362B2 (en) | 2005-12-23 | 2011-02-22 | Candela Corporation | Methods for treating pigmentary and vascular abnormalities in a dermal region |
US20070179570A1 (en) * | 2006-01-30 | 2007-08-02 | Luis De Taboada | Wearable device and method for providing phototherapy to the brain |
US7575589B2 (en) | 2006-01-30 | 2009-08-18 | Photothera, Inc. | Light-emitting device and method for providing phototherapy to the brain |
WO2007095183A2 (en) * | 2006-02-13 | 2007-08-23 | Reliant Technologies, Inc. | Laser system for treatment of skin laxity |
US8460280B2 (en) * | 2006-04-28 | 2013-06-11 | Cutera, Inc. | Localized flashlamp skin treatments |
US7465312B2 (en) | 2006-05-02 | 2008-12-16 | Green Medical, Inc. | Systems and methods for treating superficial venous malformations like spider veins |
US8246611B2 (en) * | 2006-06-14 | 2012-08-21 | Candela Corporation | Treatment of skin by spatial modulation of thermal heating |
WO2008008971A1 (en) * | 2006-07-13 | 2008-01-17 | Candela Corporation | Compact, handheld device for home-based acne treatment |
US7586957B2 (en) | 2006-08-02 | 2009-09-08 | Cynosure, Inc | Picosecond laser apparatus and methods for its operation and use |
US20080058782A1 (en) * | 2006-08-29 | 2008-03-06 | Reliant Technologies, Inc. | Method and apparatus for monitoring and controlling density of fractional tissue treatments |
US20080161745A1 (en) * | 2006-09-08 | 2008-07-03 | Oliver Stumpp | Bleaching of contrast enhancing agent applied to skin for use with a dermatological treatment system |
US9132031B2 (en) | 2006-09-26 | 2015-09-15 | Zeltiq Aesthetics, Inc. | Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile |
US8192474B2 (en) | 2006-09-26 | 2012-06-05 | Zeltiq Aesthetics, Inc. | Tissue treatment methods |
US20080077201A1 (en) | 2006-09-26 | 2008-03-27 | Juniper Medical, Inc. | Cooling devices with flexible sensors |
US8007493B2 (en) | 2006-10-16 | 2011-08-30 | Syneron Medical Ltd. | Methods and devices for treating tissue |
US8142426B2 (en) * | 2006-10-16 | 2012-03-27 | Syneron Medical Ltd. | Methods and devices for treating tissue |
US8133216B2 (en) * | 2006-10-16 | 2012-03-13 | Syneron Medical Ltd. | Methods and devices for treating tissue |
US8273080B2 (en) * | 2006-10-16 | 2012-09-25 | Syneron Medical Ltd. | Methods and devices for treating tissue |
US20080281389A1 (en) * | 2006-10-16 | 2008-11-13 | Primaeva Medical Inc. | Methods and devices for treating tissue |
US20080154247A1 (en) * | 2006-12-20 | 2008-06-26 | Reliant Technologies, Inc. | Apparatus and method for hair removal and follicle devitalization |
US20080208181A1 (en) * | 2007-01-19 | 2008-08-28 | Arbel Medical Ltd. | Thermally Insulated Needles For Dermatological Applications |
US20080262484A1 (en) * | 2007-04-23 | 2008-10-23 | Nlight Photonics Corporation | Motion-controlled laser surface treatment apparatus |
US20080287839A1 (en) | 2007-05-18 | 2008-11-20 | Juniper Medical, Inc. | Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator |
US20080312647A1 (en) * | 2007-06-15 | 2008-12-18 | Primaeva Medical, Inc. | Methods and devices for treating tissue |
US20120143178A9 (en) * | 2007-06-15 | 2012-06-07 | Primaeva Medical, Inc. | Devices and methods for percutaneous energy delivery |
US8845630B2 (en) * | 2007-06-15 | 2014-09-30 | Syneron Medical Ltd | Devices and methods for percutaneous energy delivery |
US8523927B2 (en) | 2007-07-13 | 2013-09-03 | Zeltiq Aesthetics, Inc. | System for treating lipid-rich regions |
FR2919993B1 (en) * | 2007-08-16 | 2010-05-21 | Optical System & Res For Ind & Science Osyris | COOLED HANDPIECE FOR THE TREATMENT OF SKIN BY LIGHT EMITTING |
US8285390B2 (en) | 2007-08-21 | 2012-10-09 | Zeltiq Aesthetics, Inc. | Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue |
US8920409B2 (en) * | 2007-10-04 | 2014-12-30 | Cutera, Inc. | System and method for dermatological lesion treatment using gas discharge lamp with controllable current density |
US8366703B2 (en) | 2008-04-02 | 2013-02-05 | Cutera, Inc. | Fractional scanner for dermatological treatments |
WO2009128014A1 (en) | 2008-04-16 | 2009-10-22 | Arbel Medical Ltd | Cryosurgical instrument with enhanced heat exchange |
US20100010484A1 (en) * | 2008-07-14 | 2010-01-14 | Primaeva Medical, Inc. | Devices and methods for percutaneous energy delivery |
US20100036295A1 (en) * | 2008-08-08 | 2010-02-11 | Palomar Medical Technologies, Inc. | Method and apparatus for fractional deformation and treatment of cutaneous and subcutaneous tissue |
FR2935884A1 (en) * | 2008-09-12 | 2010-03-19 | Dermeo | HAND PIECE WITH OPTICAL BLOCK OF SKIN PHOTOTRAITEMENT APPARATUS |
US7848035B2 (en) | 2008-09-18 | 2010-12-07 | Photothera, Inc. | Single-use lens assembly |
US8603073B2 (en) | 2008-12-17 | 2013-12-10 | Zeltiq Aesthetics, Inc. | Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells |
US7967814B2 (en) | 2009-02-05 | 2011-06-28 | Icecure Medical Ltd. | Cryoprobe with vibrating mechanism |
US20100217254A1 (en) * | 2009-02-25 | 2010-08-26 | Primaeva Medical, Inc. | Methods for applying energy to tissue using isolated energy sources |
US8162812B2 (en) | 2009-03-12 | 2012-04-24 | Icecure Medical Ltd. | Combined cryotherapy and brachytherapy device and method |
JP5519000B2 (en) | 2009-04-30 | 2014-06-11 | ゼルティック エステティックス インコーポレイテッド | Devices, systems, and methods for removing heat from fat-rich subcutaneous cells |
US9919168B2 (en) | 2009-07-23 | 2018-03-20 | Palomar Medical Technologies, Inc. | Method for improvement of cellulite appearance |
US9844461B2 (en) | 2010-01-25 | 2017-12-19 | Zeltiq Aesthetics, Inc. | Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants |
US7967815B1 (en) | 2010-03-25 | 2011-06-28 | Icecure Medical Ltd. | Cryosurgical instrument with enhanced heat transfer |
US7938822B1 (en) | 2010-05-12 | 2011-05-10 | Icecure Medical Ltd. | Heating and cooling of cryosurgical instrument using a single cryogen |
US8080005B1 (en) | 2010-06-10 | 2011-12-20 | Icecure Medical Ltd. | Closed loop cryosurgical pressure and flow regulated system |
US8676338B2 (en) | 2010-07-20 | 2014-03-18 | Zeltiq Aesthetics, Inc. | Combined modality treatment systems, methods and apparatus for body contouring applications |
US10722395B2 (en) | 2011-01-25 | 2020-07-28 | Zeltiq Aesthetics, Inc. | Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells |
US20130035684A1 (en) * | 2011-08-04 | 2013-02-07 | Ceramoptec Industries Inc. | Laser Treatment of Tissues at Wavelengths above 1330 nm |
RU2496442C2 (en) * | 2011-12-12 | 2013-10-27 | Федеральное государственное бюджетное учреждение науки Институт физики твердого тела Российской академии наук (ИФТТ РАН) | Cryonozzle with sapphire cold conductor-irradiator |
KR102342629B1 (en) | 2012-04-18 | 2021-12-22 | 싸이노슈어, 엘엘씨 | Picosecond laser apparatus and methods for treating target tissues with same |
US9844460B2 (en) | 2013-03-14 | 2017-12-19 | Zeltiq Aesthetics, Inc. | Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same |
US9545523B2 (en) | 2013-03-14 | 2017-01-17 | Zeltiq Aesthetics, Inc. | Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue |
EP3751684A1 (en) | 2013-03-15 | 2020-12-16 | Cynosure, Inc. | Picosecond optical radiation systems and methods of use |
US10413359B2 (en) * | 2013-07-18 | 2019-09-17 | International Business Machines Corporation | Laser-assisted transdermal delivery of nanoparticulates and hydrogels |
US10045808B2 (en) | 2013-12-03 | 2018-08-14 | Kirn Medical Design, Llc | Device for effecting change in tissue at a treatment site |
WO2015117001A1 (en) | 2014-01-31 | 2015-08-06 | Zeltiq Aesthetics, Inc. | Compositions, treatment systems and methods for improved cooling of lipid-rich tissue |
US10675176B1 (en) | 2014-03-19 | 2020-06-09 | Zeltiq Aesthetics, Inc. | Treatment systems, devices, and methods for cooling targeted tissue |
USD777338S1 (en) | 2014-03-20 | 2017-01-24 | Zeltiq Aesthetics, Inc. | Cryotherapy applicator for cooling tissue |
US10952891B1 (en) | 2014-05-13 | 2021-03-23 | Zeltiq Aesthetics, Inc. | Treatment systems with adjustable gap applicators and methods for cooling tissue |
US10568759B2 (en) | 2014-08-19 | 2020-02-25 | Zeltiq Aesthetics, Inc. | Treatment systems, small volume applicators, and methods for treating submental tissue |
US10935174B2 (en) | 2014-08-19 | 2021-03-02 | Zeltiq Aesthetics, Inc. | Stress relief couplings for cryotherapy apparatuses |
US10518104B2 (en) | 2015-04-23 | 2019-12-31 | Cynosure, Llc | Systems and methods of unattended treatment |
US10737109B2 (en) | 2015-04-23 | 2020-08-11 | Cynosure, Llc | Systems and methods of unattended treatment of a subject's head or neck |
EP3364900B1 (en) | 2015-10-19 | 2021-08-18 | Zeltiq Aesthetics, Inc. | Vascular treatment methods for cooling vascular structures |
JP6833869B2 (en) | 2016-01-07 | 2021-02-24 | ゼルティック エステティックス インコーポレイテッド | Temperature-dependent adhesion between applicator and skin during tissue cooling |
US10765552B2 (en) | 2016-02-18 | 2020-09-08 | Zeltiq Aesthetics, Inc. | Cooling cup applicators with contoured heads and liner assemblies |
ES2777634T3 (en) | 2016-04-26 | 2020-08-05 | Candela Corp | Applicator for cooling the skin during irradiation |
US10555831B2 (en) | 2016-05-10 | 2020-02-11 | Zeltiq Aesthetics, Inc. | Hydrogel substances and methods of cryotherapy |
US10682297B2 (en) | 2016-05-10 | 2020-06-16 | Zeltiq Aesthetics, Inc. | Liposomes, emulsions, and methods for cryotherapy |
US11382790B2 (en) | 2016-05-10 | 2022-07-12 | Zeltiq Aesthetics, Inc. | Skin freezing systems for treating acne and skin conditions |
KR101905830B1 (en) | 2016-11-15 | 2018-10-08 | 울산과학기술원 | Cryoanesthesia device, method for controlling cryoanesthesia device and temperature controller of coolant in cryoanesthesia device |
US11076879B2 (en) | 2017-04-26 | 2021-08-03 | Zeltiq Aesthetics, Inc. | Shallow surface cryotherapy applicators and related technology |
WO2018221848A1 (en) * | 2017-05-30 | 2018-12-06 | 주식회사 리센스메디컬 | Medical cooling device |
KR20180131357A (en) | 2017-05-30 | 2018-12-10 | 주식회사 리센스메디컬 | Medical cooling apparatus |
CN107402213B (en) * | 2017-08-29 | 2023-09-22 | 苏州欧谱曼迪科技有限公司 | Probe, probe device and microscope system |
US11400308B2 (en) | 2017-11-21 | 2022-08-02 | Cutera, Inc. | Dermatological picosecond laser treatment systems and methods using optical parametric oscillator |
KR102517065B1 (en) | 2017-12-29 | 2023-04-03 | 주식회사 리센스메디컬 | Cooling generator |
AU2019225242B2 (en) | 2018-02-26 | 2023-08-10 | Cynosure, Llc | Q-switched cavity dumped sub-nanosecond laser |
KR102144930B1 (en) * | 2018-03-09 | 2020-08-14 | (주)라메디텍 | Laser lancing device |
EP4154832B1 (en) | 2018-04-27 | 2024-05-22 | Recensmedical, Inc. | Cooling apparatus and cooling method |
US11896841B2 (en) * | 2018-06-08 | 2024-02-13 | Quanta System S.P.A. | Photo-thermal targeted treatment system with integrated pre-conditioning, and automatic triggering of photo-thermal targeted treatment via measurement of skin surface temperature and associated methods |
CN112955099B (en) | 2018-07-27 | 2024-04-26 | 雷森斯医疗有限公司 | Medical cooling device and cooling method using same |
CN112789013A (en) | 2018-07-31 | 2021-05-11 | 斯尔替克美学股份有限公司 | Method, device and system for improving skin |
US11666479B2 (en) | 2018-08-19 | 2023-06-06 | Recensmedical, Inc. | Device for cooling anesthesia by chilled fluidic cooling medium |
USD921211S1 (en) | 2019-06-21 | 2021-06-01 | Recensmedical, Inc. | Medical cooling device |
USD921911S1 (en) | 2019-06-21 | 2021-06-08 | Recensmedical, Inc. | Medical cooling device |
US11633224B2 (en) | 2020-02-10 | 2023-04-25 | Icecure Medical Ltd. | Cryogen pump |
US11253720B2 (en) | 2020-02-29 | 2022-02-22 | Cutera, Inc. | Dermatological systems and methods with handpiece for coaxial pulse delivery and temperature sensing |
US10864380B1 (en) | 2020-02-29 | 2020-12-15 | Cutera, Inc. | Systems and methods for controlling therapeutic laser pulse duration |
CN111544296B (en) * | 2020-06-18 | 2024-03-12 | 四川省人民医院 | Light energy storage bag for blood products |
US11278341B2 (en) | 2020-07-14 | 2022-03-22 | Recensmedical, Inc. | Method of safely using controlled cooling systems and devices |
USD977633S1 (en) | 2020-08-07 | 2023-02-07 | Recensmedical, Inc. | Cradle for a medical cooling device |
USD968626S1 (en) | 2020-08-07 | 2022-11-01 | Recensmedical, Inc. | Medical cooling device |
USD968627S1 (en) | 2020-08-07 | 2022-11-01 | Recensmedical, Inc. | Medical cooling device |
FR3122328A1 (en) * | 2021-04-28 | 2022-11-04 | Guilaume MODELSKI | MOBILE AND AUTONOMOUS DEVICE AND METHOD FOR MUSCLE TREATMENT BY CRYOTHERAPY |
IT202200010370A1 (en) * | 2022-05-19 | 2023-11-19 | El En Spa | HANDPIECE FOR SKIN TREATMENT USING LIGHT RADIATION |
KR102573603B1 (en) * | 2023-01-17 | 2023-09-04 | 비손메디칼 주식회사 | Handpiece for skin laser treatment and medical laser treatment apparatus including the same |
CN117717410B (en) * | 2024-02-18 | 2024-04-19 | 遂宁市中心医院 | Ring laser cooling cutting device with controllable working temperature, spray sleeve and control method |
Citations (141)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3622743A (en) | 1969-04-28 | 1971-11-23 | Hrand M Muncheryan | Laser eraser and microwelder |
US4122853A (en) | 1977-03-14 | 1978-10-31 | Spectra-Med | Infrared laser photocautery device |
JPS5886787A (en) | 1981-11-19 | 1983-05-24 | Nippon Sekigaisen Kogyo Kk | Laser emitting device |
US4587396A (en) | 1982-12-31 | 1986-05-06 | Laser Industries Ltd. | Control apparatus particularly useful for controlling a laser |
US4653495A (en) | 1984-01-13 | 1987-03-31 | Kabushiki Kaisha Toshiba | Laser medical apparatus |
US4718416A (en) | 1984-01-13 | 1988-01-12 | Kabushiki Kaisha Toshiba | Laser treatment apparatus |
US4733660A (en) | 1984-08-07 | 1988-03-29 | Medical Laser Research And Development Corporation | Laser system for providing target specific energy deposition and damage |
US4775361A (en) | 1986-04-10 | 1988-10-04 | The General Hospital Corporation | Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport |
JPH01191801A (en) | 1988-01-28 | 1989-08-01 | Sumitomo Electric Ind Ltd | Condenser lens |
US4930504A (en) | 1987-11-13 | 1990-06-05 | Diamantopoulos Costas A | Device for biostimulation of tissue and method for treatment of tissue |
US4976709A (en) | 1988-12-15 | 1990-12-11 | Sand Bruce J | Method for collagen treatment |
US5000752A (en) | 1985-12-13 | 1991-03-19 | William J. Hoskin | Treatment apparatus and method |
US5104392A (en) | 1985-03-22 | 1992-04-14 | Massachusetts Institute Of Technology | Laser spectro-optic imaging for diagnosis and treatment of diseased tissue |
US5106387A (en) | 1985-03-22 | 1992-04-21 | Massachusetts Institute Of Technology | Method for spectroscopic diagnosis of tissue |
US5128509A (en) | 1990-09-04 | 1992-07-07 | Reliant Laser Corp. | Method and apparatus for transforming and steering laser beams |
US5178617A (en) | 1991-07-09 | 1993-01-12 | Laserscope | System for controlled distribution of laser dosage |
US5192278A (en) | 1985-03-22 | 1993-03-09 | Massachusetts Institute Of Technology | Multi-fiber plug for a laser catheter |
US5282797A (en) | 1989-05-30 | 1994-02-01 | Cyrus Chess | Method for treating cutaneous vascular lesions |
US5302259A (en) | 1991-04-30 | 1994-04-12 | Reginald Birngruber | Method and apparatus for altering the properties in light absorbing material |
US5312395A (en) | 1990-03-14 | 1994-05-17 | Boston University | Method of treating pigmented lesions using pulsed irradiation |
US5312396A (en) | 1990-09-06 | 1994-05-17 | Massachusetts Institute Of Technology | Pulsed laser system for the surgical removal of tissue |
US5336217A (en) | 1986-04-24 | 1994-08-09 | Institut National De La Sante Et De La Recherche Medicale (Insepm) | Process for treatment by irradiating an area of a body, and treatment apparatus usable in dermatology for the treatment of cutaneous angio dysplasias |
US5339347A (en) | 1993-04-27 | 1994-08-16 | The United States Of America As Represented By The United States Department Of Energy | Method for microbeam radiation therapy |
US5344418A (en) * | 1991-12-12 | 1994-09-06 | Shahriar Ghaffari | Optical system for treatment of vascular lesions |
US5360447A (en) | 1993-02-03 | 1994-11-01 | Coherent, Inc. | Laser assisted hair transplant method |
US5411502A (en) | 1992-01-15 | 1995-05-02 | Laser Industries, Ltd. | System for causing ablation of irradiated material of living tissue while not causing damage below a predetermined depth |
US5421337A (en) | 1989-04-14 | 1995-06-06 | Massachusetts Institute Of Technology | Spectral diagnosis of diseased tissue |
US5423803A (en) | 1991-10-29 | 1995-06-13 | Thermotrex Corporation | Skin surface peeling process using laser |
US5474549A (en) | 1991-07-09 | 1995-12-12 | Laserscope | Method and system for scanning a laser beam for controlled distribution of laser dosage |
US5486172A (en) | 1989-05-30 | 1996-01-23 | Chess; Cyrus | Apparatus for treating cutaneous vascular lesions |
US5531740A (en) | 1994-09-06 | 1996-07-02 | Rapistan Demag Corporation | Automatic color-activated scanning treatment of dermatological conditions by laser |
US5546214A (en) | 1995-09-13 | 1996-08-13 | Reliant Technologies, Inc. | Method and apparatus for treating a surface with a scanning laser beam having an improved intensity cross-section |
US5558666A (en) | 1994-01-14 | 1996-09-24 | Coherent, Inc. | Handpiece for producing highly collimated laser beam for dermatological procedures |
US5582752A (en) | 1993-12-17 | 1996-12-10 | Laser Industries, Ltd. | Method and apparatus for applying laser beams to a working surface, particularly for ablating tissue |
US5586981A (en) | 1994-08-25 | 1996-12-24 | Xin-Hua Hu | Treatment of cutaneous vascular and pigmented lesions |
US5595568A (en) | 1995-02-01 | 1997-01-21 | The General Hospital Corporation | Permanent hair removal using optical pulses |
US5611795A (en) | 1995-02-03 | 1997-03-18 | Laser Industries, Ltd. | Laser facial rejuvenation |
US5616140A (en) | 1994-03-21 | 1997-04-01 | Prescott; Marvin | Method and apparatus for therapeutic laser treatment |
US5618284A (en) | 1985-09-27 | 1997-04-08 | Sunrise Technologies | Collagen treatment apparatus |
US5624435A (en) | 1995-06-05 | 1997-04-29 | Cynosure, Inc. | Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor |
US5624434A (en) | 1995-02-03 | 1997-04-29 | Laser Industries, Ltd. | Laser preparation of recipient holes for graft implantation in the treatment of icepick scars |
US5628744A (en) | 1993-12-21 | 1997-05-13 | Laserscope | Treatment beam handpiece |
US5632741A (en) | 1995-01-20 | 1997-05-27 | Lucid Technologies, Inc. | Epilation system |
US5643252A (en) | 1992-10-28 | 1997-07-01 | Venisect, Inc. | Laser perforator |
US5655547A (en) | 1996-05-15 | 1997-08-12 | Esc Medical Systems Ltd. | Method for laser surgery |
JPH09285471A (en) | 1996-04-25 | 1997-11-04 | Nec Corp | Keratin removing device |
US5713364A (en) | 1995-08-01 | 1998-02-03 | Medispectra, Inc. | Spectral volume microprobe analysis of materials |
EP0827219A2 (en) | 1996-08-30 | 1998-03-04 | Honda Giken Kogyo Kabushiki Kaisha | Composite magnetostrictive material, and process for producing the same |
EP0827716A2 (en) | 1996-09-04 | 1998-03-11 | ESC Medical Systems Ltd. | Device for cooling skin during laser treatment |
US5733278A (en) | 1994-11-30 | 1998-03-31 | Laser Industries Limited | Method and apparatus for hair transplantation using a scanning continuous-working CO2 laser |
US5735844A (en) * | 1995-02-01 | 1998-04-07 | The General Hospital Corporation | Hair removal using optical pulses |
US5746735A (en) | 1994-10-26 | 1998-05-05 | Cynosure, Inc. | Ultra long pulsed dye laser device for treatment of ectatic vessels and method therefor |
US5759200A (en) | 1996-09-04 | 1998-06-02 | Azar; Zion | Method of selective photothermolysis |
WO1998024502A1 (en) | 1996-12-06 | 1998-06-11 | Target Therapeutics, Inc. | Reinforced catheter with a formable distal tip |
WO1998024514A1 (en) | 1996-12-02 | 1998-06-11 | Palomar Medical Technologies Inc. | Laser dermatology with feedback control |
WO1998024507A2 (en) | 1996-12-05 | 1998-06-11 | Thermolase Corporation | Methods and devices for inhibiting hair growth and related skin treatments |
US5810801A (en) | 1997-02-05 | 1998-09-22 | Candela Corporation | Method and apparatus for treating wrinkles in skin using radiation |
US5814040A (en) * | 1994-04-05 | 1998-09-29 | The Regents Of The University Of California | Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery |
US5817089A (en) | 1991-10-29 | 1998-10-06 | Thermolase Corporation | Skin treatment process using laser |
US5820626A (en) * | 1996-07-30 | 1998-10-13 | Laser Aesthetics, Inc. | Cooling laser handpiece with refillable coolant reservoir |
US5830208A (en) * | 1997-01-31 | 1998-11-03 | Laserlite, Llc | Peltier cooled apparatus and methods for dermatological treatment |
US5843073A (en) | 1985-07-31 | 1998-12-01 | Rare Earth Medical, Inc. | Infrared laser catheter system |
US5860967A (en) | 1993-07-21 | 1999-01-19 | Lucid, Inc. | Dermatological laser treatment system with electronic visualization of the area being treated |
US5860968A (en) | 1995-11-03 | 1999-01-19 | Luxar Corporation | Laser scanning method and apparatus |
US5865754A (en) | 1995-08-24 | 1999-02-02 | Purdue Research Foundation Office Of Technology Transfer | Fluorescence imaging system and method |
US5879326A (en) | 1995-05-22 | 1999-03-09 | Godshall; Ned Allen | Method and apparatus for disruption of the epidermis |
US5879346A (en) | 1995-12-18 | 1999-03-09 | Esc Medical Systems, Ltd. | Hair removal by selective photothermolysis with an alexandrite laser |
US5885211A (en) | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
US5897549A (en) | 1995-11-29 | 1999-04-27 | Lumedics, Ltd. | Transformation of unwanted tissue by deep laser heating of water |
US5906609A (en) | 1997-02-05 | 1999-05-25 | Sahar Technologies | Method for delivering energy within continuous outline |
US5908415A (en) | 1994-09-09 | 1999-06-01 | Rare Earth Medical, Inc. | Phototherapy methods and apparatus |
WO1999027997A1 (en) | 1997-12-01 | 1999-06-10 | Esc Medical Systems Ltd. | Improved depilatory method and device |
US5925035A (en) | 1991-10-29 | 1999-07-20 | Thermolase Corporation | Hair removal method |
US5938657A (en) | 1997-02-05 | 1999-08-17 | Sahar Technologies, Inc. | Apparatus for delivering energy within continuous outline |
US5947956A (en) | 1997-11-04 | 1999-09-07 | Karell; Manuel Leon | Laser apparatus for making holes and etchings |
US5957915A (en) | 1995-01-23 | 1999-09-28 | Coherent, Inc. | Hand-held laser scanner |
US5964749A (en) | 1995-09-15 | 1999-10-12 | Esc Medical Systems Ltd. | Method and apparatus for skin rejuvenation and wrinkle smoothing |
US5968033A (en) | 1997-11-03 | 1999-10-19 | Fuller Research Corporation | Optical delivery system and method for subsurface tissue irradiation |
US5970983A (en) | 1996-05-15 | 1999-10-26 | Esc Medical Systems Ltd. | Method of laser surgery |
US5976123A (en) | 1996-07-30 | 1999-11-02 | Laser Aesthetics, Inc. | Heart stabilization |
US5980512A (en) | 1998-02-26 | 1999-11-09 | Silberg; Barry | Enhanced laser skin treatment mechanism |
US5983900A (en) | 1996-08-29 | 1999-11-16 | Clement; Robert Marc | Wrinkle removal |
US5984915A (en) | 1997-10-08 | 1999-11-16 | Trimedyne, Inc. | Percutaneous laser treatment |
US5995265A (en) | 1996-08-12 | 1999-11-30 | Black; Michael | Method and apparatus for treating a surface with a scanning laser beam having an improved intensity cross-section |
US5995866A (en) | 1995-03-21 | 1999-11-30 | Lemelson; Jerome | Method and apparatus for scanning and evaluating matter |
US5997530A (en) | 1998-04-13 | 1999-12-07 | The Regents Of The University Of California | Apparatus and method to control atmospheric water vapor composition and concentration during dynamic cooling of biological tissues in conjunction with laser irradiations |
US6022316A (en) | 1998-03-06 | 2000-02-08 | Spectrx, Inc. | Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications |
US6027496A (en) | 1997-03-25 | 2000-02-22 | Abbott Laboratories | Removal of stratum corneum by means of light |
US6059820A (en) * | 1998-10-16 | 2000-05-09 | Paradigm Medical Corporation | Tissue cooling rod for laser surgery |
US6063108A (en) | 1997-01-06 | 2000-05-16 | Salansky; Norman | Method and apparatus for localized low energy photon therapy (LEPT) |
US6074384A (en) | 1998-03-06 | 2000-06-13 | Plc Medical Systems, Inc. | Endocardial laser revascularization with single laser pulses |
US6083217A (en) | 1995-11-29 | 2000-07-04 | Lumedics, Ltd. | Destruction for unwanted tissue by deep laser heating of water |
US6096031A (en) | 1995-04-17 | 2000-08-01 | Coherent, Inc. | High repetition rate erbium:YAG laser for tissue ablation |
US6096029A (en) * | 1997-02-24 | 2000-08-01 | Laser Skin Toner, Inc. | Laser method for subsurface cutaneous treatment |
US6104959A (en) * | 1997-07-31 | 2000-08-15 | Microwave Medical Corp. | Method and apparatus for treating subcutaneous histological features |
US6106514A (en) | 1996-08-12 | 2000-08-22 | O'donnell, Jr.; Francis E. | Laser method for subsurface cutaneous treatment |
US6113559A (en) | 1997-12-29 | 2000-09-05 | Klopotek; Peter J. | Method and apparatus for therapeutic treatment of skin with ultrasound |
USRE36872E (en) | 1992-01-15 | 2000-09-12 | Laser Industries Ltd. | System for causing ablation of irradiated material of living tissue while not causing damage below a predetermined depth |
US6149645A (en) | 1998-04-03 | 2000-11-21 | Tobinick; Edward L. | Apparatus and method employing lasers for removal of hair |
US6149644A (en) | 1998-02-17 | 2000-11-21 | Altralight, Inc. | Method and apparatus for epidermal treatment with computer controlled moving focused infrared light |
US6152917A (en) | 1991-10-29 | 2000-11-28 | Thermolase Corporation | Hair removal device |
US6165170A (en) | 1998-01-29 | 2000-12-26 | International Business Machines Corporation | Laser dermablator and dermablation |
US6168590B1 (en) | 1997-08-12 | 2001-01-02 | Y-Beam Technologies, Inc. | Method for permanent hair removal |
US6173202B1 (en) | 1998-03-06 | 2001-01-09 | Spectrx, Inc. | Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue |
US6171302B1 (en) | 1997-03-19 | 2001-01-09 | Gerard Talpalriu | Apparatus and method including a handpiece for synchronizing the pulsing of a light source |
US6176854B1 (en) | 1997-10-08 | 2001-01-23 | Robert Roy Cone | Percutaneous laser treatment |
US6183773B1 (en) | 1999-01-04 | 2001-02-06 | The General Hospital Corporation | Targeting of sebaceous follicles as a treatment of sebaceous gland disorders |
US6219575B1 (en) | 1998-10-23 | 2001-04-17 | Babak Nemati | Method and apparatus to enhance optical transparency of biological tissues |
US6235015B1 (en) | 1997-05-14 | 2001-05-22 | Applied Optronics Corporation | Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm |
US6241753B1 (en) | 1995-05-05 | 2001-06-05 | Thermage, Inc. | Method for scar collagen formation and contraction |
WO2001039834A1 (en) | 1999-12-02 | 2001-06-07 | Radiancy, Inc. | Selective photothermolysis |
US6248103B1 (en) | 1994-04-05 | 2001-06-19 | The Regents Of The University Of California | Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery using long laser pulses |
US6251100B1 (en) | 1993-09-24 | 2001-06-26 | Transmedica International, Inc. | Laser assisted topical anesthetic permeation |
US6251099B1 (en) | 1996-11-27 | 2001-06-26 | The General Hospital Corporation | Compound delivery using impulse transients |
US6264649B1 (en) * | 1998-04-09 | 2001-07-24 | Ian Andrew Whitcroft | Laser treatment cooling head |
US6267771B1 (en) | 1991-10-29 | 2001-07-31 | Thermotrex Corporation | Hair removal device and method |
US6273885B1 (en) | 1997-08-16 | 2001-08-14 | Cooltouch Corporation | Handheld photoepilation device and method |
US6273884B1 (en) | 1997-05-15 | 2001-08-14 | Palomar Medical Technologies, Inc. | Method and apparatus for dermatology treatment |
US6325769B1 (en) | 1998-12-29 | 2001-12-04 | Collapeutics, Llc | Method and apparatus for therapeutic treatment of skin |
US6406474B1 (en) | 1999-09-30 | 2002-06-18 | Ceramoptec Ind Inc | Device and method for application of radiation |
US6413267B1 (en) | 1999-08-09 | 2002-07-02 | Theralase, Inc. | Therapeutic laser device and method including noninvasive subsurface monitoring and controlling means |
US6443978B1 (en) | 1998-04-10 | 2002-09-03 | Board Of Trustees Of The University Of Arkansas | Photomatrix device |
US6445491B2 (en) | 1999-01-29 | 2002-09-03 | Irma America, Inc. | Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification |
US6468229B1 (en) | 1998-10-20 | 2002-10-22 | Abbott Laboratories | Apparatus and method for the collection of interstitial fluids |
US6475138B1 (en) | 1995-07-12 | 2002-11-05 | Laser Industries Ltd. | Apparatus and method as preparation for performing a myringotomy in a child's ear without the need for anaesthesia |
US6508813B1 (en) | 1996-12-02 | 2003-01-21 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation dermatology and head for use therewith |
US6514278B1 (en) | 1998-05-28 | 2003-02-04 | Carl Baasel Lasertechnik Gmbh | Method and device for the superficial heating of tissue |
US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US6530915B1 (en) | 1998-03-06 | 2003-03-11 | Spectrx, Inc. | Photothermal structure for biomedical applications, and method therefor |
US6537270B1 (en) | 1998-08-13 | 2003-03-25 | Asclepion-Meditec Ag | Medical hand piece for a laser radiation source |
US6572637B1 (en) | 1999-03-12 | 2003-06-03 | Ya-Man Ltd. | Handbreadth-sized laser beam projecting probe for beauty treatment |
US6575963B1 (en) | 1997-07-16 | 2003-06-10 | The Lion Eye Institute Of Western Australia Incorporated | Laser scanning apparatus and method |
US6579283B1 (en) | 1998-05-22 | 2003-06-17 | Edward L. Tobinick | Apparatus and method employing a single laser for removal of hair, veins and capillaries |
US6605080B1 (en) | 1998-03-27 | 2003-08-12 | The General Hospital Corporation | Method and apparatus for the selective targeting of lipid-rich tissues |
US6607523B1 (en) | 1999-03-19 | 2003-08-19 | Asah Medico A/S | Apparatus for tissue treatment |
US6680999B1 (en) | 1995-08-15 | 2004-01-20 | Mumps Audiofax, Inc. | Interactive telephony system |
US6685699B1 (en) | 1999-06-09 | 2004-02-03 | Spectrx, Inc. | Self-removing energy absorbing structure for thermal tissue ablation |
US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6758845B1 (en) | 1999-10-08 | 2004-07-06 | Lumenis Inc. | Automatic firing apparatus and methods for laser skin treatment over large areas |
US6881212B1 (en) | 1999-03-05 | 2005-04-19 | Icn Photonics Limited | Skin wrinkle reduction using pulsed light |
US7204832B2 (en) | 1996-12-02 | 2007-04-17 | Pálomar Medical Technologies, Inc. | Cooling system for a photo cosmetic device |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4376376A (en) * | 1980-05-12 | 1983-03-15 | Virginia M. Gregory | Cryogenic device operable in single or dual phase with a range of nozzle sizes and method of using the same |
US5334016A (en) * | 1992-06-22 | 1994-08-02 | American Dental Technologies, Inc. | Combination air abrasive system and laser system for dental applications |
US5902299A (en) * | 1997-07-29 | 1999-05-11 | Jayaraman; Swaminathan | Cryotherapy method for reducing tissue injury after balloon angioplasty or stent implantation |
-
1998
- 1998-10-16 US US09/174,065 patent/US6059820A/en not_active Expired - Lifetime
-
2000
- 2000-03-10 WO PCT/US2000/006485 patent/WO2001068185A1/en active Application Filing
- 2000-03-10 DE DE60042284T patent/DE60042284D1/en not_active Expired - Lifetime
- 2000-03-10 US US09/523,225 patent/US6632219B1/en not_active Ceased
- 2000-03-10 AU AU2000237407A patent/AU2000237407A1/en not_active Abandoned
- 2000-03-10 AT AT00916279T patent/ATE432053T1/en not_active IP Right Cessation
- 2000-03-10 EP EP00916279A patent/EP1267792B8/en not_active Expired - Lifetime
- 2000-03-10 ES ES00916279T patent/ES2326256T3/en not_active Expired - Lifetime
-
2005
- 2005-10-13 US US11/250,139 patent/USRE42594E1/en not_active Expired - Lifetime
-
2011
- 2011-06-21 US US13/165,181 patent/USRE46208E1/en not_active Expired - Lifetime
- 2011-06-21 US US13/165,153 patent/USRE43881E1/en not_active Expired - Lifetime
Patent Citations (161)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3622743A (en) | 1969-04-28 | 1971-11-23 | Hrand M Muncheryan | Laser eraser and microwelder |
US4122853A (en) | 1977-03-14 | 1978-10-31 | Spectra-Med | Infrared laser photocautery device |
JPS5886787A (en) | 1981-11-19 | 1983-05-24 | Nippon Sekigaisen Kogyo Kk | Laser emitting device |
US4573465A (en) | 1981-11-19 | 1986-03-04 | Nippon Infrared Industries Co., Ltd. | Laser irradiation apparatus |
US4587396A (en) | 1982-12-31 | 1986-05-06 | Laser Industries Ltd. | Control apparatus particularly useful for controlling a laser |
US4718416A (en) | 1984-01-13 | 1988-01-12 | Kabushiki Kaisha Toshiba | Laser treatment apparatus |
US4653495A (en) | 1984-01-13 | 1987-03-31 | Kabushiki Kaisha Toshiba | Laser medical apparatus |
US4733660A (en) | 1984-08-07 | 1988-03-29 | Medical Laser Research And Development Corporation | Laser system for providing target specific energy deposition and damage |
US5104392A (en) | 1985-03-22 | 1992-04-14 | Massachusetts Institute Of Technology | Laser spectro-optic imaging for diagnosis and treatment of diseased tissue |
US5192278A (en) | 1985-03-22 | 1993-03-09 | Massachusetts Institute Of Technology | Multi-fiber plug for a laser catheter |
US5106387A (en) | 1985-03-22 | 1992-04-21 | Massachusetts Institute Of Technology | Method for spectroscopic diagnosis of tissue |
US5843073A (en) | 1985-07-31 | 1998-12-01 | Rare Earth Medical, Inc. | Infrared laser catheter system |
US5618284A (en) | 1985-09-27 | 1997-04-08 | Sunrise Technologies | Collagen treatment apparatus |
US5000752A (en) | 1985-12-13 | 1991-03-19 | William J. Hoskin | Treatment apparatus and method |
US4775361A (en) | 1986-04-10 | 1988-10-04 | The General Hospital Corporation | Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport |
US5336217A (en) | 1986-04-24 | 1994-08-09 | Institut National De La Sante Et De La Recherche Medicale (Insepm) | Process for treatment by irradiating an area of a body, and treatment apparatus usable in dermatology for the treatment of cutaneous angio dysplasias |
US4930504A (en) | 1987-11-13 | 1990-06-05 | Diamantopoulos Costas A | Device for biostimulation of tissue and method for treatment of tissue |
JPH01191801A (en) | 1988-01-28 | 1989-08-01 | Sumitomo Electric Ind Ltd | Condenser lens |
US4976709A (en) | 1988-12-15 | 1990-12-11 | Sand Bruce J | Method for collagen treatment |
US5421337A (en) | 1989-04-14 | 1995-06-06 | Massachusetts Institute Of Technology | Spectral diagnosis of diseased tissue |
US5282797A (en) | 1989-05-30 | 1994-02-01 | Cyrus Chess | Method for treating cutaneous vascular lesions |
US5486172A (en) | 1989-05-30 | 1996-01-23 | Chess; Cyrus | Apparatus for treating cutaneous vascular lesions |
US5312395A (en) | 1990-03-14 | 1994-05-17 | Boston University | Method of treating pigmented lesions using pulsed irradiation |
US5128509A (en) | 1990-09-04 | 1992-07-07 | Reliant Laser Corp. | Method and apparatus for transforming and steering laser beams |
US5312396A (en) | 1990-09-06 | 1994-05-17 | Massachusetts Institute Of Technology | Pulsed laser system for the surgical removal of tissue |
US5302259A (en) | 1991-04-30 | 1994-04-12 | Reginald Birngruber | Method and apparatus for altering the properties in light absorbing material |
US5474549A (en) | 1991-07-09 | 1995-12-12 | Laserscope | Method and system for scanning a laser beam for controlled distribution of laser dosage |
US5178617A (en) | 1991-07-09 | 1993-01-12 | Laserscope | System for controlled distribution of laser dosage |
US5925035A (en) | 1991-10-29 | 1999-07-20 | Thermolase Corporation | Hair removal method |
US5423803A (en) | 1991-10-29 | 1995-06-13 | Thermotrex Corporation | Skin surface peeling process using laser |
US6267771B1 (en) | 1991-10-29 | 2001-07-31 | Thermotrex Corporation | Hair removal device and method |
US6152917A (en) | 1991-10-29 | 2000-11-28 | Thermolase Corporation | Hair removal device |
US5817089A (en) | 1991-10-29 | 1998-10-06 | Thermolase Corporation | Skin treatment process using laser |
US6036684A (en) | 1991-10-29 | 2000-03-14 | Thermolase Corporation | Skin treatment process using laser |
USRE36634E (en) | 1991-12-12 | 2000-03-28 | Ghaffari; Shahriar | Optical system for treatment of vascular lesions |
US5344418A (en) * | 1991-12-12 | 1994-09-06 | Shahriar Ghaffari | Optical system for treatment of vascular lesions |
US5411502A (en) | 1992-01-15 | 1995-05-02 | Laser Industries, Ltd. | System for causing ablation of irradiated material of living tissue while not causing damage below a predetermined depth |
US5618285A (en) | 1992-01-15 | 1997-04-08 | Laser Industries, Limited | System for causing ablation of irradiated material of living tissue while not causing damage below a predetermined depth |
USRE36872E (en) | 1992-01-15 | 2000-09-12 | Laser Industries Ltd. | System for causing ablation of irradiated material of living tissue while not causing damage below a predetermined depth |
US5643252A (en) | 1992-10-28 | 1997-07-01 | Venisect, Inc. | Laser perforator |
US5360447A (en) | 1993-02-03 | 1994-11-01 | Coherent, Inc. | Laser assisted hair transplant method |
US5339347A (en) | 1993-04-27 | 1994-08-16 | The United States Of America As Represented By The United States Department Of Energy | Method for microbeam radiation therapy |
US5860967A (en) | 1993-07-21 | 1999-01-19 | Lucid, Inc. | Dermatological laser treatment system with electronic visualization of the area being treated |
US6315772B1 (en) | 1993-09-24 | 2001-11-13 | Transmedica International, Inc. | Laser assisted pharmaceutical delivery and fluid removal |
US6251100B1 (en) | 1993-09-24 | 2001-06-26 | Transmedica International, Inc. | Laser assisted topical anesthetic permeation |
US6142939A (en) | 1993-11-15 | 2000-11-07 | Spectrx, Inc. | Microporation of human skin for drug delivery and monitoring applications |
US5885211A (en) | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
US5582752A (en) | 1993-12-17 | 1996-12-10 | Laser Industries, Ltd. | Method and apparatus for applying laser beams to a working surface, particularly for ablating tissue |
US5814042A (en) | 1993-12-17 | 1998-09-29 | Laser Industries, Ltd. | Apparatus for applying laser beam to living tissue to cause uniform ablation of living tissue while not causing thermal damage below a predetermined depth to the surrounding tissue |
US5798498A (en) | 1993-12-17 | 1998-08-25 | Laser Industries, Ltd. | Method and apparatus for applying laser beams to a working surface, particularly for ablating tissue |
US5628744A (en) | 1993-12-21 | 1997-05-13 | Laserscope | Treatment beam handpiece |
US5558666A (en) | 1994-01-14 | 1996-09-24 | Coherent, Inc. | Handpiece for producing highly collimated laser beam for dermatological procedures |
US5616140A (en) | 1994-03-21 | 1997-04-01 | Prescott; Marvin | Method and apparatus for therapeutic laser treatment |
US6171301B1 (en) | 1994-04-05 | 2001-01-09 | The Regents Of The University Of California | Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery |
US5814040A (en) * | 1994-04-05 | 1998-09-29 | The Regents Of The University Of California | Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery |
US6248103B1 (en) | 1994-04-05 | 2001-06-19 | The Regents Of The University Of California | Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery using long laser pulses |
US5586981A (en) | 1994-08-25 | 1996-12-24 | Xin-Hua Hu | Treatment of cutaneous vascular and pigmented lesions |
US5531740A (en) | 1994-09-06 | 1996-07-02 | Rapistan Demag Corporation | Automatic color-activated scanning treatment of dermatological conditions by laser |
US5908415A (en) | 1994-09-09 | 1999-06-01 | Rare Earth Medical, Inc. | Phototherapy methods and apparatus |
US5746735A (en) | 1994-10-26 | 1998-05-05 | Cynosure, Inc. | Ultra long pulsed dye laser device for treatment of ectatic vessels and method therefor |
US5733278A (en) | 1994-11-30 | 1998-03-31 | Laser Industries Limited | Method and apparatus for hair transplantation using a scanning continuous-working CO2 laser |
US5632741A (en) | 1995-01-20 | 1997-05-27 | Lucid Technologies, Inc. | Epilation system |
US6328733B1 (en) | 1995-01-23 | 2001-12-11 | Lumenis Inc. | Hand-held laser scanner |
US5957915A (en) | 1995-01-23 | 1999-09-28 | Coherent, Inc. | Hand-held laser scanner |
US5735844A (en) * | 1995-02-01 | 1998-04-07 | The General Hospital Corporation | Hair removal using optical pulses |
US5595568A (en) | 1995-02-01 | 1997-01-21 | The General Hospital Corporation | Permanent hair removal using optical pulses |
US5807386A (en) | 1995-02-03 | 1998-09-15 | Laser Industries, Ltd. | Laser facial rejuvenation |
US5624434A (en) | 1995-02-03 | 1997-04-29 | Laser Industries, Ltd. | Laser preparation of recipient holes for graft implantation in the treatment of icepick scars |
US5611795A (en) | 1995-02-03 | 1997-03-18 | Laser Industries, Ltd. | Laser facial rejuvenation |
US5995866A (en) | 1995-03-21 | 1999-11-30 | Lemelson; Jerome | Method and apparatus for scanning and evaluating matter |
US6096031A (en) | 1995-04-17 | 2000-08-01 | Coherent, Inc. | High repetition rate erbium:YAG laser for tissue ablation |
US6241753B1 (en) | 1995-05-05 | 2001-06-05 | Thermage, Inc. | Method for scar collagen formation and contraction |
US5879326A (en) | 1995-05-22 | 1999-03-09 | Godshall; Ned Allen | Method and apparatus for disruption of the epidermis |
US5624435A (en) | 1995-06-05 | 1997-04-29 | Cynosure, Inc. | Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor |
US6475138B1 (en) | 1995-07-12 | 2002-11-05 | Laser Industries Ltd. | Apparatus and method as preparation for performing a myringotomy in a child's ear without the need for anaesthesia |
US5713364A (en) | 1995-08-01 | 1998-02-03 | Medispectra, Inc. | Spectral volume microprobe analysis of materials |
US6680999B1 (en) | 1995-08-15 | 2004-01-20 | Mumps Audiofax, Inc. | Interactive telephony system |
US5865754A (en) | 1995-08-24 | 1999-02-02 | Purdue Research Foundation Office Of Technology Transfer | Fluorescence imaging system and method |
US5546214A (en) | 1995-09-13 | 1996-08-13 | Reliant Technologies, Inc. | Method and apparatus for treating a surface with a scanning laser beam having an improved intensity cross-section |
US5964749A (en) | 1995-09-15 | 1999-10-12 | Esc Medical Systems Ltd. | Method and apparatus for skin rejuvenation and wrinkle smoothing |
US6387089B1 (en) | 1995-09-15 | 2002-05-14 | Lumenis Ltd. | Method and apparatus for skin rejuvination and wrinkle smoothing |
US5860968A (en) | 1995-11-03 | 1999-01-19 | Luxar Corporation | Laser scanning method and apparatus |
US5897549A (en) | 1995-11-29 | 1999-04-27 | Lumedics, Ltd. | Transformation of unwanted tissue by deep laser heating of water |
US6083217A (en) | 1995-11-29 | 2000-07-04 | Lumedics, Ltd. | Destruction for unwanted tissue by deep laser heating of water |
US5879346A (en) | 1995-12-18 | 1999-03-09 | Esc Medical Systems, Ltd. | Hair removal by selective photothermolysis with an alexandrite laser |
JPH09285471A (en) | 1996-04-25 | 1997-11-04 | Nec Corp | Keratin removing device |
US5970983A (en) | 1996-05-15 | 1999-10-26 | Esc Medical Systems Ltd. | Method of laser surgery |
US5655547A (en) | 1996-05-15 | 1997-08-12 | Esc Medical Systems Ltd. | Method for laser surgery |
US5820626A (en) * | 1996-07-30 | 1998-10-13 | Laser Aesthetics, Inc. | Cooling laser handpiece with refillable coolant reservoir |
US5976123A (en) | 1996-07-30 | 1999-11-02 | Laser Aesthetics, Inc. | Heart stabilization |
US6106514A (en) | 1996-08-12 | 2000-08-22 | O'donnell, Jr.; Francis E. | Laser method for subsurface cutaneous treatment |
US5995265A (en) | 1996-08-12 | 1999-11-30 | Black; Michael | Method and apparatus for treating a surface with a scanning laser beam having an improved intensity cross-section |
US6197020B1 (en) | 1996-08-12 | 2001-03-06 | Sublase, Inc. | Laser apparatus for subsurface cutaneous treatment |
US6443946B2 (en) | 1996-08-29 | 2002-09-03 | Icn Photonics Limited | Apparatus for wrinkle removal |
US5983900A (en) | 1996-08-29 | 1999-11-16 | Clement; Robert Marc | Wrinkle removal |
EP0827219A2 (en) | 1996-08-30 | 1998-03-04 | Honda Giken Kogyo Kabushiki Kaisha | Composite magnetostrictive material, and process for producing the same |
EP0827716A2 (en) | 1996-09-04 | 1998-03-11 | ESC Medical Systems Ltd. | Device for cooling skin during laser treatment |
US5759200A (en) | 1996-09-04 | 1998-06-02 | Azar; Zion | Method of selective photothermolysis |
US6251099B1 (en) | 1996-11-27 | 2001-06-26 | The General Hospital Corporation | Compound delivery using impulse transients |
US6015404A (en) | 1996-12-02 | 2000-01-18 | Palomar Medical Technologies, Inc. | Laser dermatology with feedback control |
US7204832B2 (en) | 1996-12-02 | 2007-04-17 | Pálomar Medical Technologies, Inc. | Cooling system for a photo cosmetic device |
WO1998024514A1 (en) | 1996-12-02 | 1998-06-11 | Palomar Medical Technologies Inc. | Laser dermatology with feedback control |
US6508813B1 (en) | 1996-12-02 | 2003-01-21 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation dermatology and head for use therewith |
US6050990A (en) | 1996-12-05 | 2000-04-18 | Thermolase Corporation | Methods and devices for inhibiting hair growth and related skin treatments |
US6162211A (en) | 1996-12-05 | 2000-12-19 | Thermolase Corporation | Skin enhancement using laser light |
WO1998024507A2 (en) | 1996-12-05 | 1998-06-11 | Thermolase Corporation | Methods and devices for inhibiting hair growth and related skin treatments |
WO1998024502A1 (en) | 1996-12-06 | 1998-06-11 | Target Therapeutics, Inc. | Reinforced catheter with a formable distal tip |
US6063108A (en) | 1997-01-06 | 2000-05-16 | Salansky; Norman | Method and apparatus for localized low energy photon therapy (LEPT) |
US5830208A (en) * | 1997-01-31 | 1998-11-03 | Laserlite, Llc | Peltier cooled apparatus and methods for dermatological treatment |
US6120497A (en) | 1997-02-05 | 2000-09-19 | Massachusetts General Hospital | Method and apparatus for treating wrinkles in skin using radiation |
US5810801A (en) | 1997-02-05 | 1998-09-22 | Candela Corporation | Method and apparatus for treating wrinkles in skin using radiation |
US5938657A (en) | 1997-02-05 | 1999-08-17 | Sahar Technologies, Inc. | Apparatus for delivering energy within continuous outline |
US5906609A (en) | 1997-02-05 | 1999-05-25 | Sahar Technologies | Method for delivering energy within continuous outline |
US6096029A (en) * | 1997-02-24 | 2000-08-01 | Laser Skin Toner, Inc. | Laser method for subsurface cutaneous treatment |
US6171302B1 (en) | 1997-03-19 | 2001-01-09 | Gerard Talpalriu | Apparatus and method including a handpiece for synchronizing the pulsing of a light source |
US6245060B1 (en) | 1997-03-25 | 2001-06-12 | Abbott Laboratories | Removal of stratum corneum by means of light |
US6027496A (en) | 1997-03-25 | 2000-02-22 | Abbott Laboratories | Removal of stratum corneum by means of light |
US6235015B1 (en) | 1997-05-14 | 2001-05-22 | Applied Optronics Corporation | Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm |
US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US6273884B1 (en) | 1997-05-15 | 2001-08-14 | Palomar Medical Technologies, Inc. | Method and apparatus for dermatology treatment |
US6575963B1 (en) | 1997-07-16 | 2003-06-10 | The Lion Eye Institute Of Western Australia Incorporated | Laser scanning apparatus and method |
US6104959A (en) * | 1997-07-31 | 2000-08-15 | Microwave Medical Corp. | Method and apparatus for treating subcutaneous histological features |
US6168590B1 (en) | 1997-08-12 | 2001-01-02 | Y-Beam Technologies, Inc. | Method for permanent hair removal |
US6273885B1 (en) | 1997-08-16 | 2001-08-14 | Cooltouch Corporation | Handheld photoepilation device and method |
US5984915A (en) | 1997-10-08 | 1999-11-16 | Trimedyne, Inc. | Percutaneous laser treatment |
US6176854B1 (en) | 1997-10-08 | 2001-01-23 | Robert Roy Cone | Percutaneous laser treatment |
US5968033A (en) | 1997-11-03 | 1999-10-19 | Fuller Research Corporation | Optical delivery system and method for subsurface tissue irradiation |
US5947956A (en) | 1997-11-04 | 1999-09-07 | Karell; Manuel Leon | Laser apparatus for making holes and etchings |
WO1999027997A1 (en) | 1997-12-01 | 1999-06-10 | Esc Medical Systems Ltd. | Improved depilatory method and device |
US6113559A (en) | 1997-12-29 | 2000-09-05 | Klopotek; Peter J. | Method and apparatus for therapeutic treatment of skin with ultrasound |
US6165170A (en) | 1998-01-29 | 2000-12-26 | International Business Machines Corporation | Laser dermablator and dermablation |
US6149644A (en) | 1998-02-17 | 2000-11-21 | Altralight, Inc. | Method and apparatus for epidermal treatment with computer controlled moving focused infrared light |
US5980512A (en) | 1998-02-26 | 1999-11-09 | Silberg; Barry | Enhanced laser skin treatment mechanism |
US6530915B1 (en) | 1998-03-06 | 2003-03-11 | Spectrx, Inc. | Photothermal structure for biomedical applications, and method therefor |
US6173202B1 (en) | 1998-03-06 | 2001-01-09 | Spectrx, Inc. | Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue |
US6022316A (en) | 1998-03-06 | 2000-02-08 | Spectrx, Inc. | Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications |
US6074384A (en) | 1998-03-06 | 2000-06-13 | Plc Medical Systems, Inc. | Endocardial laser revascularization with single laser pulses |
US6605080B1 (en) | 1998-03-27 | 2003-08-12 | The General Hospital Corporation | Method and apparatus for the selective targeting of lipid-rich tissues |
US6149645A (en) | 1998-04-03 | 2000-11-21 | Tobinick; Edward L. | Apparatus and method employing lasers for removal of hair |
US6264649B1 (en) * | 1998-04-09 | 2001-07-24 | Ian Andrew Whitcroft | Laser treatment cooling head |
US6443978B1 (en) | 1998-04-10 | 2002-09-03 | Board Of Trustees Of The University Of Arkansas | Photomatrix device |
US5997530A (en) | 1998-04-13 | 1999-12-07 | The Regents Of The University Of California | Apparatus and method to control atmospheric water vapor composition and concentration during dynamic cooling of biological tissues in conjunction with laser irradiations |
US6579283B1 (en) | 1998-05-22 | 2003-06-17 | Edward L. Tobinick | Apparatus and method employing a single laser for removal of hair, veins and capillaries |
US6514278B1 (en) | 1998-05-28 | 2003-02-04 | Carl Baasel Lasertechnik Gmbh | Method and device for the superficial heating of tissue |
US6537270B1 (en) | 1998-08-13 | 2003-03-25 | Asclepion-Meditec Ag | Medical hand piece for a laser radiation source |
US6059820A (en) * | 1998-10-16 | 2000-05-09 | Paradigm Medical Corporation | Tissue cooling rod for laser surgery |
US6632219B1 (en) | 1998-10-16 | 2003-10-14 | Eugene Baranov | Tissue cooling rod for laser surgery |
US6468229B1 (en) | 1998-10-20 | 2002-10-22 | Abbott Laboratories | Apparatus and method for the collection of interstitial fluids |
US6219575B1 (en) | 1998-10-23 | 2001-04-17 | Babak Nemati | Method and apparatus to enhance optical transparency of biological tissues |
US6325769B1 (en) | 1998-12-29 | 2001-12-04 | Collapeutics, Llc | Method and apparatus for therapeutic treatment of skin |
US6183773B1 (en) | 1999-01-04 | 2001-02-06 | The General Hospital Corporation | Targeting of sebaceous follicles as a treatment of sebaceous gland disorders |
US6445491B2 (en) | 1999-01-29 | 2002-09-03 | Irma America, Inc. | Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification |
US6881212B1 (en) | 1999-03-05 | 2005-04-19 | Icn Photonics Limited | Skin wrinkle reduction using pulsed light |
US6572637B1 (en) | 1999-03-12 | 2003-06-03 | Ya-Man Ltd. | Handbreadth-sized laser beam projecting probe for beauty treatment |
US6607523B1 (en) | 1999-03-19 | 2003-08-19 | Asah Medico A/S | Apparatus for tissue treatment |
US6685699B1 (en) | 1999-06-09 | 2004-02-03 | Spectrx, Inc. | Self-removing energy absorbing structure for thermal tissue ablation |
US6413267B1 (en) | 1999-08-09 | 2002-07-02 | Theralase, Inc. | Therapeutic laser device and method including noninvasive subsurface monitoring and controlling means |
US6406474B1 (en) | 1999-09-30 | 2002-06-18 | Ceramoptec Ind Inc | Device and method for application of radiation |
US6758845B1 (en) | 1999-10-08 | 2004-07-06 | Lumenis Inc. | Automatic firing apparatus and methods for laser skin treatment over large areas |
US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
WO2001039834A1 (en) | 1999-12-02 | 2001-06-07 | Radiancy, Inc. | Selective photothermolysis |
Non-Patent Citations (19)
Title |
---|
Anderson, R.R. et. Al., "Laser-Tissue Interactions," Cosmetic Laser Surgery, 2000, pp. 1-30, Mosby. |
Apfelberg, et al., Dot or Pointillistic Method for Improvement in Results of Hypertrophic Scarring in the Argon Laser Treatment of Portwine Hemangiomas, Lasers in Surgery and Medicine, 6:552-558 (1987). |
Apfelberg, Intralesional Laser Photocoagulation-Steroids as an Adjunct to Surgery for Massive Hemangiomas and Vascular Malformations, Atherton Plastic Surgery and Laser Center, Atherton, CA 1995, pp. 144-149. |
European Office Action, European Application No. 00916279.3, Aug. 28, 2006, 4 pages. |
European Office Action, European Application No. 00916279.3, Dec. 15, 2006, 4 pages. |
European Search Report, European Application No. 00916279.3, May 11, 2005, 2 pages. |
Fitzpatrick, R.E., "Laser Hair Transplanation. Tissue effects of Laser Parameters," Dermatol. Surg., Dec. 1995, pp. 1042-1046, vol. 21. No. 12. |
Fujii, et al., Fibre bundle scanner for laser photocoagulation treatment. Optics and Laser Technology, Feb. 1982, pp. 39-41. |
Fujii, et al., Multispot laser photogoagulation system using a fiber bundle scanner, Applied Optics, vol. 21, No. 19, Oct. 1982, pp. 3437-3442. |
Grevelink, J.M., "Laser Hair Tranplanation," Dermatolog Clinics, Jul. 1, 1997, pp. 479-486, vol. 15, Issue 3. |
Manstein, D. et al., "Spatially Confined Photothermolysis of dermal targets using an IR-fiberlaser in combination with focusing and contact cooling," American Society for Laser Medicine and Surgery, 2002, Abstract 92, p. 28. |
McKenzie, A.L, "A Three-Zone Model of Tissue Damage by a CO2 Laser," Phys. Med. Boil, 1986, pp. 967-983, vol. 31, No. 9. |
Nelson, J.S. et al., "Dynamic Epidermal Cooling in Conjunction with Laser-Induced Photothermolysis of Port Wine Stain Blood Vessels," Lasers in Surgery and Medicine, 1996, pp. 224-229, vol. 19. |
Partovi, F. et al., "A Model for Thermal Ablation of Biological Tissue Using Laser Radiation," Lasers in Surgery and Medicine, 1987, pp. 141-154, vol. 7. |
PCT international Search Report, PCT/US00/064085, Jul. 88, 2000, 1 page. |
Rubach, B.W. et al., "Histological and Clinical Evaluation of Facial Resurfacing Using a Carbon Dioxide Laser with the Computer Pattern Generator," Arch. Otolaryngol. Head Neck Surg., Sep. 1997, pp. 929-934, vol. 123, No. 9. |
Unger, W.P. "Laser Hair Transplanation III. Computer-Assisted Laser Tranplanting," Dermatol. Surg. Dec. 1995, pp. 1047-1055, vol. 21, No. 12. |
Unger, W.P. et al., "Laser Hair Tranplantation," J. Dermatol. Surg. Oncol., Aug. 1994, pp. 515-521, vol. 20, No. 8. |
US 6,344,051, 02/2002, Dumoulin-White et al. (withdrawn) |
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AU2000237407A1 (en) | 2001-09-24 |
EP1267792A1 (en) | 2003-01-02 |
EP1267792B8 (en) | 2009-08-19 |
USRE42594E1 (en) | 2011-08-02 |
DE60042284D1 (en) | 2009-07-09 |
US6059820A (en) | 2000-05-09 |
US6632219B1 (en) | 2003-10-14 |
EP1267792A4 (en) | 2005-06-22 |
USRE43881E1 (en) | 2012-12-25 |
EP1267792B1 (en) | 2009-05-27 |
WO2001068185A1 (en) | 2001-09-20 |
ES2326256T3 (en) | 2009-10-06 |
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