USRE37315E1 - Radiating device for hyperthermia - Google Patents

Radiating device for hyperthermia Download PDF

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Publication number
USRE37315E1
USRE37315E1 US08/889,825 US88982597A USRE37315E US RE37315 E1 USRE37315 E1 US RE37315E1 US 88982597 A US88982597 A US 88982597A US RE37315 E USRE37315 E US RE37315E
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Prior art keywords
catheter
organ
antenna
adapted
fluid
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US08/889,825
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Avigdor Lev
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Medical Enterprises Ltd
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Medical Enterprises Ltd
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Priority to ITMI912993 priority Critical patent/IT1251997B/en
Priority to US08/232,190 priority patent/US5431648A/en
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Priority to US08/889,825 priority patent/USRE37315E1/en
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Assigned to MEDICAL ENTERPRISES LIMITED reassignment MEDICAL ENTERPRISES LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: AIDA ENGINEERING LIMITED
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • A61F7/123Devices for heating or cooling internal body cavities using a flexible balloon containing the thermal element
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/02Radiation therapy using microwaves
    • A61N5/04Radiators for near-field treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/02Radiation therapy using microwaves
    • A61N5/04Radiators for near-field treatment
    • A61N5/045Radiators for near-field treatment specially adapted for treatment inside the body

Abstract

A flexible three-paths catheter provided with a balloon carries a sealingly sheathed radiofrequency radiating antenna, together with the shielded power supply cable and with some thermocouples, within a plastic lining surrounded by a flow of liquid; a second path carries the power supply cables of some outer thermocouples, flooded by the reverse liquid flow, while the third path allows a fluid to flow through for inflating the balloon. Introduction of the catheter into a hollow organ makes it possible to perform hyperthermal therapy of tumors by means of radiation.

Description

BACKGROUND OF THE INVENTION

This invention concerns a radiating device for hyperthermia and, more particularly, a radiofrequency radiating device, for hyperthermal treatment of tumors of the bladder.

Devices for hyperthermal treatment of various human body illnesses are already known, and they use heating liquids, light radiations, radiofrequency antennas, thermistors, and so on.

U.S. Pat. No. 4,776,334 describes a catheter for treating tumors by inserting within the tumor to be treated a radiofrequency device provided with temperature sensors.

French patent application 2600205 concerns an apparatus for light irradiation of a cavity with the help of an inflatable balloon and of light sensors.

In U.S. Pat. No. 4,154,246 there is described a radiofrequency resonating circuit which is introduced in natural cavities of the body or directly inserted into the tumoral mass.

German patent application No. 2,848,636 claims usage of a heated liquid which is circulated in a closed loop by means of a pump within a body cavity, wherein the liquid temperature is controlled by an external thermostat. EP-A-0 370 890 discloses a radiating urethral device for hyperthermia including a catheter provided with an inflatable balloon and adapted to receive one or more liquid flows passing therethrough, a radiofrequency radiating antenna, and one or more thermocouples, the radiating antenna being submerged within one said liquid flow coming back from the closed terminal end of the antenna. The radiating device comprises in addition a separate rectal control means.

GB-A-2 045 620 relates to an applicator for hyperthermia comprising a rectal radiating probe and a spaced apart transurethral catheter including a temperature sensing means and an inflatable balloon. U.S. Pat. No. 4,957,765 discloses a transurethral radiating applicator for hyperthermia including a multi-tubes balloon type catheter comprising closed end tubes respectively surrounding a helical coil antenna and a temperature sensor, as well as a passive drainage tube for urine.

It is an object of this invention to provide a device for hyperthermal treatment of tumors within natural cavities of the human body, which gathers the advantages of the known devices while being free from their drawbacks.

SUMMARY OF THE INVENTION

The device according to this invention substantially comprises a flexible triple path catheter carrying a radiofrequency radiating antenna, sealingly sheathed together with the shielded cable providing power supply and with several thermocouples within a plastic casing and surrounded by a flow of liquid; a second path carries the power supply cables for several outer thermocouples, which are flooded by return flow of said liquid, and a third path allowing a fluid to flow through in order to inflate a balloon located near the catheter distal end, once the latter has been introduced into the cavity to be treated.

This invention will be described more particularly in the following based on a specific embodiment thereof reported herein for exemplary and non limiting purposes, as well as on the attached schematic drawings. In connection with the above it should be pointed out that in said drawings the parts shown are not to scale and the mutual dimensions are out of proportion, the members having in fact a very thin cross-section.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows schematically, in an enlarged scale, the distal end of the device according to this invention, which has to be introduced into a natural cavity of the human body;

FIG. 1A shows an enlarged schematic cross-section of the device according to this invention, taken along line A—A of FIG. 1;

FIG. 2 is a schematic of some structural details of a radiofrequency antenna shown in general within the device of FIG. 1;

FIG. 2A shows a schematic enlarged cross-section of the radiating antenna, taken along line A—A of FIG. 2;

FIG. 3 is a schematic of the proximal end of the device according to this invention, opposite to the distal end shown in FIG. 1;

FIG. 4 is a plot of the intensity of the radiation generated by the radiating antenna of FIG. 2, along the longitudinal axis thereof;

FIG. 5 shows schematically the distal end of the device of FIG. 1, as it is seen after having been introduced into a urinary bladder; and

FIG. 6 shows schematically the structure at the distal end of the device shown in FIG. 1, when ready for introduction into the organ to be treated.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The device according to this invention has a shape and consistency of a flexible catheter whose distal end, as it is shown in FIG. 1, encloses therewithin an antenna 1 surrounded by a flow of liquid 2 which is introduced into the bladder through an opening 3 and, after being freely circulated within said bladder, is again sucked into the catheter through an opening 4. Said opening 4 is in communication with a second way or catheter side channel 5 housing the leads of several thermocouples, like for instance 6, 6′, 6″ adapted to be deflected outwards by inflating a balloon 7 in which a gaseous fluid or a liquid is made to flow through a third path or side channel 8 and through an end opening 9.

The catheter opposite (proximal) end (FIG. 3) whose tip is shown in FIG. 1, has three diverging inlets corresponding to the three paths or channels 2, 5, 8 of said catheter. Within center inlet 10 there is inserted with a pressure fit a plug 11 provided with a center through passage and with a side branch 13; in center passage 12 of plug 11 there is in turn pressure fitted a second plug 14 which is provided as well with a center opening 15. Shielded cable 16 supplying power to antenna 1 runs through the center passages 12 and 15 of said two coaxially arranged plugs, while side branch 13 is provided as an inlet and an outlet of a conditioning fluid flowing along channel 2. Thermocouple power supply cables 6, 6′, 6″ are laid through side entrance 17 provided with a branch 18, and they run along side path or channel 5 having said conditioning liquid flowing in a reverse direction therethrough, said liquid entering and exiting in turn through said branch 18. The other side entrance 19 is provided with a one-way valve 20 for introducing the fluid that, flowing along second side channel 8, is used to inflate balloon 7.

Slightly downstream from said three entrances 10, 17, 19 there is provided, in a sleeve-like fashion and in intimate contact around the catheter body, a heat exchanger 31, operated in a known fashion from outside, and used to cool or to heat said conditioning liquid flowing through central channel 2 and coming back through side channel 5, or viceversa.

Referring now to FIGS. 2 and 2A, radiating antenna 1 will be described more in detail; the useful radiating portion of linear dipole antenna 1 comprises a terminal coil-shaped segment 21 of central conductor 22 which, immediately upstream from coil 21 is tightly surrounded, in sequence, by a first plastic inner sleeve 23, by a metal braiding 24, by a second intermediate plastic sleeve 25, by a metal cylinder 26 electrically connected with shield 24, and eventually by an outer plastic sleeve 27.

Immediately beneath sleeve 27 there is provided the power supply cables for several thermocouples located in a way suitable to detect the operating temperatures in predetermined positions of the antenna and of the power supply cable thereof. For instance, a first thermocouple 28 may be located in the position of the stretch of catheter which will be located at the prostatic urethra when the catheter with its antenna are inserted within the bladder; a second thermocouple 29 slightly upstream from antenna 1, at the bladder neck, while a third thermocouple 30 is located close to central conductor 22, between metal cylinder 26 and end coil 21, after having been wrapped with one or more coils around shield 24 immediately upstream from intermediate sleeve 25 and metal cylinder 26, and a second time, with a larger number of coils, around the stretch of central lead 22 projecting out of metal cylinder 26 before winding up to form end coil 21, the stretch of thermocouple 30 power supply cable connecting said two points being inserted with intimate contact between intermediate sleeve 25 and metal cylinder 26.

In any case, the end stretches of the power supply cables, immediately ahead of the thermocouples, are wrapped in a number of helical coils in order to increase the thermal capacity and the radiofrequency resistance of the ends which are designated to detect the temperature, while reducing to a minimum, or completely avoiding the dispersive thermal conduction along said cables.

In FIG. 1A, which shows schematically a cross-section of the catheter according to this invention, taken in any position of the stretch going from heat exchanger 31 to intermediate sleeve 25, there is shown side channel 5 carrying the power supply cables of thermocouples 6, 6′, 6″ and side channel 8 for the flow of the fluid used to inflate balloon 7, both said channels 5 and 8 being managed within the thickness of the actual catheter whose inner bore 2 intended for the flow of the conditioning liquid carries, in a central position, shielded cable 16 comprised of central conductor 22, inner sleeve 23, shield 24 and outer sleeve 27, as well as inner thermocouples 28, 29 and 30 power supply cables (not shown).

FIG. 2A is a schematic cross-section of antenna 1, taken along line A—A of FIG. 2. The following are shown therein, starting from the center: conductor 22, inner sleeve 23, metal shield 24, an intermediate sleeve 25, a metal cylinder 26, and outer sleeve 27, as well as thermocouple 30 power supply conductor.

FIG. 4 is a diagram showing the radiation intensity starting from the coil-shaped end 21 of antenna 1 towards shielded power supply cable 22, 16. As it is shown, intensity is a maximum when passing from radiating coil 21 to the stretch protected by metal cylinder 26, and it tends to nil at the position of shielded cable 16.

There is shown schematically in FIG. 5 the longitudinal section of the catheter provided with a radiating antenna according to this invention, once it has been introduced into the bladder, in an operative condition. The catheter, carrying the radiating antenna therewithin, is introduced into bladder 32 through the urethra, in such a way that the rear end of protective metal cylinder 26 is located approximately at the bladder neck, in the transition area between prostrate 33 and bladder 32, while simultaneously taking care that the catheter front end does not subject the bladder internal wall to any pressure. Once the catheter has been introduced into the bladder in such a way, one actuates the supply pump of conditioning liquid 2 preferably comprising a solution of a selective citotoxicity cytotoxicity substance, which is accordingly forced to circulate through the bladder coming out from opening 3 and going back through opening 4, or viceversa, along side channel 5 which carries the power supply cables of thermocouples 6, 6′, 6″ therewithin. The liquid forced circulation, provided by the variable flowrate supply pump, suitably combined with an outer balancing and degassing chamber, allows the volume of liquid within the bladder to be balanced at will, in such a way as to compensate the pathological or physiological urine production, while thoroughly ejecting the gases generated or unwillingly introduced in circulation, out of the bladder, in order to prevent irradiation non-uniformities which would otherwise be caused by coexistance of anisotropic media. Once bladder 32 has been completely filled with conditioning liquid 2, ballon 7 is inflated by introducing a fluid, which may be a gas but it is preferably a liquid, along side channel 8 and through the end opening 9 thereof; ballon 7 inflated as mentioned above, pushes then against outer thermocouples 6, 6′, 6″ power supply cables thereby moving said thermocouples into tangential engagement against bladder wall 32 in different positions, in order to detect the temperatures prevailing therein as caused by irradiation generated by antenna 1. The possibility of changing the location and the number of the outer thermocouples, enables the thermocouples to be positioned at will, on the bladder wall, or in any case place of the body organ to be treated, while being able to individually check the temperatures in the various locations. The inflated ballon 7 protects the bladder neck wall from an excess heat caused by the proximity of the radiating antenna, and in the meantime it prevents the catheter from being accidentally displaced or from coming out through the bladder neck.

The dimensions of antenna 1 are such that it may be freely positioned along the catheter while being obviously wholly contained within the human bladder to be treated, but in the meantime they must be suitable to generate a therapeutically active radiation, in order to reach the temperatures considered lethal for the cancer cells. Since the physical length of an antenna is related to the virtual electrical length thereof through an equation involving the impedence of said antenna, as well as the impedence deriving from the environment irradiated by the antenna, the antenna electrical length comes out to be inversely proportional to the irradiated medium conductivity. Accordingly, since the conductivity of an aqueous solution is for instance many times higher than the conductivity of air, when operating in an aqueous environment it is possible to use an antenna which is physically quite shorter than the length needed if it were necessary to operate in air.

The dipole according to this invention corresponds to a dipole of the quarter wave type and in the aqueous environment comprising the solution filled bladder, it makes it possible to operate at frequencies in the range of 900-1000 MHz; in particular, a frequency of 915 MHz has been chosen since very different frequencies would result in penetration, intensity, and other effects not always exactly predictable and controllable in the body tissues, since in general high frequencies have a low penetration power and therefore they do not provide the desired local heating, while lower frequencies, having a higher penetration power, may get deeper tissues involved and damaged.

On the other hand, radiations having different wavelengths might create a disturbance for radio and telephone communications, protected by constraints imposed by the legislations of the various countries.

In order to reduce to a minimum and possibly to nil the influence of the radiofrequency field on the thermocouples, as well as the various thermoelectric effects connatural with said thermocouples, the supply cable end stretches close to the thermocouples are wound into an helical shape whereby the temperature measured in the various sensing points is a reliable data, unaffected by said influences. The above structure construction prevents measuring errors due to conduction, it provides a reliable temperature indication, for instance exactly in the area of the dipole power supply position in the case of thermocouple 30, and it reduces in an extremely effective manner the thermocouple self-heating process due to radiofrequencies, also when there is an extremely high concentration of energy, whereby said structures are almost unaffected by the disturbances in the radio-frequency field.

Since the sizes, and in particular the cross-sections of the plural device components according to this invention must be extremely small, to suit the particular field of use desired for the device, the energy losses due for instance to self-heating of the antenna power supply cable are particularly high, for instance in the range of 20-40%. Since this undesirable self-heating, due to the Joule effect, might cause excessive heating of the urethral walls, and accordingly a discomfort for the patient subjected to treatment, or even damages to the tissues, the antenna cable, and the antenna itself are continuously cooled, while in operation, by using the conditioning liquid flow directed to the bladder and then withdrawn again therefrom, whereby a simultaneous control action is obtained, for controlling the temperature prevailing both in the liquid within the bladder and along the urethra. Temperature control is effected by variations of the conditioning liquid supply flow and of the cooling source temperature. In such a way it is possible both to increase the temperature and to withdraw heat.

In order to enable outer thermocouples 6, 6′, 6″ for detecting the bladder wall temperature to be safely deflected outwards when balloon 7 is inflated, the power supply cables thereof are reinforced along their whole length by inserting within the protecting sheath thereof a thin stainless steel wire providing them with the required rigidity and flexibility. The presence of said reinforcing wire provides as well the thermocouple power supply cables with the mechanical strength necessary to bear the compressive and tensile stresses caused when the cables are inserted within side channel 5, and when thermocouples 6, 6′, 6″ are laid in the desired locations.

When the catheter, provided with all its components, is introduced into the urethral channel, all the way to the bladder, the ends of outer thermocouples 6, 6′, 6″ projecting upstream of balloon 7 through opening 4 are temporarily locked by inserting them, downstream of balloon 7, in one or more notches provided, as the case may be, in suitable positions according to the different body organ or the particular patient to be treated, close to the catheter end, as it is shown in FIG. 6. When balloon 7 is inflated it causes the thermocouple ends to come out from the notches and then to deflect outwards until the thermocouple tips come into engagement with the bladder wall. The particular outwards deflecting system of thermocouples 6, 6′, 6″ causes the ends of the respective power supply cables comprising the actual thermocouple, to tangentially engage the bladder wall, whereby no excessive concentrated pressures are generated. On the other hand, the tangential position taken by the thermocouple tips when contacting the bladder wall, makes it possible to measure the actual temperature of the wall position considered in that at the boundary between said wall and the liquid filling the bladder there is a thin liquid layer substantially stationary, which is not affected by the liquid circulation within the bladder, since it clings to the tissue because of a physical attraction, while the coil shape of the cable terminal stretches increases the thermal capacity of the thermocouple whose diameter, inclusive of the coils, is less than 0,7 mm whereby the thermocouple is completely submerged within the liquid stationary layer having a thickness of approximately 1 mm.

After the thermocouples have been deflected outwards within the bladder, it is still possible to modify their location by performing pushing and/or pulling actions on the reinforced power supply cables, as mentioned above, and possibly by rotating the catheter containing them. Control of the temperature detected on the bladder walls and/or within the circulating liquid mass, is obtained by changing the flowrate of said liquid from few cubic centimeters per minute to several tens of cubic centimeters per minute. The circulated fluid circulating system prevents permanence or formation and build-up of possible gas bubbles within the bladder or through the circuit, in that air or other gas bubbles having possibly formed or being already present, are entrained out by the continuous flow and exhausted to the outer environment in an appropriate position of the outer pumping circuit. In addition, the liquid circulation provided as above prevents the antenna and the environment thereof from overheating, therefore from causing undesirable reactions within the circulating liquid.

It is pointed out herein that all the antenna and thermocouple components contacted by the liquid circulating within the bladder are sealingly lined and insulated from the outer environment by a polytetrafluoroethylene layer whereby, after each usage and application they may be sterilized for subsequent further use.

Claims (91)

We claim:
1. A radiating device for urethral hyperthermia including a catheter provided at its distal end with an inflatable balloon (7) and adapted to receive multiple injected liquid flows (2,5,8) passing therethrough, a radiofrequency radiating antenna (1) and multiple thermocouples (6,6′, 6″), the radiating antenna being adapted to be submerged within said liquid flow, characterized in that
said radiating antenna (1) is adapted to be submerged within a liquid flow which proceeds through a central channel (2) surrounding said radiating antenna (1) towards the distal end of said catheter and passes from said catheter through a first opening (3) into the bladder to be treated, while flowing back into said catheter towards the a proximal end thereof through a second separate opening (4) of a side channel (5) surrounding the power supply cables of said thermocouples (6,6′, 6″),
the ends of said thermocouples (6,6′, 6″) are adapted to project out of said second opening (4), being thus deflected outwards into the bladder when said balloon (7) is inflated by injecting a fluid therein through a second side channel (8) and third opening (9), whereby the outwardly deflected ends of said thermocouples (6,6′, 6″) are adapted to come into tangential engagement with the bladder wall (32) irradiated by said antenna (1).
2. A radiating device including a catheter provided at its distal end with an inflatable balloon and adapted to receive multiple injected liquid fluid flows passing therethrough, a radiofrequency radiating antenna and multiple thermocouples, the radiating antenna being submerged within a fluid flow, characterized in that
said radiating antenna is adapted to be submerged within a flow which proceeds through a central channel surrounding said radiating antenna towards a distal end of said catheter and passes from said catheter through a first opening into an organ to be treated, while flowing back into said catheter towards a proximal end thereof through a second separate opening of a side channel surrounding power supply cables of said thermocouples,
ends of said thermocouples are adapted to project out of said second opening, being thus deflected outwards into the organ when said balloon is inflated by injecting a fluid through a second side channel and third opening, whereby the outwardly deflected ends of said thermocouples are adapted to come into tangential engagement with a wall of the organ irradiated by said antenna.
3. A radiating device including a catheter provided at its distal end with an inflatable balloon and adapted to receive multiple injected liquid fluid flows passing therethrough, a radiofrequency radiating antenna and multiple thermocouples, the radiating antenna being submerged within a fluid flow, characterized in that
said radiating antenna is adapted to be submerged within a flow which proceeds through a central channel surrounding said radiating antenna towards a distal end of said catheter and passes from said catheter through a first opening into an organ to be treated, while flowing back into said catheter towards a proximal end thereof through a second separate opening of a side channel surrounding power supply cables of said thermocouples,
ends of said thermocouples are adapted to project out of said second opening, being thus deflected outwards into the organ when said balloon is inflated by injecting a fluid through a second side channel and third opening, whereby outwardly deflected ends of said thermocouples are adapted to come into engagement with a wall of the organ irradiated by said antenna.
4. A radiating device for irradiating an organ comprising:
a catheter provided with an inflatable balloon and including a central channel, first and second side channels, and first, second, and third openings;
an antenna, situated at a first end portion of the catheter, the antenna adapted for being submerged in a first fluid that flows through the central channel surrounding the antenna towards the first end portion of the catheter, passes from the catheter through the first opening, and flows back into the catheter towards a second end portion thereof through the second opening; and
a plurality of thermocouples, having ends, the plurality of thermocouples extending along the first side channel of the catheter, each of the ends of the plurality of thermocouples adapted to project out of the second opening and to be deflected outwards when the balloon is inflated by injecting a second fluid through the second side channel and the third opening,
wherein the deflected ends of the plurality of thermocouples adapted to contact a wall of the organ irradiated by the antenna.
5. A radiating device for irradiating an organ comprising:
a catheter provided with an inflatable balloon and including first and second channels and a first opening;
an antenna, situated at an end portion of the catheter, the antenna adapted for being submerged in a fluid that flows through the first channel surrounding the antenna and into the organ; and
a plurality of thermocouples, having ends, the plurality of thermocouples extending along the second channel each of the ends of the plurality of thermocouples projecting out of the first opening and being deflected outwards when the balloon is inflated,
wherein the deflected ends of the plurality of thermocouples are adapted to contact a wall of the hollow organ irradiated by the antenna.
6. A radiating device for irradiating an organ comprising:
a catheter provided with an inflatable balloon;
an antenna, situated at an end portion of the catheter, adapted for irradiating the organ;
a channel for providing a fluid to the organ; and
a plurality of thermocouples, having ends, the plurality of thermocouples extending along the catheter, each of the ends of the plurality of thermocouples being deflected outwards when the balloon is inflated,
wherein the deflected ends of the plurality of thermocouples are adapted to contact a wall of the organ irradiated by the antenna.
7. A radiating device for irradiating an organ comprising:
a catheter provided with an inflatable balloon and including first and second channels and a first opening;
an antenna situated at an end portion of the catheter, the antenna adapted for being submerged in a fluid that flows through the first channel surrounding the antenna and into the organ; and
a plurality of temperature sensing devices, having ends, the plurality of temperature sensing devices extending along the catheter each of the ends of the plurality of temperature sensing devices being deflected outwards when the balloon is inflated,
wherein the deflected ends of the plurality of temperature sensing devices are adapted to contact a wall of the organ irradiated by the antenna.
8. A radiating device for irradiating an organ comprising:
a catheter provided with an inflatable balloon;
an antenna, situated at an end portion of the catheter, for irradiating the organ;
a channel for providing a fluid to the organ; and
a plurality of temperature sensing devices, having ends, the plurality of temperature sensing devices extending along the catheter, each of the ends of the plurality of temperature sensing devices being deflected outwards when the balloon is inflated,
wherein the deflected ends of the plurality of temperature sensing devices are adapted to contact a wall of the organ irradiated by the antenna.
9. A radiating device for irradiating an organ comprising:
a catheter;
an antenna, situated at an end portion of the catheter, adapted for irradiating the organ;
a channel, within the catheter, adapted for providing a fluid comprising a cytotoxic substance to the organ; and
a plurality of temperature sensing devices, having ends, the plurality of temperature sensing devices extending along the catheter, each of the ends of the plurality of temperature sensing devices adapted for being deflected outwards after the catheter is inserted into the organ,
wherein the deflected ends of the plurality of temperature sensing devices are adapted to contact a wall of the organ irradiated by the antenna.
10. A radiating device for irradiating an organ comprising:
a catheter, including a channel adapted for providing a fluid to the organ;
an antenna, situated at an end portion of the catheter, adapted for irradiating the organ; and
a plurality of temperature sensing devices, having ends, the plurality of temperature sensing devices extending along the catheter, each of the ends of the plurality of temperature sensing devices being deflected outwards after the catheter is inserted into the organ,
wherein the deflected ends of the plurality of temperature sensing devices are adapted to contact a wall of the organ irradiated by the antenna.
11. A radiating device for irradiating a cavity comprising:
a catheter;
an antenna, situated at an end portion of the catheter, for irradiating the cavity;
channel extending along the catheter and adapted for providing fluid to the cavity; and
a plurality of temperature sensing devices, having ends, the plurality of temperature sensing devices extending along the catheter, each of the ends of the plurality of temperature sensing devices being deflected outwards after the catheter is inserted into the cavity,
wherein the deflected ends of the plurality of temperature sensing devices are adapted to contact a wall of the cavity irradiated by the antenna.
12. The radiating device as recited in claim 11, wherein the channel is within the catheter.
13. The radiating device as recited in claim 12, wherein the antenna is within the channel.
14. The radiating device as recited in claim 13, adapted for fluid flow by the antenna and into the cavity.
15. The radiating device as recited in claim 11, further comprising a shielded cable coupled to the antenna.
16. The radiating device as recited in claim 15, adapted for fluid flow by the shielded cable and the antenna and into the cavity.
17. The radiating device as recited in claim 11, further comprising means for providing a second fluid around the antenna.
18. The radiating device as recited in claim 11, adapted for flow of a conditioning liquid.
19. The radiating device as recited in claim 11, adapted for flow of a solution of a selective cytotoxicity substance.
20. The radiating device as recited in claim 11, wherein the antenna is adapted for a frequency range of 900-1000 MHZ.
21. The radiating device according to claim 11, wherein the antenna comprises a linear dipole antenna.
22. The radiating device according to claim 21, wherein the linear dipole antenna comprises a coil-shaped segment and a linear conductor.
23. The radiating device according to claim 22, further comprising:
a first plastic sleeve surrounding a portion of the linear conductor;
a metal braiding surrounding the first plastic sleeve;
a second plastic sleeve surrounding the metal braiding;
a metal cylinder surrounding the second plastic sleeve and electrically coupled to the metal briading; and
a third plastic sleeve surrounding the metal cylinder.
24. The radiating device as recited in claim 11, further comprising a stainless steel wire coupled to each of the plurality of temperature sensing devices.
25. The radiating device as recited in claim 11, further comprising means for retaining the plurality of temperature sensing devices prior to deflection.
26. The radiating device according to claim 25, wherein the retaining means comprises at least one notch.
27. The radiating device according to claim 11, further comprising a sealing member for sealing the antenna.
28. The radiating device according to claim 27, further comprising a sealing member for each of the plurality of temperature sensing devices.
29. The radiating device according to claim 27, wherein the sealing member comprises a polytetrafluoroethylene layer.
30. The radiating device according to claim 11, further comprising a second plurality of temperature sensing devices for detecting temperatures at predetermined positions along the antenna.
31. The radiating device according to claim 30, wherein each of the second plurality of temperature sensing devices is coupled to a power supply cable.
32. The radiating device according to claim 31, wherein each of the power supply cables is wound into a helical coil.
33. The radiating device according to claim 11, wherein the deflected ends of the plurality of temperature sensing devices tangentially contact the wall of the cavity.
34. The radiating device according to claim 11, wherein the catheter further comprises an inflatable balloon.
35. The radiating device according to claim 34, wherein the balloon is adapted to be inflated by a second fluid.
36. The radiating device according to claim 35, wherein the second fluid is a liquid.
37. The radiating device according to claim 35, wherein the second fluid is a gas.
38. The radiating device according to claim 34, wherein the catheter comprises a second channel in communication with the balloon for providing a second fluid to inflate the balloon.
39. The radiating device according to claim 34, wherein each of the ends of the plurality of temperature sensing devices is deflected outwards when the balloon is inflated.
40. The radiating device according to claim 11, wherein the catheter comprises a first opening adapted to provide the fluid into the cavity and a second opening adapted to allow for circulation out of the cavity.
41. The radiating device according to claim 34, wherein the catheter comprises a first opening adapted to provide the fluid into the cavity and a second opening adapted to allow for circulation out of the cavity.
42. The radiating device according to claim 41, wherein the catheter comprises a third opening adapted to provide a second fluid to inflate the balloon.
43. The radiating device according to claim 11, adapted to contact a cavity that is an organ.
44. The radiating device according to claim 11, adapted to contact a cavity that is a hollow organ.
45. The radiating device according to claim 11, adapted to contact a cavity that is a bladder.
46. The radiating device according to claim 11, further comprising means for protecting the cavity wall from excess heat from the antenna.
47. The radiating device according to claim 11, further comprising means for preventing the catheter from being displaced from the cavity.
48. A method of performing hyperthermal therapy comprising the steps of:
inserting a catheter, including an inflatable balloon, an antenna and a plurality of thermocouples, into an organ;
providing a supply of a first fluid such that the first fluid flows through a first channel of the catheter and circulates out a first opening in the catheter through the organ and into a second opening in the catheter and through a second channel of the catheter; and
inflating the balloon by passing a second fluid through a third channel of the catheter and out a third hole in the catheter and into the balloon, such that the plurality of thermocouples are deflected by the inflated balloon and contact a wall of the organ.
49. A method of performing hyperthermal therapy comprising the steps of:
inserting a catheter, including an inflatable balloon, an antenna, and a plurality of temperature sensing devices, into an organ;
providing a supply of a first fluid such that the first fluid flows through a first channel of the catheter and circulates out a first opening in the catheter through the organ and into a second opening in the catheter and through a second channel of the catheter; and
inflating the balloon by passing a second fluid through a third channel of the catheter and out a third hole in the catheter and into the balloon, such that the plurality of temperature sensing devices, carried in the second channel, are deflected by the inflated balloon and contact a wall of the organ.
50. A method of performing hyperthermal therapy comprising the steps of:
inserting a catheter including an inflatable balloon, an antenna, and a plurality thermocouples, into an organ;
irradiating the organ by generating radiation using the antenna;
providing a supply of a fluid through the catheter and into the organ; and
inflating the balloon such that the plurality of thermocouples are deflected by the inflated balloon and contact a wall of the organ.
51. A method of performing hyperthermal therapy comprising the steps of:
inserting a catheter including an inflatable balloon, an antenna and a plurality of temperature sensing devices into an organ;
irradiating the organ by generating radiation using the antenna;
providing a supply of a fluid through the catheter and into the organ; and
inflating the balloon such that the plurality of temperature sensing devices are deflected by the inflated balloon and contact a wall of the organ.
52. A method of performing hyperthermal therapy comprising the steps of:
inserting a catheter, including an antenna and a plurality of temperature sensing devices, into an organ;
irradiating the organ by generating radiation using the antenna;
providing a supply of a fluid comprising a cytotoxic substance through the catheter and into the organ; and
deflecting the plurality of temperature sensing devices to contact a wall of the organ.
53. A method of performing hyperthermal therapy comprising the steps of:
inserting a catheter, including an antenna and a plurality of temperature sensing devices, into an organ;
irradiating the organ by generating radiation using the antenna;
providing a supply of a fluid through the catheter and into the organ; and
deflecting the plurality of temperature sensing devices to contact a wall of the organ.
54. A method of performing hyperthermal therapy comprising the steps of:
inserting a catheter, including an antenna and a plurality of temperature sensing devices, into a cavity;
irradiating the tin radiation using the antenna;
providing a supply of a fluid into the cavity; and
deflecting the plurality of temperature sensing devices to contact a wall of the cavity.
55. The method of performing hyperthermal therapy according to claim 54, wherein the providing step comprises the step of providing the fluid through the catheter and into the cavity.
56. The method of performing hyperthermal therapy according to claim 55, wherein the step of providing comprises the step of flowing the fluid past the antenna.
57. The method of performing hyperthermal therapy according to claim 54, wherein the fluid comprises a conditioning liquid.
58. The method of performing hyperthermal therapy according to claim 54, wherein the fluid comprises a solution of a selective cytotoxicity substance.
59. The method of performing hyperthermal therapy according to claim 54, wherein the catheter includes a balloon.
60. The method of performing hyperthermal therapy according to claim 59, further comprising the step of:
inflating the balloon such that the plurality of temperature sensing devices are deflected by the inflated balloon and contact the wall of the cavity.
61. The method of performing hyperthermal therapy according to claim 60, wherein the inflating step comprises the step of inflating the balloon with a liquid.
62. The method of performing hyperthermal therapy according to claim 60, wherein the inflating step comprises the step of inflating the balloon with a gas.
63. The method of performing hyperthermal therapy according to claim 54, further comprising the step of controlling a volume of the fluid in the cavity.
64. The method of performing hyperthermal therapy according to claim 54, further comprising the step of evacuating gas introduced by the providing step to prevent irradiation non-uniformities.
65. The method of performing hyperthermal therapy according to claim 54, further comprising the step of controlling a temperature of the fluid.
66. The method of performing hyperthermal therapy according to claim 54, further comprising the step of controlling a flowrate of the fluid.
67. The method of performing hyperthermal therapy according to claim 54, further comprising the step of sensing temperatures at different locations by modifying a location of the temperature sensing devices.
68. The method of performing hyperthermal therapy according to claim 54, further comprising the step of generating therapeutically active radiation using the antenna to achieve a temperature within the cavity lethal for cancer cells.
69. The method of performing hyperthermal therapy according to claim 54, further comprising sensing a temperature at various positions along the antenna with a second plurality of temperature sensing devices.
70. The method of performing hyperthermal therapy according to claim 54, further comprising sensing a temperature at various positions along the antenna and a shielded cable coupled to the antenna with a second plurality of temperature sensing devices.
71. The method of performing hyperthermal therapy according to claim 54, wherein the plurality of temperature sensing devices come into tangential contact with the wall of the cavity.
72. The method of performing hyperthermal therapy according to claim 54, wherein a second plurality of temperature sensing devices come into tangential contact with the wall of the cavity.
73. The method of performing hyperthermal therapy according to claim 54, further comprising the step of controlling a temperature of the wall of the cavity.
74. The method of performing hyperthermal therapy according to claim 54, further comprising the step of controlling a temperature of the antenna.
75. The method of performing hyperthermal therapy according to claim 54, wherein the inserting step comprises inserting the catheter into an organ.
76. The method of performing hyperthermal therapy according to claim 54, wherein the inserting step comprises inserting the catheter into a hollow organ.
77. The method of performing hyperthermal therapy according to claim 54, wherein the inserting step comprises inserting the catheter into a bladder.
78. The method of performing hyperthermal therapy according to claim 54, further comprising the step of protecting the cavity wall from excess heat from the antenna.
79. The method of hyperthermal therapy according to claim 54, further comprising the step of preventing the catheter from being displaced from the cavity.
80. A radiating device for irradiating a cavity comprising:
a catheter;
an antenna, situated at an end portion of the catheter, for irradiating the cavity;
a first channel adapted to Provide a fluid to the cavity;
a second channel adapted to receive the fluid from the cavity; and
at least one temperature sensing device, having an end, the end of the at least one temperature sensing device extending outward from the catheter after the catheter is inserted into the cavity,
wherein the end of the at least one temperature sensing device is adapted to detect a temperature of a wall of the cavity irradiated by the antenna.
81. A radiating device for irradiating a cavity comprising:
a catheter;
an antenna, situated at an end portion of the catheter, for irradiating the cavity;
a first channel adapted to provide a fluid to the cavity;
a second channel adapted to receive the fluid from the cavity; and
at least one temperature sensing device, having an end, the end of the at least one temperature sensing device extending outward from the catheter after the catheter is inserted into the cavity,
wherein the end of the at least one temperature sensing device is adapted to detect a temperature of the cavity irradiated by the antenna.
82. The radiating device as claimed in claim 81, wherein the at least one temperature sensing device is released from the catheter after the catheter is inserted into the cavity.
83. A radiating device for irradiating an organ comprising:
a catheter;
an antenna, situated at an end portion of the catheter, for irradiating the organ;
a channel, within the catheter, adapted to provide a fluid comprising a treatment substance to the organ; and
at least one temperature sensing device, having an end, the end of the at least one temperature sensing device extending outwards from the catheter after the catheter is inserted into the organ,
wherein the end of the at least one temperature sensing device is adapted to contact a wall of the organ irradiated by the antenna and wherein the fluid is adapted to be provided to the organ simultaneously with the irradiation of the organ.
84. The radiating device according to claim 83, wherein the treatment substance comprises a cytotoxic substance.
85. A radiating device for irradiating an organ comprising:
a catheter;
an antenna, situated at an end portion of the catheter, for irradiating the organ;
a first channel, within the catheter, adapted to provide a fluid comprising a cytotoxic substance to the organ;
a second channel, within the catheter, adapted to receive the fluid from the cavity; and
at least one temperature sensing device, having an end, the end of the at least one temperature sensing device extending outward from the catheter after the catheter is inserted into the organ;
wherein the end of the at least one temperature sensing device is adapted to contact a wall of the organ irradiated be the antenna and wherein the fluid is adapted to be provided to the organ simultaneously with the irradiation of the organ.
86. A radiating device for irradiating an organ comprising:
a catheter;
an antenna, situated at an end portion of the catheter, for irradiating the organ;
a first channel, within the catheter, adapted to provide a fluid comprising a cytotoxic substance to the organ;
a second channel, within the catheter, adapted to receive the fluid from the cavity; and
at least one temperature sensing device, having an end, the end of the at least one temperature sensing device extending outward after the catheter is inserted into the organ,
wherein the end of the at least one temperature sensing device is adapted to detect a temperature of the fluid and wherein the fluid is adapted to be provided to the organ simultaneously with the irradiation of the organ.
87. A method of performing hyperthermal therapy comprising the steps of:
inserting a catheter, including an antenna and at least one temperature sensing device, into an organ;
irradiating the organ by generating radiation using the antenna;
providing a supply of a fluid through the catheter and into the organ;
extracting the fluid from the organ through the catheter; and
extending the at least one temperature sensing device adapted to detect a temperature of a wall of the organ.
88. A method of performing hyperthermal therapy comprising the steps of:
inserting a catheter, including an antenna and at least one temperature sensing device, into a cavity;
irradiating the cavity by generating radiation using the antenna;
providing a supply of a fluid through the catheter and into the cavity;
extracting the fluid from the cavity through the catheter; and
extending the at least one temperature sensing device within the cavity; and
detecting a temperature of the cavity.
89. The method as recited in claim 88, wherein
the detecting step comprises detecting a temperature of the fluid.
90. A method of performing hyperthermal therapy comprising the steps of:
inserting a catheter, including an antenna and at least one temperature sensing device, into an organ;
irradiating the organ by generating radiation using the antenna;
simultaneously with irradiating, providing a supply of a fluid comprising a cytotoxic substance through the catheter and into the organ; and
extending the at least one temperature sensing device adapted to contact a wall of the organ.
91. A method of performing hyperthermal therapy comprising the steps of:
inserting a catheter, including an antenna and at least one temperature sensing device, into an organ;
irradiating the organ by generating radiation using the antenna;
simultaneously with irradiating, providing a supply of a fluid comprising a cytotoxic substance through the catheter and into the organ.
US08/889,825 1991-11-11 1997-07-08 Radiating device for hyperthermia Expired - Lifetime USRE37315E1 (en)

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ITMI912993 IT1251997B (en) 1991-11-11 1991-11-11 radiating device for hyperthermia
US08/232,190 US5431648A (en) 1991-11-11 1992-11-10 Radiating device for hyperthermia
US08/889,825 USRE37315E1 (en) 1991-11-11 1997-07-08 Radiating device for hyperthermia

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US09/923,279 US20020077625A1 (en) 1991-11-11 2001-08-06 Radiating device for hyperthermia

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US08/889,825 Expired - Lifetime USRE37315E1 (en) 1991-11-11 1997-07-08 Radiating device for hyperthermia
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030229384A1 (en) * 2000-06-20 2003-12-11 Celsion Corporation Method and apparatus for treatment of tissue adjacent a bodily conduit with a compression balloon
US20050070888A1 (en) * 2004-10-29 2005-03-31 Boston Scientific Corporation Medical device systems and methods
US6958075B2 (en) 2001-09-18 2005-10-25 Celsion Corporation Device and method for treatment of tissue adjacent a bodily conduit by thermocompression
US20070112342A1 (en) * 2001-05-10 2007-05-17 Rita Medical Systems, Inc. Tissue ablation apparatus and method
US20110034976A1 (en) * 2002-02-15 2011-02-10 John Mon Drug delivery

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5549559A (en) 1990-03-22 1996-08-27 Argomed Ltd. Thermal treatment apparatus
US5429582A (en) * 1991-06-14 1995-07-04 Williams; Jeffery A. Tumor treatment
US5931774A (en) * 1991-06-14 1999-08-03 Proxima Therapeutics, Inc. Inflatable devices for tumor treatment
US5618266A (en) * 1994-03-31 1997-04-08 Liprie; Samuel F. Catheter for maneuvering radioactive source wire to site of treatment
US5957917A (en) * 1995-01-20 1999-09-28 Miravant Systems, Inc. Transluminal hyperthermia catheter and method for use
US5735817A (en) * 1995-05-19 1998-04-07 Shantha; T. R. Apparatus for transsphenoidal stimulation of the pituitary gland and adjoining brain structures
US6302878B1 (en) * 1995-06-27 2001-10-16 S.L.T. Japan Co., Ltd. System for laser light irradiation to living body
IL120674A (en) * 1996-04-16 2001-03-19 Argomed Ltd Thermal treatment apparatus
US5891134A (en) * 1996-09-24 1999-04-06 Goble; Colin System and method for applying thermal energy to tissue
IT1290866B1 (en) * 1996-12-24 1998-12-14 Francesco Garbagnati A catheter for the treatment of parenchymatous organs tumors with interstitial hyperthermia induced by radiofrequency
US5913854A (en) * 1997-02-04 1999-06-22 Medtronic, Inc. Fluid cooled ablation catheter and method for making
US6139570A (en) * 1997-05-19 2000-10-31 Gynelab Products, Inc. Disposable bladder for intrauterine use
US5913813A (en) 1997-07-24 1999-06-22 Proxima Therapeutics, Inc. Double-wall balloon catheter for treatment of proliferative tissue
SE518946C2 (en) * 1997-07-28 2002-12-10 Prostalund Operations Ab Arrangement in combined heat treatment of body tissue
US9023031B2 (en) * 1997-08-13 2015-05-05 Verathon Inc. Noninvasive devices, methods, and systems for modifying tissues
GB9809536D0 (en) * 1998-05-06 1998-07-01 Microsulis Plc Sensor positioning
US6022342A (en) * 1998-06-02 2000-02-08 Mukherjee; Dipankar Catheter introducer for antegrade and retrograde medical procedures
SE521014C2 (en) 1999-02-04 2003-09-23 Prostalund Operations Ab Device for heat treatment of prostate
US6868290B2 (en) 2001-11-05 2005-03-15 Prostalund Operations Ab Thermotherapy catheter and method of prostate thermotherapy with improved guide and heat confinement
SE521275C2 (en) 1999-05-07 2003-10-14 Prostalund Operations Ab Device for heat treatment of body tissue
US6275738B1 (en) * 1999-08-19 2001-08-14 Kai Technologies, Inc. Microwave devices for medical hyperthermia, thermotherapy and diagnosis
US7306591B2 (en) 2000-10-02 2007-12-11 Novasys Medical, Inc. Apparatus and methods for treating female urinary incontinence
CN100528074C (en) * 2000-10-23 2009-08-19 伊西康公司 Apparatus and method for the measurement and assessment of sling-tension for treatment of female urinary incontinence
JP2005503227A (en) * 2001-09-27 2005-02-03 ガリル メディカル リミテッド Apparatus and method for cryosurgical treatment of tumors of the breast
WO2003026719A2 (en) * 2001-09-27 2003-04-03 Galil Medical Ltd. Cryoplasty apparatus and method
US6706040B2 (en) * 2001-11-23 2004-03-16 Medlennium Technologies, Inc. Invasive therapeutic probe
US6755849B1 (en) * 2002-03-28 2004-06-29 Board Of Regents, The University Of Texas System Method for delivering energy to tissue and apparatus
US6695760B1 (en) 2002-10-11 2004-02-24 Proxima Therapeutics Treatment of spinal metastases
US6749555B1 (en) 2003-02-13 2004-06-15 Proxima Therapeutics, Inc. System and method for the treatment of spinal metastases
US7018398B2 (en) * 2003-03-18 2006-03-28 Elmedical Ltd. System and method for treating urinary tract disorders
US7524274B2 (en) 2003-11-07 2009-04-28 Cytyc Corporation Tissue positioning systems and methods for use with radiation therapy
US7354391B2 (en) 2003-11-07 2008-04-08 Cytyc Corporation Implantable radiotherapy/brachytherapy radiation detecting apparatus and methods
US7494457B2 (en) 2003-11-07 2009-02-24 Cytyc Corporation Brachytherapy apparatus and method for treating a target tissue through an external surface of the tissue
US7524275B2 (en) 2003-11-14 2009-04-28 Cytyc Corporation Drug eluting brachytherapy methods and apparatus
US7905822B2 (en) 2003-11-20 2011-03-15 Cytyc Corporation Brachytherapy method and applicator for treatment of metastatic lesions in a load bearing region
GB2416307A (en) * 2004-07-16 2006-01-25 Microsulis Ltd Microwave applicator head with null forming conductors allowing for sensor placement
US7662082B2 (en) 2004-11-05 2010-02-16 Theragenics Corporation Expandable brachytherapy device
US20060135953A1 (en) * 2004-12-22 2006-06-22 Wlodzimierz Kania Tissue ablation system including guidewire with sensing element
US20070055328A1 (en) * 2005-09-02 2007-03-08 Mayse Martin L Device and method for esophageal cooling
US8079946B2 (en) 2005-11-18 2011-12-20 Senorx, Inc. Asymmetrical irradiation of a body cavity
US20070270627A1 (en) * 2005-12-16 2007-11-22 North American Scientific Brachytherapy apparatus for asymmetrical body cavities
US8137256B2 (en) * 2005-12-16 2012-03-20 Portola Medical, Inc. Brachytherapy apparatus
US8486127B2 (en) * 2006-05-24 2013-07-16 Kambiz Dowlatshahi High temperature thermal therapy of breast cancer
WO2008058089A2 (en) * 2006-11-03 2008-05-15 North American Scientific, Inc. Brachytherapy device having seed tubes with individually-settable tissue spacings
US8328711B2 (en) 2007-12-18 2012-12-11 Cytyc Corporation Selectable multi-lumen brachytherapy devices and methods
US9050069B2 (en) * 2008-05-16 2015-06-09 Medtronic Cryocath Lp Thermocouple-controlled catheter cooling system
US9248311B2 (en) 2009-02-11 2016-02-02 Hologic, Inc. System and method for modifying a flexibility of a brachythereapy catheter
US9579524B2 (en) 2009-02-11 2017-02-28 Hologic, Inc. Flexible multi-lumen brachytherapy device
US10207126B2 (en) 2009-05-11 2019-02-19 Cytyc Corporation Lumen visualization and identification system for multi-lumen balloon catheter
US8382650B2 (en) 2009-05-11 2013-02-26 Cytyc Corporation Catheter marking for multi-lumen catheter identification
US9089315B1 (en) * 2009-09-02 2015-07-28 The Regents Of The University Of California Methods and devices for adjunctive local hypothermia
US9352172B2 (en) 2010-09-30 2016-05-31 Hologic, Inc. Using a guide member to facilitate brachytherapy device swap
CN106901830A (en) * 2011-04-12 2017-06-30 热医学公司 Devices and methods for shaping therapy in fluid enhanced ablation
US10022176B2 (en) 2012-08-15 2018-07-17 Thermedical, Inc. Low profile fluid enhanced ablation therapy devices and methods
US9033972B2 (en) 2013-03-15 2015-05-19 Thermedical, Inc. Methods and devices for fluid enhanced microwave ablation therapy
US9610396B2 (en) 2013-03-15 2017-04-04 Thermedical, Inc. Systems and methods for visualizing fluid enhanced ablation therapy
WO2016100901A1 (en) * 2014-12-19 2016-06-23 Memorial Sloan-Kettering Cancer Center Urinary catheter for facilitating control of bladder content volume and methods for use thereof
CN104434015A (en) * 2014-12-31 2015-03-25 杨幼林 Multifunctional outer cannula device for colonoscope
US9743984B1 (en) 2016-08-11 2017-08-29 Thermedical, Inc. Devices and methods for delivering fluid to tissue during ablation therapy

Citations (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154246A (en) 1977-07-25 1979-05-15 Leveen Harry H Field intensification in radio frequency thermotherapy
DE2848636A1 (en) 1978-11-09 1980-05-22 Mark Cavity scavenging device for cancer hyperthermia treatment - has inlet and outlet channels coupled to external scavenging liq. circuit contg. pump, thermostat and heater
GB2045620A (en) 1979-03-23 1980-11-05 Rca Corp Coaxial applicator for hyperthermic treatment of the body
US4375220A (en) 1980-05-09 1983-03-01 Matvias Fredrick M Microwave applicator with cooling mechanism for intracavitary treatment of cancer
EP0115420A2 (en) 1983-01-24 1984-08-08 Kureha Kagaku Kogyo Kabushiki Kaisha A device for hyperthermia
US4662383A (en) 1982-09-27 1987-05-05 Kureha Kagaku Kogyo Kabushiki Kaisha Endotract antenna device for hyperthermia
DE3707921A1 (en) 1986-03-12 1987-09-17 Olympus Optical Co Medical treatment device
FR2600205A1 (en) 1986-06-14 1987-12-18 Strahlen Umweltforsch Gmbh Apparatus for measuring and irradiating cavities
US4776334A (en) 1985-03-22 1988-10-11 Stanford University Catheter for treatment of tumors
US4813429A (en) 1986-05-12 1989-03-21 Biodan Medical Systems Ltd. Catheter and probe
EP0321614A1 (en) 1987-12-21 1989-06-28 Reynaldo Calderon Systems for retrograde perfusion in the body for curing it of a disease or immune deficiency
WO1989011311A1 (en) 1988-05-18 1989-11-30 Kasevich Associates, Inc. Microwave balloon angioplasty
WO1990003152A1 (en) 1988-09-24 1990-04-05 John Considine Electro-surgical apparatus for removing tumours from hollow organs of the body
US4924863A (en) 1988-05-04 1990-05-15 Mmtc, Inc. Angioplastic method for removing plaque from a vas
EP0368161A2 (en) 1988-11-07 1990-05-16 Omron Tateisi Electronics Co. Electrode structure for high frequency hyperthermia device
EP0370890A1 (en) 1988-11-21 1990-05-30 Technomed Medical Systems Apparatus for the surgical treatment of tissues by hyperthermia, preferably the prostate, equipped with heat protection means preferably comprising means forming radioreflecting screen
US4967765A (en) 1988-07-28 1990-11-06 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
US4979948A (en) 1989-04-13 1990-12-25 Purdue Research Foundation Method and apparatus for thermally destroying a layer of an organ
US5000734A (en) 1988-02-01 1991-03-19 Georges Boussignac Probe intended to be introduced within a living body
US5007437A (en) 1989-06-16 1991-04-16 Mmtc, Inc. Catheters for treating prostate disease
US5084044A (en) * 1989-07-14 1992-01-28 Ciron Corporation Apparatus for endometrial ablation and method of using same
US5090958A (en) 1988-11-23 1992-02-25 Harvinder Sahota Balloon catheters
US5103804A (en) 1990-07-03 1992-04-14 Boston Scientific Corporation Expandable tip hemostatic probes and the like
US5114423A (en) 1989-05-15 1992-05-19 Advanced Cardiovascular Systems, Inc. Dilatation catheter assembly with heated balloon
US5150717A (en) * 1988-11-10 1992-09-29 Arye Rosen Microwave aided balloon angioplasty with guide filament
US5168880A (en) 1986-07-17 1992-12-08 Olympus Optical Co., Ltd. Apparatus for dielectric-heating living body by high-frequency current and apparatus therefor
FR2679456A1 (en) 1991-07-26 1993-01-29 Technomed Int Sa Apparatus for in situ thermotherapy treatment of the mucous membrane of the uterine cavity
US5191883A (en) 1988-10-28 1993-03-09 Prutech Research And Development Partnership Ii Device for heating tissue in a patient's body
US5195965A (en) 1991-03-07 1993-03-23 Shantha Totada R Method and apparatus for localized treatment of human viral infections and cancers
US5220927A (en) 1988-07-28 1993-06-22 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
US5249585A (en) 1988-07-28 1993-10-05 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
US5257977A (en) 1990-03-22 1993-11-02 Argomed Ltd. Technique for localized thermal treatment of mammals
US5292321A (en) * 1990-06-08 1994-03-08 Lee Benjamin I Thermal balloon angioplasty with thermoplastic stent
US5292320A (en) * 1992-07-06 1994-03-08 Ceramoptec, Inc. Radial medical laser delivery device
US5301687A (en) 1991-06-06 1994-04-12 Trustees Of Dartmouth College Microwave applicator for transurethral hyperthermia
US5330518A (en) * 1992-03-06 1994-07-19 Urologix, Inc. Method for treating interstitial tissue associated with microwave thermal therapy
US5336222A (en) * 1993-03-29 1994-08-09 Boston Scientific Corporation Integrated catheter for diverse in situ tissue therapy
US5344435A (en) 1988-07-28 1994-09-06 Bsd Medical Corporation Urethral inserted applicator prostate hyperthermia
US5403311A (en) * 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
US5472441A (en) 1993-11-08 1995-12-05 Zomed International Device for treating cancer and non-malignant tumors and methods
US5505730A (en) * 1994-06-24 1996-04-09 Stuart D. Edwards Thin layer ablation apparatus
US5599346A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment system
US5697927A (en) 1992-12-01 1997-12-16 Cardiac Pathways Corporation Catheter for RF ablation with cooled electrode and apparatus for use therewith

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0241971B2 (en) 1983-12-01 1990-09-20
JPS6294152A (en) 1985-10-18 1987-04-30 Olympus Optical Co Medical heat treatment apparatus

Patent Citations (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154246A (en) 1977-07-25 1979-05-15 Leveen Harry H Field intensification in radio frequency thermotherapy
DE2848636A1 (en) 1978-11-09 1980-05-22 Mark Cavity scavenging device for cancer hyperthermia treatment - has inlet and outlet channels coupled to external scavenging liq. circuit contg. pump, thermostat and heater
GB2045620A (en) 1979-03-23 1980-11-05 Rca Corp Coaxial applicator for hyperthermic treatment of the body
US4375220A (en) 1980-05-09 1983-03-01 Matvias Fredrick M Microwave applicator with cooling mechanism for intracavitary treatment of cancer
US4662383A (en) 1982-09-27 1987-05-05 Kureha Kagaku Kogyo Kabushiki Kaisha Endotract antenna device for hyperthermia
EP0115420A2 (en) 1983-01-24 1984-08-08 Kureha Kagaku Kogyo Kabushiki Kaisha A device for hyperthermia
US4776334A (en) 1985-03-22 1988-10-11 Stanford University Catheter for treatment of tumors
DE3707921A1 (en) 1986-03-12 1987-09-17 Olympus Optical Co Medical treatment device
US4813429A (en) 1986-05-12 1989-03-21 Biodan Medical Systems Ltd. Catheter and probe
FR2600205A1 (en) 1986-06-14 1987-12-18 Strahlen Umweltforsch Gmbh Apparatus for measuring and irradiating cavities
US5168880A (en) 1986-07-17 1992-12-08 Olympus Optical Co., Ltd. Apparatus for dielectric-heating living body by high-frequency current and apparatus therefor
EP0321614A1 (en) 1987-12-21 1989-06-28 Reynaldo Calderon Systems for retrograde perfusion in the body for curing it of a disease or immune deficiency
US5000734A (en) 1988-02-01 1991-03-19 Georges Boussignac Probe intended to be introduced within a living body
US4924863A (en) 1988-05-04 1990-05-15 Mmtc, Inc. Angioplastic method for removing plaque from a vas
WO1989011311A1 (en) 1988-05-18 1989-11-30 Kasevich Associates, Inc. Microwave balloon angioplasty
US5220927A (en) 1988-07-28 1993-06-22 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
US4967765A (en) 1988-07-28 1990-11-06 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
US5249585A (en) 1988-07-28 1993-10-05 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
US5344435A (en) 1988-07-28 1994-09-06 Bsd Medical Corporation Urethral inserted applicator prostate hyperthermia
WO1990003152A1 (en) 1988-09-24 1990-04-05 John Considine Electro-surgical apparatus for removing tumours from hollow organs of the body
US5191883A (en) 1988-10-28 1993-03-09 Prutech Research And Development Partnership Ii Device for heating tissue in a patient's body
EP0368161A2 (en) 1988-11-07 1990-05-16 Omron Tateisi Electronics Co. Electrode structure for high frequency hyperthermia device
US5150717A (en) * 1988-11-10 1992-09-29 Arye Rosen Microwave aided balloon angioplasty with guide filament
EP0370890A1 (en) 1988-11-21 1990-05-30 Technomed Medical Systems Apparatus for the surgical treatment of tissues by hyperthermia, preferably the prostate, equipped with heat protection means preferably comprising means forming radioreflecting screen
US5090958A (en) 1988-11-23 1992-02-25 Harvinder Sahota Balloon catheters
US4979948A (en) 1989-04-13 1990-12-25 Purdue Research Foundation Method and apparatus for thermally destroying a layer of an organ
US5114423A (en) 1989-05-15 1992-05-19 Advanced Cardiovascular Systems, Inc. Dilatation catheter assembly with heated balloon
US5007437A (en) 1989-06-16 1991-04-16 Mmtc, Inc. Catheters for treating prostate disease
US5084044A (en) * 1989-07-14 1992-01-28 Ciron Corporation Apparatus for endometrial ablation and method of using same
US5257977A (en) 1990-03-22 1993-11-02 Argomed Ltd. Technique for localized thermal treatment of mammals
US5292321A (en) * 1990-06-08 1994-03-08 Lee Benjamin I Thermal balloon angioplasty with thermoplastic stent
US5103804A (en) 1990-07-03 1992-04-14 Boston Scientific Corporation Expandable tip hemostatic probes and the like
US5195965A (en) 1991-03-07 1993-03-23 Shantha Totada R Method and apparatus for localized treatment of human viral infections and cancers
US5301687A (en) 1991-06-06 1994-04-12 Trustees Of Dartmouth College Microwave applicator for transurethral hyperthermia
FR2679456A1 (en) 1991-07-26 1993-01-29 Technomed Int Sa Apparatus for in situ thermotherapy treatment of the mucous membrane of the uterine cavity
US5330518A (en) * 1992-03-06 1994-07-19 Urologix, Inc. Method for treating interstitial tissue associated with microwave thermal therapy
US5292320A (en) * 1992-07-06 1994-03-08 Ceramoptec, Inc. Radial medical laser delivery device
US5697927A (en) 1992-12-01 1997-12-16 Cardiac Pathways Corporation Catheter for RF ablation with cooled electrode and apparatus for use therewith
US5336222A (en) * 1993-03-29 1994-08-09 Boston Scientific Corporation Integrated catheter for diverse in situ tissue therapy
US5403311A (en) * 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
US5472441A (en) 1993-11-08 1995-12-05 Zomed International Device for treating cancer and non-malignant tumors and methods
US5599346A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment system
US5599345A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment apparatus
US5505730A (en) * 1994-06-24 1996-04-09 Stuart D. Edwards Thin layer ablation apparatus

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
L. Da Pozzo et al., "Intravesical Microwave-induced Hyperthermia and Mitomycin C for Selected Multifocal Unresectable Superficial Bladder Tumors," Poster presented at the XIIth Congress of The European Association of Urology, Paris, Sep. 1-4, 1996.
R. Colombo et al., "A New Approach Using Local Combined Microwave Hyperthermia and Chemotherapy in Superficial Transitional Bladder Carcinoma Treatment," J. Urology, vol. 153, pp. 959-963, (Mar. 1995).
R. Colombo et al., "Neoadjuvant Combined Microwave Induced Local Hyperthermia and Topical Chemotherapy Versus Chemotherapy Alone for Superficial Bladder Cancer," J. Urology, vol. 155, No. 4, pp. 1227-1232, (Apr. 1996).
Z. Leib et al., "Mitomycin C (MMC) vs. MMC Combined with Local Microwave Hyperthermia (LMWH) as Prophylaxis of Recurrence of Superficial Transitional Bladder Cancer: A Preliminary Report," Poster presented at The XIIth Congress of The European Association of Urology, Paris, Sep. 1-4, 1996.

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110028886A1 (en) * 2000-06-20 2011-02-03 Boston Scientific Corporation Catheter
US20030229384A1 (en) * 2000-06-20 2003-12-11 Celsion Corporation Method and apparatus for treatment of tissue adjacent a bodily conduit with a compression balloon
US8221414B2 (en) 2000-06-20 2012-07-17 Boston Scientific Corporation Catheter
US7837720B2 (en) 2000-06-20 2010-11-23 Boston Scientific Corporation Apparatus for treatment of tissue adjacent a bodily conduit with a gene or drug-coated compression balloon
US20070112342A1 (en) * 2001-05-10 2007-05-17 Rita Medical Systems, Inc. Tissue ablation apparatus and method
US6958075B2 (en) 2001-09-18 2005-10-25 Celsion Corporation Device and method for treatment of tissue adjacent a bodily conduit by thermocompression
US7811313B2 (en) 2001-09-18 2010-10-12 Boston Scientific Corporation Device for treatment of tissue adjacent a bodily conduit by thermocompression
US8221413B2 (en) 2001-09-18 2012-07-17 Boston Scientific Corporation Device and method for treatment of tissue adjacent a bodily conduit by thermocompression
US20100298913A1 (en) * 2001-09-18 2010-11-25 Boston Scientific Corporation Device and method for treatment of tissue adjacent a bodily conduit by thermocompression
US20110034976A1 (en) * 2002-02-15 2011-02-10 John Mon Drug delivery
US8224455B2 (en) 2002-02-15 2012-07-17 Boston Scientific Corporation Drug delivery
US8374702B2 (en) 2002-02-15 2013-02-12 Medifocus, Inc. Drug delivery
US7753907B2 (en) 2004-10-29 2010-07-13 Boston Scientific Scimed, Inc. Medical device systems and methods
US20050070888A1 (en) * 2004-10-29 2005-03-31 Boston Scientific Corporation Medical device systems and methods

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US5431648A (en) 1995-07-11

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