US9480806B2 - Laryngeal mask airway device with drug delivery means - Google Patents

Laryngeal mask airway device with drug delivery means Download PDF

Info

Publication number
US9480806B2
US9480806B2 US12518776 US51877607A US9480806B2 US 9480806 B2 US9480806 B2 US 9480806B2 US 12518776 US12518776 US 12518776 US 51877607 A US51877607 A US 51877607A US 9480806 B2 US9480806 B2 US 9480806B2
Authority
US
Grant status
Grant
Patent type
Prior art keywords
airway
device
tube
conduit
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US12518776
Other versions
US20100089393A1 (en )
Inventor
Archibald I. J. Brain
Massimo Micaglio
Daniele Trevisanuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teleflex Life Sciences Unlimited Co
Original Assignee
Laryngeal Mask Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0402Special features for tracheal tubes not otherwise provided for
    • A61M16/0409Special features for tracheal tubes not otherwise provided for with mean for closing the oesophagus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0402Special features for tracheal tubes not otherwise provided for
    • A61M16/0415Special features for tracheal tubes not otherwise provided for with access means to the stomach
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0402Special features for tracheal tubes not otherwise provided for
    • A61M16/0431Special features for tracheal tubes not otherwise provided for with a cross-sectional shape other than circular
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0434Cuffs
    • A61M16/0445Special cuff forms, e.g. undulated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0475Tracheal tubes having openings in the tube
    • A61M16/0477Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids
    • A61M16/0484Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids at the distal end

Abstract

The invention relates to a laryngeal mask airway device to facilitate lung ventilation in a patient, comprising an airway tube extending from a proximal end to a distal end and opening, at the distal end, into the interior of a hollow mask portion shaped to fit readily in use into the actual and potential space behind the larynx and to seal around the circumference of the laryngeal inlet without penetrating into the interior of the larynx, wherein the device comprises a conduit adapted to direct a liquid substance through the glottic opening. The invention further relates to a kit comprising the laryngeal mask airway device and a method for using the laryngeal mask airway device.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of priority of International Application No. PCT/GB2007/004788, filed on Dec. 14, 2007, which claims the benefit of priority of United Kingdom patent application 0624981.7, filed on Dec. 14, 2006, the disclosure of which are hereby incorporated by reference in their entirety.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The invention relates to a laryngeal mask airway device with drug delivery means. More specifically, the invention relates to a paediatric laryngeal mask airway device with a liquid drug delivery means.

2. Description of Related Art Including Information Disclosed Under 37 C.F.R. 1.97 and 1.98

The laryngeal mask airway device is a well-known device that is useful for establishing airways in unconscious patients. U.S. Pat. No. 4,509,514 is one of the many publications that describe laryngeal mask airway devices. Such devices have been in use for many years and offer an alternative to the older, even better known, endotracheal tube. For at least seventy years, endotracheal tubes comprising a long slender tube with an inflatable balloon disposed at the tube's distal end have been used for establishing airways in unconscious patients. In operation, the endotracheal tube's distal end is inserted through the mouth of the patient, past the patient's laryngeal inlet (or glottic opening), and into the patient's trachea. Once so positioned, the balloon is inflated so as to form a seal with the interior lining of the trachea. After this seal is established, positive pressure may be applied to the tube's proximal end to ventilate the patient's lungs. Also, the seal between the balloon and the inner lining of the trachea protects the lungs from aspiration (e.g., the seal prevents material regurgitated from the stomach from being aspirated into the patient's lungs).

Although they have been enormously successful, endotracheal tubes suffer from several major disadvantages. The principal disadvantage of the endotracheal tube relates to the difficulty of properly inserting the tube. Inserting an endotracheal tube into a patient is a procedure that requires a high degree of skill, even more so when the patient is a child or and infant. Also, even for skilled practitioners, insertion of an endotracheal tube is sometimes difficult or not possible. Also, inserting an endotracheal tube normally requires manipulations of the patient's head and neck and further requires the patient's jaw to be forcibly opened widely. These necessary manipulations make it difficult, or undesirable, to insert an endotracheal tube into a patient who may be suffering from a neck injury.

In contrast to the endotracheal tube, it is relatively easy to insert a laryngeal mask airway device into a patient and thereby establish an airway. Also, the laryngeal mask airway device is a “forgiving” device in that even if it is inserted improperly, it still tends to establish an airway. Also, the laryngeal mask airway device may be inserted with only relatively minor manipulations of the patient's head, neck, and jaw. Further, the laryngeal mask airway device provides for ventilation of the patient's lungs without requiring contact with the sensitive inner lining of the trachea and the size of the airway established is typically significantly larger than the size of the airway established with an endotracheal tube. Also, the laryngeal mask airway device does not interfere with coughing to the same extent as endotracheal tubes. Largely due to these advantages, the laryngeal mask airway device has enjoyed increasing popularity in recent years.

In the case of respiratory diseases, it is sometimes necessary to deliver drug directly into the lungs. Respiratory Distress Syndrome (RDS) is an example of such a disease, in which the patient has a deficiency in pulmonary surfactant. Pulmonary surfactant is a substance naturally found in the lungs, which reduces alveolar collapse by decreasing surface tension in the alveoli. This condition affects more particularly newborns and is a major cause of mortality in premature infants. It has been observed that the more premature the infant, the less pulmonary surfactant production because of lung immaturity and the higher the probability for RDS.

Respiratory failure may be avoided by administrating an exogeneous surfactant, which may be naturally or synthetically obtained, directly into the pulmonary system. This can for example be achieved by intubating the trachea but this method presents obvious disadvantages for the patient.

Attempts have been made to inject exogeneous surfactant through an endotracheal tube. However, due to the difficulty of properly inserting and positioning the tube, the substance is not properly administered to the lungs. It has to be pointed out that a major issue with this treatment is its considerable expense and any loss of exogeneous surfactant by improper administration should be avoided. Improper administration of exogeneous surfactant may also be harmful to the patient, in particular when the patient is a premature infant. Indeed, if the surfactant is splashed against the vocal cords, it might trigger a laryngeal spasm, which is likely to provoke the cords into closing. There is therefore the need for a device, which delivers liquid drugs, such as exogeneous surfactant, safely and efficiently to the pulmonary system, with minimum loss of drug.

BRIEF SUMMARY OF THE INVENTION

It is an object of this invention to mitigate problems such as those described above.

According to a first aspect of the invention, there is provided a laryngeal mask airway device to facilitate lung ventilation in a patient, comprising an airway tube extending from a proximal end to a distal end and opening, at the distal end, into the interior of a hollow mask portion shaped to fit readily in use into the actual and potential space behind the larynx and to seal around the circumference of the laryngeal inlet without penetrating into the interior of the larynx, wherein the device comprises a conduit adapted to direct a liquid substance through the glottic opening.

According to an embodiment, the conduit has an opening adapted to direct the liquid substance through the glottic opening, without the liquid substance contacting the patient's vocal chords.

The opening may have a cross section, the dimensions of which are similar to those of the glottis opening. Preferably, the opening has a generally triangular cross-section.

The opening may comprise a nozzle with a cross section, the dimensions of which are similar to those of the glottis opening. Preferably, the nozzle has a generally triangular cross-section.

According to another embodiment, the conduit is at least partially attached to the airway tube.

The airway tube comprises an inner and an outer surface and the conduit may be at least partially attached to the inner or outer surface. Preferably, the conduit is at least partially embedded within the airway tube. The conduit may be integrally molded with the airway tube.

According to a further embodiment, the airway tube comprises a channel adapted to receive the conduit and the channel is at least partially attached to the airway tube.

The airway tube comprises an inner and an outer surface and the channel may be at least partially attached to the inner or outer surface. Preferably, the channel is at least partially embedded within the airway tube. The channel may be integrally molded with the airway tube.

The airway tube has a pharyngeal or dorsal side and the conduit is preferably located on the dorsal side of the tube.

According to a further embodiment, the conduit is in fluid communication with a liquid delivery means at the proximal end thereof.

According to a second aspect of the invention, there is provided a kit comprising a laryngeal mask airway device as described above and a liquid delivery means for fluid delivery into the conduit.

According to a third aspect of the invention, there is provided, a method for delivering a liquid substance through a patient's glottic opening, without the liquid substance contacting the patient's vocal chords, comprising the step of inserting a laryngeal mask airway device as described above into the patient's airway; connecting a liquid delivery means to the proximal end of the at least one conduit; and dispensing liquid into the conduit.

BRIEF DESCRIPTION OF THE DRAWINGS

The invention will further be described by way of example and with reference to the following drawings, in which:

FIG. 1 shows the device in position for use in a patient;

FIG. 2 shows the larynx of a patient;

FIG. 3 is a ventral view of a device according to the invention;

FIG. 4 is a dorsal view of the device of FIG. 3;

FIG. 5 is a right-side view of the device of FIG. 3;

FIG. 6 is a dorsal three-quarter perspective view of the device of FIG. 3;

FIG. 7 is an end view, looking from the distal towards the proximal end of the mask of the device of FIG. 3;

FIG. 8 is a schematic side view of the device of FIG. 3;

FIG. 9 is a cross section of a conduit for use in a device according to the invention;

FIG. 10A is a schematic view of a radial cross section of the airway tube and conduit of the device of FIG. 3;

FIG. 10B is a schematic view of a longitudinal cross section of the airway tube and conduit of the device of FIG. 10A;

FIG. 11A is a schematic view of a radial cross section of the airway tube and conduit of a device according to a second embodiment;

FIG. 11B is a schematic view of a longitudinal cross section of the airway tube and conduit of the device of FIG. 11A;

FIG. 12A is a schematic view of a radial cross section of the airway tube and conduit of a device according to a third embodiment;

FIG. 12B is a schematic view of a longitudinal cross section of the airway tube and conduit of the device of FIG. 12A;

FIG. 13A is a schematic view of a longitudinal cross section of the airway tube, channel and conduit according to a fourth embodiment;

FIG. 13B is a schematic view of a longitudinal cross section of the airway tube, channel and conduit according to a fifth embodiment; and

FIG. 13C is a schematic view of a longitudinal cross section of the airway tube, channel and conduit according to a sixth embodiment;

DETAILED DESCRIPTION OF THE INVENTION

Referring now to the drawings, there is illustrated a laryngeal mask airway device 1 to facilitate lung ventilation in a patient, comprising an airway tube 2 extending from a proximal end 3 to a distal end 4 and opening, at the distal end 4, into the interior of a hollow mask portion 5 shaped to fit readily in use into the actual and potential space behind the larynx and to seal around the circumference of the laryngeal inlet without penetrating into the interior of the larynx, wherein the device comprises a conduit 10 adapted to direct a liquid substance through the glottic opening.

By “liquid substance” is meant a substance essentially in a liquid or fluid state, and may therefore include substances in the form of emulsions, dispersions and the like.

As can be seen from the drawings, the device 1 in terms of overall appearance, is somewhat similar to prior art devices, in that it consists of the basic parts which make up most, if not all, laryngeal mask airway devices, i.e. an airway tube 2 and a mask portion 5 which usually includes a body part 6 and a cuff 7.

For the purposes of description, it is appropriate to assign reference names to areas of the device 1 and, accordingly, with reference to FIGS. 3 to 5, the device 1 has a dorsal or pharyngeal side 11, a ventral or laryngeal side 12, a proximal end 3 (in a sense that this is the end nearest the user rather than the patient), a distal end 4 and right and left sides 13 and 14.

The device illustrated in FIGS. 3 to 8 comprises an airway tube 2, which may be resiliently deformable or rigid, to enable it to assist in insertion of the device 1 into a patient, acting as a handle and a guide. The device may comprise a tube 2 made of, for example, silicone rubber material, moulded into an appropriately anatomically-curved shape. Alternatively, where the device is intended to be a re-usable device, the airway tube 2 and mask portion 5 may be made of a relatively rigid sterilisable material, e.g. of metal, shaped to conform and fit readily into the space behind the larynx and to seal around the laryngeal inlet.

The mask portion 5 generally consists of two parts, a body part 6, often referred to as a backplate, and an inflatable tubular peripheral cuff 7. The cuff 7 is capable of conforming to, and to readily fit within, the space behind the larynx to form a seal around the circumference of the laryngeal inlet without the device 1 penetrating into the interior of the larynx. Different sizes of mask are needed for different sizes of patient.

The device according to the invention comprises means for delivery of a liquid substance comprising at least one conduit 10 adapted to convey liquid from the proximal end 3 of the device to the outlet 8 of the mask portion 5.

As illustrated in FIGS. 10A and 10B, the conduit 10 may be bonded to the outer surface of the wall on the dorsal side 11 of the airway tube 2. The conduit 10 passes through and aperture in the wall of the dorsal side 11 of the airway tube 2 at the distal end of the tube and the conduit 10 ends with an opening 30 in the hollow outlet portion 8 of the mask portion 5. The conduit 10 may be bonded to the inner surface of the wall on the dorsal side 11 of the airway tube 2, as shown in FIGS. 12A and 12B, or may be partially embedded in the wall on the dorsal side of the airway tube 2, as shown in FIGS. 11A and 11B.

Alternatively, the conduit 10 may be inserted into a channel 15, which is bonded to the outer or inner side of the wall of the airway tube, or is embedded in the airway tube 2, preferably in the wall on the dorsal side 11 of the tube 2, as shown in FIGS. 13A, 13B and 13C. The channel 15 may have an aperture 16 at the proximal end of the tube 2 and an aperture 17 at the distal end of the tube 2, so that the conduit 10 ends in the outlet 8 of the mask 5.

The conduit 10 is advantageous in that it provides a built-in means of conveying the drug substance into the pulmonary system, without any further invasive procedure. Indeed, the use of a separate drug delivery means tube that a second invasive procedure is to be carried out on the patient, on top of the insertion of the laryngeal mask airway device. This also means that because of the presence of the laryngeal mask airway device, it may be difficult to install the drug delivery tube, accurately and without harming the patient, and an additional guiding device is often required. Moreover, the drug delivery tube could slide or rotate relative to the laryngeal airway device and cause damage to the patient's airway. Thus, a safe delivery of the liquid drug substance can be achieved using devices according to the invention.

Preferably, the outlet end of the conduit 10 is arranged so that, in use, the end of the conduit 10 is directed towards the centre of the glottic opening of the patient's airway. This arrangement permits injection of the drug substance through the glottis towards the lungs thereby minimising loss of liquid substance.

The outlet end of the conduit 10 has preferably a generally triangular cross section, as shown in FIG. 9. This may be achieved for example by adding a triangular nozzle at the end of the conduit 10. Alternatively, the inner diameter of the channel 15 may be of dimensions such that the conduit 10 is compressed and distorted into an essentially triangular shape. Also, the aperture 16, at the proximal end of the tube 2, may be laterally compressed, so that the aperture 16 is narrower than the outer diameter of the conduit 10. The resulting mechanical compression causes the conduit 10 to be distorted into a conduit with a generally triangular cross section.

The advantage of this triangular cross section is that the liquid substance emerges from the conduit 10 as a jet whose cross-sectional area forms a narrow triangle similar to the narrow triangle of the glottis itself. FIG. 2 is a diagram of the larynx 23 of a patient showing the epiglottis 19, the opening of glottic opening 24, the vocal chords 25 and the vocal fold 26. The bulk of the liquid passes through the glottis 24, without excessive splashing against the vocal cords 25, thereby minimising the risk of laryngeal spasm.

In use, the device 1 is inserted as shown in FIG. 1 through the patient's mouth 17 and down through the throat 18 past the epiglottis 19 until the mask 5 comes to rest with the distal end of the cuff 7 in the base 20 of the throat 18, lying against the upper end of the normally closed oesophagus 21 which the mask 5 cannot easily enter because of its dimensions. The outlet end of the conduit 10 is directed towards the centre of the glottic 24 opening. The cuff 7 is then inflated as shown to seal around the inlet 22 to the larynx 23.

Thus, when the device 1 is in position and the patient's airway is secure and unobstructed, the drug substance can safely and efficiently be administered to the patient's lungs using means of delivering, dispensing or injecting a drug substance, such as for example a syringe, in fluid communication with the distal end of the conduit 10.

Thus, it has been demonstrated that the invention provides a device, which allows the safe administration of a liquid drug substance to a patient, through the glottis to the pulmonary system, in such a way that drug loss is minimised.

Claims (17)

The invention claimed is:
1. A laryngeal mask airway device to facilitate lung ventilation in a patient, comprising an airway tube extending from a proximal end to a distal end and opening, at the distal end, into the interior of a hollow mask portion shaped to fit readily in use into the actual and potential space behind the larynx and to seal around the circumference of the laryngeal inlet without penetrating into the interior of the larynx, said mask portion comprising a backplate and an inflatable tubular peripheral cuff, wherein the device comprises a conduit at least partially attached to the airway tube and adapted to direct a liquid substance through a glottic opening, wherein the conduit ends with an opening in the hollow outlet portion of the mask portion, and wherein the conduit has an opening adapted to direct the liquid substance through the glottic opening, without the liquid substance contacting the patient's vocal cords.
2. The device according to claim 1, wherein the conduit has an opening adapted to direct the liquid substance through the glottic opening, without the liquid substance contacting the patient's vocal chords.
3. The device according to claim 2, wherein the opening has a cross section having dimensions similar to those of the glottic opening.
4. The device according to claim 2, wherein the opening has a generally triangular cross-section.
5. The device according to claim 2, wherein the opening comprises a nozzle with a cross section having dimensions similar to those of the glottic opening.
6. The device according to claim 5, wherein the nozzle has a generally triangular cross-section.
7. The device according to claim 1, wherein the airway tube comprises an inner and an outer surface and the conduit is at least partially attached to the inner or outer surface.
8. The device according to claim 1, wherein the conduit is at least partially embedded within the airway tube.
9. The device according to claim 1, wherein the conduit is integrally molded with the airway tube.
10. The device according to claim 1, wherein the airway tube comprises a channel adapted to receive the conduit and the channel is at least partially attached to the airway tube.
11. The device according to claim 10, wherein the airway tube comprises an inner and an outer surface and the channel is at least partially attached to the inner or outer surface.
12. The device according to claim 10, wherein the channel is at least partially embedded within the airway tube.
13. The device according to claim 10, wherein the channel is integrally molded with the airway tube.
14. The device according to claim 10, wherein the airway tube has a pharyngeal side or dorsal side and the conduit is located on the dorsal side of the tube.
15. The device according to claim 1, wherein the airway tube has a pharyngeal side or dorsal side and the conduit is located on the dorsal side of the tube.
16. A method for delivering a liquid substance through a patient's glottic opening, without the liquid substance contacting the patient's vocal chords, comprising the steps of:
inserting a laryngeal mask airway device into the patient's airway, wherein the laryngeal mask airway device comprises an airway tube extending from a proximal end to a distal end and opening, at the distal end, into the interior of a hollow mask portion shaped to fit readily in use into the actual and potential space behind the larynx and to seal around the circumference of the laryngeal inlet without penetrating into the interior of the larynx, said mask portion comprising a backplate and an inflatable tubular peripheral cuff, wherein the device comprises at least one conduit adapted to direct a liquid substance through the glottic opening, wherein the conduit ends with an opening in the hollow outlet portion of the mask portion, and wherein the conduit has an opening adapted to direct the liquid substance through the glottic opening, without the liquid substance contacting the patient's vocal cords;
delivering a liquid to the proximal end of the at least one conduit;
and dispensing the liquid into the at least one conduit.
17. The method according to claim 16, wherein the airway tube comprises a channel adapted to receive the conduit and the channel is at least partially attached to the airway tube.
US12518776 2006-12-14 2007-12-14 Laryngeal mask airway device with drug delivery means Active 2029-09-09 US9480806B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB0624981.7 2006-12-14
GB0624981A GB0624981D0 (en) 2006-12-14 2006-12-14 Laryngeal mask airway device with drug delivery means
PCT/GB2007/004788 WO2008071977A1 (en) 2006-12-14 2007-12-14 Laryngeal mask airway device with drug delivery means

Publications (2)

Publication Number Publication Date
US20100089393A1 true US20100089393A1 (en) 2010-04-15
US9480806B2 true US9480806B2 (en) 2016-11-01

Family

ID=37712150

Family Applications (1)

Application Number Title Priority Date Filing Date
US12518776 Active 2029-09-09 US9480806B2 (en) 2006-12-14 2007-12-14 Laryngeal mask airway device with drug delivery means

Country Status (6)

Country Link
US (1) US9480806B2 (en)
EP (1) EP2101854A1 (en)
JP (1) JP5572389B2 (en)
CN (1) CN101657227B (en)
GB (1) GB0624981D0 (en)
WO (1) WO2008071977A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0218868D0 (en) 2002-08-14 2002-09-25 Nasir Muhammed A Improved airway management device
GB0721300D0 (en) * 2007-10-30 2007-12-12 Laryngeal Mask Company The Ltd Laryngeal mask with tape tab
GB0810446D0 (en) 2008-06-06 2008-07-09 Laryngeal Mask Company The Ltd Laryngosocpe
EP2560719A4 (en) * 2010-02-27 2016-06-08 King Systems Corp Laryngeal tube
DE102010025045B4 (en) * 2010-06-22 2016-11-03 Frank Jochum Device for administration of surfactant
GB201010647D0 (en) 2010-06-24 2010-08-11 Docsinnovent Ltd Stopper device
GB201014773D0 (en) * 2010-09-06 2010-10-20 Laryngeal Mask Company The Ltd Laryngeal mask airway device
CN103221087B (en) 2010-10-15 2016-08-03 喉罩有限公司 Artificial airway device
GB201201438D0 (en) 2012-01-27 2012-03-14 Docsinnovent Ltd Improved stopper device
RU2632522C2 (en) * 2012-06-04 2017-10-05 Сингьюларити Аг Laryngeal mask with tube installed over glottis
USD761952S1 (en) 2012-07-27 2016-07-19 Docsinnovent Limited Airway device
US9409003B2 (en) 2012-12-07 2016-08-09 Cook Medical Technologies, LLC System for reducing local discomfort
WO2015059037A1 (en) * 2013-10-22 2015-04-30 Chiesi Farmaceutici S.P.A. Improved method and system for the administration of a pulmonary surfactant by atomization
KR20170140249A (en) * 2015-04-28 2017-12-20 키에시 파르마슈티시 엣스. 피. 에이. Device for facilitating the administration of drugs to the lung by catheter
WO2016173634A1 (en) 2015-04-28 2016-11-03 Chiesi Farmaceutici S.P.A Device for facilitating the administration of a medicament to the lung by a catheter
WO2017136470A1 (en) * 2016-02-01 2017-08-10 Ony Inc. System and method for delivering medicament
WO2018077623A1 (en) 2016-10-26 2018-05-03 Chiesi Farmaceutici S.P.A. Device for facilitating the administration of a medicament to the lung by a catheter

Citations (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2099127A (en) 1936-12-30 1937-11-16 Foregger Co Inc Pharyngeal bulb gasway
US4056104A (en) * 1976-01-15 1977-11-01 Burton Jaffe Endotracheal tube
GB1529190A (en) 1977-09-06 1978-10-18 Jaffe B Endotracheal tube
US4231365A (en) * 1978-01-30 1980-11-04 Scarberry Eugene N Emergency resuscitation apparatus
US4327720A (en) * 1979-01-22 1982-05-04 Bronson Paul A Esophageal-endotracheal airway
US4453545A (en) * 1981-05-07 1984-06-12 Hiroshi Inoue Endotracheal tube with movable endobronchial blocker for one-lung anesthesia
US4509514A (en) * 1981-12-16 1985-04-09 Brain Archibald Ian Jeremy Artificial airway device
US4693243A (en) * 1983-01-14 1987-09-15 Buras Sharon Y Conduit system for directly administering topical anaesthesia to blocked laryngeal-tracheal areas
US4977894A (en) * 1987-03-30 1990-12-18 Sheridan Catheter Corporation Laryngo-tracheal analgesia endotracheal tube
EP0294200B1 (en) 1987-06-05 1992-04-15 Archibald Ian Jeremy Dr. Brain Artificial airway device
US5174283A (en) 1989-11-08 1992-12-29 Parker Jeffrey D Blind orolaryngeal and oroesophageal guiding and aiming device
WO1994002191A1 (en) 1992-07-23 1994-02-03 Archibald Ian Jeremy Brain Laryngeal mask airway with concentric drainage of oesophagus discharge
US5297547A (en) 1992-07-30 1994-03-29 Brain Archibald Ian Jeremy Laryngeal mask construction
US5303697A (en) 1991-02-11 1994-04-19 Brain Archibald Ian Jeremy Artificial airway device
US5305743A (en) 1992-03-05 1994-04-26 Brain Archibald Ian Jeremy Artificial airway device
US5355879A (en) 1992-09-28 1994-10-18 Brain Archibald Ian Jeremy Laryngeal-mask construction
US5438982A (en) * 1992-03-10 1995-08-08 Macintyre; Neil R. Endotracheal tube adapted for aerosol generation at distal end thereof
US5443063A (en) 1993-08-31 1995-08-22 The Johns Hopkins University Cuffed oro-pharyngeal airway
WO1995033506A1 (en) 1994-06-04 1995-12-14 Archibald Ian Jeremy Brain A fibreoptic intubating laryngeal mask airway
US5477851A (en) * 1995-01-26 1995-12-26 Callaghan; Eric B. Laryngeal mask assembly and method for removing same
EP0712638A1 (en) 1994-05-31 1996-05-22 Mallinckrodt Medical, Inc. Airway for pharyngeal cavity
DE4447186A1 (en) 1994-12-30 1996-07-11 Johann Dr Med Wittenbeck Larynx mask for fibre optic endotracheal intubation with simultaneous artificial respiration
EP0732116A2 (en) 1995-03-14 1996-09-18 Smiths Industries Public Limited Company Laryngeal mask airways
WO1997012640A1 (en) 1995-10-03 1997-04-10 Archibald Ian Jeremy Brain Artificial airway device
US5632271A (en) 1996-03-22 1997-05-27 Brain; Archibald I. J. Laryngeal mask with gastric-drainage feature
US5682880A (en) 1996-07-26 1997-11-04 Brain; Archibald Ian Jeremy Laryngeal-mask airway with guide element, stiffener, and fiberoptic access
US5711293A (en) 1994-01-12 1998-01-27 Brain; Archibald Ian Jeremy Forming tool for use with a laryngeal mask
GB2317830A (en) 1996-10-03 1998-04-08 Smiths Industries Plc Laryngeal mask assembly
WO1998016273A1 (en) 1996-10-16 1998-04-23 Augustine Medical, Inc. Laryngeal airway device
GB2318735A (en) 1996-11-02 1998-05-06 Smiths Industries Plc Laryngeal mask airway and manufacture thereof
GB2321854A (en) 1997-02-05 1998-08-12 Smiths Industries Plc Laryngeal mask
US5794617A (en) 1995-10-19 1998-08-18 Louis M. Gerson Co., Inc. Face mask and retainer
GB2324737A (en) 1997-05-03 1998-11-04 Smiths Industries Plc Laryngeal mask assembly
WO1998050096A1 (en) 1997-05-02 1998-11-12 Kamen Jack M Foam cuff for laryngeal mask airway
WO1999006093A1 (en) 1997-08-02 1999-02-11 Garry Hamilton Nimmo Apparatus for shaping a laryngeal mask
US5881726A (en) 1996-11-19 1999-03-16 Smiths Industries Public Limited Company Laryngeal mask airways and their manufacture
US5896858A (en) * 1995-10-03 1999-04-27 Brain; Archibald Ian Jeremy Endotracheal-tube guidance system with epiglottis-elevating feature
EP0922465A2 (en) 1997-12-02 1999-06-16 Smiths Industries Public Limited Company Laryngeal mask assemblies
GB2334215A (en) 1998-02-17 1999-08-18 Smiths Industries Plc Laryngeal mask airways and their manufacture
US5983897A (en) 1997-03-18 1999-11-16 Smiths Industries Public Limited Company Laryngeal mask assemblies
US6012452A (en) 1997-10-16 2000-01-11 Smiths Industries Public Limited Company Laryngeal mask assemblies
WO2000009189A1 (en) 1998-08-13 2000-02-24 Archibald Ian Jeremy Brain Laryngeal mask airway device
US6079409A (en) * 1997-07-25 2000-06-27 Brain; Archibald Ian Jeremy Intubating laryngeal mask
WO2001024860A2 (en) 1999-10-07 2001-04-12 Archibald Ian Jeremy Brain Laryngeal mask with large-bore gastric drainage
US20020010417A1 (en) * 1999-12-24 2002-01-24 Volker Bertram Transpharyngeal tube
GB2371990A (en) 2000-12-22 2002-08-14 Smiths Group Plc Laryngeal Mask Assemblies
US20030000534A1 (en) * 1999-09-29 2003-01-02 Alfery David D. Perilaryngeal oral airway
US20030213492A1 (en) * 2002-05-16 2003-11-20 Alfery David D. Perilaryngeal oral airway with flexible tip guide
WO2004030527A1 (en) 2002-10-03 2004-04-15 Etview Ltd. Tube for inspecting internal organs of a body
US6766801B1 (en) * 2003-05-05 2004-07-27 Medical Device Group, Inc. Intra-tracheal aerosol delivery system and method of using same
WO2004089453A2 (en) 2003-04-11 2004-10-21 Ambu A/S A laryngeal mask and a method manufacturing same
US20050139220A1 (en) * 1996-02-26 2005-06-30 Evergreen Medical Incorporated Method and apparatus for ventilation / oxygenation during guided insertion of an endotracheal tube
US7156100B1 (en) 1998-10-06 2007-01-02 The Laryngeal Mask Company Ltd. Laryngeal mask airway device
US20070017527A1 (en) * 2005-07-25 2007-01-25 Totz Kenneth A Device and method for placing within a patient an enteral tube after endotracheal intubation
US20070240722A1 (en) * 2006-04-06 2007-10-18 Kessler Joel D Combination laryngeal mask airway with dual blocking and fluid removal features and method
US20080283052A1 (en) * 2004-05-27 2008-11-20 Young Peter J Artificial Airway Apparatus
US7900632B2 (en) * 2006-08-18 2011-03-08 Cookgas, L.L.C. Laryngeal mask with esophageal blocker and bite block

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5060647A (en) * 1989-02-23 1991-10-29 Alessi David M Endotrachael tube
GB8906570D0 (en) 1989-03-22 1989-05-04 Brain Archibald Ian Jeremy Artificial airway device
US5791341A (en) * 1995-12-19 1998-08-11 Bullard; James Roger Oropharyngeal stent with laryngeal aditus shield and nasal airway with laryngeal aditus shield
EP1409055A4 (en) * 2000-11-20 2009-09-09 Evergreen Medical Inc Laryngeal mask airway
US5623921A (en) * 1996-04-10 1997-04-29 Kinsinger; J. William Laryngeal mask airway and method for its use
JP2000152995A (en) * 1998-11-19 2000-06-06 Keishichiro Moroi Thin artificial air duct device
US7883032B2 (en) * 2000-04-03 2011-02-08 Battelle Memorial Institute Devices and formulations
US7128071B2 (en) * 2003-09-10 2006-10-31 Indian Ocean Medical Inc. Intubating laryngeal mask airway device with fiber optic assembly
WO2006026237A1 (en) * 2004-05-20 2006-03-09 Discovery Laboratories, Inc. Methods, systems and devices for noninvasive pulmonary delivery
US20060254594A1 (en) * 2005-05-12 2006-11-16 Edward Gologorsky Laryngeal mask airway

Patent Citations (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2099127A (en) 1936-12-30 1937-11-16 Foregger Co Inc Pharyngeal bulb gasway
US4056104A (en) * 1976-01-15 1977-11-01 Burton Jaffe Endotracheal tube
GB1529190A (en) 1977-09-06 1978-10-18 Jaffe B Endotracheal tube
US4231365A (en) * 1978-01-30 1980-11-04 Scarberry Eugene N Emergency resuscitation apparatus
US4327720A (en) * 1979-01-22 1982-05-04 Bronson Paul A Esophageal-endotracheal airway
US4453545A (en) * 1981-05-07 1984-06-12 Hiroshi Inoue Endotracheal tube with movable endobronchial blocker for one-lung anesthesia
US4509514A (en) * 1981-12-16 1985-04-09 Brain Archibald Ian Jeremy Artificial airway device
US4693243A (en) * 1983-01-14 1987-09-15 Buras Sharon Y Conduit system for directly administering topical anaesthesia to blocked laryngeal-tracheal areas
US4977894A (en) * 1987-03-30 1990-12-18 Sheridan Catheter Corporation Laryngo-tracheal analgesia endotracheal tube
EP0294200B1 (en) 1987-06-05 1992-04-15 Archibald Ian Jeremy Dr. Brain Artificial airway device
US5174283A (en) 1989-11-08 1992-12-29 Parker Jeffrey D Blind orolaryngeal and oroesophageal guiding and aiming device
US5303697A (en) 1991-02-11 1994-04-19 Brain Archibald Ian Jeremy Artificial airway device
US5305743A (en) 1992-03-05 1994-04-26 Brain Archibald Ian Jeremy Artificial airway device
US5438982A (en) * 1992-03-10 1995-08-08 Macintyre; Neil R. Endotracheal tube adapted for aerosol generation at distal end thereof
WO1994002191A1 (en) 1992-07-23 1994-02-03 Archibald Ian Jeremy Brain Laryngeal mask airway with concentric drainage of oesophagus discharge
US5297547A (en) 1992-07-30 1994-03-29 Brain Archibald Ian Jeremy Laryngeal mask construction
US5355879A (en) 1992-09-28 1994-10-18 Brain Archibald Ian Jeremy Laryngeal-mask construction
US5443063A (en) 1993-08-31 1995-08-22 The Johns Hopkins University Cuffed oro-pharyngeal airway
US5711293A (en) 1994-01-12 1998-01-27 Brain; Archibald Ian Jeremy Forming tool for use with a laryngeal mask
EP0712638A1 (en) 1994-05-31 1996-05-22 Mallinckrodt Medical, Inc. Airway for pharyngeal cavity
WO1995033506A1 (en) 1994-06-04 1995-12-14 Archibald Ian Jeremy Brain A fibreoptic intubating laryngeal mask airway
DE4447186A1 (en) 1994-12-30 1996-07-11 Johann Dr Med Wittenbeck Larynx mask for fibre optic endotracheal intubation with simultaneous artificial respiration
US5477851A (en) * 1995-01-26 1995-12-26 Callaghan; Eric B. Laryngeal mask assembly and method for removing same
EP0732116A2 (en) 1995-03-14 1996-09-18 Smiths Industries Public Limited Company Laryngeal mask airways
WO1997012640A1 (en) 1995-10-03 1997-04-10 Archibald Ian Jeremy Brain Artificial airway device
US5896858A (en) * 1995-10-03 1999-04-27 Brain; Archibald Ian Jeremy Endotracheal-tube guidance system with epiglottis-elevating feature
US5794617A (en) 1995-10-19 1998-08-18 Louis M. Gerson Co., Inc. Face mask and retainer
US20050139220A1 (en) * 1996-02-26 2005-06-30 Evergreen Medical Incorporated Method and apparatus for ventilation / oxygenation during guided insertion of an endotracheal tube
US5632271A (en) 1996-03-22 1997-05-27 Brain; Archibald I. J. Laryngeal mask with gastric-drainage feature
US5682880A (en) 1996-07-26 1997-11-04 Brain; Archibald Ian Jeremy Laryngeal-mask airway with guide element, stiffener, and fiberoptic access
GB2317830A (en) 1996-10-03 1998-04-08 Smiths Industries Plc Laryngeal mask assembly
WO1998016273A1 (en) 1996-10-16 1998-04-23 Augustine Medical, Inc. Laryngeal airway device
US6070581A (en) * 1996-10-16 2000-06-06 Augustine Medical, Inc. Laryngeal airway device
GB2318735A (en) 1996-11-02 1998-05-06 Smiths Industries Plc Laryngeal mask airway and manufacture thereof
US5881726A (en) 1996-11-19 1999-03-16 Smiths Industries Public Limited Company Laryngeal mask airways and their manufacture
GB2321854A (en) 1997-02-05 1998-08-12 Smiths Industries Plc Laryngeal mask
US5983897A (en) 1997-03-18 1999-11-16 Smiths Industries Public Limited Company Laryngeal mask assemblies
WO1998050096A1 (en) 1997-05-02 1998-11-12 Kamen Jack M Foam cuff for laryngeal mask airway
GB2324737A (en) 1997-05-03 1998-11-04 Smiths Industries Plc Laryngeal mask assembly
US6079409A (en) * 1997-07-25 2000-06-27 Brain; Archibald Ian Jeremy Intubating laryngeal mask
WO1999006093A1 (en) 1997-08-02 1999-02-11 Garry Hamilton Nimmo Apparatus for shaping a laryngeal mask
US6012452A (en) 1997-10-16 2000-01-11 Smiths Industries Public Limited Company Laryngeal mask assemblies
EP0922465A2 (en) 1997-12-02 1999-06-16 Smiths Industries Public Limited Company Laryngeal mask assemblies
GB2334215A (en) 1998-02-17 1999-08-18 Smiths Industries Plc Laryngeal mask airways and their manufacture
WO2000009189A1 (en) 1998-08-13 2000-02-24 Archibald Ian Jeremy Brain Laryngeal mask airway device
US7156100B1 (en) 1998-10-06 2007-01-02 The Laryngeal Mask Company Ltd. Laryngeal mask airway device
US20030000534A1 (en) * 1999-09-29 2003-01-02 Alfery David D. Perilaryngeal oral airway
WO2001024860A2 (en) 1999-10-07 2001-04-12 Archibald Ian Jeremy Brain Laryngeal mask with large-bore gastric drainage
US20020010417A1 (en) * 1999-12-24 2002-01-24 Volker Bertram Transpharyngeal tube
GB2371990A (en) 2000-12-22 2002-08-14 Smiths Group Plc Laryngeal Mask Assemblies
US20030213492A1 (en) * 2002-05-16 2003-11-20 Alfery David D. Perilaryngeal oral airway with flexible tip guide
WO2004030527A1 (en) 2002-10-03 2004-04-15 Etview Ltd. Tube for inspecting internal organs of a body
WO2004089453A2 (en) 2003-04-11 2004-10-21 Ambu A/S A laryngeal mask and a method manufacturing same
US6766801B1 (en) * 2003-05-05 2004-07-27 Medical Device Group, Inc. Intra-tracheal aerosol delivery system and method of using same
US20080283052A1 (en) * 2004-05-27 2008-11-20 Young Peter J Artificial Airway Apparatus
US20070017527A1 (en) * 2005-07-25 2007-01-25 Totz Kenneth A Device and method for placing within a patient an enteral tube after endotracheal intubation
US20070240722A1 (en) * 2006-04-06 2007-10-18 Kessler Joel D Combination laryngeal mask airway with dual blocking and fluid removal features and method
US7900632B2 (en) * 2006-08-18 2011-03-08 Cookgas, L.L.C. Laryngeal mask with esophageal blocker and bite block

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
Benumof, J.L., "The Glottic Aperture Seal Airway a New Ventilatory Device", Anesthesiology, 88:1219-1226, 1998 (8 pages).
Brain, A.I.J., et al., "A new laryngeal mask prototype," Anaesthesia, 1995, vol. 50, pp. 42-48.
Brimacombe, J.R., "Chapter 3: Anatomy", Laryngeal Mask Anesthesia: Principles and Practice, Second Edition, Saunders, Philadelphia, PA, pp. 73-101, 2005 (32 pages).
Brimacombe, Laryngeal Mask Anesthesia: Principles and Practice, Second Edition, Saunders, Philadelphia, 2005 (684 pages in 3 parts).
International Search Report and Written Opinion issued by the European Patent Office for International Application No. PCT/GB2007/004788 mailed May 8, 2008 (11 pgs.).
International Standard Controlled; "Anaesthetic and Respiratory Equipment-Supralaryngeal Airways and Connectors", ISO 11712, First Edition, May 15, 2009 (36 pages).
Ishimura, H. et al., "Impossible Insertion of the Laryngeal Mask Airway and Oropharyngeal Axes", Anesthesiology, 83:867-869, 1995 (3 pages).
Mcintyre, J.W.R., "History of Anaesthesia: Oropharyngeal and nasopharyngeal airways: I (1880-1995)", Canadian Journal of Anaesthesia, 43(6):629-635 (1996) (7 pages).
Miller, D.M., "A Proposed Classification and Scoring System for Supraglottic Sealing Airways: a Brief Review", Anesth Analg 99:1553-1559, 2004 (7 pages).
Verghese, C. et al., "Clinical assessment of the single use laryngeal mask airway-the LMA-Unique", British Journal of Anaesthesia, 80:677-679, 1998 (3 pages).

Also Published As

Publication number Publication date Type
WO2008071977A1 (en) 2008-06-19 application
GB2444779A (en) 2008-06-18 application
GB0624981D0 (en) 2007-01-24 grant
JP2010514464A (en) 2010-05-06 application
JP5572389B2 (en) 2014-08-13 grant
EP2101854A1 (en) 2009-09-23 application
CN101657227B (en) 2013-04-17 grant
CN101657227A (en) 2010-02-24 application
US20100089393A1 (en) 2010-04-15 application

Similar Documents

Publication Publication Date Title
Miller A proposed classification and scoring system for supraglottic sealing airways: a brief review
US5853004A (en) Pharyngeal bulb airway
US5303697A (en) Artificial airway device
US6079409A (en) Intubating laryngeal mask
US5937858A (en) Oro/nasopharyngeal airway for administering/sampling inhalent/expired gases
US5277178A (en) Medico-surgical device
US6390093B1 (en) Artificial airway device and method of its use
US5042469A (en) Tracheal intubation guide
US4700700A (en) Endotracheal tube
US6923176B2 (en) Resuscitation tube
US6792943B2 (en) Intubating ventilatory face mask
US6705320B1 (en) Methods for performing tracheal intubation on an animal and endotracheal tubes therefore
US20080011304A1 (en) Endotracheal tube with suction attachment
US4256099A (en) Two-tube resuscitation system
US4832020A (en) Tracheal intubation guide
US20060180156A1 (en) Laryngeal mask
Asai et al. The laryngeal tube
US7128071B2 (en) Intubating laryngeal mask airway device with fiber optic assembly
US20020108610A1 (en) Method and apparatus for endotracheal intubation using a light wand and curved guide
Hernandez et al. Evolution of the extraglottic airway: a review of its history, applications, and practical tips for success
US4338930A (en) Airway intubator
EP0389272A2 (en) Artifical airway device
US5791341A (en) Oropharyngeal stent with laryngeal aditus shield and nasal airway with laryngeal aditus shield
US7013899B2 (en) Perilaryngeal oral airway with multi-lumen esophogeal-obturator
US6729325B2 (en) Perilaryngeal oral airway

Legal Events

Date Code Title Description
AS Assignment

Owner name: THE LARYNGEAL MASK COMPANY LTD.,SEYCHELLES

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BRAIN, ARCHIBALD I. J.;REEL/FRAME:023732/0259

Effective date: 20091210

Owner name: THE LARYNGEAL MASK COMPANY LTD., SEYCHELLES

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BRAIN, ARCHIBALD I. J.;REEL/FRAME:023732/0259

Effective date: 20091210

AS Assignment

Owner name: THE LARYNGEAL MASK COMPANY LTD., SEYCHELLES

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MICAGLIO, MASSIMO;TREVISANUTO, DANIELE;SIGNING DATES FROM 20160527 TO 20160603;REEL/FRAME:039205/0906

AS Assignment

Owner name: TELEFLEX LIFE SCIENCES UNLIMITED COMPANY, BERMUDA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:THE LARYNGEAL MASK COMPANY LTD;REEL/FRAME:044232/0586

Effective date: 20161209