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Vascular device for emboli, thrombus and foreign body removal and methods of use

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USRE43882E1
USRE43882E1 US13162769 US201113162769A USRE43882E1 US RE43882 E1 USRE43882 E1 US RE43882E1 US 13162769 US13162769 US 13162769 US 201113162769 A US201113162769 A US 201113162769A US RE43882 E1 USRE43882 E1 US RE43882E1
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Prior art keywords
vascular
device
support
delivery
hoop
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US13162769
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Leo N. Hopkins
Farhad Khosravi
Amr Salahieh
Jackson F. Demond
Jonah Lepak
Stephen Ramee
Jeff A. Krolik
Richard Renati
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Incept LLC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2/013Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stending
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A61B2017/2212Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having a closed distal end, e.g. a loop
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2002/011Instruments for their placement or removal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2002/018Filters implantable into blood vessels made from tubes or sheets of material, e.g. by etching or laser-cutting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/09175Guide wires having specific characteristics at the distal tip
    • A61M2025/09183Guide wires having specific characteristics at the distal tip having tools at the distal tip
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M2025/1043Balloon catheters with special features or adapted for special applications
    • A61M2025/1052Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M2025/1043Balloon catheters with special features or adapted for special applications
    • A61M2025/109Balloon catheters with special features or adapted for special applications having balloons for removing solid matters, e.g. by grasping or scraping plaque, thrombus or other matters that obstruct the flow

Abstract

Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.

Description

REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of is a continuation-in-part of U.S. patent application Ser. No. 09/364,064, filed Jul. 30, 1999, now U.S. Pat. No. 6,530,939.

This application is also a continuation-in-part of U.S. patent application Ser. No. 09/430,211, filed Oct. 29, 1999, now U.S. Pat. No. 6,589,263.

This application is also a continuation-in-part of U.S. patent application Ser. No. 09/470,681, filed Dec. 23, 1999, now U.S. Pat. No. 6,203,561.

This application is also a continuation-in-part of U.S. Pat.patent application Ser. No. 09/470,682, filed Dec. 23, 1999, now U.S. Pat. No. 6,214,026.

This application is also a continuation-in-part of U.S. Pat.patent application Ser. No. 09/470,703, filed Dec. 23, 1999, now U.S. Pat. No. 6,179,861.

This application is also a continuation-in-part of U.S. Pat.patent application Ser. No. 09/470,857, filed Dec. 23, 1999, now U.S. Pat. No. 6,129,739 and.

This application is also a continuation-in-part of U.S. Pat.patent application Ser. No. 09/611,428, filed Jul. 7, 2000, all of whichnow U.S. Pat. No. 6,616,678.

Each of the above-cited documents are incorporated herein by reference.

FIELD OF THE INVENTION

The present invention relates to apparatus and methods for filtering or removing matter from within a vascular system. More particularly, the present invention provides a low profile self-expanding vascular device useful for capturing emboli or foreign bodies generated during interventional procedures, and for thrombectomy and embolectomy.

BACKGROUND OF THE INVENTION

Percutaneous interventional procedures to treat occlusive vascular disease, such as angioplasty, atherectomy and stenting, often dislodge material from the vessel walls. This dislodged material, known as emboli, enters the bloodstream, and may be large enough to occlude smaller downstream vessels, potentially blocking blood flow to tissue. The resulting ischemia poses a serious threat to the health or life of a patient if the blockage occurs in critical tissue, such as the heart, lungs, or brain.

The deployment of stents and stent-grafts to treat vascular disease, such as aneurysms, also involves the introduction of foreign objects into the bloodstream, and also may result in the formation of clots or release of emboli. Such particulate matter, if released into the bloodstream, also may cause infarction or stroke.

Furthermore, interventional procedures may generate foreign bodies that are left within a patient's bloodstream, thereby endangering the life of the patient. Foreign bodies may include, for example, a broken guide wire, pieces of a stent, or pieces of a catheter.

Numerous previously known methods and apparatus have been proposed to reduce complications associated with embolism, release of thrombus, or foreign body material generation. U.S. Pat. No. 5,833,644 to Zadno-Azizi et al., for example, describes the use of a balloon-tipped catheter to temporarily occlude flow through a vessel from which a stenosis is to be removed. Stenotic material removed during a treatment procedure is evacuated from the vessel before the flow of blood is restored. A drawback of such previously known systems, however, is that occlusion of antegrade flow through the vessel may result in damage to the tissue normally fed by the blocked vessel.

U.S. Pat. No. 5,814,064 to Daniel et al. describes an emboli filter system having a radially expandable mesh filter disposed on the distal end of a guide wire. The filter is deployed distal to a region of stenosis, and any interventional devices, such as angioplasty balloons or stent delivery systems, are advanced along the guide wire. The filter is designed to capture emboli generated during treatment of the stenosis while permitting blood to flow through the filter. Similar filter systems are described in U.S. Pat. No. 4,723,549 to Wholey et al. and U.S. Pat. No. 5,827,324 to Cassell et al.

One disadvantage of radially expandable filter systems such as described in the foregoing patents is the relative complexity of the devices, which typically comprise numerous parts. Connecting more than a minimal number of such parts to a guide wire generally increases delivery complications. The ability of the guide wire to negotiate tortuous anatomy is reduced, and the profile of the device in its delivery configuration increases. Consequently, it may be difficult or impossible to use such devices in small diameter vessels, such as are commonly found in the carotid artery and cerebral vasculature. Moreover, such filter devices are generally incapable of preventing material from escaping from the filter during the process of collapsing the filter for removal.

International Publication No. WO 98/39053 describes a filter system comprising an elongated member, a radially expandable hoop and a cone-shaped basket. The hoop is affixed to the elongated member, and the cone-shaped basket is attached to the hoop and the elongated member, so that the hoop forms the mouth of the basket. The filter system includes a specially configured delivery catheter that retains the mouth of the basket in a radially retracted position during delivery.

While the filter system described in the foregoing International Publication reduces the number of components used to deploy the cone-shaped basket, as compared to the radial strut-type filter elements described hereinabove, it too has drawbacks. Chief among these, it is expected that it will be difficult to reduce the diameter of the radially expandable hoop to its retracted position. In particular, as the hoop is contracted through smaller radii of curvature, the stiffness of the hoop is expected to increase dramatically. This increased stiffness prevents the hoop from being contracted more tightly, and is expected to result in a delivery profile too large to permit use of the device in critical regions of the body, such as the smaller coronary arteries, carotid arteries, and cerebral vasculature.

In view of the foregoing disadvantages of previously known apparatus and methods, it would be desirable to provide a vascular device, e.g., for use as a vascular filter, that overcomes such disadvantages and employs few components.

It would be desirable to provide a reliable and multi-functional delivery system for use with the vascular device.

It would be desirable to provide an integrated vascular device with a thrombectomy element and a vascular filter.

It also would be desirable to provide a vascular device that is capable of being contracted to a small delivery profile, thus permitting use of the device in small vessels.

It further would be desirable to provide a vascular device that is capable of being contracted to a sufficiently small profile that it may be retrieved using the guide wire lumen of previously known treatment devices, and without the need for specialized delivery catheters.

It still further would be desirable to provide a vascular device that reduces the risk of emboli or thrombus removed from the vessel wall escaping from the device when the device is collapsed and removed.

It also would be desirable to provide a vascular device that permits a rapid exchange deployment modality.

SUMMARY OF THE INVENTION

In view of the foregoing, it is an object of the present invention to provide a vascular device that overcomes disadvantages of previously known vascular filters, thrombectomy/embolectomy and foreign body removal devices, and employs few components.

It is an object of the present invention to provide a reliable and multi-functional delivery system for use with the vascular device.

It is an object to provide an integrated vascular device with a thrombectomy element and a vascular filter.

It also is an object of this invention to provide a vascular device that is capable of being contracted to a small delivery profile, thus permitting use of the device in small vessels.

It is a further object to provide a vascular device that is capable of being contracted to a sufficiently small profile that it may be retrieved using the guide wire lumen of previously known treatment devices, and without the need for specialized delivery catheters.

It is another object to provide a vascular device that reduces the risk of emboli or thrombus removed from the vessel wall escaping from the device when the device is collapsed and removed.

It also is an object to provide a vascular device that permits a rapid exchange deployment modality.

These and other objects of the present invention are accomplished by providing a vascular device, suitable for use as a vascular filter or thrombectomy/embolectomy device that comprises a blood permeable sac affixed at its perimeter to a support hoop having an articulation region. The support hoop is attached to a distal region of an elongated member, such as a guide wire, and supports a proximally-oriented mouth of the sac when the device is deployed in a vessel. The device may also comprise a nose cone to facilitate percutaneous introduction, and a delivery sheath having one or more lumens. The lumens may further be configured for a rapid exchange mode of introduction along the guide wire.

In a first embodiment, the support hoop includes one or more reduced-thickness articulation regions that enable the support hoop to be contracted to very small radii of curvature without the problems of increased stiffness and kinking of previously known devices. In an alternative embodiment, the articulation region may comprise a gap in the support hoop bridged by the perimeter of the blood permeable sac.

The support hoop preferably also has a curved profile that prevents the articulation region, when folded, from damaging the wall of the vessel. The curved profile permits the device to effectively contact the walls of the vessel and reduce emboli or thrombus removed from the vessel wall from bypassing the sac. Moreover, the articulation region, when combined with a support hoop having a curved profile, causes the sides of the support hoop to fold inwards towards one-another when the vascular device is collapsed into a sheath for removal. This, in turn, closes the mouth of the sac and reduces the potential for emboli or thrombus to be released from the vascular device during removal.

Advantageously, use of an articulation region permits vascular devices of the present invention to be contracted to very small diameters, thereby enabling the use of delivery catheters having diameters as small as 3 Fr. Moreover, the vascular devices may be retracted within the guide wire lumens of conventional treatment devices, such as angioplasty catheters and stunt delivery systems, thereby obviating the need to re-insert a specialized delivery catheter to remove the vascular device. However, a retrieval sheath having a distal region that flares or expands outwardly to receive the emboli-filled sac upon completion of an interventional procedure, and which reduces risk of rupture to the sac, optionally may be provided in accordance with the present invention.

In embodiments suitable for use as embolic filters, the vascular device may include a separate guide wire for introducing treatment devices proximal of the deployed vascular device. Additionally, the vascular device may have a second support hoop attached to the distal end of the sac. During retrieval, multiple hoops ensure that emboli are retained within the sac and prevent the sac from bunching. Where multiple hoops are rotated, they may be arranged such that they rotate independently of the guide wire, thereby reducing risk that the sac wall will become twisted during advancement.

In alternative embodiments, sac bunching is mitigated by tapering the sac and attaching it to one or more support hoops, or to the guide wire. Sac porosity may also be specified to ensure passage of blood cells and capture of emboli, as well as to control a pressure drop across the vascular device. In other embodiments, a delivery sheath is provided that permits a lesion to first be crossed with an unencumbered guide wire prior to passing the vascular device across the lesion. In still further embodiments, several support hoops may be provided at the mouth of a single sac to facilitate opening and closing of the sac.

In thrombectomy applications, a separate thrombectomy element may be provided in addition to the vascular filter. The thrombectomy element may be attached to the elongated member proximal of the vascular filter or may comprise a separate catheter. In a preferred embodiment, the thrombectomy element is similar in construction to the vascular filter and may be retracted independently. Alternatively, the thrombectomy element may be any conventional atherectomy device used in conjunction with the vascular filter and may be advanced and retracted either in conjunction or independently of the vascular filter.

A delivery system in accordance with the present invention, configured for use with the vascular devices described herein, is also provided. The delivery system integrates the functions of a Touhy Borst, a torquer, and a pusher into a single device, thereby facilitating introduction and retrieval of embodiments of the present invention. The torqueing function allows a vascular device to navigate tortuous anatomy. For example, the distal end of a guide wire may be rotated to selectively orient the vascular device in a selected branch of a bifurcated vessel.

The Touhy-Borst adapter permits liquid to be introduced or withdrawn through the lumen of the vascular device delivery catheter. The pusher feature of the delivery system allows deployment and retraction of the vascular device from within the delivery catheter.

Methods of using embodiments of the present invention are also provided, including use of novel radiopaque features, and use of a previously known balloon catheter to arrest antegrade flow through a vessel until the vascular device of the present invention is deployed.

BRIEF DESCRIPTION OF THE DRAWINGS

The above and other objects and advantages of the present invention will be apparent upon consideration of the following detailed description, taken in conjunction with the accompanying drawings, in which like reference characters refer to like parts throughout, and in which:

FIGS. 1A and 1B are, respectively, a side-sectional view of a previously known vascular device contracted within a delivery sheath, and an end view of that vascular device deployed in a vessel;

FIGS. 2A and 2B are, respectively, a perspective view of a vascular device constructed in accordance with the principles of the present invention in a deployed state, and a detailed view of the articulation region of the device of FIG. 2A;

FIG. 3 is a perspective view of the vascular device of FIGS. 2 in a folded configuration, prior to removal;

FIG. 4 is a plan view of the vascular device of FIGS. 2;

FIGS. 5A-5D are side sectional views depicting a method of deploying, using, and retrieving the vascular device of FIGS. 2-4;

FIG. 6 is a perspective view of an alternative embodiment of a vascular device of the present invention in a deployed state;

FIGS. 7A and 7B are, respectively, a perspective view and a plan view of a further alternative embodiment of the present invention in a deployed state;

FIGS. 8A-8E are sectional views of a vascular device disposed within alternative embodiments of delivery sheaths of the present invention;

FIG. 9 is a side view of a previously known balloon catheter;

FIGS. 10A-10D are views illustrating the steps of using the balloon catheter of FIG. 9 with the vascular device of FIGS. 2;

FIGS. 11A-11C are perspective views of further alternative embodiments of vascular devices constructed in accordance with the principles of the present invention;

FIG. 12 is a perspective view of an alternative embodiment of the vascular device of the present invention with two support hoops, shown in a deployed state;

FIG. 13 is a perspective view of an alternative embodiment of the vascular device of FIG. 12 with a smaller distal support hoop;

FIG. 14 is a perspective view of a still further alternative embodiment of the vascular device of FIG. 12 that allows the vascular device to independently rotate with respect to the guide wire;

FIG. 15 is a perspective view of an alternative embodiment of the present invention with a tapered blood permeable sac, shown in a deployed state;

FIG. 16 is a perspective view of a radiopaque support hoop constructed in accordance with one aspect of the present invention;

FIGS. 17A-17C illustrate another alternative embodiment of the vascular device of the present invention in which the articulation region comprises a gap in the support hoop bridged by the perimeter of the blood permeable sac;

FIGS. 18A and 18B are side-sectional views depicting an integrated vascular device of the present invention suitable for thrombectomy, disposed, respectively, within a delivery sheath and in a deployed state;

FIGS. 19A-19E are side-sectional views depicting a method of deploying, using, and retrieving the integrated vascular device of FIGS. 18;

FIGS. 20A and 20B are side-sectional views depicting an alternative embodiment of the integrated vascular device of FIGS. 18, disposed, respectively, within a delivery sheath and in a deployed state;

FIGS. 21A and 21B are side sectional views of delivery system constructed in accordance with the resent invention coupled to the vascular device of FIG. 5A, shown, respectively, in a delivery configuration and in a deployed configuration;

FIGS. 22A-22E are side sectional views depicting a method of deploying, using, and retrieving a vascular device of the present invention in conjunction with a specially configured retrieval sheath; and

FIGS. 23A and 23B are side sectional views depicting a method of using and retrieving the vascular device in conjunction with an alternative embodiment of the specially configured retrieval sheath.

DETAILED DESCRIPTION OF THE INVENTION

Referring to FIGS. 1A and 1B, some of the disadvantages associated with previously known vascular devices, such as the emboli filters described in the above-mentioned International Publication WO 98/39053, are described. In FIGS. 1, the vascular filter comprises guide wire 10 having hoop 12 coupled to its end. Filter sac 14 is affixed to hoop 12, so that when delivery catheter 16 is retracted proximally and guide wire 10 is held stationary, hoop 12 radially expands to contact the walls of vessel V.

As described hereinabove, one difficulty with such vascular filters is that the hoop used to support the filter sac experiences increased stiffness when contracted to small diameters, i.e., due to the sharp directional change at the tip of the hoop, thereby limiting the minimum delivery profile achievable for such instruments. Although this effect may be reduced by decreasing the thickness of the wire employed in hoop 12, at the point at which the wire becomes sufficiently thin to accommodate the bending stresses, the wire is too thin to effectively radially expand and urge the filter sac into engagement with the vessel wall.

On the other hand, as shown in FIGS. 1A and 1B, the bending stresses imposed upon the hoop of such previously known devices, if drawn within a delivery catheter, may be sufficiently high to result in the formation of kink 18 at the tip of the hoop. This “kinking” effect becomes more severe in sheaths having a small inner diameter. Thus, for example, applicant has observed that when sheaths having inner diameters of 0.035″ or smaller are used, a hoop of nitinol or multi-strand nitinol cable having a diameter of 0.0055″ will form kink 18. Kink 18 in turn may apply relatively high localized pressure and friction against wall 17 of sheath 16, thereby making the vascular filter difficult to deploy. In particular, the kink may impale wall 17 of delivery sheath 16 and may make it difficult or impossible to deploy the vascular filter, especially in tortuous anatomy.

In addition, when the filter is subsequently deployed in vessel V, as shown in FIG. 1B, kink 18 may deform the pre-formed shape of hoop 12, impairing the ability of the filter to seal against the walls of vessel V. This may in turn lead to the presence of gaps G between the perimeter of the hoop and the vessel wall, depending upon the severity of the kink. Consequently, emboli may pass through the gaps with antegrade flow and significantly reduce the efficacy of the filter. Additionally, kink 18 may be sufficiently sharp to damage or dissect the wall of vessel V when the filter is deployed.

The vascular device of the present invention solves the above-described disadvantages, providing a vascular device, suitable for use as a vascular filter or thrombectomy/embolectomy device, with a self-expanding support hoop that is sufficiently thick to radially expand and urge a blood permeable sac into engagement with the vessel wall, but which includes an articulation region that overcomes the problems associated with kinking. In particular, the vascular device of the present invention includes a reduced thickness articulation region and a pre-formed curved profile that avoids the difficulties of previously known systems while providing a high degree of efficacy in capturing emboli or thrombus, and ease of deployment and retrieval.

Referring now to FIGS. 2A and 2B, vascular device 20 constructed in accordance with the principles of the present invention, illustratively an embolic filler, comprises guide wire 22, support hoop 24 having articulation region 26, and blood permeable sac 28 affixed to support hoop 24. Sac 28 is coupled to support hoop 24 so that the support hoop 24 forms an opening for the sac. Support hoop 24 preferably is connected to guide wire 22 near distal end 23 of the guide wire.

Sac 28 preferably is constructed of a thin, flexible biocompatible material, such as polyethylene, polypropylene, polyurethane, polyester, polyethylene tetraphlalate, nylon or polytetrafluoroethylene, or combinations thereof. The material should be sufficiently thin, such that the sac is non-thrombogenic. Sac 28 includes openings or pores 30 that permit blood cells to pass through the sac substantially unhindered, while capturing any larger emboli, thrombus, or foreign bodies that may be released during a procedure, such as angioplasty or stent placement. In a preferred embodiment, sac 28 has openings or pores 30 in a range of about 20 to 400 microns in diameter, and more preferably, about approximately 80 microns. These pore sizes permit red blood cells (which have a diameter of approximately 5 microns) to easily pass through the sac, while capturing thrombus or emboli.

Pores 30 are preferably formed by a laser drilling process. For example, a thin sheet of the flexible biocompatible material may be thermoformed to create sac 28, for example, by stretching the sheet over a mandrel, by dip forming, or by blow molding. Sac 28 may alternatively be fabricated from an extruded tube of the biocompatible material. A flat metal mask, with tiny holes approximately the size of pores 30, may then be placed in front of the sac. Alaser having a beam diameter equal to or greater than the diameter of the material illuminates the mask. The laser beam passes through the holes in the mask and strikes the material, thereby forming pores 30 in sac 28.

Laser drilling may also be accomplished with a laser having a beam diameter approximately the size of pores 30, in which case pores 30 may drilled individually. Sac 28 may alternatively comprise a woven material, for example, formed from the above-mentioned polymers, having a pore diameter determined as a function of the pattern and tightness of the weave.

Support hoop 24 comprises a hoop having a circular or rectangular cross-section that is formed of a super-elastic material, such as a nickel-titanium alloy (“nitinol”). During deployment and retrieval of vascular device 20, described hereinafter, support hoop 24 folds in half and collapses to fit within a small diameter delivery sheath. When vascular device 20 is in a deployed state, as depicted in FIG. 2A, support hoop 24 resumes its pre-formed shape. Support hoop 24 preferably comprises nitinol wire, although it may also be formed from a multi-strand nitinol cable, a spring tempered stainless steel, or other super-elastic material.

In accordance with the principles of the present invention, support hoop 24 includes one or more reduced-thickness articulation regions 26, and pre-formed curved regions 34. As depicted in FIG. 2B, articulation region 26 includes a region having reduced thickness t1 compared to thickness t of the remainder of support hoop 24. Articulation region 26 and curved regions 34 enable support hoop 24 to fold with a predetermined shape when vascular device 20 is collapsed to a contracted state for delivery or retrieval.

In FIG. 2B, articulation region 26 is depicted as a localized reduction in the thickness of support hoop 24, as may be achieved, for example, using conventional grinding, chemical etching, or electroless polishing processes. Alternatively, support hoop 24 may be continuously tapered along its circumference, so that articulation region 26 results from a more gradual reduction in the wall thickness of the support hoop. Tapering support hoop 24 may permit greater flexibility in the vicinity of articulation region 26, thus enabling support hoop 24 to fold more easily at the articulation region. Such tapering of the thickness of the support hoop along a portion of its circumference also may reduce the potential for stress-induced fracture typically associated with abrupt changes in diameter.

In a preferred embodiment of vascular device 20 of the present invention, vascular device 20 easily fits within a delivery sheath having an inner diameter of 0.033″, and, more preferably, may be used with a delivery sheath having an inner diameter as small as 0.026″. The deployed diameter of support hoop 24 preferably is approximately 7 mm, while guide wire 22 preferably has a diameter of 0.014″. The distal end of guide wire 22 also may be tipped with a spring section or coil tip, as is per se known.

Support hoop 24 preferably is constructed of 0.0055″ nitinol wire tapered (by a grinding, chemical etching, or electroless polishing process) to 0.0025″ at articulation region 26. Specifically, articulation region 26 preferably consists of a length about 0.05″ long and having a diameter of 0.0025″, coupled on either side to curved regions 34. Each of curved regions 34 includes a length of wire that is tapered from a diameter of 0.055″ to a diameter of 0.0025″ over a length of about 0.025″. Support hoop 24 also may include radiopaque features, such as gold or platinum bands 33, spaced at intervals around the circumference of support hoop 24, or a coil of radiopaque material wrapped around the support hoop, as described hereinafter with respect to FIG. 16, or a gold plated coating.

Referring to FIGS. 3 and 4, additional features of vascular device 20 are described. FIG. 3 depicts vascular device 20 of FIG. 2A in a contracted state, while FIG. 4 illustrates a directional change in support hoop 24 preferably caused by the presence of curved regions 34. Advantageously, use of articulation region 26 and the curved profile of support hoop 24 introduced by curved regions 34 also cause support hoop 24 to fold in half during retrieval. As shown in FIG, 3, support hoop 24 folds in half, effectively closing the mouth of blood permeable sac 28 and preventing the escape of collected emboli or thrombus. This feature also may permit the use of a smaller or shallower sac than would otherwise be possible, without increasing the risk of material escaping from the device when the sac is collapsed for retrieval. Use of a smaller or shallower sac also enables vascular device 20 to be delivered in a smaller delivery sheath, having an inner diameter as small as 0.026″ for the preferred embodiment.

Referring now to FIGS. 5A-5D, methods of using the vascular device of the present invention as a vascular filter are described. In FIG. 5A, guide wire 22 and delivery sheath 40 are manipulated into position within vessel V using well-known percutaneous techniques. Vascular device 20 of FIG. 2A is disposed in its contracted delivery state within distal end 42 of delivery sheath 40, and delivery sheath 40 is advanced through the vessel using distal end 23 of guide wire 22. Articulation region 26 and curved regions 34 of support hoop 24 enable the sides of the support hoop to fold together and become elongated when drawn within delivery sheath 40. The size of delivery sheath 40 and guide wire 22 have been exaggerated to illustrate structure. In reality, the diameter of delivery sheath 40 is approximately an order of magnitude smaller than the internal diameter of vessel V.

With respect to FIG. 5B, once delivery sheath 40 is disposed at a desired location within a patient's vessel V, such as a coronary artery or carotid artery, as determined, for example, by the position of radiopaque band 43 under a fluoroscope, guide wire 22 is held stationary while delivery sheath 40 is retracted proximally. Alternatively, delivery sheath 40 may be held stationary while guide wire 22 is advanced. In either case, when vascular device 20 is no longer confined within delivery sheath 40, support hoop 24 expands to seal against the walls of vessel V. When in its deployed state, curved regions 34 of support hoop 24 orient articulation region 26 concentrically against the inside wall of the vessel, thus reducing the risk of impaling the vessel wall, as might be expected of the kinked support hoop of FIG. 1B. Blood continues to flow unimpeded through vessel V in direction D.

In FIG. 5C, once vascular device 20 is deployed in vessel V, other interventional instruments, such as angioplasty catheters, atherectomy devices, or stent delivery systems may be advanced along guide wire 22 to position such devices at treatment zones located proximally of vascular device 20. For example, in FIG. 5C, angioplasty balloon catheter 44 has been advanced along guide wire 22 to a position proximal of vascular device 20 to trap emboli E, i.e., pieces of plaque dislodged from the walls of vessel V by balloon 46.

With respect to FIG. 5D, upon completion of the angioplasty procedure using angioplasty balloon catheter 44, guide wire 22 is pulled proximally to cause the sides of support hoop 24 to collapse together to close the mouth of sac 28 (see FIG. 3). Additional proximal retraction of guide wire 22 causes support hoop 24 and sac 28 to enter at least partially within the guide wire lumen of angioplasty catheter 44. As depicted in FIG. 5D, only a portion of support hoop 24, near articulation region 26, and a distal portion of sac 28 extend out of the guide wire lumen of angioplasty catheter 44. Alternatively, vascular device 20 may be fully retracted within the guide wire lumen. Angioplasty catheter 44 then is withdrawn with vascular device 20 and any trapped emboli E.

Advantageously, the compliant design of vascular device 20 permits the device to be contracted to its delivery state within the guide wire lumen of conventional previously known interventional devices. Accordingly, unlike previously known vascular devices, which require removal of the interventional device followed by re-insertion of a specially designed catheter to retrieve the vascular device, the system of the present invention reduces the time, effort and trauma of this additional step. Instead, the vascular device may be readily closed and retrieved upon completion of the interventional procedure.

Vascular device 20 alternatively may be used in performing thrombectomy/embolectomy. In this case, the vascular device is deployed in a vessel at a location distal to a lesion, in the manner depicted in FIGS. 5A and 5B. Once support hoop 24 is deployed into contact with the vessel wall, vascular device 20 may be retracted proximally to scrape along the wall of the vessel, and excise thrombus so that it is captured in sac 28. Delivery sheath 44 may then be re-inserted into the vessel along guide wire 22, and vascular device 20 is retracted and removed from the vessel. Additional thrombectomy embodiments are described hereinbelow with respect to FIGS. 18-20.

As discussed hereinabove, sac 28 is porous so that blood cells may pass through while emboli E are captured. As seen in FIG. 5B, if the sum of the area of all these pores A1 is less than the internal cross-sectional area A2 of vessel V, a pressure drop is expected across the vascular device. This may lead to hemolysis and insufficient downstream flow. If A1 is greater than or equal to A2, the pressure drop is expected to decrease. Proper selection of pore diameter (in the range of 20-400 microns) and pore density ensures that A1 is greater than or equal to A2.

Selection of a larger pore diameter within the provided range may also reduce the pressure drop by decreasing drag as blood passes through sac 28. Drag may further be decreased by providing elliptical pores through the sac that project round relative to blood flow when sac 28 is deployed. Furthermore, the porosity of sac 28 may be specified such that, if distal pores become occluded with thrombus, emboli, etc., proximal pores remain open to ensure continuous blood low. It should also be noted that flow through vessel V is substantially unaffected by placement of sac 28 and hoop 24 in the flow path.

Referring now to FIG. 6, an alternative embodiment of the vascular device of the present invention, again illustratively a vascular filter, is described. Vascular device 50 comprises guide wire 51 and support hoops 52 and 53 connected to blood permeable sac 54. As discussed hereinabove, vascular device 50 includes articulation regions 55 and 56 formed at the intersection of opposing curved regions 57 and 58 of support hoops 52 and 53. Sac 54 preferably also is connected to guide wire 51 along its entire length, thereby providing more controlled deployment and removal of vascular device 50. Support hoop 53 serves to stabilize and deploy the distal portion of sac 54. In addition, affixing sac 54 to guide wire 51 may provide a more compact arrangement within a delivery sheath, and prevent bunching of the sac material.

In FIGS. 7A and 7B, a further alternative embodiment of the vascular device of the present invention is described. Vascular device 60, shown in the deployed state, comprises guide wire 61 having multi-turn helical support hoop 63 connected at weld point 62. Blood permeable sac 64 is affixed to the distal-most portion of support hoop 63. Support hoop 63 includes one or more side turns 65 that terminate in curved regions 66, as described hereinabove. Curved regions 66 in turn are joined together by articulation region 67. Preferably, side turns 65 are coupled to one another and to the distal region of guide wire 61, e.g., by a weld bead, at point 68.

In accordance with this aspect of the present invention, vascular device 60 may be contracted to small profile delivery state. When deployed from a delivery catheter, such as delivery sheath 40 of FIG. 5A, side turns 65 expand into contact with the walls of the vessel proximal to the location at which curved regions 66 contact the vessel wall. Side turns 65 serve to stabilize the support hoop 63 and sac 64 when vascular device 60 is deployed within a blood vessel. In addition, side turns 64 are expected to assist in orienting the axis of support hoop 63 and sac 64 in alignment with the longitudinal axis of vessel V. Accordingly, support hoop 63 is expected to reduce the risk of tilting of the vascular device within the vessel, and thus enhance the safety and reliability of the device.

Referring now to FIGS. 8A-8E, several embodiments of a delivery sheath suitable for use with the vascular device of the present invention are described. Each of these embodiments are designed to permit the physician to first pass a guide wire across a lesion before passing the vascular device of the present invention across the lesion. Thus, the risk of generating emboli, during the step of positioning the vascular device of the present invention distal to a lesion, is expected to be reduced.

In particular, in FIG. 8A, vascular device 70 of the present invention comprises guide wire 71, support hoop 72 92 and blood permeable sac 73 93 folded in a contracted delivery state within lumen 74 96 of delivery sheath 75 95. Vascular device 70 in FIG. 8A is similar in design to vascular device 20 of FIG. 2A, except that the device 70 in FIG. 8A includes nose cone 76 affixed to distal region 77 of guide wire 71. Delivery sheath 75 95 includes hemostatic fitting 78 at its proximal end and guide wire lumen 79.

In accordance with the methods of the present invention, the vascular device 70 and guide wire 80 are used as follows. First, unencumbered guide wire 80 is advanced through a vessel until distal region 81 of the guide wire crosses a lesion. The proximal end of guide wire 80 then is inserted into the distal end of guide wire lumen 79 of delivery sheath 75 95 using previously known “over the wire” techniques.

Delivery sheath 75 95 then is advanced over guide wire 80, which is held stationary, until nose cone 76 and a distal portion of the delivery sheath cross the lesion. Once support hoop 72 92 and sac 73 93 of the vascular device 70 are positioned distal to the lesion, guide wire 80 is withdrawn from the vessel and delivery sheath 75 95 is retracted proximally, thereby deploying the vascular device 70 to its deployed state. As will of course be understood, nose cone 76 remains in the vessel, distal to sac 73 93, during deployment of the vascular device. Upon completion of use of the vascular device 70, delivery sheath 75 95 may once again be advanced along guide wire 71 and the support hoop and sac retracted within lumen 74 96 of delivery sheath 75 95. Alternatively, an interventional device may be advanced over guide wire 71 to perform a medical procedure, and the vascular device may be retrieved within a guide wire lumen of the interventional device, as discussed hereinabove with respect to FIGS. 5.

Vascular device 90 of FIG. 8B is similar in construction to that of FIG. 8A, and includes guide wire 91, support hoop 92, blood permeable sac 93 and nose cone 94. Delivery sheath 95 includes lumen 96 housing device 90, guide wire lumen 97, and hemostatic fitting 98. Guide wire lumen 97 opens through skive 99 in lateral wall 100 of delivery sheath 95. Guide wire 101 therefore may be used in accordance with well-known “rapid exchange” techniques, wherein the length of unencumbered guide wire 101 may be significantly shorter than in the case of the “over the wire” arrangement depicted in FIG. 8B. Operation of delivery sheath 95 and vascular device 90 is similar to that described hereinabove with respect to FIG. 8A, except that the proximal end of unencumbered guide wire 101 is passed through the distal end of lumen 97 and passes out through skive 99.

In FIG. 8C, delivery sheath 105 includes lumen 106 that opens through the lateral wall via skive 107, and guide wire lumen 108 that opens through the lateral wall via skive 109. Accordingly, as will be apparent to one of ordinary skill, both vascular device 110 and guide wire 112 may be used as described hereinabove with respect to FIG. 8A and further in accordance with “rapid exchange” techniques.

Vascular device 113 of FIG. 8D is similar in construction to those described hereinabove. Delivery sheath 114 includes lumen 115, guide tube 116, and hemostatic fitting 117. Lumen 115 houses device 113 during delivery and retrieval. Guide tube 116 comprises guide wire lumen 118, which is configured to receive unencumbered guide wire 119. In operation, the proximal end of guide wire 119 is passed through guide wire lumen 118 of guide tube 116. Thus, guide wire 119 may be used in accordance with “rapid exchange” techniques described with respect to FIG. 8B and with “over the wire” techniques described with respect to FIG. 8A.

Vascular device 120 of FIG. 8E is also similar to those described hereinabove. Delivery sheath 121 includes lumen 122 and hemostatic fitting 123. Lumen 122 houses device 120. Guide wire 124 is coupled to and terminates at the proximal end of delivery sheath 121. Thus, distal end 126 of guide wire 125 of vascular device 120 is first to cross the lesion. Then, nose cone 127, attached to guide wire 125, and a distal portion of delivery sheath 121 cross the lesion. Guide wire 124 and attached delivery sheath 121 are retracted proximally, thereby deploying vascular device 120 to its deployed state. Device 120 may then be retrieved within sheath 121 or within an interventional device, as discussed hereinabove.

Referring now to FIG. 9, a previously known balloon catheter is described. Catheter 130 is constructed of materials typically used in catheters, such as polyethylene or polyurethane, and includes compliant balloon 131 disposed in distal region 132. Compliant balloon, which may be formed of nylon or latex, is inflated using inflation port 133 at proximal end 134 of the catheter. Catheter 135 also includes hemostatic port 136 and an interior lumen through which a delivery sheath may be advanced to pass out of an opening in distal end 137.

With respect to FIGS. 10A-10C, a method of using catheter 130 of FIG. 9 in conjunction with the vascular device of the present invention is described. In accordance with this aspect of the present invention, antegrade blood flow through a vessel is occluded while a vascular device constructed in accordance with the present invention is advanced across a lesion. Once the vascular device, illustratively a vascular filter, is deployed, the balloon is deflated, thereby permitting antegrade flow to be established. Importantly, because flow through the vessel is stopped prior to deployment of the vascular device, few or no emboli are expected to bypass the filter.

More particularly, with respect to FIG. 10A, catheter 130 is disposed in vessel V at a location proximal to lesion L, with the vascular device of the present invention disposed in its contracted delivery state in delivery sheath 138. In FIG. 10B, balloon 131 is inflated via inflation port 133 to engage the interior wall of vessel V, thereby arresting antegrade flow in the vessel.

As shown in FIG. 10C, delivery sheath 130 then is advanced across lesion L so that the support hoop and sac of the vascular device will be disposed distal to lesion L when deployed. During this step, delivery sheath 138 may generate emboli E as it passes across the lesion. However, because antegrade flow in the vessel is stopped, the emboli will not travel distally in the vessel.

With respect to FIG. 10D, once vascular device 140 is deployed, so that support hoop 141 and sac 142 span vessel V, balloon 131 is deflated. This, in turn, causes antegrade flow to become re-established in vessel V, urging emboli E into sac 142. Catheter 130 then may be withdrawn, and additional treatment devices advanced along guide wire 143 of vascular device 140. Removal of vascular device 140 may be by any of the methods described hereinabove with respect to FIG. 5D.

Referring now to FIGS. 11A-11C, still further alternative embodiments of vascular devices constructed in accordance with the present invention are described. Each of the devices of FIGS. 11A-11C, which are shown in the deployed state, includes two or more support hoops to support the blood permeable sac. Each of those support hoops in turn includes an articulation region that permits the sides of the support hoops to collapse inwards to each other as described hereinabove with-respect to FIGS. 3 and 4.

Specifically, in FIG. 11A vascular device 150, illustratively an embolic filter, comprises guide wire 151, support hoops 152 and 153 having articulation regions 154 and 155, respectively, and blood permeable sac 156 affixed to support hoops 152 and 153. Sac 156 is coupled to support hoops 152 and 153 so that the support hoops form an opening for the sac. Support hoops 152 and 153 preferably are connected to guide wire 151 near its distal end.

Sac 156 is also attached to the distal end of guide wire 151 at point 157. Sac 156 preferably is constructed of a thin, flexible biocompatible material, as for the embodiments described hereinabove, and includes openings or pores 158 that permit blood cells to pass through the sac substantially unhindered, while capturing any larger material that may be released during a procedure such as angioplasty or stent placement. Pore sizes are selected as described hereinabove with respect to FIG. 2A.

Support hoops 152 and 153 comprise hoops having circular or rectangular cross-sections that are formed of a super-elastic material, such as a nickel-titanium alloy (“nitinol”). During deployment and retrieval of vascular device 150, support hoops 152 and 153 fold in half and collapse to fit within a small diameter delivery sheath. When the delivery sheath is retracted, support hoops 152 and 153 resume their pre-formed shape and deploy the perimeter of sac 156 into contact with the vessel walls. Support hoops 152 and 153 preferably comprise a nitinol wire, but also may be formed from a multistrand nitinol cable, or other superelastic material.

In accordance with the principles of the present invention, support hoops 152 and 153 are affixed to guide wire 151 at ring 159 and include reduced-thickness articulation regions 154 and 155, constructed as described hereinabove. More particularly, support hoops 152 and 153 are pre-formed to form structures having curved regions 160 and 161, respectively, so that articulation regions 154 and 155 are disposed in a portion of the support hoop that is approximately concentric with a vessel wall when vascular device 150 is deployed. Articulation regions 154 and 155 and curved regions 160 and 161 thus enable support hoops 152 and 153 to fold with a pre-determined shape when vascular device 150 is collapsed to a contracted state for delivery or retrieval.

In a preferred embodiment of vascular device 150 of the present invention, vascular device 150 easily fits within a delivery sheath having an inner diameter of 0.033″, and more preferably, may be used with a delivery sheath having an inner diameter as small as 0.026″. The deployed diameter of vascular device 150 preferably is approximately 7 mm.

Compared to vascular device 20 of FIGS. 2-4, vascular device 150 of FIG. 11A employs two support hoops instead of one and provides central location of guide wire 151 and attachment of blood permeable sac 156 to the distal end of the guide wire. These differences may provide more controlled deployment and removal of vascular device 150. In addition, affixing sac 156 to guide wire 151 may provide a more compact arrangement within a delivery sheath, and prevent bunching of the sac material.

Referring now to FIG. 11B, another alternative embodiment of the vascular device of the present invention, again illustratively a vascular filter, is described. Vascular device 170 is similar in construction to vascular device 150, except that vascular device 170 employs three support hoops instead of two. Device 170 comprises guide wire 151 and support hoops 171, 172 and 173 connected to blood permeable sac 156.

As discussed hereinabove, vascular device 170 includes articulation regions 174, 175 and 176 formed at the intersection of opposing curved regions 178, 179 and 180 of support hoops 171, 172 and 173. Support hoops 171, 172 and 173 preferably are connected to the distal end of guide wire 151 at ring 177. Sac 156 preferably also is connected to guide wire 151 at point 157. Vascular device 170 is expected to provide similar advantages to those contemplated for vascular device 150.

With reference to FIG. 11C, yet another alternative embodiment of the vascular device of the present invention, again illustratively a vascular filter, is described. Vascular device 190 is similar in construction to vascular devices 150 and 170, except that vascular device 190 employs four articulated support hoops. Device 190 comprises guide wire 151 and support hoops 191, 192, 193 and 194 connected to blood permeable sac 156, with articulation regions 195, 196, 197 and 198 formed at the intersection of opposing curved regions 200, 201, 202 and 203 of the respective support hoops 191-194. Support hoops 191-194 are preferably connected to the distal end of guide wire 151 at ring 199.

Alternative embodiments of vascular devices of the present invention have been described with one to four support hoops. As will be apparent to one of ordinary skill in the art of interventional device design, any number of support hoops may be used with minor modifications to the designs described hereinabove.

Referring now to FIGS. 12-15, further alternative embodiments of the vascular device of the present invention are described. In FIG. 12, vascular device 250, illustratively an embolic filter, comprises guide wire 252, support hoops 253 and 254 having articulation regions 255 and 256, respectively, and blood permeable sac 258 affixed to support hoops 253 and 254. Sac 258 is coupled to support hoop 253 at its proximal end so that the support hoop forms an opening for the sac. Sac 258 is coupled to support hoop 254 at its distal end to prevent emboli from spilling from sac 258 during retrieval. Support hoops 253 and 254 preferably are connected to guide wire 252 near distal end 259 of the guide wire. Sac 258 has openings or pores 260 that permit red blood cells to easily pass through the sac.

During deployment and retrieval of vascular device 250, support hoops 253 and 254 expand and collapse as discussed hereinabove with respect to support hoop 24 of FIGS. 2. Support hoops 253 and 254 are attached to guide wire 252 at attachment points 261 and 262, respectively, and further comprise curved regions 263 and 264, respectively. Support hoops 253 and 254 may include radiopaque features, such as gold or platinum bands 265, spaced at intervals around the circumference of the hoops.

Applicant expects that vascular device 250 may further reduce the risk that captured emboli could spill during retrieval, and also may provide a better seal against the artery.

With reference to FIG. 13, an alternative embodiment of vascular device 250 that prevents bunching is disclosed that may provide even further benefits. Vascular device 270 comprises guide wire 272 on which proximal support hoop 273 and distal support hoop 274 are disposed. The proximal and distal portions of blood permeable sac 275 are affixed to support hoops 273 and 274, respectively. Proximal support hoop 273 is attached to distal end 271 of guide wire 272 at attachment point 276 and includes articulation region 277 and curved regions 278. Likewise, distal support hoop 274 is attached to guide wire 272 at attachment point 279 and includes articulation region 280 and curved regions 281. Sac 275 includes blood permeable pores 282. Hoops 273 and 274 may include radiopaque features, such as gold or platinum bands 283, spaced at intervals around the circumference of the hoops.

Proximal support hoop 273 is significantly larger in circumference than distal hoop 274. Proximal hoop 273 seals against the artery walls and defines the diameter of the mouth of sac 275. Smaller distal hoop 274 prevents emboli from spilling from sac 275 when retrieving device 270. It also allows the diameter of sac 275 to decrease along its length. This taper in sac 275 is expected to reduce the risk that sac 275 will bunch when the sac is retrieved. Sac 275 may further by attached to guide wire 272.

Applicant has determined that where multiple support hoops are employed, as in the embodiments of FIGS. 12 and 13, twisting of the guide wire during deployment may prevent the sac of the vascular device from properly sealing against the vessel wall. For example, if guide wire 252 in the embodiment of FIG. 12 is rotated after distal hoop 254 has been deployed, but before proximal hoop 253 has been deployed, proximal hoop 253 may deploy at an angle with respect to distal hoop 254. This, in turn, may constrict, or all together close, the opening of sac 258, thereby rendering the vascular device ineffective.

FIG. 14 discloses a vascular device in accordance with the present invention that overcomes problems associated with twisting of the guide wire during deployment. Vascular device 290 comprises guide wire 292 with distal end 293, and support hoops 294 and 295. Support hoops 294 and 295 further comprise articulation regions 296 and 297, respectively, and curved regions 298 and 299, respectively. The proximal and distal portions of blood permeable sac 300 are attached to support hoops 294 and 295, respectively. Sac 300 includes pores 301. Support hoops 294 and 295 are attached to sheath 302 at attachment points 303 and 304, respectively. Sheath 302 preferably comprises a flexible, 0.001″ thick tube made of a biocompatible material, such as polyamide or polytetraethylene. Guide wire 292 passes through the lumen of sheath 302. Sheath 302 is able to rotate with respect to guide wire 292 but is translationally restrained by stops 305 and 306, for example, solder beads.

By attaching support hoops 294 and 295 to sheath 302, rotational problems are mitigated. Sheath 302 only transmits translational motion of guide wire 292 to support hoops 294 and 295. Thus, twisting moments applied to wire 292 will not affect the performance of vascular device 290. Sac 300 may also be attached to sheath 302.

With reference to FIG. 15, a further alternative embodiment of the vascular device of the present invention is disclosed that also prevents bunching. Vascular device 310 comprises guide wire 312 on which support hoop 313 is disposed. Tapered blood permeable sac 314 is affixed to support hoop 313. Hoop 313 is attached to distal end 311 of guide wire 312 at attachment point 315 and includes articulation region 316 and curved regions 317. Tapered sac 314 includes blood permeable pores 318. Hoop 313 may include radiopaque features, such as gold or platinum bands 319, spaced at intervals around the circumference of the hoop.

As with vascular device 270 of FIG. 13, the diameter of tapered sac 314 decreases along its length to reduce the risk of bunching when the sac is retrieved. Tapering also reduces the amount of material that must fit within the lumen of a delivery sheath, and thereby allows a delivery sheath of smaller profile to be used. Furthermore, tapering the blood permeable sac reduces the risk that the sac will snag on a stent during retrieval.

Because vascular device 310 lacks the distal support hoop of the embodiments of FIGS. 12 and 13, there is a reduced risk of problems associated with twisting. In a preferred embodiment, the diameter at the distal end of tapered sac 314 is less than the internal diameter of the retrieval sheath with which the apparatus is used. Tapered sac 314 may optionally be attached to guide wire 312, for example, to further mitigate bunching.

Referring now to FIG. 16, a support hoop including a radiopaque feature is disclosed. Support hoop 320, illustratively shown in the deployed state, comprises articulation region 321, curved regions 322, attachment point 323, and wound radiopaque wire 324. In the preferred embodiment, wire 324 is platinum and is either round or a strip approximately 0.001″ in diameter. Wire 324 is wrapped around hoop 320 all along its circumference.

One method of making a vascular device radiopaque is to electroplate platinum or gold onto the device. However, electroplating can be complex and expensive, and may cause manufacturing difficulties. Because the hoop must change shape during deployment and retrieval, increased thickness or flaking of plated gold are undesirable characteristics and may promote failure of the support hoop. By wrapping wire 324, hoop 320 maintains its strength and flexibility. Radiopaque wire 324 may be used in conjunction with any of the vascular devices discussed herein. Radiopaque wire 324 may further be used with a wide variety of other vascular filter devices, as are known in the art.

Referring now to FIGS. 17A-17C, another alternative embodiment of the vascular device of the present invention is described. As illustrated in FIG. 17A, vascular device 330 comprises guide wire 332 with distal region 333, wishbone support hoop 335, and blood permeable sac 336. Wishbone hoop 335 comprises spines 337 and 338 separated by a gap that serves as articulation region 339. Articulation region 339 is shown in greater detail in FIG. 17B, which corresponds to the area circled in FIG. 17A taken along section B-B. Blood permeable sac 336 is wrapped around and attached to itself all along its perimeter, creating hem bond 340 and lumen 341. Sac 336 includes pores 347. Lumen 341 is configured to receive spines 337 and 338 and bridge the gap between them. FIG. 17C is a sectional view taken along line C-C of FIG. 17A, showing hem bond 340 and lumen 341 with spine 338 passing there through.

Referring again to FIG. 17A, wishbone support hoop 335 is attached to sheath 343 at attachment point 344. Sheath 343 is similar to sheath 302 of the embodiment of FIGS. 14, and preferably comprises a flexible, 0.001″ thick tube made of a biocompatible material, such as polyamide or polytetraethylene. Distal end 333 of guide wire 332 passes through the lumen of sheath 343. Sheath 343 may rotate with respect to guide wire 332 but is translationally restrained by stops 345 and 346, for example, solder beads. Sheath 343 mitigates rotational problems by only transmitting translational motion of guide wire 332 to wishbone hoop 335. Twisting moments applied to wire 332 do not affect the performance of vascular device 330.

The wishbone design of support hoop 335 advantageously enables a wider variety of materials to be used to fabricate the support hoop. Articulation region 339 allows vascular device 330 to deploy and contract in a manner similar to that described above for alternative embodiments. Deployment and retraction of wishbone hoop 335 induces minimal deformation of spines 337 and 338, thereby permitting use of materials such as spring steel. As will of course be apparent, the support hoop of the embodiment of FIGS. 17A-17C may advantageously he incorporated in any of the foregoing embodiments.

Referring now to FIGS. 18A and 18B, an integrated vascular device suitable for thrombectomy is described. The integrated device comprises a thrombectomy element and a vascular filter. In a preferred embodiment, the thrombectomy element is similar in construction to vascular filter 20 described above and is connected to the guide wire proximal of the vascular filter. Alternatively, the thrombectomy element may be disposed on a separate catheter. The thrombectomy element may be retracted independently of the vascular filter.

In FIGS. 18, integrated vascular device 350 comprises guide wire 351, thrombectomy element 352 including support port hoop 353 and blood permeable sac 354, and vascular filter element 355 including support hoop 356 and blood permeable sac 357. Filter hoop 356 is attached to guide wire 351 while thrombectomy hoop 353 is attached to ring 358. Ring 358 is attached to pull wire 359 and has a bore through which guide wire 351 passes. Ring 358 therefore acts as a linear bearing and allows thrombectomy hoop 353 to be moved by pull wire 359 independently of guide wire 351. Alternatively, thrombectomy element 352 may omit sac 354 and simply comprise a wire hoop; in this case severed thrombus is captured by vascular filter 355.

In FIG. 18A, support hoops 353 and 356 and blood permeable sacs 354 and 356 are contracted to a delivery state within lumen 360 of delivery sheath 361. Delivery sheath 361 includes nose cone 362 affixed to distal region 363 of guide wire 351. In FIG. 18B, integrated vascular device 350 is shown deployed in a vessel. As illustrated in FIG. 18B, vascular filter 355 expands to engage the perimeter of the vessel and prevent thrombus from bypassing the blood permeable sac, while thrombectomy element 352 engages the vessel wall proximal of vascular filter 355. As described hereinbelow, proximal movement of thrombectomy device 352 scrapes thrombus from the wall of the vessel when pull wire 359 pulls ring 358 and support hoop 353 proximally.

Referring now to FIGS. 19A-19E, an illustrative method of using the integrated vascular device of the present invention for thrombectomy is described. In FIG. 19A, guide wire 351 is manipulated into position proximal to thrombus T within vessel V using well-known percutaneous techniques. Vascular device 350 of FIGS. 18A and 18B is disposed in its contracted delivery state within the distal end of delivery sheath 361 and the delivery sheath is advanced through the vessel using distal end 363 of guide wire 351. The sides of support hoops 353 and 356 are folded together and become elongated when drawn within delivery sheath 361, as described with respect to vascular device 20 of FIGS. 2-4.

With respect to FIG. 19B, once delivery sheath 361 is disposed at the desired location proximal to thrombus T within a patient's vessel V, such as a coronary artery or carotid artery, based on the position of, for example, radiopaque bands under a fluoroscope, integrated vascular device 350 is advanced through thrombus T. Distal end 363 of guide wire 351 is advanced through the lesion, then nose cone 362 gradually increases the diameter of the void within thrombus T so that the remainder of delivery sheath 361 can be advanced far enough that thrombectomy element 352 (still within delivery sheath 361) is located distal to thrombus T.

With integrated vascular device 350 in position, guide wire 351 is held stationary while delivery sheath 361 is retracted proximally, as seen in FIG. 19C. Alternatively, delivery sheath 361 may be held stationary while guide wire 351 is advanced. In either case, when vascular device 350 is no longer confined within delivery sheath 361, support hoops 353 and 356 expand to seal against the walls of the vessel V and deploy blood permeable sacs 354 and 357, respectively. Blood continues to flow through vessel V in direction A, impeded only by thrombus T.

In FIG. 19D, once vascular device 350 is deployed in vessel V, thrombus T is removed in the following manner. Vascular filter support hoop 353 is rigidly attached to guide wire 351, while thrombectomy support hoop 353 is attached to pull wire 359 via ring 358. Thrombectomy element 352 then is retracted proximally to scrape along the wall of the vessel V by motion at the proximal end of pull wire 359. Thrombus T, located proximal to thrombectomy element 352, is excised so that it is captured in blood permeable sac 354 during the retraction.

With respect to FIG. 19E, once thrombus T has been captured within sac 354, pull wire 359 is pulled proximally to cause the sides of thrombectomy support hoop 353 to collapse together to close the mouth of sac 354 (see FIG. 3). Additional proximal retraction of pull wire 359 causes support hoop 353 and sac 354 to enter within lumen 360 of delivery sheath 361, restoring normal blood flow to vessel V. Meanwhile, vascular filter 355 is in a position distal to thrombectomy element 352 to trap emboli E, i.e., pieces of plaque dislodged from either thrombus T or the walls of vessel V by thrombectomy element 352. Once any emboli E have been collected, filter hoop 356 and sac 357 are retracted into delivery sheath 361 by motion at the proximal end of guide wire 351, in a manner similar to the retraction of hoop 353 and sac 354. Once guide wire 351 has been fully retracted, and nose cone 362 at the distal end 363 of guide wire 351 is again in contact with delivery sheath 361, the delivery sheath is withdrawn with integrated vascular device 350, the trapped thrombus T, and any trapped emboli E.

As with previous embodiments, the compliant design of integrated vascular device 350 permits the device to be contracted to its delivery state within the guide wire lumen of conventional previously known interventional devices, thereby reducing time, effort, and trauma. The vascular device may be readily closed and retrieved upon completion of the interventional procedure.

Referring now to FIGS. 20A and 20B, an alternative embodiment of the integrated vascular device is described. Integrated vascular device 370 comprises guide wire 371, thrombectomy element 372, and vascular filter 373 having support hoop 374 and blood permeable sac 375. Filter hoop 374 is attached to guide wire 371, while thrombectomy element 372 is disposed to slide along guide wire 371. Alternatively, thrombectomy element 372 may be disposed on a separate catheter element that extends either through lumen 377 of delivery sheath 378 or is separately disposed proximal to vascular filter 373. FIG. 20A shows thrombectomy element 372 and vascular filter 373 contracted in a delivery state within lumen 377 of delivery sheath 378. Delivery sheath 378 includes nose cone 379 affixed to distal region 380 of guide wire 371. In FIG. 20B, integrated vascular device 370 is shown in the deployed state.

Thrombectomy element 372 may comprise any of a family of known thrombectomy, atherectomy, or, alternatively, drug delivery devices suitable for use in conjunction with vascular filter 373. Thrombectomy element 372 may, for example, comprise any of: a rotary ablation device, such as described in U.S. Pat. No. 4,867,156 to Stack et at, U.S. Pat. No. 4,990,134 to Auth, and U.S. Pat. No. 5,314,407 to Auth et al.; an atherectomy technology, such as described in U.S. Pat. No. 5,181,920 to Mueller et al., and U.S. Pat. No. 5,074,841 to Ademovic et al.; or a balloon embolectomy technology, such as described in U.S. Pat. No. 3,923,065 to Nozick et al., U.S. Pat. No. 5,769,871 to Mers Kelly et al., U.S. Pat. No. 5,192,290 to Hilal, U.S. Pat. No. 5,112,347 to Taheri, and U.S. Pat. No. 4,030,503 to Clark III. All of the foregoing patents are incorporated herein by reference. Thrombectomy element 372 may alternatively comprise a wire loop or ring, such as described for the embodiment of FIGS. 18A and 18B, a laser ablation device, a chemical flushing system, etc.

Referring now to FIGS. 21A and 21B, a delivery system configured for use with embodiments of the present invention is described. The delivery system facilitates deployment and retrieval of the embodiments by integrating the functions of a torquer, a Touhy Borst adapter, and a pusher into a single device. In FIGS. 21, the delivery system is illustratively used in conjunction with vascular device 20 of FIGS. 2-5. In FIG. 21A, vascular device 20 is in the retracted delivery configuration, while in FIG. 21B vascular device 20 is in the expanded deployed configuration. Delivery system 450 comprises proximal screw cap 452, collect 456, handle 460, rod 464, central screw cap 468, lumen flushing section 472, distal hub 479, and nose piece 486.

Proximal screw cap 452 includes bore 453 with female screw thread 454 and guide wire lumen 455. Bore 453 extends proximally from the distal face of cap 452. Guide wire lumen 455 extends from the proximal end of bore 453 to the proximal end of cap 452.

Handle 460 comprises proximal male screw thread 461 configured to engage female screw thread 454 of cap 452, and lumen 462 configured to receive collet 456 in its proximal end and rod 464 in its distal end. Lumen 462 has a reduced diameter at the distal end of handle 460 that captures a step on the proximal end of rod 464. Thus, while collet 456 is removable received within lumen 462, rod 464 may translate and rotate within, but may not be removed from, lumen 462. Guide wire 422 freely passes through collet 456 when screw cap 452 is not securely fastened to handle 460. When cap 452 is securely fastened to handle 460, it causes collet 456 to elastically deform, decreasing the diameter of the lumen extending through the collet, and frictionally locking guide wire 422 into rigid attachment with collet 456. Guide wire 422 is thereby rigidly connected to handle 460.

Rod 464 further comprises guide wire lumen 465 extending therethrough. Rod 464 has its distal end rigidly and permanently affixed to central screw cap 468. Cap 468 comprises female screw thread 469 and lumen 470. Lumen 470 includes a proximal reduced-diameter step that captures rod 464 within the proximal end of cap 468, and a distal portion that receives lumen flushing or fluid port section 472.

Section 472 comprises male screw thread 473, side port 474, bore 475, guide wire lumen 476, and fluid lumen 477. Male screw thread 473 is configured to engage female thread 469 of cap 468. Section 472 includes a flange disposed just distal of thread 473 that is captured within lumen 470 of cap 468. Thus, cap 468 may be tightened onto and loosened from, but not removed from, section 472.

Rod 464 is received within bore 475 of section 472. Guide wire 22 passes between bore 475 and fluid lumen 477 within guide wire lumen 476. Fluid lumen 477 connects side port 474 to the guide wire lumen of delivery sheath 40. O-rings 478 provide a fluid seal at the distal end of lumen 477.

Distal hub 479 connects section 472 to nose piece 486. Hub 479 comprises bore 483, female screw thread 484, and annulus 485 containing tapered projection 481. Bore 483 includes flange 482 that rotatably receives section 472 in its proximal end. Nose piece 486 comprises male screw thread 487, tapered bore 488, and delivery sheath lumen 489. Male screw thread 487 is configured to engage female thread 484 in annulus 485 of hub 479. Tapered bore 488 allows tapered projection 481 of hub 479 to extend within nose piece 486 and permit delivery sheath 40 from delivery sheath lumen 489 to extend therethrough. O-rings 478 are disposed between the hub 479 and nose piece 486 and between hub 479 and section 472.

Delivery system 450 advantageously may be implemented in a variety of ways. For example, the delivery system may be offered with a delivery catheter or sheath pre-attached. In this embodiment, proximal screw cap 452 is loosened, and the proximal end of guide wire 22 may be passed through the delivery catheter or sheath, and delivery system 450, until vascular device 20 is in its retracted state within the delivery catheter or sheath. Insertion of the vascular device into the patient may then proceed. Alternatively, delivery system 450 may be commercially supplied in the configuration shown in FIG. 5A, i.e., pre-loaded with a delivery catheter or sheath, such as sheath 40, already attached and a vascular device, such as vascular device 20, retracted therein. As another alternative, delivery system 450 may be offered without either a delivery sheath or vascular device attached, or the delivery catheter or sheath may be an interventional instrument, such as an angioplasty, atherectomy, or stent delivery catheter.

Referring again to FIGS. 5A-5D in conjunction with FIGS, 21A and 21B, a method of using the delivery system of the present invention in conjunction with a vascular filter is described. With vascular device 20 contracted within distal end 42 of delivery sheath 40 (FIGS. 5A and 21A), delivery sheath 40 is attached to delivery system 450 by loosening proximal screw cap 452 and extending the proximal end of guide wire 22 through delivery system 450, with handle 460 in its proximal-most position (FIG. 21A). Screw cap 452 is then tightened to cause collet 456 to engage guide wire 22 to handle 460.

Delivery sheath 40 then is advanced through a patient's vasculature using well-known percutaneous techniques using distal end 23 of guide wire 22. If a vessel bifurcation is to be crossed during advancement, handle 460 may be rotated to divert the distal end of sheath 40 into the desired branch of the bifurcation. The rotational moment or torque applied to handle 460 is transmitted to guide wire 22 (when screw cap 452 is tightened), which causes distal end 23 to rotate and facilitates positioning of vascular device 20 in the proper side of the bifurcation. As shown in FIG. 5A, advancement continues until delivery sheath 40 is disposed at a desired location within a patient's vessel V, such as a coronary or carotid artery, as determined, for example, by the position of radiopaque band 43 under a fluoroscope.

With the vascular device in position, handle 460, and thus guide wire 22, is held stationary while section 472 and attached delivery sheath 40 are retracted proximally. Alternatively, handle 460 may be advanced while section 472 and sheath 40 are held stationary. In either case, when vascular device 20 is no longer confined within delivery sheath 40, support hoop 24 expands to seal against the walls of the vessel V, as depicted in FIGS. 5B and 21B. Blood continues to flow unimpeded through vessel V in direction A.

Depending on the medical procedure prescribed in conjunction with the use of vascular device 20, delivery sheath 40 may retrieve vascular device 20 at the conclusion of the procedure, or sheath 40 may be detached from delivery system 450 and removed from the patient. If sheath 40 is detached, guide wire 22 may be removed from delivery system 450 so that other interventional instruments, such as angioplasty catheters, atherectomy devices, or stent delivery systems may be advanced along guide wire 22 to position such devices at treatment zones located proximally of vascular device 20. Guide wire 22 and the interventional catheter then may be passed through and fastened to delivery system 450. For example, as shown in FIG. 5C, angioplasty balloon catheter 44 may be advanced along guide wire 22 to a position proximal of vascular device 20 so that device 20 may trap emboli E, i.e., pieces of plaque dislodged from the walls of vessel V by balloon 46.

Upon completion of the angioplasty procedure using angioplasty balloon catheter 44, handle 460 with attached guide wire 22 is pulled proximally to cause the sides of support hoop 24 to collapse together to close the mouth of sac 28 (FIG. 3). Additional proximal retraction of guide wire 22 causes support hoop 24 and sac 28 to enter at least partially within the guide wire lumen of angioplasty catheter 44. As depicted in FIG. 4D, only a portion of support hoop 24, near articulation region 26, and a distal portion of sac 28 extend out of the guide wire lumen of angioplasty catheter 44. Angioplasty catheter 44 then is withdrawn with vascular device 20 and any trapped emboli E.

It also may be beneficial during a medical procedure to introduce or withdraw fluids from the operative site. For example, it may be beneficial to deliver medicaments, or draw suction to remove blood. The delivery sheath lumen also may require flushing with saline to prevent clotting within the lumen. These and other procedures are made possible by side port 474 of section 472, which, as described hereinabove, is in fluid communication with the lumen of delivery sheath 40.

In addition to applications with vascular filters, delivery system 450 may be used as part of the thrombectomy/embolectomy procedure described herein above, as well as in a variety of other procedures.

Embodiments of the present invention may optionally be used in conjunction with a specially configured retrieval sheath. Applicant has determined that bunching of sac 28 in FIG. 5D may occur during retraction into catheter 44, resulting in a retrieval profile that may be difficult to navigate through a patient's vasculature. However, additional proximal retraction of guide wire 22 in an attempt to decrease the profile of sac 28 may generate stress loads sufficient to tear sac 28 and release captured emboli.

With reference to FIGS. 22A-22E, a specially configured retrieval sheath and methods of use with the vascular device of the present invention are described. As with FIGS. 5, sizes have been exaggerated to illustrate structure. In FIG. 22A, guide wire 556 is positioned within vessel V using well-known percutaneous techniques. Vascular device 550 is disposed in its contracted delivery state within distal end 554 of delivery sheath 552. Retrieval sheath 560 and guide catheter 562 are advanced over delivery sheath 552 to a position located just proximal of distal end 554.

Retrieval sheath 560 includes collapsible flared end region 564, which is shown in a contracted delivery state within catheter 562 in FIG. 22A. Flared end region 564 has a deployed state, wherein the wall flares outward to form a frustrum of a cone, and a contracted state, wherein the wall is substantially cylindrical. Flared end region 564 preferably includes radiopaque band 566.

With respect to FIG. 22B, once delivery sheath 552 is disposed at a desired location within a patient's vessel V, guide wire 556 is held stationary while delivery sheath 552 is retracted proximally. Alternatively, delivery sheath 552 may be held stationary while guide wire 556 is advanced. In either case, when vascular device 550 is no longer confined within delivery sheath 552, support hoop 568 and attached blood permeable sac 570, expands to seal against the walls of the vessel V. Sac 570 further comprises radiopaque band 572. When in the deployed state, the curved regions of support hoop orient its articulation region concentrically against the inside wall of the vessel. Blood continues to flow unimpeded through vessel V in direction A.

With vascular device 550 deployed, an interventional procedure is performed proximal of the device. For example, guide catheter 562 may be an angioplasty balloon catheter similar to catheter 44 of FIGS. 5C and 5D. The interventional procedure generates emboli E proximal of device 550, which travel downstream and are captured in sac 570.

With respect to FIG. 22C, upon completion of the interventional procedure, guide wire 556 is pulled proximally to cause the sides of support hoop 568 to collapse together to close the mouth of sac 570 (see FIG. 3). Additional proximal retraction of guide wire 556 causes support hoop 568 and sac 570 to partially enter within distal end 554 of delivery sheath 552. If bunching of the sac is anticipated or suspected, flared sheath 560 may be advanced distally to expand end region 564, which comprises a suitable elastomeric material, such as latex, rubber, or a synthetic variant thereof.

As depicted in FIG. 22D, delivery sheath 552 is retracted proximally while retrieval sheath 560 is held stationary, until radiopaque bands 572 and 566 are concentrically aligned, as determined, for example, with a fluoroscope. Then, as illustrated in FIG. 22E, sheaths 552 and 560 are simultaneously withdrawn proximally while guide catheter 562 is held stationary. This motion causes flared end region 564 to collapse sac 570 to its contracted state. In so doing, flared end region 564 applies a distributed load over the surface of sac 570, thereby decreasing the retrieval profile of sac 570 with reduced risk of rupture of sac 570.

Vascular device 550 also may be used in performing thrombectomy/embolectomy. In this case, vascular device 550 is advanced in its retracted state within delivery sheath 552 to a location distal of a lesion. Delivery sheath 552 is withdrawn proximally, and vascular device 550 is deployed. With support hoop 568 in contact with the vessel wall, vascular device 550 may be retracted proximally to scrape along the wall of the vessel and excise thrombus so that it is captured in sac 570. Delivery sheath 552, as well as flared sheath 560 and guide catheter 562, then may be reinserted into the vessel along guide wire 556, and vascular device 550 may be retracted and removed from the vessel in the manner described hereinabove.

With reference to FIGS. 23A and 23B, an alternative embodiment of the specially configured retrieval sheath, and methods of use with the vascular device of the present invention, are described. Again, sizes have been exaggerated to illustrate structure. In FIG. 23A, guide wire 582 has been positioned within vessel V using well-known percutaneous techniques. Vascular device 580 has been expanded to its deployed state after delivery within delivery sheath 584, in the manner discussed hereinabove. Support hoop 586 seals against the walls of vessel V, and blood permeable sac 588 is positioned to capture emboli E generated by, for example, an upstream interventional procedure. Blood continues to flow unimpeded through vessel V in direction A.

Delivery sheath 584 further comprises atraumatic expander 590 disposed on a distal end. Retrieval sheath 592 is advanced over delivery sheath 584 to a position located just proximal of expander 590. Retrieval sheath 592 includes expandable end region 594, which is shown in a contracted delivery state in FIG. 23A. Expandable end region 594 has a deployed state, wherein the wall flares outward to form a frustrum of a cone, and a contracted state, wherein the wall is substantially cylindrical. Expander 590 has a larger maximum diameter than end region 594. Expandable end region 594 preferably includes radiopaque band 596, while expander 590 preferably includes radiopaque band 598 so that their positions relative to one another may be accurately determined.

With respect to FIG. 23B, upon completion of the interventional procedure, guide wire 582 is pulled proximally to cause the sides of support hoop 586 to collapse together to close the mouth of sac 588 (see FIG. 3). Additional proximal retraction of guide wire 582 causes support hoop 586 and sac 588 to partially enter within the distal end of delivery sheath 584.

If bunching of the sac is anticipated or suspected, delivery sheath 584 may be retracted proximally while retrieval sheath 592 is held stationery to expand end region 594 of retrieval sheath 592 with expander 590. Delivery sheath 584 is retracted a sufficient distance to protect sac 588 and its embolic contents within end region 594. The distance may be determined by means of radiopaque bands 596 and 598. End region 594 comprises a suitable elastomeric material, such as latex, rubber or a synthetic variant thereof.

The profile of end region 594 in the expanded state allows for retraction of retrieval sheath 592, as well as delivery sheath 584 and vascular device 580 disposed therein, in a manner that mitigates dangerous interaction with the vascular wall. It also allows vascular device 580 to be retrieved in a partially collapsed state that reduces the risk of sac 588 tearing. As with vascular device 550, vascular device 580 may be used in performing thrombectomy/embolectomy.

The support hoops depicted herein illustratively are shown as oval or heart-shaped in the deployed state, where the shape is exaggerated for the sake of clarity. In preferred embodiments, the support hoops are substantially round when deployed, to ensure contact around the circumference of the support hoop and provide a positive seal against the arterial wall.

Although preferred illustrative embodiments of the present invention are described above, it will be evident to one skilled in the art that various changes and modifications may be made without departing from the invention. It is intended in the appended claims to cover all such changes and modifications that fall within the true spirit and scope of the invention.

Claims (69)

1. Apparatus suitable for filtering emboli or performing thrombectomy, embolectomy or foreign body removal, comprising:
an elongated member having a distal region;
a first support hoop attached to the distal region, the first support hoop having an articulation region interposed between curved regions;
a blood permeable sac affixed to the first support hoop so that the first support hoop forms a mouth of the blood permeable sac;
wherein the apparatus has a deployed state, wherein the first support hoop engages an interior wall of a patient's vessel, and a delivery state, wherein the apparatus has a contracted configuration to permit insertion within a delivery sheath; and
wherein the first support hoop is folded at the articulation region when the apparatus is in the delivery state.
2. The apparatus of claim 1, wherein the blood permeable sac comprises a biocompatible material.
3. The apparatus of claim 2, wherein the biocompatible material comprises a material chosen from a group consisting of polyethylene, polypropylene, polyurethane, polyester, polyethylene tetraphlalate, nylon and polytetrafluoroethylene.
4. The apparatus of claim 2, wherein the biocompatible material is substantially non-thrombogenic.
5. The apparatus of claim 2, wherein the biocompatible material is formed into the blood permeable sac by a thermoforming process.
6. The apparatus of claim 1, wherein the blood permeable sac comprises a woven material having a plurality of pores, the pores having a size determined by a weave pattern of the woven material.
7. The apparatus of claim 4, wherein each one of the plurality of pores has a diameter in a range of 20 to 400 microns.
8. The apparatus of claim 4, wherein each one of the plurality of pores has a cross-sectional area, and a sum area of the cross-sectional areas is greater than or equal to a cross-sectional area of a patient's vessel.
9. The apparatus of claim 1, wherein the first support hoop comprises a super-elastic material.
10. The apparatus of claim 6, wherein the super-elastic material comprises a nickel-titanium alloy.
11. The apparatus of claim 6, wherein the super-elastic material comprises a spring tempered stainless steel.
12. The apparatus of claim 1, wherein the first support hoop comprises a wire having a thickness that tapers to a minimum thickness at the articulation region.
13. The apparatus of claim 1, wherein the mouth of the blood permeable sac is closed when the apparatus is in the contracted configuration, thereby preventing emboli from escaping from the blood permeable sac.
14. The apparatus of claim 11 wherein opposite sides of the first support hoop close towards one another when the apparatus is contracted to its contracted configuration.
15. The apparatus of claim 1, wherein the first support hoop comprises a radiopaque feature. member.
16. The apparatus of claim 13, wherein the radiopaque feature comprises a radiopaque wire wrapped around the first support hoop.
17. The apparatus of claim 1, wherein the blood permeable sac is affixed to the elongated member along a length of the blood permeable sac.
18. The apparatus of claim 1 wherein the first support hoop includes one or more side turns that stabilize and orient the apparatus in the deployed state.
19. The apparatus of claim 1 wherein the elongated member serves as a guide wire.
20. The apparatus of claim 1 further comprising:
a nose cone disposed on the distal region of the elongated member distal to the first support hoop; and
a delivery sheath having a first lumen for accepting the elongated member, first support hoop and blood permeable sac.
21. The apparatus of claim 17, wherein the delivery sheath further comprises a second lumen for accepting a guide wire.
22. The apparatus of claim 18 wherein the first lumen of the delivery sheath opens to a skive in a lateral wall of the delivery sheath in a distal region of the delivery sheath.
23. The apparatus of claim 18 wherein the second lumen of the delivery sheath opens to a skive in a lateral wall of the delivery sheath in a distal region of the delivery sheath.
24. The apparatus of claim 18, wherein the delivery sheath further comprises a guide tube attached to an exterior surface of the delivery sheath, the guide tube having a portion defining the second lumen.
25. The apparatus of claim 17 further comprising a guide wire in communication with the delivery sheath.
26. The apparatus of claim 23, wherein a distal end of the guide wire is attached to a proximal end of the delivery sheath.
27. The apparatus of claim 1 further comprising a balloon catheter.
28. The apparatus of claim 1, wherein the articulation region comprises a gap, the gap bridged by a portion of the blood permeable sac.
29. The apparatus of claim 25, wherein the proximal end of the blood permeable sac comprises a lumen.
30. The apparatus of claim 29, wherein the lumen is configured to receive the curved regions and bridge the gap.
31. The apparatus of claim 25, wherein the curved regions of the first support hoop comprise an elastic material.
32. The apparatus of claim 1, wherein the blood permeable sac is further affixed to the elongated member.
33. The apparatus of claim 1, wherein the blood permeable sac has a length and a diameter that tapers along the length.
34. The apparatus of claim 29, wherein tapering the blood permeable sac reduces bunching of the sac during retrieval within a delivery sheath.
35. The apparatus of claim 29, wherein tapering the blood permeable sac reduces a delivery profile of the apparatus.
36. The apparatus of claim 29, wherein tapering the blood permeable sac reduces a risk of snagging the sac on a stent during retrieval.
37. The apparatus of claim 1, wherein the first support hoop is attached to a sheath slidably disposed on the elongated member.
38. The apparatus of claim 33 further comprising means for constraining longitudinal motion of the sheath with respect to the elongated member.
39. The apparatus of claim 1 further comprising a second support hoop disposed circumferentially adjacent to the first support hoop, the blood permeable sac further affixed to the second support hoop.
40. The apparatus of claim 1 further comprising: Apparatus suitable for filtering emboli or performing thrombectomy, embolectomy or foreign body removal, comprising:
an elongated member having a distal region;
a first support hoop attached to the distal region, the first support hoop having an articulation region interposed between curved regions;
a blood permeable sac affixed to the first support hoop so that the first support hoop forms a mouth of the blood permeable sac;
wherein the apparatus has a deployed state, wherein the first support hoop engages an interior wall of a patient's vessel, and a delivery state, wherein the apparatus has a contracted configuration to permit insertion within a delivery sheath;
wherein the first support hoop is folded at the articulation region when the apparatus is in the delivery state; and
a second support hoop coupled to the distal region and spaced apart longitudinally from the first support hoop,
the blood permeable sac further affixed to the second support hoop.
41. The apparatus of claim 36 40, wherein the second support hoop comprises a wire having a thickness that tapers to a minimum thickness at an articulation region.
42. The apparatus of claim 36 40, wherein the blood permeable sac has a length and a diameter that tapers along the length.
43. The apparatus of claim 36 40, wherein the second support hoop is smaller than the first support hoop.
44. The apparatus of claim 36 40, wherein the second support hoop comprises an articulation region having a gap, the gap bridged by a portion of the blood permeable sac.
45. The apparatus of claim 36 40, wherein the first and second support hoops are attached to a sheath slidably disposed on the elongated member.
46. The apparatus of claim 41 45, further comprising means for constraining longitudinal motion of the sheath with respect to the elongated member.
47. The apparatus of claim 1 40, further comprising:
a delivery sheath having a lumen for accepting the elongated member, support hoop and blood permeable sac;
a retrieval sheath having a flared end region and a lumen for accepting the delivery sheath; and
a guide catheter having a lumen for accepting the retrieval sheath.
48. The apparatus of claim 43 47, wherein the apparatus has a deployed state, wherein the support hoop engages an interior wall of a patient's vessel, and a delivery state, wherein the apparatus has a contracted configuration to permit insertion within the delivery sheath.
49. The apparatus of claim 44 48, wherein the first support hoop folds at the articulation region when the apparatus is contracted to the delivery state.
50. The apparatus of claim 44 48, wherein the mouth of the blood permeable sac closes when the apparatus is contracted to the delivery state.
51. The apparatus of claim 43 47, wherein the flared end region comprises a radiopaque feature.
52. The apparatus of claim 43 47, wherein the retrieval sheath has a deployed state, wherein the flared end region extends distal of the guide catheter and is expanded, and a contracted state, wherein the flared end region is collapsed to fit within the guide catheter lumen.
53. The apparatus of claim 48 52, wherein the retrieval sheath is retracted from the deployed state to the contracted state when a radiopaque feature on the flared end region is aligned with a radiopaque feature on the blood permeable sac.
54. The apparatus of claim 48 52, wherein the flared end region contracts the portion of the vascular device remaining in the deployed state within the guide catheter lumen when the retrieval sheath is retracted from the deployed state to the contracted state.
55. The apparatus of claim 43 47, wherein the flared end region comprises an elastomeric material.
56. The apparatus of claim 1 further comprising: Apparatus suitable for filtering emboli or performing thrombectomy, embolectomy or foreign body removal, comprising:
an elongated member having a distal region;
a first support hoop attached to the distal region, the first support hoop having an articulation region interposed between curved regions;
a blood permeable sac affixed to the first support hoop so that the first support hoop forms a mouth of the blood permeable sac;
wherein the apparatus has a deployed state, wherein the first support hoop engages an interior wall of a patient's vessel, and a delivery state, wherein the apparatus has a contracted configuration to permit insertion within a delivery sheath;
wherein the first support hoop is folded at the articulation region when the apparatus is in the delivery state;
a delivery sheath having a lumen for accepting the elongated member, support hoop and blood permeable sac, and having an atraumatic expander; and
a retrieval sheath having an expandable end region and a lumen for accepting the delivery sheath.
57. The apparatus of claim 1 further comprising:
a handle having a collet for selectively grasping and releasing the elongated member;
and a lumen flushing section coupled to the handle to allow translation and rotation therebetween, the lumen flushing section having a side port in fluid communication with the lumen of the delivery sheath and configured to allow the elongated member to pass therethrough to the handle.
58. The apparatus of claim 53, wherein the apparatus has a delivery state, wherein the handle is translated longitudinally to a proximal-most position relative to the lumen flushing section, and the first support hoop is retracted within the delivery sheath, and a deployed state wherein the handle is translated longitudinally to a distal-most position adjacent the lumen flushing section, wherein the first support hoop extends beyond a distal end of the delivery sheath and engages an interior wall of a patient's vessel.
59. The apparatus of claim 1 further comprising:
a handle configured to selectively grasp and release the elongated member; and
a fluid port section coupled to the handle to allow translation and rotation therebetween, the fluid port section having a side port in fluid communication with the lumen of the delivery sheath and configured to allow the elongated member to pass therethrough to the handle.
60. The apparatus of claim 55, wherein the apparatus has a delivery state, wherein the handle is translated longitudinally to a proximal-most position relative to the fluid port section, and the first support hoop is retracted within the delivery sheath, and a deployed state wherein the handle is translated longitudinally to a distal-most position adjacent the fluid port section, wherein the first support hoop extends beyond a distal end of the delivery sheath and engages an interior wall of a patient's vessel.
61. The apparatus of claim 1 56, further comprising:
a thrombus removal element disposed proximal of the first support hoop, the thrombus removal element movable in a proximal direction independent of the elongated member.
62. The apparatus of claim 57 61, wherein the thrombus removal element comprises a third support hoop with blood permeable sac.
63. The apparatus of claim 58 62, wherein the third support hoop is slidably disposed on the elongated member.
64. The apparatus of claim 57 61, wherein the removal element is configured to excise or ablate thrombus from within a patient's vessel.
65. The apparatus of claim 57 61, further comprising:
a nose cone disposed on the distal region of the elongated member distal to the support hoop;
and a delivery sheath having a lumen for accepting the elongated member, thrombus removal element, first support hoop, and blood permeable sac.
66. The apparatus of claim 1 40, wherein the blood permeable sac comprises a plurality of pores formed by laser drilling.
67. The apparatus of claim 62 66, wherein each one of the plurality of pores has a diameter in a range of 20 to 400 microns.
68. The apparatus of claim 1 40, wherein the blood permeable sac comprises a plurality of elliptical pores.
69. The apparatus of claim 1 40, wherein the blood permeable sac comprises a plurality of pores provided in sufficient density, such that proximal pores remain open when distal pores become occluded, thereby ensuring continuous blood flow through a patient's vessel.
US13162769 1999-07-30 2011-06-17 Vascular device for emboli, thrombus and foreign body removal and methods of use Active USRE43882E1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US09364064 US6530939B1 (en) 1999-07-30 1999-07-30 Vascular device having articulation region and methods of use
US09430211 US6589263B1 (en) 1999-07-30 1999-10-29 Vascular device having one or more articulation regions and methods of use
US09470682 US6214026B1 (en) 1999-07-30 1999-12-23 Delivery system for a vascular device with articulation region
US09470703 US6179861B1 (en) 1999-07-30 1999-12-23 Vascular device having one or more articulation regions and methods of use
US09470857 US6129739A (en) 1999-07-30 1999-12-23 Vascular device having one or more articulation regions and methods of use
US09470681 US6203561B1 (en) 1999-07-30 1999-12-23 Integrated vascular device having thrombectomy element and vascular filter and methods of use
US09611428 US6616679B1 (en) 1999-07-30 2000-07-07 Rapid exchange vascular device for emboli and thrombus removal and methods of use
US09636040 US6544279B1 (en) 2000-08-09 2000-08-09 Vascular device for emboli, thrombus and foreign body removal and methods of use
US13162769 USRE43882E1 (en) 1999-07-30 2011-06-17 Vascular device for emboli, thrombus and foreign body removal and methods of use

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080255651A1 (en) * 2007-04-12 2008-10-16 Medtronic Vascular, Inc. Telescoping Stability Sheath and Method of Use
US20130030519A1 (en) * 2011-07-27 2013-01-31 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US8679150B1 (en) 2013-03-15 2014-03-25 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy methods
US8690907B1 (en) 2013-03-15 2014-04-08 Insera Therapeutics, Inc. Vascular treatment methods
US8715316B1 (en) 2013-07-29 2014-05-06 Insera Therapeutics, Inc. Offset vascular treatment devices
US9034007B2 (en) 2007-09-21 2015-05-19 Insera Therapeutics, Inc. Distal embolic protection devices with a variable thickness microguidewire and methods for their use
US9314324B2 (en) 2013-07-29 2016-04-19 Insera Therapeutics, Inc. Vascular treatment devices and methods

Citations (274)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592186A (en) 1969-01-28 1971-07-13 Claude Oster Cytologic scraper
US3683904A (en) 1970-10-05 1972-08-15 Howard B Forster Pessaries
US3952747A (en) 1974-03-28 1976-04-27 Kimmell Jr Garman O Filter and filter insertion instrument
US3996938A (en) 1975-07-10 1976-12-14 Clark Iii William T Expanding mesh catheter
US4046150A (en) 1975-07-17 1977-09-06 American Hospital Supply Corporation Medical instrument for locating and removing occlusive objects
DE2821048C2 (en) 1978-05-13 1980-07-17 Willy Ruesch Gmbh & Co Kg, 7053 Kernen
US4425908A (en) 1981-10-22 1984-01-17 Beth Israel Hospital Blood clot filter
US4447227A (en) 1982-06-09 1984-05-08 Endoscopy Surgical Systems, Inc. Multi-purpose medical devices
US4580568A (en) 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
US4590938A (en) 1984-05-04 1986-05-27 Segura Joseph W Medical retriever device
DE3417738C2 (en) 1984-05-12 1986-10-02 Ing. Walter Hengst Gmbh & Co Kg, 4400 Muenster, De
US4619246A (en) 1984-05-23 1986-10-28 William Cook, Europe A/S Collapsible filter basket
EP0200688A1 (en) 1985-03-27 1986-11-05 ITAL IDEE s.r.l. Member for indicating clogging of the air intake filter, particularly for motor vehicle engines
US4631052A (en) 1984-01-03 1986-12-23 Intravascular Surgical Instruments, Inc. Method and apparatus for surgically removing remote deposits
US4643184A (en) 1982-09-29 1987-02-17 Mobin Uddin Kazi Embolus trap
US4650466A (en) 1985-11-01 1987-03-17 Angiobrade Partners Angioplasty device
US4662885A (en) 1985-09-03 1987-05-05 Becton, Dickinson And Company Percutaneously deliverable intravascular filter prosthesis
FR2580504B1 (en) 1985-04-22 1987-07-10 Pieronne Alain Filter for the partial and at least temporary interruption of a vein catheter and the filter carrier
US4705517A (en) 1985-09-03 1987-11-10 Becton, Dickinson And Company Percutaneously deliverable intravascular occlusion prosthesis
US4706671A (en) 1985-05-02 1987-11-17 Weinrib Harry P Catheter with coiled tip
US4723549A (en) 1986-09-18 1988-02-09 Wholey Mark H Method and apparatus for dilating blood vessels
US4728319A (en) 1986-03-20 1988-03-01 Helmut Masch Intravascular catheter
US4733665A (en) 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
EP0293605A1 (en) 1987-05-22 1988-12-07 Boston Scientific Corporation Implantable filter
US4790812A (en) 1985-11-15 1988-12-13 Hawkins Jr Irvin F Apparatus and method for removing a target object from a body passsageway
US4790813A (en) 1984-12-17 1988-12-13 Intravascular Surgical Instruments, Inc. Method and apparatus for surgically removing remote deposits
US4794928A (en) 1987-06-10 1989-01-03 Kletschka Harold D Angioplasty device and method of using the same
US4794931A (en) 1986-02-28 1989-01-03 Cardiovascular Imaging Systems, Inc. Catheter apparatus, system and method for intravascular two-dimensional ultrasonography
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4807626A (en) 1985-02-14 1989-02-28 Mcgirr Douglas B Stone extractor and method
US4842579A (en) 1984-05-14 1989-06-27 Surgical Systems & Instruments, Inc. Atherectomy device
US4857046A (en) 1987-10-21 1989-08-15 Cordis Corporation Drive catheter having helical pump drive shaft
US4857045A (en) 1987-04-30 1989-08-15 Schneider (Usa) Inc., A Pfizer Company Atherectomy catheter
US4867157A (en) 1987-08-13 1989-09-19 Baxter Travenol Laboratories, Inc. Surgical cutting instrument
US4873978A (en) 1987-12-04 1989-10-17 Robert Ginsburg Device and method for emboli retrieval
US4898575A (en) 1987-08-31 1990-02-06 Medinnovations, Inc. Guide wire following tunneling catheter system and method for transluminal arterial atherectomy
US4907336A (en) 1987-03-13 1990-03-13 Cook Incorporated Method of making an endovascular stent and delivery system
US4921478A (en) 1988-02-23 1990-05-01 C. R. Bard, Inc. Cerebral balloon angioplasty system
US4921484A (en) 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
US4926858A (en) 1984-05-30 1990-05-22 Devices For Vascular Intervention, Inc. Atherectomy device for severe occlusions
US4950277A (en) 1989-01-23 1990-08-21 Interventional Technologies, Inc. Atherectomy cutting device with eccentric wire and method
FR2643250A1 (en) 1989-02-20 1990-08-24 Lg Medical Sa Device for operating on the cardiovascular system and permitting in particular the treatment of thrombi
US4955895A (en) 1986-12-23 1990-09-11 Terumo Kabushiki Kaisha Vasodilating catheter
US4957482A (en) 1988-12-19 1990-09-18 Surgical Systems & Instruments, Inc. Atherectomy device with a positive pump means
US4969891A (en) 1989-03-06 1990-11-13 Gewertz Bruce L Removable vascular filter
US4979951A (en) 1984-05-30 1990-12-25 Simpson John B Atherectomy device and method
US4986807A (en) 1989-01-23 1991-01-22 Interventional Technologies, Inc. Atherectomy cutter with radially projecting blade
EP0411118A1 (en) 1987-03-25 1991-02-06 Terumo Kabushiki Kaisha Instrument for securing inner diameter of inner cavity of tubular organ and catheter equipped with the instrument
US4998539A (en) 1987-12-18 1991-03-12 Delsanti Gerard L Method of using removable endo-arterial devices to repair detachments in the arterial walls
US5002560A (en) 1989-09-08 1991-03-26 Advanced Cardiovascular Systems, Inc. Expandable cage catheter with a rotatable guide
USRE33569E (en) 1986-02-28 1991-04-09 Devices For Vascular Intervention, Inc. Single lumen atherectomy catheter device
US5007917A (en) 1990-03-08 1991-04-16 Stryker Corporation Single blade cutter for arthroscopic surgery
US5007896A (en) 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
DE4030998A1 (en) 1989-10-04 1991-04-18 Ernst Peter Prof Dr M Strecker Percutaneously implanted filter in blood vessel - is made from biologically decomposable material and has hooks to engage walls of blood vessel
US5011488A (en) 1988-12-07 1991-04-30 Robert Ginsburg Thrombus extraction system
US5019088A (en) 1989-11-07 1991-05-28 Interventional Technologies Inc. Ovoid atherectomy cutter
US5041126A (en) 1987-03-13 1991-08-20 Cook Incorporated Endovascular stent and delivery system
EP0427429A3 (en) 1989-10-25 1991-09-11 C.R. Bard, Inc. Occluding catheter for treating cerebral arteries
US5053044A (en) 1988-01-11 1991-10-01 Devices For Vascular Intervention, Inc. Catheter and method for making intravascular incisions
US5053008A (en) 1990-11-21 1991-10-01 Sandeep Bajaj Intracardiac catheter
US5071407A (en) 1990-04-12 1991-12-10 Schneider (U.S.A.) Inc. Radially expandable fixation member
US5071425A (en) 1988-09-12 1991-12-10 Devices For Vascular Intervention, Inc. Atherectomy catheter and method of forming the same
US5085662A (en) 1989-11-13 1992-02-04 Scimed Life Systems, Inc. Atherectomy catheter and related components
US5087265A (en) 1989-02-17 1992-02-11 American Biomed, Inc. Distal atherectomy catheter
EP0472368A2 (en) 1990-08-21 1992-02-26 Med Institute, Inc. Ablation catheter
EP0472334A1 (en) 1990-08-14 1992-02-26 Cook Incorporated Apparatus for filtering blood in a blood vessel of a patient
WO1992003097A1 (en) 1990-08-16 1992-03-05 Evi Corporation Endovascular filter and method for use thereof
US5100424A (en) 1990-05-21 1992-03-31 Cardiovascular Imaging Systems, Inc. Intravascular catheter having combined imaging abrasion head
US5100425A (en) 1989-09-14 1992-03-31 Medintec R&D Limited Partnership Expandable transluminal atherectomy catheter system and method for the treatment of arterial stenoses
US5102415A (en) 1989-09-06 1992-04-07 Guenther Rolf W Apparatus for removing blood clots from arteries and veins
US5104399A (en) 1986-12-10 1992-04-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US5133733A (en) 1989-11-28 1992-07-28 William Cook Europe A/S Collapsible filter for introduction in a blood vessel of a patient
US5135531A (en) 1984-05-14 1992-08-04 Surgical Systems & Instruments, Inc. Guided atherectomy system
US5152777A (en) 1989-01-25 1992-10-06 Uresil Corporation Device and method for providing protection from emboli and preventing occulsion of blood vessels
US5152771A (en) 1990-12-31 1992-10-06 The Board Of Supervisors Of Louisiana State University Valve cutter for arterial by-pass surgery
US5160342A (en) 1990-08-16 1992-11-03 Evi Corp. Endovascular filter and method for use thereof
US5171233A (en) 1990-04-25 1992-12-15 Microvena Corporation Snare-type probe
US5190546A (en) 1983-10-14 1993-03-02 Raychem Corporation Medical devices incorporating SIM alloy elements
US5192286A (en) 1991-07-26 1993-03-09 Regents Of The University Of California Method and device for retrieving materials from body lumens
US5195955A (en) 1989-11-14 1993-03-23 Don Michael T Anthony Device for removal of embolic debris
EP0533511A1 (en) 1991-07-22 1993-03-24 Thomas Schmitz-Rode Device for maintaining the patency of a bodily duct, and especially of a blood vessel, and uses thereof
US5224953A (en) 1992-05-01 1993-07-06 The Beth Israel Hospital Association Method for treatment of obstructive portions of urinary passageways
FR2666980B1 (en) 1990-09-26 1993-07-23 Lg Medical blood filtration unit and input device of such a unit on the blood path.
US5306286A (en) 1987-06-25 1994-04-26 Duke University Absorbable stent
US5314472A (en) 1991-10-01 1994-05-24 Cook Incorporated Vascular stent
US5318576A (en) 1992-12-16 1994-06-07 Plassche Jr Walter M Endovascular surgery systems
WO1994014389A1 (en) 1992-12-28 1994-07-07 Cardial Device for preventing thrombus circulation in vascular ducts
US5330500A (en) 1990-10-18 1994-07-19 Song Ho Y Self-expanding endovascular stent with silicone coating
US5330484A (en) 1990-08-16 1994-07-19 William Cook Europe A/S Device for fragmentation of thrombi
US5350398A (en) 1991-05-13 1994-09-27 Dusan Pavcnik Self-expanding filter for percutaneous insertion
FR2694687B1 (en) 1992-08-12 1994-09-30 Celsa Lg vascular prosthesis to filter the blood in a vessel and the interventional device for such a temporary filter.
US5354310A (en) 1993-03-22 1994-10-11 Cordis Corporation Expandable temporary graft
US5356423A (en) 1991-01-04 1994-10-18 American Medical Systems, Inc. Resectable self-expanding stent
WO1994024946A1 (en) 1993-04-29 1994-11-10 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal device
US5366464A (en) 1993-07-22 1994-11-22 Belknap John C Atherectomy catheter device
US5366473A (en) 1992-08-18 1994-11-22 Ultrasonic Sensing And Monitoring Systems, Inc. Method and apparatus for applying vascular grafts
US5370683A (en) 1992-03-25 1994-12-06 Cook Incorporated Vascular stent
US5370657A (en) 1993-03-26 1994-12-06 Scimed Life Systems, Inc. Recoverable thrombosis filter
US5376100A (en) 1991-12-23 1994-12-27 Lefebvre; Jean-Marie Rotary atherectomy or thrombectomy device with centrifugal transversal expansion
US5383892A (en) 1991-11-08 1995-01-24 Meadox France Stent for transluminal implantation
US5383926A (en) 1992-11-23 1995-01-24 Children's Medical Center Corporation Re-expandable endoprosthesis
US5383887A (en) 1992-12-28 1995-01-24 Celsa Lg Device for selectively forming a temporary blood filter
US5387235A (en) 1991-10-25 1995-02-07 Cook Incorporated Expandable transluminal graft prosthesis for repair of aneurysm
US5395349A (en) 1991-12-13 1995-03-07 Endovascular Technologies, Inc. Dual valve reinforced sheath and method
US5405377A (en) 1992-02-21 1995-04-11 Endotech Ltd. Intraluminal stent
US5409454A (en) 1991-02-19 1995-04-25 Arrow International Investment Corp. Apparatus for atherectomy
US5415630A (en) 1991-07-17 1995-05-16 Gory; Pierre Method for removably implanting a blood filter in a vein of the human body
US5419774A (en) 1993-07-13 1995-05-30 Scimed Life Systems, Inc. Thrombus extraction device
EP0655228A1 (en) 1993-11-29 1995-05-31 B. BRAUN CELSA, Société Anonyme Endovascular blood filter with petal shaped two-stage filtering elements
US5421832A (en) 1989-12-13 1995-06-06 Lefebvre; Jean-Marie Filter-catheter and method of manufacturing same
US5423885A (en) 1992-01-31 1995-06-13 Advanced Cardiovascular Systems, Inc. Stent capable of attachment within a body lumen
US5423742A (en) 1989-09-12 1995-06-13 Schneider Europe Method for the widening of strictures in vessels carrying body fluid
US5425765A (en) 1993-06-25 1995-06-20 Tiefenbrun; Jonathan Surgical bypass method
US5443498A (en) 1991-10-01 1995-08-22 Cook Incorporated Vascular stent and method of making and implanting a vacsular stent
US5449372A (en) 1990-10-09 1995-09-12 Scimed Lifesystems, Inc. Temporary stent and methods for use and manufacture
US5456667A (en) 1993-05-20 1995-10-10 Advanced Cardiovascular Systems, Inc. Temporary stenting catheter with one-piece expandable segment
US5462529A (en) 1993-09-29 1995-10-31 Technology Development Center Adjustable treatment chamber catheter
EP0686379A2 (en) 1994-06-08 1995-12-13 Cardiovascular Concepts, Inc. Apparatus for endoluminal graft placement
US5476104A (en) 1994-08-01 1995-12-19 Sheahon; John A. Cervical and endometrial biopsy instrument
WO1996001591A1 (en) 1994-07-08 1996-01-25 Microvena Corporation Method of forming medical devices; intravascular occlusion devices
EP0696447A2 (en) 1994-08-12 1996-02-14 Cardiovascular Concepts, Inc. Apparatus and methods for deployment release of intraluminal prostheses
WO1996010375A1 (en) 1994-10-04 1996-04-11 Cardiovascular Concepts, Inc. Assembly for treating blood vessels and a method therefor
US5507767A (en) 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
US5512044A (en) 1994-10-11 1996-04-30 Duer; Edward Y. Embolic cutting catheter
US5527354A (en) 1991-06-28 1996-06-18 Cook Incorporated Stent formed of half-round wire
WO1996019941A1 (en) 1994-12-23 1996-07-04 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Vena caval filter
US5536242A (en) 1994-07-01 1996-07-16 Scimed Life Systems, Inc. Intravascular device utilizing fluid to extract occlusive material
JPH08187294A (en) 1995-01-12 1996-07-23 Clinical Supply:Kk Filter for thrombus catching
US5540707A (en) 1992-11-13 1996-07-30 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal devices and methods of use
WO1996023441A1 (en) 1995-01-31 1996-08-08 Microvena Corporation Guidewire having bimetallic coil
US5562724A (en) 1993-12-15 1996-10-08 William Cook Europe A/S Endovascular graft prosthesis and an implantation method for such a prosthesis
EP0737450A1 (en) 1995-04-10 1996-10-16 Cordis Europa N.V. Catheter with filter and thrombidischarge device
US5569274A (en) 1993-02-22 1996-10-29 Heartport, Inc. Endoscopic vascular clamping system and method
US5569275A (en) 1991-06-11 1996-10-29 Microvena Corporation Mechanical thrombus maceration device
WO1996033677A1 (en) 1995-04-28 1996-10-31 Alexander Shaknovich Shuttle stent delivery catheter
EP0743046A1 (en) 1995-05-19 1996-11-20 Cordis Europa N.V. Filter catheter
EP0759287A1 (en) 1995-08-10 1997-02-26 B. Braun Celsa Filter for permanent use having an opening for the passage of medical devices and method of manufacture
EP0771549A2 (en) 1989-12-13 1997-05-07 Jean-Marie Lefebvre Filter-catheter
WO1997017100A1 (en) 1995-11-07 1997-05-15 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US5634897A (en) 1993-10-08 1997-06-03 Lake Region Manufacturing, Inc. Rheolytic occlusion removal catheter system and method
EP0784988A1 (en) 1996-01-18 1997-07-23 Filtertek, Inc. Intravenous filter device
WO1997027808A1 (en) 1996-02-02 1997-08-07 Regents Of The University Of California Clot capture coil
US5658296A (en) 1994-11-21 1997-08-19 Boston Scientific Corporation Method for making surgical retrieval baskets
US5662671A (en) 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5669933A (en) 1996-07-17 1997-09-23 Nitinol Medical Technologies, Inc. Removable embolus blood clot filter
WO1997042879A1 (en) 1996-05-14 1997-11-20 Embol-X, Inc. Aortic occluder with associated filter and methods of use during cardiac surgery
US5695519A (en) 1995-11-30 1997-12-09 American Biomed, Inc. Percutaneous filter for carotid angioplasty
US5709704A (en) 1994-11-30 1998-01-20 Boston Scientific Corporation Blood clot filtering
WO1998002112A1 (en) 1996-07-12 1998-01-22 Alain Fouere Extensible filtering sheath for surgical use for vena cava or large blood vessels
US5720764A (en) 1994-06-11 1998-02-24 Naderlinger; Eduard Vena cava thrombus filter
US5728066A (en) 1995-12-13 1998-03-17 Daneshvar; Yousef Injection systems and methods
US5746758A (en) 1992-11-09 1998-05-05 Evi Corporation Intra-artery obstruction clearing apparatus and methods
US5749848A (en) 1995-11-13 1998-05-12 Cardiovascular Imaging Systems, Inc. Catheter system having imaging, balloon angioplasty, and stent deployment capabilities, and method of use for guided stent deployment
WO1998023322A1 (en) 1996-11-27 1998-06-04 Boston Scientific Corporation Atraumatic anchoring and disengagement mechanism for permanent implant device
US5776183A (en) * 1996-08-23 1998-07-07 Kanesaka; Nozomu Expandable stent
EP0852132A1 (en) 1997-01-03 1998-07-08 B. BRAUN CELSA (société anonyme) Blood filter with improved permeability
US5779716A (en) 1995-10-06 1998-07-14 Metamorphic Surgical Devices, Inc. Device for removing solid objects from body canals, cavities and organs
WO1998033443A1 (en) 1997-02-03 1998-08-06 Angioguard, Inc. Vascular filter
US5792157A (en) 1992-11-13 1998-08-11 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal devices and methods of use
US5792300A (en) 1994-01-21 1998-08-11 Cordis Corporation Perfusion catheter and striped extrusion method of manufacture
WO1998034673A1 (en) 1997-02-12 1998-08-13 Prolifix Medical, Inc. Apparatus for removal of material from stents
US5795322A (en) 1995-04-10 1998-08-18 Cordis Corporation Catheter with filter and thrombus-discharge device
US5797952A (en) 1996-06-21 1998-08-25 Localmed, Inc. System and method for delivering helical stents
WO1998036786A1 (en) 1997-02-19 1998-08-27 The University Of Iowa Research Foundation Retrievable inferior vena cava filter system
US5800525A (en) 1997-06-04 1998-09-01 Vascular Science, Inc. Blood filter
US5800457A (en) 1997-03-05 1998-09-01 Gelbfish; Gary A. Intravascular filter and associated methodology
WO1998038920A1 (en) 1997-03-06 1998-09-11 Scimed Life Systems, Inc. Distal protection device
WO1998039053A1 (en) 1997-03-06 1998-09-11 Scimed Life Systems, Inc. Distal protection device and method
WO1998039046A1 (en) 1997-03-06 1998-09-11 Percusurge, Inc. Catheter system for emboli containment
WO1998038929A1 (en) 1997-03-06 1998-09-11 Percusurge, Inc. Intravascular aspiration system
US5810874A (en) 1996-02-22 1998-09-22 Cordis Corporation Temporary filter catheter
US5817102A (en) 1992-05-08 1998-10-06 Schneider (Usa) Inc. Apparatus for delivering and deploying a stent
WO1998046297A1 (en) 1997-04-16 1998-10-22 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US5827324A (en) 1997-03-06 1998-10-27 Scimed Life Systems, Inc. Distal protection device
WO1998047447A1 (en) 1997-04-23 1998-10-29 Dubrul William R Bifurcated stent and distal protection system
US5833650A (en) 1995-06-05 1998-11-10 Percusurge, Inc. Catheter apparatus and method for treating occluded vessels
US5833644A (en) 1996-05-20 1998-11-10 Percusurge, Inc. Method for emboli containment
WO1998050103A1 (en) 1997-05-08 1998-11-12 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
WO1998049952A1 (en) 1997-05-08 1998-11-12 Embol-X, Inc. Modular filter with delivery system
WO1998051237A1 (en) 1997-05-16 1998-11-19 Jonathan Gertler Catheter-filter set having a compliant seal
WO1998055175A1 (en) 1997-06-06 1998-12-10 Samuels Shaun L W Temporary inflatable filter device and method of use
US5876367A (en) 1996-12-05 1999-03-02 Embol-X, Inc. Cerebral protection during carotid endarterectomy and downstream vascular protection during other surgeries
WO1999009895A1 (en) 1997-08-29 1999-03-04 Boston Scientific Limited Fast-detaching electrically insulated implant
FR2768326A1 (en) 1997-09-18 1999-03-19 De Bearn Olivier Despalle Temporary blood filter for protecting cerebral tracts following angioplasty
US5893867A (en) 1996-11-06 1999-04-13 Percusurge, Inc. Stent positioning apparatus and method
US5902263A (en) 1997-02-12 1999-05-11 Prolifix Medical, Inc. Apparatus and method for removing stenotic material from stents
WO1999022673A1 (en) 1997-11-03 1999-05-14 C.R. Bard, Inc. Temporary vascular filter guide wire
WO1999023976A1 (en) 1997-11-07 1999-05-20 Salviac Limited An embolic protection device
US5906618A (en) 1997-03-20 1999-05-25 Vanderbilt University Microcatheter with auxiliary parachute guide structure
WO1999025252A1 (en) 1997-11-19 1999-05-27 Cordis Corporation Vascular filter
US5908435A (en) 1997-10-23 1999-06-01 Samuels; Shaun L. W. Expandable lumen device and method of use
WO1999030766A1 (en) 1997-12-18 1999-06-24 Embol-X, Inc. Cardioplegia occluder
US5916193A (en) 1991-07-16 1999-06-29 Heartport, Inc. Endovascular cardiac venting catheter and method
US5922020A (en) * 1996-08-02 1999-07-13 Localmed, Inc. Tubular prosthesis having improved expansion and imaging characteristics
US5925016A (en) 1995-09-27 1999-07-20 Xrt Corp. Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure
US5925062A (en) 1992-09-02 1999-07-20 Board Of Regents, The University Of Texas System Intravascular device
US5925063A (en) 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US5925060A (en) 1998-03-13 1999-07-20 B. Braun Celsa Covered self-expanding vascular occlusion device
US5928218A (en) 1994-12-16 1999-07-27 Gelbfish; Gary A. Medical material removal method and associated instrumentation
US5928203A (en) 1997-10-01 1999-07-27 Boston Scientific Corporation Medical fluid infusion and aspiration
US5934284A (en) 1989-08-18 1999-08-10 Endovascular Instruments, Inc Method for increasing blood flow in vessels
US5935139A (en) 1996-05-03 1999-08-10 Boston Scientific Corporation System for immobilizing or manipulating an object in a tract
US5938645A (en) 1995-05-24 1999-08-17 Boston Scientific Corporation Northwest Technology Center Inc. Percutaneous aspiration catheter system
WO1999040964A1 (en) 1998-02-16 1999-08-19 Medicorp S.A. Angioplasty and stent delivery catheter
US5941896A (en) 1997-09-08 1999-08-24 Montefiore Hospital And Medical Center Filter and method for trapping emboli during endovascular procedures
US5947995A (en) 1997-06-06 1999-09-07 Samuels; Shaun Lawrence Wilkie Method and apparatus for removing blood clots and other objects
WO1999044510A1 (en) 1998-03-04 1999-09-10 Bioguide Consulting, Inc. Guidewire filter device
WO1999044535A1 (en) * 1998-03-05 1999-09-10 Boston Scientific Limited Intraluminal stent
US5951585A (en) 1995-05-23 1999-09-14 Boston Scientific Corporation Vena cava delivery system
US5954745A (en) 1997-05-16 1999-09-21 Gertler; Jonathan Catheter-filter set having a compliant seal
US5976172A (en) 1996-07-03 1999-11-02 Cordis Corporation Retractable temporary vena cava filter
WO1999055236A1 (en) 1998-04-29 1999-11-04 Embol-X, Inc. Adjustable blood filtration system
US5989271A (en) 1998-11-09 1999-11-23 Possis Medical, Inc. Flexible tip rheolytic thrombectomy catheter and method of constructing same
US5989210A (en) 1998-02-06 1999-11-23 Possis Medical, Inc. Rheolytic thrombectomy catheter and method of using same
US6013085A (en) 1997-11-07 2000-01-11 Howard; John Method for treating stenosis of the carotid artery
WO2000007521A1 (en) 1998-08-04 2000-02-17 Advanced Cardiovascular Systems, Inc. Assembly for collecting emboli and method of use
WO2000009054A1 (en) 1998-08-13 2000-02-24 Alsius, Inc. Indwelling heat exchange catheter and method of using same
WO2000016705A1 (en) 1998-09-21 2000-03-30 Angioguard, Inc. Vascular filter system
US6051014A (en) 1998-10-13 2000-04-18 Embol-X, Inc. Percutaneous filtration catheter for valve repair surgery and methods of use
US6059814A (en) 1997-06-02 2000-05-09 Medtronic Ave., Inc. Filter for filtering fluid in a bodily passageway
US6066158A (en) 1996-07-25 2000-05-23 Target Therapeutics, Inc. Mechanical clot encasing and removal wire
US6066149A (en) 1997-09-30 2000-05-23 Target Therapeutics, Inc. Mechanical clot treatment device with distal filter
US6068645A (en) 1999-06-07 2000-05-30 Tu; Hosheng Filter system and methods for removing blood clots and biological material
WO2000049970A1 (en) 1999-02-24 2000-08-31 Scimed Life Systems, Inc. Intravascular filter and method
WO2000053120A1 (en) 1994-07-08 2000-09-14 Microvena Corporation Minimally invasive medical device deployment and retrieval system
US6129739A (en) 1999-07-30 2000-10-10 Incept Llc Vascular device having one or more articulation regions and methods of use
DE19916162A1 (en) 1999-04-11 2000-10-26 Oralia Gmbh Modular dental laser system; has laser unit with soft or hard laser, transfer unit to transmit laser beam to applicator and operation element to control laser unit, along with optional modules
US6142987A (en) 1999-08-03 2000-11-07 Scimed Life Systems, Inc. Guided filter with support wire and methods of use
WO2000067665A1 (en) 1999-05-07 2000-11-16 Salviac Limited Support frame for embolic protection device
WO2000067664A1 (en) 1999-05-07 2000-11-16 Salviac Limited An embolic protection device
WO2000067668A1 (en) 1999-05-07 2000-11-16 Salviac Limited Improved filter element for embolic protection device
WO2000067666A1 (en) 1999-05-07 2000-11-16 Salviac Limited Improved filter element for embolic protection device
US6152946A (en) 1998-03-05 2000-11-28 Scimed Life Systems, Inc. Distal protection device and method
US6168604B1 (en) * 1995-10-06 2001-01-02 Metamorphic Surgical Devices, Llc Guide wire device for removing solid objects from body canals
US6168579B1 (en) 1999-08-04 2001-01-02 Scimed Life Systems, Inc. Filter flush system and methods of use
US6171328B1 (en) 1999-11-09 2001-01-09 Embol-X, Inc. Intravascular catheter filter with interlocking petal design and methods of use
WO2001005462A1 (en) 1999-07-14 2001-01-25 Heuser Richard R Embolism prevention device
US6179859B1 (en) 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
US6179861B1 (en) 1999-07-30 2001-01-30 Incept Llc Vascular device having one or more articulation regions and methods of use
WO2001008595A1 (en) 1999-08-03 2001-02-08 Medtronic Ave Inc. Distal protection device
WO2001008743A1 (en) 1999-07-30 2001-02-08 Incept Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
WO2001008742A1 (en) 1999-07-30 2001-02-08 Incept Llc Vascular filter having articulation region and methods of use in the ascending aorta
US6187025B1 (en) * 1999-09-09 2001-02-13 Noble-Met, Ltd. Vascular filter
WO2001010320A1 (en) 1999-08-04 2001-02-15 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of myocardial or vascular tissue
WO2001015629A1 (en) 1999-08-27 2001-03-08 Microvena Corporation Slideable vascular filter
US6203561B1 (en) 1999-07-30 2001-03-20 Incept Llc Integrated vascular device having thrombectomy element and vascular filter and methods of use
US6206868B1 (en) 1998-03-13 2001-03-27 Arteria Medical Science, Inc. Protective device and method against embolization during treatment of carotid artery disease
WO2001021100A1 (en) 1999-09-21 2001-03-29 Microvena Corporation Temporary vascular filter
US6214026B1 (en) 1999-07-30 2001-04-10 Incept Llc Delivery system for a vascular device with articulation region
WO2001026726A1 (en) 1999-10-07 2001-04-19 Prodesco, Inc. Intraluminal filter
US6221006B1 (en) 1998-02-10 2001-04-24 Artemis Medical Inc. Entrapping apparatus and method for use
WO2001035857A1 (en) 1999-11-15 2001-05-25 Boston Scientific Limited Guidewire filter and methods of use
US6238412B1 (en) 1997-11-12 2001-05-29 William Dubrul Biological passageway occlusion removal
US6245088B1 (en) 1997-07-07 2001-06-12 Samuel R. Lowery Retrievable umbrella sieve and method of use
US6245087B1 (en) 1999-08-03 2001-06-12 Embol-X, Inc. Variable expansion frame system for deploying medical devices and methods of use
WO2001043662A1 (en) 1999-12-17 2001-06-21 Advanced Cardiovascular Systems, Inc. System for blocking the passage of emboli through a body vessel and method of use
WO2001047579A1 (en) 1999-12-28 2001-07-05 Embol-X, Inc. Arterial filter with aspiration and methods of use
WO2001049209A1 (en) 1999-12-30 2001-07-12 Advanced Cardiovascular Systems, Inc. Catheter apparatus for treating occluded vessels and filtering embolic debris and method of use
WO2001049355A1 (en) 1999-12-30 2001-07-12 Advanced Cardiovascular Systems, Inc. Guide wire with damped force vibration mechanism
WO2001049208A1 (en) 1999-12-30 2001-07-12 Advanced Cardiovascular Systems, Inc. Embolic protection system
US6264663B1 (en) 1995-10-06 2001-07-24 Metamorphic Surgical Devices, Llc Device for removing solid objects from body canals, cavities and organs including an invertable basket
US6264672B1 (en) 1999-10-25 2001-07-24 Biopsy Sciences, Llc Emboli capturing device
WO2001052768A1 (en) 2000-01-24 2001-07-26 Advanced Cardiovascular Systems, Inc. Embolic protection devices
US6277138B1 (en) 1999-08-17 2001-08-21 Scion Cardio-Vascular, Inc. Filter for embolic material mounted on expandable frame
US6277139B1 (en) 1999-04-01 2001-08-21 Scion Cardio-Vascular, Inc. Vascular protection and embolic material retriever
WO2001060442A1 (en) 2000-02-18 2001-08-23 The Foundry Llc Filtering devices and methods for filtering flow through a body structure
US6280413B1 (en) 1995-06-07 2001-08-28 Medtronic Ave, Inc. Thrombolytic filtration and drug delivery catheter with a self-expanding portion
US6290710B1 (en) 1999-12-29 2001-09-18 Advanced Cardiovascular Systems, Inc. Embolic protection device
WO2001070326A1 (en) 2000-03-22 2001-09-27 Arteria Medical Science, Inc. Device and method of guide wire balloon inflation and deflation to prevent cerebral embolization during carotid stenting
WO2001072205A2 (en) 1998-01-26 2001-10-04 Advanced Cardiovascular Systems, Inc. Method and apparatus for capturing objects beyond an operative site in medical procedures
WO2001091824A2 (en) 2000-05-30 2001-12-06 Zuli Holdings Ltd. Active arterial embolization filter
WO2001087183A3 (en) 2000-05-15 2002-02-28 Intratherapeutics Inc Emboli filter
WO2001089413A3 (en) 2000-05-24 2002-11-28 Medtronic Ave Inc Distal protection device
US6511492B1 (en) * 1998-05-01 2003-01-28 Microvention, Inc. Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders

Patent Citations (332)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592186A (en) 1969-01-28 1971-07-13 Claude Oster Cytologic scraper
US3683904A (en) 1970-10-05 1972-08-15 Howard B Forster Pessaries
US3952747A (en) 1974-03-28 1976-04-27 Kimmell Jr Garman O Filter and filter insertion instrument
US3996938A (en) 1975-07-10 1976-12-14 Clark Iii William T Expanding mesh catheter
US4046150A (en) 1975-07-17 1977-09-06 American Hospital Supply Corporation Medical instrument for locating and removing occlusive objects
GB2020557B (en) 1978-05-13 1983-01-19 Ruesch Gmbh & Co Kg Willy Medical instrument for removing foreign bodies
DE2821048C2 (en) 1978-05-13 1980-07-17 Willy Ruesch Gmbh & Co Kg, 7053 Kernen
US4425908A (en) 1981-10-22 1984-01-17 Beth Israel Hospital Blood clot filter
US4447227A (en) 1982-06-09 1984-05-08 Endoscopy Surgical Systems, Inc. Multi-purpose medical devices
US4643184A (en) 1982-09-29 1987-02-17 Mobin Uddin Kazi Embolus trap
US5190546A (en) 1983-10-14 1993-03-02 Raychem Corporation Medical devices incorporating SIM alloy elements
US5397345A (en) 1983-12-09 1995-03-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US4631052A (en) 1984-01-03 1986-12-23 Intravascular Surgical Instruments, Inc. Method and apparatus for surgically removing remote deposits
US4590938A (en) 1984-05-04 1986-05-27 Segura Joseph W Medical retriever device
DE3417738C2 (en) 1984-05-12 1986-10-02 Ing. Walter Hengst Gmbh & Co Kg, 4400 Muenster, De
US5135531A (en) 1984-05-14 1992-08-04 Surgical Systems & Instruments, Inc. Guided atherectomy system
US4842579B1 (en) 1984-05-14 1995-10-31 Surgical Systems & Instr Inc Atherectomy device
US4842579A (en) 1984-05-14 1989-06-27 Surgical Systems & Instruments, Inc. Atherectomy device
US4619246A (en) 1984-05-23 1986-10-28 William Cook, Europe A/S Collapsible filter basket
US4926858A (en) 1984-05-30 1990-05-22 Devices For Vascular Intervention, Inc. Atherectomy device for severe occlusions
US4979951A (en) 1984-05-30 1990-12-25 Simpson John B Atherectomy device and method
US4580568A (en) 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
US4790813A (en) 1984-12-17 1988-12-13 Intravascular Surgical Instruments, Inc. Method and apparatus for surgically removing remote deposits
US4807626A (en) 1985-02-14 1989-02-28 Mcgirr Douglas B Stone extractor and method
EP0200688A1 (en) 1985-03-27 1986-11-05 ITAL IDEE s.r.l. Member for indicating clogging of the air intake filter, particularly for motor vehicle engines
FR2580504B1 (en) 1985-04-22 1987-07-10 Pieronne Alain Filter for the partial and at least temporary interruption of a vein catheter and the filter carrier
US4706671A (en) 1985-05-02 1987-11-17 Weinrib Harry P Catheter with coiled tip
US4705517A (en) 1985-09-03 1987-11-10 Becton, Dickinson And Company Percutaneously deliverable intravascular occlusion prosthesis
US4662885A (en) 1985-09-03 1987-05-05 Becton, Dickinson And Company Percutaneously deliverable intravascular filter prosthesis
US4650466A (en) 1985-11-01 1987-03-17 Angiobrade Partners Angioplasty device
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4733665B1 (en) 1985-11-07 1994-01-11 Expandable Grafts Partnership Expandable intraluminal graft,and method and apparatus for implanting an expandable intraluminal graft
US4733665A (en) 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4790812A (en) 1985-11-15 1988-12-13 Hawkins Jr Irvin F Apparatus and method for removing a target object from a body passsageway
US4794931A (en) 1986-02-28 1989-01-03 Cardiovascular Imaging Systems, Inc. Catheter apparatus, system and method for intravascular two-dimensional ultrasonography
USRE33569E (en) 1986-02-28 1991-04-09 Devices For Vascular Intervention, Inc. Single lumen atherectomy catheter device
US4728319A (en) 1986-03-20 1988-03-01 Helmut Masch Intravascular catheter
US4723549A (en) 1986-09-18 1988-02-09 Wholey Mark H Method and apparatus for dilating blood vessels
US5104399A (en) 1986-12-10 1992-04-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US4955895A (en) 1986-12-23 1990-09-11 Terumo Kabushiki Kaisha Vasodilating catheter
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US5314444A (en) 1987-03-13 1994-05-24 Cook Incorporated Endovascular stent and delivery system
US4907336A (en) 1987-03-13 1990-03-13 Cook Incorporated Method of making an endovascular stent and delivery system
US5041126A (en) 1987-03-13 1991-08-20 Cook Incorporated Endovascular stent and delivery system
EP0411118A1 (en) 1987-03-25 1991-02-06 Terumo Kabushiki Kaisha Instrument for securing inner diameter of inner cavity of tubular organ and catheter equipped with the instrument
US4857045A (en) 1987-04-30 1989-08-15 Schneider (Usa) Inc., A Pfizer Company Atherectomy catheter
EP0293605A1 (en) 1987-05-22 1988-12-07 Boston Scientific Corporation Implantable filter
US4794928A (en) 1987-06-10 1989-01-03 Kletschka Harold D Angioplasty device and method of using the same
US5306286A (en) 1987-06-25 1994-04-26 Duke University Absorbable stent
US4867157A (en) 1987-08-13 1989-09-19 Baxter Travenol Laboratories, Inc. Surgical cutting instrument
US4898575A (en) 1987-08-31 1990-02-06 Medinnovations, Inc. Guide wire following tunneling catheter system and method for transluminal arterial atherectomy
US4857046A (en) 1987-10-21 1989-08-15 Cordis Corporation Drive catheter having helical pump drive shaft
US4873978A (en) 1987-12-04 1989-10-17 Robert Ginsburg Device and method for emboli retrieval
US4998539A (en) 1987-12-18 1991-03-12 Delsanti Gerard L Method of using removable endo-arterial devices to repair detachments in the arterial walls
US5053044A (en) 1988-01-11 1991-10-01 Devices For Vascular Intervention, Inc. Catheter and method for making intravascular incisions
US4921478A (en) 1988-02-23 1990-05-01 C. R. Bard, Inc. Cerebral balloon angioplasty system
US4921484A (en) 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
US5071425A (en) 1988-09-12 1991-12-10 Devices For Vascular Intervention, Inc. Atherectomy catheter and method of forming the same
US5011488A (en) 1988-12-07 1991-04-30 Robert Ginsburg Thrombus extraction system
US4957482A (en) 1988-12-19 1990-09-18 Surgical Systems & Instruments, Inc. Atherectomy device with a positive pump means
US5007896A (en) 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
US4986807A (en) 1989-01-23 1991-01-22 Interventional Technologies, Inc. Atherectomy cutter with radially projecting blade
US4950277A (en) 1989-01-23 1990-08-21 Interventional Technologies, Inc. Atherectomy cutting device with eccentric wire and method
US5152777A (en) 1989-01-25 1992-10-06 Uresil Corporation Device and method for providing protection from emboli and preventing occulsion of blood vessels
US5087265A (en) 1989-02-17 1992-02-11 American Biomed, Inc. Distal atherectomy catheter
FR2643250B1 (en) 1989-02-20 1997-12-26 Lg Medical Sa The interventional device on the cardiovascular system in particular for the treatment of thrombus
FR2643250A1 (en) 1989-02-20 1990-08-24 Lg Medical Sa Device for operating on the cardiovascular system and permitting in particular the treatment of thrombi
US4969891A (en) 1989-03-06 1990-11-13 Gewertz Bruce L Removable vascular filter
US5934284A (en) 1989-08-18 1999-08-10 Endovascular Instruments, Inc Method for increasing blood flow in vessels
US5102415A (en) 1989-09-06 1992-04-07 Guenther Rolf W Apparatus for removing blood clots from arteries and veins
US5002560A (en) 1989-09-08 1991-03-26 Advanced Cardiovascular Systems, Inc. Expandable cage catheter with a rotatable guide
US5423742A (en) 1989-09-12 1995-06-13 Schneider Europe Method for the widening of strictures in vessels carrying body fluid
US5100425A (en) 1989-09-14 1992-03-31 Medintec R&D Limited Partnership Expandable transluminal atherectomy catheter system and method for the treatment of arterial stenoses
DE4030998A1 (en) 1989-10-04 1991-04-18 Ernst Peter Prof Dr M Strecker Percutaneously implanted filter in blood vessel - is made from biologically decomposable material and has hooks to engage walls of blood vessel
DE4030998C2 (en) 1989-10-04 1995-11-23 Ernst Peter Prof Dr M Strecker Percutaneous vascular filter
EP0427429A3 (en) 1989-10-25 1991-09-11 C.R. Bard, Inc. Occluding catheter for treating cerebral arteries
US5019088A (en) 1989-11-07 1991-05-28 Interventional Technologies Inc. Ovoid atherectomy cutter
US5085662A (en) 1989-11-13 1992-02-04 Scimed Life Systems, Inc. Atherectomy catheter and related components
US5195955A (en) 1989-11-14 1993-03-23 Don Michael T Anthony Device for removal of embolic debris
US5133733A (en) 1989-11-28 1992-07-28 William Cook Europe A/S Collapsible filter for introduction in a blood vessel of a patient
US5421832A (en) 1989-12-13 1995-06-06 Lefebvre; Jean-Marie Filter-catheter and method of manufacturing same
EP0771549A2 (en) 1989-12-13 1997-05-07 Jean-Marie Lefebvre Filter-catheter
EP0437121B1 (en) 1989-12-13 1997-08-20 Jean-Marie Lefebvre Filter-catheter combination
US5007917A (en) 1990-03-08 1991-04-16 Stryker Corporation Single blade cutter for arthroscopic surgery
US5071407A (en) 1990-04-12 1991-12-10 Schneider (U.S.A.) Inc. Radially expandable fixation member
US5171233A (en) 1990-04-25 1992-12-15 Microvena Corporation Snare-type probe
US5100424A (en) 1990-05-21 1992-03-31 Cardiovascular Imaging Systems, Inc. Intravascular catheter having combined imaging abrasion head
US5329942A (en) 1990-08-14 1994-07-19 Cook, Incorporated Method for filtering blood in a blood vessel of a patient
EP0472334A1 (en) 1990-08-14 1992-02-26 Cook Incorporated Apparatus for filtering blood in a blood vessel of a patient
WO1992003097A1 (en) 1990-08-16 1992-03-05 Evi Corporation Endovascular filter and method for use thereof
US5160342A (en) 1990-08-16 1992-11-03 Evi Corp. Endovascular filter and method for use thereof
US5108419A (en) 1990-08-16 1992-04-28 Evi Corporation Endovascular filter and method for use thereof
US5330484A (en) 1990-08-16 1994-07-19 William Cook Europe A/S Device for fragmentation of thrombi
US5100423A (en) 1990-08-21 1992-03-31 Medical Engineering & Development Institute, Inc. Ablation catheter
EP0472368A2 (en) 1990-08-21 1992-02-26 Med Institute, Inc. Ablation catheter
FR2666980B1 (en) 1990-09-26 1993-07-23 Lg Medical blood filtration unit and input device of such a unit on the blood path.
US5449372A (en) 1990-10-09 1995-09-12 Scimed Lifesystems, Inc. Temporary stent and methods for use and manufacture
US5330500A (en) 1990-10-18 1994-07-19 Song Ho Y Self-expanding endovascular stent with silicone coating
US5053008A (en) 1990-11-21 1991-10-01 Sandeep Bajaj Intracardiac catheter
US5152771A (en) 1990-12-31 1992-10-06 The Board Of Supervisors Of Louisiana State University Valve cutter for arterial by-pass surgery
US5356423A (en) 1991-01-04 1994-10-18 American Medical Systems, Inc. Resectable self-expanding stent
US5409454A (en) 1991-02-19 1995-04-25 Arrow International Investment Corp. Apparatus for atherectomy
US5350398A (en) 1991-05-13 1994-09-27 Dusan Pavcnik Self-expanding filter for percutaneous insertion
US5569275A (en) 1991-06-11 1996-10-29 Microvena Corporation Mechanical thrombus maceration device
US5527354A (en) 1991-06-28 1996-06-18 Cook Incorporated Stent formed of half-round wire
US5916193A (en) 1991-07-16 1999-06-29 Heartport, Inc. Endovascular cardiac venting catheter and method
US5415630A (en) 1991-07-17 1995-05-16 Gory; Pierre Method for removably implanting a blood filter in a vein of the human body
EP0533511A1 (en) 1991-07-22 1993-03-24 Thomas Schmitz-Rode Device for maintaining the patency of a bodily duct, and especially of a blood vessel, and uses thereof
US5192286A (en) 1991-07-26 1993-03-09 Regents Of The University Of California Method and device for retrieving materials from body lumens
US5314472A (en) 1991-10-01 1994-05-24 Cook Incorporated Vascular stent
US5443498A (en) 1991-10-01 1995-08-22 Cook Incorporated Vascular stent and method of making and implanting a vacsular stent
US5387235A (en) 1991-10-25 1995-02-07 Cook Incorporated Expandable transluminal graft prosthesis for repair of aneurysm
US5383892A (en) 1991-11-08 1995-01-24 Meadox France Stent for transluminal implantation
US5395349A (en) 1991-12-13 1995-03-07 Endovascular Technologies, Inc. Dual valve reinforced sheath and method
US5484418A (en) 1991-12-13 1996-01-16 Endovascular Technologies, Inc. Dual valve reinforced sheath and method
US5376100A (en) 1991-12-23 1994-12-27 Lefebvre; Jean-Marie Rotary atherectomy or thrombectomy device with centrifugal transversal expansion
US5507767A (en) 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
US5423885A (en) 1992-01-31 1995-06-13 Advanced Cardiovascular Systems, Inc. Stent capable of attachment within a body lumen
US5405377A (en) 1992-02-21 1995-04-11 Endotech Ltd. Intraluminal stent
US5370683A (en) 1992-03-25 1994-12-06 Cook Incorporated Vascular stent
US5224953A (en) 1992-05-01 1993-07-06 The Beth Israel Hospital Association Method for treatment of obstructive portions of urinary passageways
US5817102A (en) 1992-05-08 1998-10-06 Schneider (Usa) Inc. Apparatus for delivering and deploying a stent
FR2694687B1 (en) 1992-08-12 1994-09-30 Celsa Lg vascular prosthesis to filter the blood in a vessel and the interventional device for such a temporary filter.
US5366473A (en) 1992-08-18 1994-11-22 Ultrasonic Sensing And Monitoring Systems, Inc. Method and apparatus for applying vascular grafts
US5925062A (en) 1992-09-02 1999-07-20 Board Of Regents, The University Of Texas System Intravascular device
US5746758A (en) 1992-11-09 1998-05-05 Evi Corporation Intra-artery obstruction clearing apparatus and methods
US5792157A (en) 1992-11-13 1998-08-11 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal devices and methods of use
US5540707A (en) 1992-11-13 1996-07-30 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal devices and methods of use
US5383926A (en) 1992-11-23 1995-01-24 Children's Medical Center Corporation Re-expandable endoprosthesis
US5318576A (en) 1992-12-16 1994-06-07 Plassche Jr Walter M Endovascular surgery systems
WO1994014389A1 (en) 1992-12-28 1994-07-07 Cardial Device for preventing thrombus circulation in vascular ducts
US5383887A (en) 1992-12-28 1995-01-24 Celsa Lg Device for selectively forming a temporary blood filter
US5569274A (en) 1993-02-22 1996-10-29 Heartport, Inc. Endoscopic vascular clamping system and method
US5354310A (en) 1993-03-22 1994-10-11 Cordis Corporation Expandable temporary graft
US5370657A (en) 1993-03-26 1994-12-06 Scimed Life Systems, Inc. Recoverable thrombosis filter
WO1994024946A1 (en) 1993-04-29 1994-11-10 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal device
US5456667A (en) 1993-05-20 1995-10-10 Advanced Cardiovascular Systems, Inc. Temporary stenting catheter with one-piece expandable segment
US5425765A (en) 1993-06-25 1995-06-20 Tiefenbrun; Jonathan Surgical bypass method
US5419774A (en) 1993-07-13 1995-05-30 Scimed Life Systems, Inc. Thrombus extraction device
US5366464A (en) 1993-07-22 1994-11-22 Belknap John C Atherectomy catheter device
US5462529A (en) 1993-09-29 1995-10-31 Technology Development Center Adjustable treatment chamber catheter
US5634897A (en) 1993-10-08 1997-06-03 Lake Region Manufacturing, Inc. Rheolytic occlusion removal catheter system and method
EP0655228A1 (en) 1993-11-29 1995-05-31 B. BRAUN CELSA, Société Anonyme Endovascular blood filter with petal shaped two-stage filtering elements
US5562724A (en) 1993-12-15 1996-10-08 William Cook Europe A/S Endovascular graft prosthesis and an implantation method for such a prosthesis
US5792300A (en) 1994-01-21 1998-08-11 Cordis Corporation Perfusion catheter and striped extrusion method of manufacture
EP0686379A2 (en) 1994-06-08 1995-12-13 Cardiovascular Concepts, Inc. Apparatus for endoluminal graft placement
US5720764A (en) 1994-06-11 1998-02-24 Naderlinger; Eduard Vena cava thrombus filter
US5536242A (en) 1994-07-01 1996-07-16 Scimed Life Systems, Inc. Intravascular device utilizing fluid to extract occlusive material
WO2000053120A1 (en) 1994-07-08 2000-09-14 Microvena Corporation Minimally invasive medical device deployment and retrieval system
WO1996001591A1 (en) 1994-07-08 1996-01-25 Microvena Corporation Method of forming medical devices; intravascular occlusion devices
US5476104A (en) 1994-08-01 1995-12-19 Sheahon; John A. Cervical and endometrial biopsy instrument
EP0696447A2 (en) 1994-08-12 1996-02-14 Cardiovascular Concepts, Inc. Apparatus and methods for deployment release of intraluminal prostheses
WO1996010375A1 (en) 1994-10-04 1996-04-11 Cardiovascular Concepts, Inc. Assembly for treating blood vessels and a method therefor
US5512044A (en) 1994-10-11 1996-04-30 Duer; Edward Y. Embolic cutting catheter
US5658296A (en) 1994-11-21 1997-08-19 Boston Scientific Corporation Method for making surgical retrieval baskets
US5709704A (en) 1994-11-30 1998-01-20 Boston Scientific Corporation Blood clot filtering
US5928218A (en) 1994-12-16 1999-07-27 Gelbfish; Gary A. Medical material removal method and associated instrumentation
WO1996019941A1 (en) 1994-12-23 1996-07-04 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Vena caval filter
US5549626A (en) 1994-12-23 1996-08-27 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Vena caval filter
JPH08187294A (en) 1995-01-12 1996-07-23 Clinical Supply:Kk Filter for thrombus catching
WO1996023441A1 (en) 1995-01-31 1996-08-08 Microvena Corporation Guidewire having bimetallic coil
EP0737450A1 (en) 1995-04-10 1996-10-16 Cordis Europa N.V. Catheter with filter and thrombidischarge device
US5795322A (en) 1995-04-10 1998-08-18 Cordis Corporation Catheter with filter and thrombus-discharge device
WO1996033677A1 (en) 1995-04-28 1996-10-31 Alexander Shaknovich Shuttle stent delivery catheter
EP0743046A1 (en) 1995-05-19 1996-11-20 Cordis Europa N.V. Filter catheter
US5951585A (en) 1995-05-23 1999-09-14 Boston Scientific Corporation Vena cava delivery system
US5938645A (en) 1995-05-24 1999-08-17 Boston Scientific Corporation Northwest Technology Center Inc. Percutaneous aspiration catheter system
US5833650A (en) 1995-06-05 1998-11-10 Percusurge, Inc. Catheter apparatus and method for treating occluded vessels
US6280413B1 (en) 1995-06-07 2001-08-28 Medtronic Ave, Inc. Thrombolytic filtration and drug delivery catheter with a self-expanding portion
EP0759287A1 (en) 1995-08-10 1997-02-26 B. Braun Celsa Filter for permanent use having an opening for the passage of medical devices and method of manufacture
US5925016A (en) 1995-09-27 1999-07-20 Xrt Corp. Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure
US6264663B1 (en) 1995-10-06 2001-07-24 Metamorphic Surgical Devices, Llc Device for removing solid objects from body canals, cavities and organs including an invertable basket
US5779716A (en) 1995-10-06 1998-07-14 Metamorphic Surgical Devices, Inc. Device for removing solid objects from body canals, cavities and organs
US6168604B1 (en) * 1995-10-06 2001-01-02 Metamorphic Surgical Devices, Llc Guide wire device for removing solid objects from body canals
US6117154A (en) 1995-11-07 2000-09-12 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
WO1997017100A1 (en) 1995-11-07 1997-05-15 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US5989281A (en) 1995-11-07 1999-11-23 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US5769816A (en) 1995-11-07 1998-06-23 Embol-X, Inc. Cannula with associated filter
US6235045B1 (en) 1995-11-07 2001-05-22 Embol-X, Inc. Cannula with associated filter and methods of use
US6136016A (en) 1995-11-07 2000-10-24 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US5980555A (en) 1995-11-07 1999-11-09 Embol-X, Inc. Method of using cannula with associated filter during cardiac surgery
US5749848A (en) 1995-11-13 1998-05-12 Cardiovascular Imaging Systems, Inc. Catheter system having imaging, balloon angioplasty, and stent deployment capabilities, and method of use for guided stent deployment
US5695519A (en) 1995-11-30 1997-12-09 American Biomed, Inc. Percutaneous filter for carotid angioplasty
US5728066A (en) 1995-12-13 1998-03-17 Daneshvar; Yousef Injection systems and methods
EP0784988A1 (en) 1996-01-18 1997-07-23 Filtertek, Inc. Intravenous filter device
WO1997027808A1 (en) 1996-02-02 1997-08-07 Regents Of The University Of California Clot capture coil
US5810874A (en) 1996-02-22 1998-09-22 Cordis Corporation Temporary filter catheter
US5935139A (en) 1996-05-03 1999-08-10 Boston Scientific Corporation System for immobilizing or manipulating an object in a tract
WO1997042879A1 (en) 1996-05-14 1997-11-20 Embol-X, Inc. Aortic occluder with associated filter and methods of use during cardiac surgery
US6231544B1 (en) 1996-05-14 2001-05-15 Embol-X, Inc. Cardioplegia balloon cannula
US5833644A (en) 1996-05-20 1998-11-10 Percusurge, Inc. Method for emboli containment
US5797952A (en) 1996-06-21 1998-08-25 Localmed, Inc. System and method for delivering helical stents
US5976172A (en) 1996-07-03 1999-11-02 Cordis Corporation Retractable temporary vena cava filter
WO1998002112A1 (en) 1996-07-12 1998-01-22 Alain Fouere Extensible filtering sheath for surgical use for vena cava or large blood vessels
US6179851B1 (en) 1996-07-17 2001-01-30 Scimed Life Systems, Inc. Guiding catheter for positioning a medical device within an artery
US5993469A (en) 1996-07-17 1999-11-30 Embol-X, Inc. Guiding catheter for positioning a medical device within an artery
US6309399B1 (en) 1996-07-17 2001-10-30 Scimed Life Systems, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
WO1998002084A3 (en) 1996-07-17 1998-12-10 Embol X Inc Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5997557A (en) 1996-07-17 1999-12-07 Embol-X, Inc. Methods for aortic atherectomy
US6010522A (en) 1996-07-17 2000-01-04 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5669933A (en) 1996-07-17 1997-09-23 Nitinol Medical Technologies, Inc. Removable embolus blood clot filter
US5662671A (en) 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5895399A (en) 1996-07-17 1999-04-20 Embol-X Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US6066158A (en) 1996-07-25 2000-05-23 Target Therapeutics, Inc. Mechanical clot encasing and removal wire
US5922020A (en) * 1996-08-02 1999-07-13 Localmed, Inc. Tubular prosthesis having improved expansion and imaging characteristics
US5776183A (en) * 1996-08-23 1998-07-07 Kanesaka; Nozomu Expandable stent
US5893867A (en) 1996-11-06 1999-04-13 Percusurge, Inc. Stent positioning apparatus and method
WO1998023322A1 (en) 1996-11-27 1998-06-04 Boston Scientific Corporation Atraumatic anchoring and disengagement mechanism for permanent implant device
US5876367A (en) 1996-12-05 1999-03-02 Embol-X, Inc. Cerebral protection during carotid endarterectomy and downstream vascular protection during other surgeries
EP0852132A1 (en) 1997-01-03 1998-07-08 B. BRAUN CELSA (société anonyme) Blood filter with improved permeability
WO1998033443A1 (en) 1997-02-03 1998-08-06 Angioguard, Inc. Vascular filter
WO1998034673A1 (en) 1997-02-12 1998-08-13 Prolifix Medical, Inc. Apparatus for removal of material from stents
US5941869A (en) 1997-02-12 1999-08-24 Prolifix Medical, Inc. Apparatus and method for controlled removal of stenotic material from stents
US5902263A (en) 1997-02-12 1999-05-11 Prolifix Medical, Inc. Apparatus and method for removing stenotic material from stents
WO1998036786A1 (en) 1997-02-19 1998-08-27 The University Of Iowa Research Foundation Retrievable inferior vena cava filter system
US5800457A (en) 1997-03-05 1998-09-01 Gelbfish; Gary A. Intravascular filter and associated methodology
WO1998038929A1 (en) 1997-03-06 1998-09-11 Percusurge, Inc. Intravascular aspiration system
WO1998039046A1 (en) 1997-03-06 1998-09-11 Percusurge, Inc. Catheter system for emboli containment
WO1998039053A1 (en) 1997-03-06 1998-09-11 Scimed Life Systems, Inc. Distal protection device and method
US6245089B1 (en) 1997-03-06 2001-06-12 Scimed Life Systems, Inc. Distal protection device and method
US6053932A (en) 1997-03-06 2000-04-25 Scimed Life Systems, Inc. Distal protection device
US6001118A (en) 1997-03-06 1999-12-14 Scimed Life Systems, Inc. Distal protection device and method
US5814064A (en) 1997-03-06 1998-09-29 Scimed Life Systems, Inc. Distal protection device
US5827324A (en) 1997-03-06 1998-10-27 Scimed Life Systems, Inc. Distal protection device
WO1998038920A1 (en) 1997-03-06 1998-09-11 Scimed Life Systems, Inc. Distal protection device
US5906618A (en) 1997-03-20 1999-05-25 Vanderbilt University Microcatheter with auxiliary parachute guide structure
WO1998046297A1 (en) 1997-04-16 1998-10-22 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US6086605A (en) 1997-04-16 2000-07-11 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US6258115B1 (en) 1997-04-23 2001-07-10 Artemis Medical, Inc. Bifurcated stent and distal protection system
WO1998047447A1 (en) 1997-04-23 1998-10-29 Dubrul William R Bifurcated stent and distal protection system
US6165200A (en) 1997-05-08 2000-12-26 Scimed Life Systems, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6224620B1 (en) 1997-05-08 2001-05-01 Embol-X, Inc. Devices and methods for protecting a patient from embolic material during surgery
US5846260A (en) 1997-05-08 1998-12-08 Embol-X, Inc. Cannula with a modular filter for filtering embolic material
US6027520A (en) 1997-05-08 2000-02-22 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6270513B1 (en) 1997-05-08 2001-08-07 Embol-X, Inc. Methods of protecting a patient from embolization during surgery
US5911734A (en) 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US5910154A (en) 1997-05-08 1999-06-08 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment
WO1998049952A1 (en) 1997-05-08 1998-11-12 Embol-X, Inc. Modular filter with delivery system
WO1998050103A1 (en) 1997-05-08 1998-11-12 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6042598A (en) 1997-05-08 2000-03-28 Embol-X Inc. Method of protecting a patient from embolization during cardiac surgery
US6051015A (en) 1997-05-08 2000-04-18 Embol-X, Inc. Modular filter with delivery system
WO1998051237A1 (en) 1997-05-16 1998-11-19 Jonathan Gertler Catheter-filter set having a compliant seal
US5954745A (en) 1997-05-16 1999-09-21 Gertler; Jonathan Catheter-filter set having a compliant seal
US6059814A (en) 1997-06-02 2000-05-09 Medtronic Ave., Inc. Filter for filtering fluid in a bodily passageway
US5800525A (en) 1997-06-04 1998-09-01 Vascular Science, Inc. Blood filter
WO1998055175A1 (en) 1997-06-06 1998-12-10 Samuels Shaun L W Temporary inflatable filter device and method of use
US5947995A (en) 1997-06-06 1999-09-07 Samuels; Shaun Lawrence Wilkie Method and apparatus for removing blood clots and other objects
US5848964A (en) 1997-06-06 1998-12-15 Samuels; Shaun Lawrence Wilkie Temporary inflatable filter device and method of use
US6245088B1 (en) 1997-07-07 2001-06-12 Samuel R. Lowery Retrievable umbrella sieve and method of use
WO1999009895A1 (en) 1997-08-29 1999-03-04 Boston Scientific Limited Fast-detaching electrically insulated implant
US5941896A (en) 1997-09-08 1999-08-24 Montefiore Hospital And Medical Center Filter and method for trapping emboli during endovascular procedures
FR2768326A1 (en) 1997-09-18 1999-03-19 De Bearn Olivier Despalle Temporary blood filter for protecting cerebral tracts following angioplasty
US5925063A (en) 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6066149A (en) 1997-09-30 2000-05-23 Target Therapeutics, Inc. Mechanical clot treatment device with distal filter
US5928203A (en) 1997-10-01 1999-07-27 Boston Scientific Corporation Medical fluid infusion and aspiration
US5908435A (en) 1997-10-23 1999-06-01 Samuels; Shaun L. W. Expandable lumen device and method of use
WO1999022673A1 (en) 1997-11-03 1999-05-14 C.R. Bard, Inc. Temporary vascular filter guide wire
WO1999023976A1 (en) 1997-11-07 1999-05-20 Salviac Limited An embolic protection device
US6336934B1 (en) * 1997-11-07 2002-01-08 Salviac Limited Embolic protection device
US6013085A (en) 1997-11-07 2000-01-11 Howard; John Method for treating stenosis of the carotid artery
US6238412B1 (en) 1997-11-12 2001-05-29 William Dubrul Biological passageway occlusion removal
WO1999025252A1 (en) 1997-11-19 1999-05-27 Cordis Corporation Vascular filter
WO1999030766A1 (en) 1997-12-18 1999-06-24 Embol-X, Inc. Cardioplegia occluder
WO2001072205A2 (en) 1998-01-26 2001-10-04 Advanced Cardiovascular Systems, Inc. Method and apparatus for capturing objects beyond an operative site in medical procedures
EP0934729B1 (en) 1998-02-06 2004-06-09 Possis Medical, Inc. Apparatus for tissue excision and removal by fluid jet
US5989210A (en) 1998-02-06 1999-11-23 Possis Medical, Inc. Rheolytic thrombectomy catheter and method of using same
US6221006B1 (en) 1998-02-10 2001-04-24 Artemis Medical Inc. Entrapping apparatus and method for use
WO1999040964A1 (en) 1998-02-16 1999-08-19 Medicorp S.A. Angioplasty and stent delivery catheter
WO1999044510A1 (en) 1998-03-04 1999-09-10 Bioguide Consulting, Inc. Guidewire filter device
WO1999044535A1 (en) * 1998-03-05 1999-09-10 Boston Scientific Limited Intraluminal stent
US6152946A (en) 1998-03-05 2000-11-28 Scimed Life Systems, Inc. Distal protection device and method
US6206868B1 (en) 1998-03-13 2001-03-27 Arteria Medical Science, Inc. Protective device and method against embolization during treatment of carotid artery disease
US5925060A (en) 1998-03-13 1999-07-20 B. Braun Celsa Covered self-expanding vascular occlusion device
US6319268B1 (en) 1998-04-29 2001-11-20 Embol-X, Inc. Adjustable blood filtration system
US6007557A (en) 1998-04-29 1999-12-28 Embol-X, Inc. Adjustable blood filtration system
WO1999055236A1 (en) 1998-04-29 1999-11-04 Embol-X, Inc. Adjustable blood filtration system
US6511492B1 (en) * 1998-05-01 2003-01-28 Microvention, Inc. Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
WO2000007521A1 (en) 1998-08-04 2000-02-17 Advanced Cardiovascular Systems, Inc. Assembly for collecting emboli and method of use
WO2000007655A1 (en) 1998-08-06 2000-02-17 Samuels Shaun L W Method and apparatus for removing blood clots and other objects
WO2000009054A1 (en) 1998-08-13 2000-02-24 Alsius, Inc. Indwelling heat exchange catheter and method of using same
WO2000016705A1 (en) 1998-09-21 2000-03-30 Angioguard, Inc. Vascular filter system
US6287321B1 (en) 1998-10-13 2001-09-11 Embol-X, Inc. Percutaneous filtration catheter for valve repair surgery
US6051014A (en) 1998-10-13 2000-04-18 Embol-X, Inc. Percutaneous filtration catheter for valve repair surgery and methods of use
US5989271A (en) 1998-11-09 1999-11-23 Possis Medical, Inc. Flexible tip rheolytic thrombectomy catheter and method of constructing same
WO2000049970A1 (en) 1999-02-24 2000-08-31 Scimed Life Systems, Inc. Intravascular filter and method
US6171327B1 (en) 1999-02-24 2001-01-09 Scimed Life Systems, Inc. Intravascular filter and method
US6277139B1 (en) 1999-04-01 2001-08-21 Scion Cardio-Vascular, Inc. Vascular protection and embolic material retriever
DE19916162A1 (en) 1999-04-11 2000-10-26 Oralia Gmbh Modular dental laser system; has laser unit with soft or hard laser, transfer unit to transmit laser beam to applicator and operation element to control laser unit, along with optional modules
WO2000067666A1 (en) 1999-05-07 2000-11-16 Salviac Limited Improved filter element for embolic protection device
WO2000067665A1 (en) 1999-05-07 2000-11-16 Salviac Limited Support frame for embolic protection device
WO2000067669A1 (en) 1999-05-07 2000-11-16 Salviac Limited A support frame for an embolic protection device
WO2000067668A1 (en) 1999-05-07 2000-11-16 Salviac Limited Improved filter element for embolic protection device
WO2000067664A1 (en) 1999-05-07 2000-11-16 Salviac Limited An embolic protection device
US6068645A (en) 1999-06-07 2000-05-30 Tu; Hosheng Filter system and methods for removing blood clots and biological material
WO2001005462A1 (en) 1999-07-14 2001-01-25 Heuser Richard R Embolism prevention device
US6179859B1 (en) 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
US6214026B1 (en) 1999-07-30 2001-04-10 Incept Llc Delivery system for a vascular device with articulation region
US6203561B1 (en) 1999-07-30 2001-03-20 Incept Llc Integrated vascular device having thrombectomy element and vascular filter and methods of use
WO2001008743A1 (en) 1999-07-30 2001-02-08 Incept Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
US6129739A (en) 1999-07-30 2000-10-10 Incept Llc Vascular device having one or more articulation regions and methods of use
US6179861B1 (en) 1999-07-30 2001-01-30 Incept Llc Vascular device having one or more articulation regions and methods of use
WO2001008742A1 (en) 1999-07-30 2001-02-08 Incept Llc Vascular filter having articulation region and methods of use in the ascending aorta
WO2001008595A1 (en) 1999-08-03 2001-02-08 Medtronic Ave Inc. Distal protection device
US6245087B1 (en) 1999-08-03 2001-06-12 Embol-X, Inc. Variable expansion frame system for deploying medical devices and methods of use
WO2001008596A1 (en) 1999-08-03 2001-02-08 Scimed Life Systems, Inc. Guided filter with support wire and methods of use
US6142987A (en) 1999-08-03 2000-11-07 Scimed Life Systems, Inc. Guided filter with support wire and methods of use
US6235044B1 (en) 1999-08-04 2001-05-22 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of mycardial or vascular tissue
WO2001010320A1 (en) 1999-08-04 2001-02-15 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of myocardial or vascular tissue
US6168579B1 (en) 1999-08-04 2001-01-02 Scimed Life Systems, Inc. Filter flush system and methods of use
US6277138B1 (en) 1999-08-17 2001-08-21 Scion Cardio-Vascular, Inc. Filter for embolic material mounted on expandable frame
US6344049B1 (en) 1999-08-17 2002-02-05 Scion Cardio-Vascular, Inc. Filter for embolic material mounted on expandable frame and associated deployment system
EP1127556A2 (en) 1999-08-17 2001-08-29 Scion Cardio-Vascular, Inc., a Florida corporation Vascular filter for embolic material
WO2001015629A1 (en) 1999-08-27 2001-03-08 Microvena Corporation Slideable vascular filter
US6187025B1 (en) * 1999-09-09 2001-02-13 Noble-Met, Ltd. Vascular filter
WO2001021077A1 (en) 1999-09-21 2001-03-29 Metamorphic Surgical Devices, Llc Guide wire device for removing solid objects from body canals
WO2001021100A1 (en) 1999-09-21 2001-03-29 Microvena Corporation Temporary vascular filter
WO2001026726A1 (en) 1999-10-07 2001-04-19 Prodesco, Inc. Intraluminal filter
US6264672B1 (en) 1999-10-25 2001-07-24 Biopsy Sciences, Llc Emboli capturing device
US6171328B1 (en) 1999-11-09 2001-01-09 Embol-X, Inc. Intravascular catheter filter with interlocking petal design and methods of use
WO2001035857A1 (en) 1999-11-15 2001-05-25 Boston Scientific Limited Guidewire filter and methods of use
WO2001043662A1 (en) 1999-12-17 2001-06-21 Advanced Cardiovascular Systems, Inc. System for blocking the passage of emboli through a body vessel and method of use
WO2001047579A1 (en) 1999-12-28 2001-07-05 Embol-X, Inc. Arterial filter with aspiration and methods of use
US6290710B1 (en) 1999-12-29 2001-09-18 Advanced Cardiovascular Systems, Inc. Embolic protection device
WO2001049355A1 (en) 1999-12-30 2001-07-12 Advanced Cardiovascular Systems, Inc. Guide wire with damped force vibration mechanism
WO2001049209A1 (en) 1999-12-30 2001-07-12 Advanced Cardiovascular Systems, Inc. Catheter apparatus for treating occluded vessels and filtering embolic debris and method of use
WO2001049208A1 (en) 1999-12-30 2001-07-12 Advanced Cardiovascular Systems, Inc. Embolic protection system
WO2001052768A1 (en) 2000-01-24 2001-07-26 Advanced Cardiovascular Systems, Inc. Embolic protection devices
WO2001060442A1 (en) 2000-02-18 2001-08-23 The Foundry Llc Filtering devices and methods for filtering flow through a body structure
WO2001070326A1 (en) 2000-03-22 2001-09-27 Arteria Medical Science, Inc. Device and method of guide wire balloon inflation and deflation to prevent cerebral embolization during carotid stenting
WO2001087183A3 (en) 2000-05-15 2002-02-28 Intratherapeutics Inc Emboli filter
WO2001089413A3 (en) 2000-05-24 2002-11-28 Medtronic Ave Inc Distal protection device
WO2001091824A2 (en) 2000-05-30 2001-12-06 Zuli Holdings Ltd. Active arterial embolization filter

Non-Patent Citations (34)

* Cited by examiner, † Cited by third party
Title
"Atherosclerotic Disease of the Aortic Arch as a Risk Factor of Recurrent Ischemic Stroke," The New England Journal of Medicine, pp. 1216-1221 (May 1996).
"Endovascular Grafts, Stents Drive Interventional Radiology Growth," Cardiovascular Device Update, 2(3):1-12 (Mar. 1996).
"Protruding Atheromas in the Thoracic Aortic and Systemic Embolization," American College of Physicians, pp. 423-427(1991).
"Protruding Atheromas in the Thoracic Aortic and Systemic Embolization," pp. 423-427 American College of Physicians (1991).
"Recognition and Embolic Potential of Intraaortic Atherosclerotic Debris," Americal College of Cardiology (Jan. 1991).
"Recognition and Embolic Potential of Intraaortic Atherosclerotic Debris," American College of Cardiology (Jan. 1991).
Cragg, Andrew et al., "A New Percutaneous Vena Cava Filger," AJR, 141:601-604 (Sep. 1983).
Cragg, Andrew et al., "Nonsurgical Placement of Arterial Endoprosthesis: A New Technique Using Nitinol Wire," AJR, pp. 261-263 (Apr. 1983).
Diethrich et al., "Percutaneous Techniques for Endoluminal Carotid Interventions," J. Endovasc. Surg., 3:182-202 (1996).
Diethrich et al., "Percutaneous Techniques for Endoluminal Carotid Interventions," Journal of Endovascular Surgery, 3:182-202 (1996).
Fadali, A. Moneim, "A filtering device for the prevention of particulate embolization during the course of cardiac surgery", Surgery, 64(3), pp. 634-639 (Sep. 1968).
Fadali, A. Moneim, "A filtering device for the prevention of particulate embolization during the course of cardiac surgery", Surgery, vol. 64(3), pp. 634-639 (Sep. 1968).
Haissaguerre et al., "Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins," The New England Journal of Medicine, 339(10):659-666 (Sep. 1988).
Jordan, Jr. et al., "Microemboli Detected by Transcranial Doppler Monitoring . . . ," Cardiovascular Surgery, 7(1):33-38 (Jan. 1999).
Lesh, "Can Catheter Ablation Cure Atrial Fibrillation?" ACC Current Journal Review, pp. 38-40 (Sep./Oct. 1997).
Lund et al., "Long-Term Patentcy of Ductus Arteriosus After Balloon Dilation: an Experimental Study," Laboratory Investigation, 69 (4):772-774 (Apr. 1984).
Lund et al., "Long-Term Patentcy of Ductus Arteriosus After Balloon Dilation: an Experimental Study," Laboratory Investigation, 69(4):772-774 (Apr. 1984).
Marache et al., "Percutaneous Transluminal Venous Angioplasty . . . ," American Heart Journal, 125(2 Pt 1):362-366 (Feb. 1993).
Mazur et al., "Directional Atherectomy with the Omnucath(TM): A Unique New Catheter System," Catheterization and Cardiovascular Diagnosis, 31:17-84 (1994).
Mazur et al., "Directional Atherectomy with the Omnucath.TM.: A Unique New Catheter System," Catheterization and Cardiovascular Diagnosis, 31:17-84 (1994).
Mazur et al., "Directional Atherectomy with the Omnucath™: A Unique New Catheter System," Catheterization and Cardiovascular Diagnosis, 31:17-84 (1994).
Moussa, MD, Issaam "Stents Don't Require Systemic Anticoagulation . . . But the Technique (and Results) Must be Optimal," Journal of Invasive Cardiol., 8(E):3E-7E, (1996).
Nakanishi et al., "Catheter Intervention to Venous System Using Expandable Metallic Stents," Rinsho Kyobu Geka, 14 (2): English Abstract Only (Apr. 1994).
Nakanishi et al., "Catheter Intervention to Venous System Using Expandable Metallic Stents," Rinsho Kyobu Geka, 14(2): English Abstract Only (Apr. 1994).
Onal et al., "Primary Stenting for Complex Atherosclerotic Plaques in Aortic and Iliac Stenoses," Cardiovascular & Interventional Radiology, 21(5):386-392 (1998).
Onal et al., "Primary Stenting for Complex Atherosclerotic Plaques in Aortic and Iliac Stenoses," Cardiovascular & Interventional Radiology, 21(5):386-392(1998).
Theron et al., "New Triple Coaxial Catheter System for Carotid Angioplasty with Cerebral Protection," Americal Journal of Neurotadiology, 11:869-874 (1990).
Theron et al., "New Triple Coaxial Catheter System for Carotid Angioplasty with Cerebral Protection," American Journal of Neuroradiology, 11:869-874 (1990).
Tunick et al., "Protruding atherosclerotic plaque in the aortic arch of patients with systemic embolization: A new finding seen by transesophageal echocardiography," American Heart Journal, 120(3):658-660 (Sep. 1990).
Tunick et al., "Protruding atherosclerotic plaque in the aortic archo f patients with systemic embolization: A new finding seen by transesophageal echocardiography," American Heart Journal 120(3):658-660 (Sep. 1990).
Waksman et al., "Distal Embolization is Common After Directional Atherectomy . . . ," American Heart Journal, 129 (3):430-435 (1995).
Waksman et al., "Distal Embolization is Common After Directional Atherectomy . . . ," American Heart Journal, 129(3):430-435 (1995).
Wholey, Mark H. et al., "PTA and Stents in the Treatment of Extracranial Circulation," The Journal of Invasive Cardiology, Health Management Publications, Inc., vol. 8 Supplement E, pp. 25E-30E (1996).
Wholey, Mark H. et al., "PTA and Stents in the Treatment of Extracranial Circulation," The Journal of Invasive Cardiology: vol. 8/Supplement E, Health Management Publications, Inc., 1996, pp. 25E-30E.

Cited By (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080255651A1 (en) * 2007-04-12 2008-10-16 Medtronic Vascular, Inc. Telescoping Stability Sheath and Method of Use
US9034007B2 (en) 2007-09-21 2015-05-19 Insera Therapeutics, Inc. Distal embolic protection devices with a variable thickness microguidewire and methods for their use
US20130030519A1 (en) * 2011-07-27 2013-01-31 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US9119716B2 (en) 2011-07-27 2015-09-01 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US9795477B2 (en) 2011-07-27 2017-10-24 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US9339384B2 (en) * 2011-07-27 2016-05-17 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US8852227B1 (en) 2013-03-15 2014-10-07 Insera Therapeutics, Inc. Woven radiopaque patterns
US9750524B2 (en) 2013-03-15 2017-09-05 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy systems
US8721677B1 (en) 2013-03-15 2014-05-13 Insera Therapeutics, Inc. Variably-shaped vascular devices
US8721676B1 (en) 2013-03-15 2014-05-13 Insera Therapeutics, Inc. Slotted vascular treatment devices
US9592068B2 (en) 2013-03-15 2017-03-14 Insera Therapeutics, Inc. Free end vascular treatment systems
US8715314B1 (en) 2013-03-15 2014-05-06 Insera Therapeutics, Inc. Vascular treatment measurement methods
US9179995B2 (en) 2013-03-15 2015-11-10 Insera Therapeutics, Inc. Methods of manufacturing slotted vascular treatment devices
US8733618B1 (en) 2013-03-15 2014-05-27 Insera Therapeutics, Inc. Methods of coupling parts of vascular treatment systems
US8747432B1 (en) 2013-03-15 2014-06-10 Insera Therapeutics, Inc. Woven vascular treatment devices
US8753371B1 (en) 2013-03-15 2014-06-17 Insera Therapeutics, Inc. Woven vascular treatment systems
US8783151B1 (en) 2013-03-15 2014-07-22 Insera Therapeutics, Inc. Methods of manufacturing vascular treatment devices
US9179931B2 (en) 2013-03-15 2015-11-10 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy systems
US8789452B1 (en) 2013-03-15 2014-07-29 Insera Therapeutics, Inc. Methods of manufacturing woven vascular treatment devices
US8690907B1 (en) 2013-03-15 2014-04-08 Insera Therapeutics, Inc. Vascular treatment methods
US8679150B1 (en) 2013-03-15 2014-03-25 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy methods
US8910555B2 (en) 2013-03-15 2014-12-16 Insera Therapeutics, Inc. Non-cylindrical mandrels
US8904914B2 (en) 2013-03-15 2014-12-09 Insera Therapeutics, Inc. Methods of using non-cylindrical mandrels
US8895891B2 (en) 2013-03-15 2014-11-25 Insera Therapeutics, Inc. Methods of cutting tubular devices
US8882797B2 (en) 2013-03-15 2014-11-11 Insera Therapeutics, Inc. Methods of embolic filtering
US8715315B1 (en) 2013-03-15 2014-05-06 Insera Therapeutics, Inc. Vascular treatment systems
US9833251B2 (en) 2013-03-15 2017-12-05 Insera Therapeutics, Inc. Variably bulbous vascular treatment devices
US8845678B1 (en) 2013-07-29 2014-09-30 Insera Therapeutics Inc. Two-way shape memory vascular treatment methods
US8859934B1 (en) 2013-07-29 2014-10-14 Insera Therapeutics, Inc. Methods for slag removal
US8866049B1 (en) 2013-07-29 2014-10-21 Insera Therapeutics, Inc. Methods of selectively heat treating tubular devices
US8863631B1 (en) 2013-07-29 2014-10-21 Insera Therapeutics, Inc. Methods of manufacturing flow diverting devices
US8872068B1 (en) 2013-07-29 2014-10-28 Insera Therapeutics, Inc. Devices for modifying hypotubes
US8870910B1 (en) 2013-07-29 2014-10-28 Insera Therapeutics, Inc. Methods of decoupling joints
US8870901B1 (en) 2013-07-29 2014-10-28 Insera Therapeutics, Inc. Two-way shape memory vascular treatment systems
US8869670B1 (en) 2013-07-29 2014-10-28 Insera Therapeutics, Inc. Methods of manufacturing variable porosity devices
US8828045B1 (en) 2013-07-29 2014-09-09 Insera Therapeutics, Inc. Balloon catheters
US8816247B1 (en) 2013-07-29 2014-08-26 Insera Therapeutics, Inc. Methods for modifying hypotubes
US8813625B1 (en) 2013-07-29 2014-08-26 Insera Therapeutics, Inc. Methods of manufacturing variable porosity flow diverting devices
US8803030B1 (en) 2013-07-29 2014-08-12 Insera Therapeutics, Inc. Devices for slag removal
US8932321B1 (en) 2013-07-29 2015-01-13 Insera Therapeutics, Inc. Aspiration systems
US8932320B1 (en) 2013-07-29 2015-01-13 Insera Therapeutics, Inc. Methods of aspirating thrombi
US8795330B1 (en) 2013-07-29 2014-08-05 Insera Therapeutics, Inc. Fistula flow disruptors
US8790365B1 (en) 2013-07-29 2014-07-29 Insera Therapeutics, Inc. Fistula flow disruptor methods
US8784446B1 (en) 2013-07-29 2014-07-22 Insera Therapeutics, Inc. Circumferentially offset variable porosity devices
US8735777B1 (en) 2013-07-29 2014-05-27 Insera Therapeutics, Inc. Heat treatment systems
US9314324B2 (en) 2013-07-29 2016-04-19 Insera Therapeutics, Inc. Vascular treatment devices and methods
US8728116B1 (en) 2013-07-29 2014-05-20 Insera Therapeutics, Inc. Slotted catheters
US8728117B1 (en) 2013-07-29 2014-05-20 Insera Therapeutics, Inc. Flow disrupting devices
US8715317B1 (en) 2013-07-29 2014-05-06 Insera Therapeutics, Inc. Flow diverting devices
US8715316B1 (en) 2013-07-29 2014-05-06 Insera Therapeutics, Inc. Offset vascular treatment devices
US8845679B1 (en) 2013-07-29 2014-09-30 Insera Therapeutics, Inc. Variable porosity flow diverting devices

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